CN102697734A - Method for preparing water-soluble metronidazole - Google Patents
Method for preparing water-soluble metronidazole Download PDFInfo
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- CN102697734A CN102697734A CN2012101745116A CN201210174511A CN102697734A CN 102697734 A CN102697734 A CN 102697734A CN 2012101745116 A CN2012101745116 A CN 2012101745116A CN 201210174511 A CN201210174511 A CN 201210174511A CN 102697734 A CN102697734 A CN 102697734A
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- metronidazole
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Abstract
The invention belongs to the field of preparation of veterinary medicines, and in particular relates to a method for preparing water-soluble metronidazole. The method comprises the following steps of: uniformly mixing 50 to 70 mass parts of metronidazