CN108743709A - The new application of the composition of preventing piglet diarrhea, the preparation method of composition and barley worm lipid extracts - Google Patents
The new application of the composition of preventing piglet diarrhea, the preparation method of composition and barley worm lipid extracts Download PDFInfo
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- CN108743709A CN108743709A CN201810969799.3A CN201810969799A CN108743709A CN 108743709 A CN108743709 A CN 108743709A CN 201810969799 A CN201810969799 A CN 201810969799A CN 108743709 A CN108743709 A CN 108743709A
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Abstract
The invention belongs to feed additive fields, disclose a kind of composition of preventing piglet diarrhea, including not less than the barley worm lipid extracts for being equivalent to composition total weight 10wt%；The advantage of the composition is that it is possible to effectively inhibit grice diarrhoea, improves the immunity of piglet.Meanwhile the invention also discloses the preparation method of the composition and the new applications of barley worm lipid extracts.
Description
Technical field
The present invention relates to animal feed additive field, especially a kind of composition of preventing piglet diarrhea, composition system
The new application of Preparation Method and barley worm lipid extracts.
Background technology
The method that CN201610865786.2 discloses a prevention piglet virus diarrhea, the application of vaccine, pig are infected
Property gastroenteritis, pig epidemic diarrhea bivalent inactivated vaccine：It is noted in Houhai acupoint (i.e. the alveole position of root of the tail and anus intermediate recess)
Penetrate, the depth of needle vaccinated by pig age size be 0.5-4 centimetres, 3 age in days piglets be 0.5 centimetre, with pig age increase then into
Needle depth increases, and pregnant sow vaccinates 4 milliliters in first 20~30 days in farrowing；Its newborn pig is injected after wean in 7 days
1 milliliter of vaccine；1 milliliter of 25 kilograms of weight or less piglet every；When finding to have virus diarrhea generation in piglet group, it should adopt rapidly
Anti-epidemic measure is taken, reinforces disinfection, first spray disinfectant agent is answered to vomitus and diarrhea object, is about rinsed again after half an hour, it is dirty
The apparatus of dye should also sterilize, and feed digestible feed to sick pig, drink clear water, to prevent secondary infection, to 1 week old son below more
Pig can suitably use antibiotic and other antibacterials, such as intramuscular injection Amoxicillin, kanamycins, amikacin, orfloxacin, to the state of an illness
More serious piglet, except in addition to above-mentioned medicine, the sick pig of individual serious dehydrations should carry out G/NS venous transfusion in time
Or intraperitoneal injection infusion should be infused immediately if diarrhea phenomenon occurs for milking sow, in order to avoid influence piglet；Usually carry out field
Interior disinfecting work, reinforces feeding management, is conducive to the generation for preventing and controlling communicable disease；At night it is noted that protecting
It is warm, door and window is shut, pig farm sanitation and hygiene are carried out in ventilation on daytime, and timing sterilization is fed for cleaning drinking-water, and reinforces feeding management, increases
It should gradually restore to be fed from less to more after adding the resistance of piglet, symptom of diarrhea to mitigate；Usually notice that feed nutrition is balanced, ensures
Each production phase nutritional need can effectively improve sow and piglet disease-resistant poison and bacterium ability, improve antibody content in breast milk,
Enhance piglet blood cycle, enhance piglet disease-resistant ability, occurs to effectively prevent piglet virus diarrhea.
The program has problems in that, needs to carry out the prevention of diarrhea by way of vaccinating, and operation is special
Expenditure is high, program is cumbersome and cost is higher.
CN201611183063.0 discloses a kind of medicinal granule for treating grice diarrhoea, by following parts by weight
Raw material is formulated：15-20 parts of green plum, 15-20 parts of felwort, 8-13 parts of dittany bark, 10-15 parts of kudzu-vine root powder, 6-10 parts of Poria cocos,
8-13 parts of Radix Codonopsis, 5-10 parts of Radix Glycyrrhizae, 5-10 parts of hawthorn, 5-10 parts of dried orange peel, 8-13 parts of Chinese yam, 10-15 parts of raddle, gluconic acid
6-10 parts of calcium, 12-18 parts of simple syrup.
CN 201210525054.0 discloses a kind of pure Chinese medicine formula that treating various animal diarrhea diseases and its preparation side
Method, including following component：Radix Paeoniae Alba 1g, Rhizoma Atractylodis Macrocephalae 1g, Chinese bulbul 1g, rhizoma atractylodis 1g, dried orange peel 2g, folium isatidis 1g, Cortex Phellodendri 1g, Fructus Forsythiae
0.75g, dandelion 3g, bark of ash 1.5g, garden burnet 5g, granatum 1g, Poria cocos 1g.Various diarrhoeal diseases of the Chinese medicine compound prescription to animal
Disease, such as piglet yellow-white dysentery, epidemic diarrhea, transmissible gastroenteritis are significant in efficacy, and preparation method is easy to operate, are suitble to promote
Using.
The technical solution of above two traditional Chinese medicinal components, in use, mostly with coordinating intestines and stomach for main effect side
To, in practical applications, especially piglet viral enteritis when, above-mentioned Chinese medicine preparation is unable to reach the mesh cured rapidly
's.
Invention content
The object of the present invention is to provide a kind of composition of preventing piglet diarrhea, the preparation method of composition and barley laccas
The new application of class extract, the advantage of the composition are that it is possible to inhibit intestine of young pigs harmful bacteria, effectively inhibit grice diarrhoea,
Improve the immunity of piglet.
Technical solution provided by the invention is：A kind of composition of preventing piglet diarrhea, including not less than composition is equivalent to
The barley worm lipid extracts of total weight 10wt%.
In the composition of above-mentioned preventing piglet diarrhea, the barley worm lipid extracts are equivalent to composition total weight
11.9%-29.1%.
Also include the medium-height grass raw material for improving piglet stomach in the composition of above-mentioned preventing piglet diarrhea.
In the composition of above-mentioned preventing piglet diarrhea, the content of the herbal raw material accounts for composition total weight
24.6%-52.2%.
In the composition of above-mentioned preventing piglet diarrhea, the Chinese herbal medicine is made of following parts by weight of component：Dried orange peel 10-
20 parts, 10-20 parts of Cortex Phellodendri, 10-20 parts of rhizoma atractylodis, 7-14 parts of cassia bark, 5-10 parts of the root of Dahurain angelica, 5-10 parts of Poria cocos, 7-14 parts of Radix Glycyrrhizae.
Further include the olive for being equivalent to composition total weight 1%-3.3% in the composition of above-mentioned preventing piglet diarrhea
Oil.
Specifically, this composition is microcapsule formulation, core material formula：10-20 parts of dried orange peel, 10-20 parts of Cortex Phellodendri, rhizoma atractylodis
10-20 parts, 7-14 parts of cassia bark, 5-10 parts of the root of Dahurain angelica, 5-10 parts of Poria cocos, 7-14 parts of Radix Glycyrrhizae, 30-50 parts of barley worm lipid extracts,
3 parts -5 parts of olive oil；
Wall material formula：50-80 parts of hydroxypropyl methyl cellulose (HPMC), 10-20 parts of sucrose, 5-10 parts of carragheen (CAS).
In the composition of above-mentioned preventing piglet diarrhea, the composition is microcapsule formulation.
In the composition of above-mentioned preventing piglet diarrhea, be used to form in the composition wall material of microcapsule formulation by
Hydroxypropyl methyl cellulose, sucrose, carragheen composition, the hydroxypropyl methyl cellulose, sucrose, carragheen weight ratio be
50-80：10-20：5-10；The wall material accounts for the 28.6%-55.8% of the total amount of composition.
Meanwhile the invention also discloses the preparation method of the composition of above-mentioned preventing piglet diarrhea, including the following steps：
(1) Crushing of Ultrafine：The medium-height grass raw material of each parts by weight of coring material makes water content in 60-80 DEG C of difference freeze-day with constant temperature respectively
≤ 1.0%, obtain Chinese herbal medicine micro mist after crushed 100-200 mesh sieve；
(2) it stirs and evenly mixs：Recipe quantity step (1) Chinese herbal medicine micro mist accurately is taken, mixes well, barley is added by weight
Worm lipid extracts and olive oil, side edged stir, and Chinese herbal medicine micro mist-barley lacca class extract mixtures are made；
(3) prepared by wall material solution：Preparation weighs each parts by weight wall material, by weight 1:5 are added purified water, are heated to 60-
It 70 DEG C, is fully stirred evenly in heating process, keeps the temperature 10-20min；
(4) ultrasound is homogeneous：Recipe quantity step (2) Chinese herbal medicine micro mist-barley lacca class extract mixtures accurately are taken, by weight
Amount is slowly added to than 50%~80% in wall material solution, and ultrasonic homogenizer is added after fully dissolving, homogenization 20-30min,
Obtain it is homogeneous after mixed solution；
(5) it is spray-dried：The mixed solution of step (4) is subjected to spray drying treatment and obtains microencapsulation Chinese herbal medicine-barley
Worm lipid extracts；Spray drying condition：Compression gas-pressure is 50psi, and inlet temperature is 90-150 DEG C；Outlet temperature is 55-70
DEG C, feed flow is 1.0-1.5L/h, and the flow velocity of dry air is 50m3/h；
(6) oscillation squeezes sieving：The microencapsulation Chinese herbal medicine made-barley worm lipid extracts input oscillation screen(ing) machine (type
Number：XZS-800), oscillation squeezes sieving, filters out the uniform particle of granule size between 40-60 mesh.
(7) technical parameter：
(1) shaking screen technical parameter is set：Sieve mesh number is 40-60 mesh, treating capacity 250-3500kg/h, vibration frequency
1500HZ, power 0.75Kw, a diameter of 800mm of sieve；
(2) particle overall particle size requirement cannot be sieved by 40 mesh and can must not be surpassed by the particle and powder summation that 60 mesh sieve
Cross 9%；
(3) granule moisture level requirement, water content≤8.0%.
In addition, the invention also discloses the new application of barley worm lipid extracts, it is specifically used for that intestine of young pigs is inhibited to have
Evil bacterium
The present invention after adopting the above technical scheme, its have the advantage that for：
This programme is used as functional additive of the treatment of grice diarrhoea using barley worm lipid extracts, can be effective
Inhibition intestinal harmful bacillus growth.
This programme is using barley worm lipid extracts and herbal raw material come compatibility, wherein herbal raw material is for improving
Gastrointestinal tract, harmful bacteria of the barley worm lipid extracts for killing cause grice diarrhoea, raising body and gastrointestinal mucosa system are exempted from
Epidemic disease power.The two combines, and can effectively reduce the incidence of grice diarrhoea, improves pigling immunity.
As the further preferred of this programme, this programme is finally added in the form of microcapsules in feed, can be kept away
Exempt from destruction of the hydrochloric acid in gastric juice to barley worm lipid extracts and medium-height grass raw material, core material is enable to be rapidly reached enteron aisle, to show effect.
Specific implementation mode
With reference to embodiment, technical scheme of the present invention is described in further detail, but do not constituted pair
Any restrictions of the present invention.
Embodiment 1
The present embodiment is microcapsule formulation, specifically：
Core material formula：10 parts of dried orange peel, 10 parts of Cortex Phellodendri, 10 parts of rhizoma atractylodis, 7 parts of cassia bark, 5 parts of the root of Dahurain angelica, 5 parts of Poria cocos, 7 parts of Radix Glycyrrhizae,
30 parts of barley worm lipid extracts, 3 parts of olive oil；
Wall material formula：50 parts of hydroxypropyl methyl cellulose (HPMC), 10 parts of sucrose, 3 parts of carragheen (CAS)；
Preparation process is as follows：
(1) Crushing of Ultrafine：In 60 DEG C of difference freeze-day with constant temperature, water content is the herbal raw material of each parts by weight of coring material respectively
0.85%, crushing obtains micro mist after sieving with 100 mesh sieve；
(2) it stirs and evenly mixs：Recipe quantity step (1) raw material micro mist accurately is taken, is mixed well, barley worm is added by weight
Lipid extracts and olive oil, side edged stir, and Chinese herbal medicine micro mist-barley lacca class extract mixtures are made；
(3) prepared by wall material solution：Preparation weighs each parts by weight wall material, by weight 1:5 are added purified water, are heated to 60
DEG C, it is fully stirred evenly in heating process, keeps the temperature 20min；
(4) ultrasound is homogeneous：Recipe quantity step (2) Chinese herbal medicine micro mist-barley lacca class extract mixtures accurately are taken, by weight
Amount ratio 50% is slowly added in wall material solution, and ultrasonic homogenizer fully is added after dissolving, power be 250W, temperature 60
Homogenization 20min at DEG C, the mixed solution after acquisition is homogeneous；
(5) it is spray-dried：The mixed solution of step (4) is subjected to spray drying treatment and obtains microencapsulation Chinese herbal medicine-barley
Worm lipid extracts；Spray drying condition：Compression gas-pressure is 50psi, and inlet temperature is 90-150 DEG C；Outlet temperature is 55-70
DEG C, feed flow is 1.0-1.5L/h, and the flow velocity of dry air is 50m3/h；
(6) oscillation squeezes sieving：The microencapsulation Chinese herbal medicine made-barley worm lipid extracts input oscillation screen(ing) machine (type
Number：XZS-800), oscillation squeezes sieving, filters out the uniform particle of granule size between 40-60 mesh.
Technical parameter：
(1) shaking screen technical parameter is set：Sieve mesh number be 40 mesh, treating capacity 300kg/h, vibration frequency 1500HZ,
Power is 0.75Kw, a diameter of 800mm of sieve；
(2) particle overall particle size requirement：Particle and powder summation are 8.8%；
(3) granule moisture level requirement：Water content is 7.5%.
Embodiment 2
The present embodiment is microcapsule formulation, specifically：
Core material formula：14 parts of dried orange peel, 14 parts of Cortex Phellodendri, 14 parts of rhizoma atractylodis, 9.8 parts of cassia bark, 7 parts of the root of Dahurain angelica, 7 parts of Poria cocos, Radix Glycyrrhizae 9.8
Part, 40 parts of barley worm lipid extracts, 3.5 parts of olive oil；
Wall material formula：58 parts of hydroxypropyl methyl cellulose (HPMC), 13 parts of sucrose, 5 parts of carragheen (CAS)；
Preparation process is as follows：
(1) Crushing of Ultrafine：In 65 DEG C of difference freeze-day with constant temperature, water content is the herbal raw material of each parts by weight of coring material respectively
0.80%, obtain micro mist after crushed 120 mesh sieve；
(2) it stirs and evenly mixs：Recipe quantity step (1) raw material micro mist accurately is taken, is mixed well, barley worm is added by weight
Lipid extracts and olive oil, side edged stir, and Chinese herbal medicine micro mist-barley lacca class extract mixtures are made；
(3) prepared by wall material solution：Preparation weighs each parts by weight wall material, by weight 1:5 are added purified water, are heated to 62
DEG C, it is fully stirred evenly in heating process, keeps the temperature 18min；
(4) ultrasound is homogeneous：Recipe quantity step (2) Chinese herbal medicine micro mist-barley lacca class extract mixtures accurately are taken, by weight
Amount is slowly added to than 55% in wall material solution, ultrasonic homogenizer is added after fully dissolving, power is 250W, temperature is 60 DEG C
Lower homogenization 22min, the mixed solution after acquisition is homogeneous；
(5) it is spray-dried：The mixed solution of step (4) is subjected to spray drying treatment and obtains microencapsulation Chinese herbal medicine-barley
Worm lipid extracts；Spray drying condition：Compression gas-pressure is 50psi, and inlet temperature is 90-150 DEG C；Outlet temperature is 55-70
DEG C, feed flow is 1.0-1.5L/h, and the flow velocity of dry air is 50m3/h；
(6) oscillation squeezes sieving：The microencapsulation Chinese herbal medicine made-barley worm lipid extracts input oscillation screen(ing) machine (type
Number：XZS-800), oscillation squeezes sieving, filters out the uniform particle of granule size between 40~60 mesh.
Technical parameter：
(1) shaking screen technical parameter is set：Sieve mesh number be 45 mesh, treating capacity 500kg/h, vibration frequency 1500HZ,
Power is 0.75Kw, a diameter of 800mm of sieve；
(2) particle overall particle size requirement：Particle and powder summation are 8.5%；
(3) granule moisture level requirement：Water content is 7.4%.
Embodiment 3
The present embodiment is microcapsule formulation, specifically：
Core material formula：16 parts of dried orange peel, 16 parts of Cortex Phellodendri, 16 parts of rhizoma atractylodis, 11.2 parts of cassia bark, 8 parts of the root of Dahurain angelica, 8 parts of Poria cocos, Radix Glycyrrhizae
11.2 parts, 45 parts of barley worm lipid extracts, 4 parts of olive oil；
Wall material formula：65 parts of hydroxypropyl methyl cellulose (HPMC), 15 parts of sucrose, 5 parts of carragheen (CAS)；
Preparation process is as follows：
(1) Crushing of Ultrafine：In 70 DEG C of difference freeze-day with constant temperature, water content is the medium-height grass raw material of each parts by weight of coring material respectively
0.68%, obtain micro mist after crushed 140 mesh sieve；
(2) it stirs and evenly mixs：Recipe quantity step (1) raw material micro mist accurately is taken, is mixed well, barley worm is added by weight
Lipid extracts and olive oil, side edged stir, and Chinese herbal medicine micro mist-barley lacca class extract mixtures are made；
(3) prepared by wall material solution：Preparation weighs each parts by weight wall material, by weight 1:5 are added purified water, are heated to 65
DEG C, it is fully stirred evenly in heating process, keeps the temperature 15min；
(4) ultrasound is homogeneous：Recipe quantity step (2) Chinese herbal medicine micro mist-barley lacca class extract mixtures accurately are taken, by weight
Amount is slowly added to than 65% in wall material solution, ultrasonic homogenizer is added after fully dissolving, power is 250W, temperature is 60 DEG C
Lower homogenization 24min, the mixed solution after acquisition is homogeneous；
(5) it is spray-dried：The mixed solution of step (4) is subjected to spray drying treatment and obtains microencapsulation Chinese herbal medicine-barley
Worm lipid extracts；Spray drying condition：Compression gas-pressure is 50psi, and inlet temperature is 90~150 DEG C；Outlet temperature is 55-70
DEG C, feed flow is 1.0-1.5L/h, and the flow velocity of dry air is 50m3/h；
(6) oscillation squeezes sieving：The microencapsulation Chinese herbal medicine made-barley worm lipid extracts input oscillation screen(ing) machine (type
Number：XZS-800), oscillation squeezes sieving, filters out the uniform particle of granule size between 40-60 mesh.
Technical parameter：
(1) shaking screen technical parameter is set：Sieve mesh number be 48 mesh, treating capacity 600kg/h, vibration frequency 1500HZ,
Power is 0.75Kw, a diameter of 800mm of sieve；
(2) particle overall particle size requirement：Particle and powder summation are 8.0%；
(3) granule moisture level requirement：Water content is 7.6%.
Embodiment 4
The present embodiment is microcapsule formulation, specifically：
Core material formula：18 parts of dried orange peel, 18 parts of Cortex Phellodendri, 18 parts of rhizoma atractylodis, 13 parts of cassia bark, 9 parts of the root of Dahurain angelica, 9 parts of Poria cocos, Radix Glycyrrhizae 13
Part, 48 parts of barley worm lipid extracts, 4.5 parts of olive oil；
Wall material formula：75 parts of hydroxypropyl methyl cellulose (HPMC), 18 parts of sucrose, 8 parts of carragheen (CAS)；
Preparation process is as follows：
(1) Crushing of Ultrafine：In 75 DEG C of difference freeze-day with constant temperature, water content is the medium-height grass raw material of each parts by weight of coring material respectively
0.65%, obtain micro mist after crushed 180 mesh sieve；
(2) it stirs and evenly mixs：Recipe quantity step (1) raw material micro mist accurately is taken, is mixed well, barley worm is added by weight
Lipid extracts and olive oil, side edged stir, and Chinese herbal medicine micro mist-barley lacca class extract mixtures are made；
(3) prepared by wall material solution：Preparation weighs each parts by weight wall material, by weight 1:5 are added purified water, are heated to 68
DEG C, it is fully stirred evenly in heating process, keeps the temperature 12min；
(4) ultrasound is homogeneous：Recipe quantity step (2) Chinese herbal medicine micro mist-barley lacca class extract mixtures accurately are taken, by weight
Amount is slowly added to than 65% in wall material solution, ultrasonic homogenizer is added after fully dissolving, power is 250W, temperature is 60 DEG C
Lower homogenization 25min, the mixed solution after acquisition is homogeneous；
(5) it is spray-dried：The mixed solution of step (4) is subjected to spray drying treatment and obtains microencapsulation Chinese herbal medicine-barley
Worm lipid extracts；Spray drying condition：Compression gas-pressure is 50psi, and inlet temperature is 90-150 DEG C；Outlet temperature is 55-70
DEG C, feed flow is 1.0-1.5L/h, and the flow velocity of dry air is 50m3/h；
(6) oscillation squeezes sieving：The microencapsulation Chinese herbal medicine made-barley worm lipid extracts input oscillation screen(ing) machine (type
Number：XZS-800), oscillation squeezes sieving, filters out the uniform particle of granule size between 40-60 mesh.
Technical parameter：
(1) shaking screen technical parameter is set：Sieve mesh number be 50 mesh, treating capacity 650kg/h, vibration frequency 1500HZ,
Power is 0.75Kw, a diameter of 800mm of sieve；
(2) particle overall particle size requirement：Particle and powder summation are 7.9%；；
(3) granule moisture level requirement：Water content is 7.3%.
Embodiment 5
The present embodiment is microcapsule formulation, specifically：
Core material formula：20 parts of dried orange peel, 20 parts of Cortex Phellodendri, 20 parts of rhizoma atractylodis, 14 parts of cassia bark, 10 parts of the root of Dahurain angelica, 10 parts of Poria cocos, Radix Glycyrrhizae 14
Part, 50 parts of barley worm lipid extracts, 5 parts of olive oil；
Wall material formula：80 parts of hydroxypropyl methyl cellulose (HPMC), 20 parts of sucrose, 10 parts of carragheen (CAS)；
Preparation process is as follows：
(1) Crushing of Ultrafine：In 80 DEG C of difference freeze-day with constant temperature, water content is the medium-height grass raw material of each parts by weight of coring material respectively
0.58%, obtain micro mist after crushed 200 mesh sieve；
(2) it stirs and evenly mixs：Recipe quantity step (1) raw material micro mist accurately is taken, is mixed well, barley worm is added by weight
Lipid extracts and olive oil, side edged stir, and Chinese herbal medicine micro mist-barley lacca class extract mixtures are made；
(3) prepared by wall material solution：Preparation weighs each parts by weight wall material, by weight 1:5 are added purified water, are heated to 70
DEG C, it is fully stirred evenly in heating process, keeps the temperature 10min；
(4) ultrasound is homogeneous：Recipe quantity step (2) Chinese herbal medicine micro mist-barley lacca class extract mixtures accurately are taken, by weight
Amount is slowly added to than 65% in wall material solution, ultrasonic homogenizer is added after fully dissolving, power is 250W, temperature is 60 DEG C
Lower homogenization 30min, the mixed solution after acquisition is homogeneous；
(5) it is spray-dried：The mixed solution of step (4) is subjected to spray drying treatment and obtains microencapsulation Chinese herbal medicine-barley
Worm lipid extracts；Spray drying condition：Compression gas-pressure is 50psi, and inlet temperature is 90-150 DEG C；Outlet temperature is 55-70
DEG C, feed flow is 1.0-1.5L/h, and the flow velocity of dry air is 50m3/h；
(6) oscillation squeezes sieving：The microencapsulation Chinese herbal medicine made-barley worm lipid extracts input oscillation screen(ing) machine (type
Number：XZS-800), oscillation squeezes sieving, filters out the uniform particle of granule size between 40-60 mesh.
Technical parameter：
(1) shaking screen technical parameter is set：Sieve mesh number be 60 mesh, treating capacity 850kg/h, vibration frequency 1500HZ,
Power is 0.75Kw, a diameter of 800mm of sieve；
(2) particle overall particle size requirement：Particle and powder summation are 7.0%；；
(3) granule moisture level requirement：Water content is 6.9%.
Comparative example 1
The bacteriostatic test of barley worm lipid extracts
Sensitivity Detection is carried out using Odontothrips loti.Reference frame：NCCLS drug sensitive tests standard and antibiotic microorganism inspection
Determine method.E.coli K88 and e. coli k99 bacterium source：Institute of Animal Health,Guangdong Academy Of Agricultural Sciences provides.
Step 1：Prepare solid culture basal layer.It draws M-H solid mediums 30ml and pours into culture dish (diameter：12.0cm
± 0.1cm), it is to be solidified.
Step 2：Prepare bacterium layer.Draw a certain amount of (ratio：3 drops/100ml) aimed strain (K88 and K99) and Quality-control strains
((bacterium is dense for Escherichia coli (ATCC 25922) bacteria suspension：OD values 2.0), it is added to after fully being shaken up in M-H culture mediums (50-60 DEG C),
It draws 20ml to pour into the plate for having filled culture basal layer, stands 10min；
Step 3：Bacteriostatic activity detects.With aseptic nipper by Oxford cup (internal diameter 6.0 (± 0.1) mm, outer diameter 7.8 (± 0.1)
Mm, high by 10.0 (± 0.1) mm) it uniformly places on the tablet made.Positive controls and induction group sample 200ul are drawn respectively；
If positive control：Ampicillin (AMP) and organic solvent group.Tablet is placed in (36.9 ± 0.1) DEG C incubator and cultivates 18-
Result is observed for 24 hours, is taken pictures and is measured antibacterial circle diameter size (mm).It the results are shown in Table 1.
1 barley worm larva lipid material of table measures several antimicrobial susceptibilities
Note：Antibacterial circle diameter=Φ, numerical value are indicated with mean+SD.EA：Organic solvent；AMP：Ammonia benzyl mould
Element；Extract group：Induction group；Sensitive sex determination：Φ >=17.0mm is sensitivity.
As shown in Table 1, barley worm larva lipid extracts pole, which significantly inhibits, causes diarrhoeic Escherichia coli K88 and K99 (p <
0.001)。
It can not deny, some experiments of this field have confirmed that common part common fats acid includes saturated fat
Acid, unsaturated fatty acid have certain bacteriostasis efficacy.In particular, document《The bacteriostatic activity of aliphatic acid and its derivative》It delivers
In journal of Zhejiang university 2012.11.066；Author Zhang Xi etc. has confirmed that long-chain, whether contains unsaturated bond to bacteriostatic activity
Influence.
But the expection that bacteriostatic activity is mentioned in above-mentioned document has been had exceeded using barley worm lipid extracts, press down
Bacterium activity is substantially better than the ampicillin of normal concentration, this is that those skilled in the art are difficult to expect, for the present invention
One of advantageous characteristic.
Comparative example 2
The efficiency of microencapsulation proves experiment
It is prepared by ordinary preparation：The Chinese herbal medicine for taking each parts by weight crushes sieving, obtains micro mist, and parts by weight are added
Barley worm lipid extracts and olive oil, be sufficiently mixed and stir evenly, a certain amount of starch or wheat bran is then added, is sufficiently mixed
With stir evenly.
Experimental design：
It is miscellaneous (Du × length × big) weanling pig of 7.48 ± 0.94kg ternarys to choose 216 26 ± 2d original body mass, according to
Gender and weight are randomly divided into 3 processing groups (control group, ordinary preparation group and microencapsulated formulation group reference implementation example 1), each
It handles 6 repetitions, each repeats 12 weanling pigs (male and female is fifty-fifty).Control group fed corn-soybean meal basal diet, commonly
Preparation group feeds+3% ordinary preparation of corn-soybean meal basal diet and microencapsulated formulation group feeding corn-soybean meal basic day
+ 3% microencapsulated formulation of grain, experimental period 14d.Basal diet preparation is prepared according to NRC (2012) standard.
All feeding piglets are in the closed house of temperature control, and initial temperature is maintained at 28 DEG C or so, and temperature control drops 1 in every 7d
℃.During experiment, all piglets are freely eaten and free water.When off-test, weighed to weanling pig and ramming material, meter
Calculate each repeating groups ADG, ADFI and F:G.During entire experiment, every morning 8：30 record the excrement or piglet anus of every pig
Situation records diarrhea rate.
Index determining：
Related immune index：Serum cytokines and jejunum, ileal mucosa immune molecule are all made of porcine interleukin 6 (IL-6)
Detection kit, Porcine interferon-gamma (IFN-γ) detection kit, pig IL-1 β detection kits, pig tumor necrosis factor α
(TNF-α) detection kit and mucous membrane SlgA detection kits are detected.
2 ordinary preparation of table and influence of the microencapsulated formulation to 14d piglet growth performances and diarrhea rate after wean
3 ordinary preparation of table and influence (μ g/ml) of the microencapsulated formulation to 14d piglets serum cytokines after wean
4 ordinary preparation of table is with microencapsulated formulation to the influence (μ g/ml) to 14d piglets intestinal segment mucosa-immune molecule after wean
It can be seen that microencapsulation processing can effectively improve Antidiarrheal efficacy by above-mentioned table 2-4, and can have
The raising intestine of young pigs immunity of effect.
Comparative example 3
The effect of herbal composite and barley worm lipid extracts, proves experiment
Preparation method：The Chinese herbal medicine for taking each parts by weight crushes sieving, obtains micro mist, by weight/volume ratio difference
Purified water (100 DEG C) is added and absolute ethyl alcohol extracts 2 times, filtering and concentrating obtains I (concentration of concentrate：1g/mL) and concentrate II
(concentration：1g/mL).
Extracorporeal bacteria inhibitor test：Method is the same as comparative example 1.
It the results are shown in Table 5.
5 three kinds of extracts of table measure (mm) several antimicrobial susceptibilities
Note：Antibacterial circle diameter=Φ, numerical value are indicated with mean+SD.EL：Absolute ethyl alcohol；AMP：Ammonia benzyl mould
Element；Lipid extracts concentration：1g/mL.Sensitive sex determination：Φ >=17.0mm is sensitivity." 0 " indicates no inhibition zone.
By table 5 it could be assumed that, in the present solution, Chinese medicine composition only plays opsonic action, harmful intestinal tract is not played
The effect that bacterium is killed and inhibits.
Experimental infection：
It is prepared by Chinese herb compound micro mist：
The Chinese herbal medicine for taking each parts by weight crushed 100-200 mesh sieve, and obtained micro mist, be sufficiently mixed to obtain medium-height grass
Medicine compound micro mist.
Test design method：
Choose that 180 28d original body mass are close, healthy ternary is miscellaneous (Du × length × greatly) weanling pig, according to gender and body
It is randomly divided into 5 processing groups (healthy control group, I group, II group, III group and positive controls) again, each handles 3 repetitions, often
12 weanling pigs of a repetition (male and female is fifty-fifty).Healthy control group, I group and positive controls feed corn-soybean meal basis
Daily ration, II group and III group to feed+5% barley worm lipid extracts of basal diet ,+5% Chinese herb compound of basal diet respectively micro-
Powder.Preliminary trial period is 7d, experimental period 7d.During prerun, find to have the weanling pig of diarrhea to reject.Basal diet prepare according to
NRC (2012) standard is prepared.Preliminary trial period, terminates, and the weanling pig of I group, II group, III group and positive controls attacks malicious first half
Hour gavages the 1.2% sodium bicarbonate 2ml/ heads that sterilization treatment is crossed, and artificial challenge is carried out after half an hour and attacks poison, gavages 1ml large intestine bars
Bacterium K88 bacterium solutions/head (concentration：1×109CFU/mL).After attacking poison, healthy control group, II group, III group and positive controls are normal
Each group feed is fed, I group on the basis of feeding basal diet, gavages 10% barley worm lipid extracts, by weight 0.5mL/
3d is used in conjunction 2 times a day in kg.7d is observed continuously after attacking poison, is freely eaten, records grice diarrhoea situation.Son dead not yet after 7d
Pig takes euthanasia.
As a result：
The result shows that artificial sense can be significantly improved by adding barley worm lipid extracts and Chinese herb compound micro mist in diet
Contaminate growth performance (p < 0.05) and diarrhea rate (p < 0.01 and p < 0.05) after K88 cause diarrhea of weaned piglets.Wherein, barley
The control effect of worm lipid extracts is better than Chinese herb compound micro mist (p < 0.05).It is shown in Table 6 and table 7.
Young changes of weight (the unit before and after onset of 6 different disposal group of table wean：kg)
7 different disposal group diarrhea of weaned piglets record case of table
By table 6 and table 7 as can be seen that either using Chinese medicine composition, barley worm lipid extracts and feeding
The unrestricted choice on opportunity can reach a degree of effect for preventing grice diarrhoea.
Meanwhile can be found by table 6 and table 7, barley worm lipid extracts have the piglet of morbidity more apparent
Therapeutic effect, if by the way of Long-term Feeding come pre- anti-diarrhea not as good as after the onset of immediately perfusion barley worm lipid extraction
Object；It can be proved from side, barley worm lipid extracts have more excellent sterilization disease-resistant effect, but come from angle is prevented
It says, Chinese herb compound prevents and conditioning effect is more preferable.
The feeding effect of embodiment 1-3 is tested
Test method：
1, experimental animal feeding management
It is miscellaneous (Du × length × big) weanling pig of 7.42 ± 0.82kg ternarys to choose 144 26 ± 2d original body mass, according to
Gender and weight are randomly divided into 2 processing groups (control group and microencapsulated formulation processing group), each handle 6 repetitions, Mei Gechong
Multiple 12 weanling pigs (male and female is fifty-fifty).Control group fed corn-soybean meal basal diet, the feeding of microencapsulated formulation processing group are beautiful
+ 3% microencapsulated formulation of rice-bean pulp type basal diet (Chinese herbal medicine-barley lacca class extract microcapsule preparation), experimental period be
14d.Basal diet preparation is prepared according to NRC (2012) standard.
All feeding piglets are in the closed house of temperature control, and initial temperature is maintained at 28 DEG C or so, and temperature control drops 1 in every 7d
℃.During experiment, all piglets are freely eaten and free water.When off-test, weighed to weanling pig and ramming material, meter
Calculate each repeating groups ADG, ADFI and F:G.During entire experiment, every morning 8：30 record the excrement or piglet anus of every pig
Situation records diarrhea rate.
2, experimental animal is butchered and sample collection
(14d) removes material for first 1 day and does not remove water after the test, and each repeating groups randomly select 1 health and have the disconnected of diarrhea
Milk piglet is butchered and is taken a blood sample.Jejunum (2.5m at pylorus) and ileum (apart from caecum 20cm) tissue is acquired, it is slow through PBS
After fliud flushing rinses chyme well, it is collected in the centrifuge tube of sterile clean and immerses liquid nitrogen immediately, then then move to -80 DEG C of refrigerators
It preserves, is tested and analyzed for mucosa-immune molecule (SlgA).
3, sample detection analysis and data processing
Serum cytokines and jejunum, ileal mucosa immune molecule are all made of porcine interleukin 6 (IL-6) detection kit, pig
Interferon gamma (IFN-γ) detection kit, pig IL-1 β detection kits, pig tumor necrosis factor α (TNF-α) detection kit
And mucous membrane SlgA detection kits are detected.
It is for statistical analysis that test data is all made of SPSS 13.0, using One-Way ANOVA variance analyses and
Duncan's carries out Multiple range test, and data result is with average ± standard error (M ± SE).Diarrhea rate uses χ2Check analysis.
Examples 1 and 2 are carried out to the experiment of above-mentioned test method respectively, result is as follows：
It is microencapsulated formulation with embodiment 1, test result is as follows：
8 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d piglet growth performances and diarrhea after wean
The influence of rate
Note：Same letter is indicated with column data shoulder or indicates difference not significantly (P without letter>0.05) small letter, is differed
Matrix shows significant difference (P<0.05), different capitalizations indicate difference extremely significantly (P<0.01).Similarly hereinafter.
9 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d piglets serum cytokines after wean
It influences
10 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d Jejunum of Piglets and ileal mucosa after wean
The influence of immune molecule
It is microencapsulated formulation with embodiment 2：
11 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d piglet growth performances and diarrhea after wean
The influence of rate
12 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d piglets serum cytokines after wean
It influences
13 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d Jejunum of Piglets and ileal mucosa after wean
The influence of immune molecule
It is microencapsulated formulation with embodiment 3：
14 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d piglet growth performances and diarrhea after wean
The influence of rate
15 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d piglets serum cytokines after wean
It influences
16 Chinese herbal medicine of table combines barley lacca class extract microcapsule preparation to 14d Jejunum of Piglets and ileal mucosa after wean
The influence of immune molecule
Brief summary：
Test result is shown, adds 3% Chinese herbal medicine-barley lacca class extract microcapsule compared with the control group, in daily ration
The weightening of 14d piglet feed consumptions significantly reduces diarrhea of weaned piglets rate (p < than (p < 0.05) after preparation can significantly improve wean
0.01) content (p < 0.01) of weanling pig serum cytokines, jejunum and ileal mucosa immune molecule, is significantly improved.
It summarizes：
Table 1, which demonstrates barley worm lipid extracts, has excellent fungistatic effect；
Table 2-4 demonstrates the herbal composite of this programme, barley worm lipid extracts need to carry out effective microencapsulation,
Grice diarrhoea rate can be effectively reduced, there is apparent help to improving pigling immunity.
Table 5 demonstrates herbal composite from a side and only plays the role of coordinating intestines and stomach.
Table 6-7, which demonstrates barley worm lipid extracts, to be had the function of preventing and treating grice diarrhoea, herbal composite
Also there is similar effect；But barley worm lipid extracts are more to reach corresponding up from the angle of restraining and sterilizing bacteria
Purpose, and herbal composite is to reach the purpose from the angle of conditioning.And from the feeding side of different times before and after onset
From the point of view of formula, barley worm lipid extracts carry out acute treatment after the onset of being more suitable for.
The combination that table 8-16 demonstrates herbal composite, barley worm lipid extracts and microencapsulation processing can reach
The effect of effective prevention and treatment diarrhea, can effectively improve immunity.
The present invention proves to obtain as drawn a conclusion by the above embodiments and comparative example：
Barley worm lipid extracts have contribution for the treatment and prevention of the diarrhea of piglet；
Barley worm lipid extracts combine above-mentioned Chinese medicine composition and microencapsulation processing for the effective, aobvious of diarrhea rate
The control of work is vital.For another angle, if to reach especially excellent and ideal effect, three
It is indispensable.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, it is other it is any without departing from the spirit and principles of the present invention made by changes, modifications, substitutions, combinations, simplifications,
Equivalent substitute mode is should be, is included within the scope of the present invention.
Claims (10)
1. a kind of composition of preventing piglet diarrhea, which is characterized in that comprising not less than being equivalent to composition total weight 10wt%'s
Barley worm lipid extracts.
2. the composition of preventing piglet diarrhea according to claim 1, which is characterized in that the barley worm lipid extracts
It is equivalent to the 11.9%-29.1% of composition total weight.
3. the composition of preventing piglet diarrhea according to claim 1, which is characterized in that also include for improving piglet stomach
Herbal raw material.
4. the composition of preventing piglet diarrhea according to claim 3, which is characterized in that the content of the herbal raw material
Account for the 24.6%-52.2% of composition total weight.
5. the composition of preventing piglet diarrhea according to claim 4, which is characterized in that the Chinese herbal medicine is by following weight
Part group is grouped as：10-20 parts of dried orange peel, 10-20 parts of Cortex Phellodendri, 10-20 parts of rhizoma atractylodis, 7-14 parts of cassia bark, 5-10 parts of the root of Dahurain angelica, Poria cocos 5-10
Part, 7-14 parts of Radix Glycyrrhizae.
6. the composition of preventing piglet diarrhea according to claim 4, which is characterized in that further include being equivalent to composition gross weight
Measure the olive oil of 1%-3.3%.
7. the composition of preventing piglet diarrhea according to claim 4, which is characterized in that the composition is microcapsules system
Agent.
8. the composition of preventing piglet diarrhea according to claim 7, which is characterized in that be used to form in the composition
The wall material of microcapsule formulation is made of hydroxypropyl methyl cellulose, sucrose, carragheen, the hydroxypropyl methyl cellulose, sugarcane
Sugared, carragheen weight ratio is 50-80：10-20：5-10；The wall material accounts for the 28.6%-55.8% of the total amount of composition.
9. a kind of preparation method of the composition of preventing piglet diarrhea as claimed in claim 7 or 8, which is characterized in that including such as
Lower step：
(1) Crushing of Ultrafine：The medium-height grass raw material of each parts by weight of coring material is in 60~80 DEG C of difference freeze-day with constant temperature respectively, make water content≤
1.0%, obtain Chinese herbal medicine micro mist after crushed 100~200 mesh sieve；
(2) it stirs and evenly mixs：Recipe quantity step (1) Chinese herbal medicine micro mist accurately is taken, is mixed well, barley lacca is added by weight
Class extract and olive oil, side edged stir, and Chinese herbal medicine micro mist-barley lacca class extract mixtures are made；
(3) prepared by wall material solution：Preparation weighs each parts by weight wall material, by weight 1:5 are added purified water, are heated to 60~70
DEG C, it is fully stirred evenly in heating process, keeps the temperature 10~20min；
(4) ultrasound is homogeneous：Recipe quantity step (2) Chinese herbal medicine micro mist-barley lacca class extract mixtures accurately are taken, by weight
50%~80% is slowly added in wall material solution, ultrasonic homogenizer fully is added after dissolving, 20~30min of homogenization is obtained
It is homogeneous after mixed solution；
(5) it is spray-dried：The mixed solution of step (4) is subjected to spray drying treatment and obtains microencapsulation Chinese herbal medicine-barley lacca
Class extract；Spray drying condition：Compression gas-pressure is 50psi, and inlet temperature is 90~150 DEG C；Outlet temperature is 55~70 DEG C,
Feed flow is 1.0~1.5L/h, and the flow velocity of dry air is 50m3/h；
(6) oscillation squeezes sieving：The microencapsulation Chinese herbal medicine made-barley worm lipid extracts input oscillation screen(ing) machine (model：
XZS-800), oscillation squeezes sieving, filters out the uniform particle of granule size between 40~60 mesh.
10. the new application of barley worm lipid extracts, which is characterized in that for inhibiting intestine of young pigs harmful bacteria.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109497103A (en) * | 2018-11-28 | 2019-03-22 | 广东省农业科学院动物科学研究所 | A kind of complex lipid reduces livestock and poultry feces stink foul smell discharge complex lipid spray and its preparation method and application |
| CN113855768A (en) * | 2021-11-22 | 2021-12-31 | 河南宝威生物工程技术有限公司 | Traditional Chinese medicine composition for preventing piglet diarrhea and preparation method and application thereof |
-
2018
- 2018-08-24 CN CN201810969799.3A patent/CN108743709A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109497103A (en) * | 2018-11-28 | 2019-03-22 | 广东省农业科学院动物科学研究所 | A kind of complex lipid reduces livestock and poultry feces stink foul smell discharge complex lipid spray and its preparation method and application |
| CN109497103B (en) * | 2018-11-28 | 2020-07-07 | 广东省农业科学院动物科学研究所 | Compound lipid, compound lipid spray for reducing odor emission of livestock and poultry feces and preparation method and application thereof |
| CN113855768A (en) * | 2021-11-22 | 2021-12-31 | 河南宝威生物工程技术有限公司 | Traditional Chinese medicine composition for preventing piglet diarrhea and preparation method and application thereof |
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Application publication date: 20181106 |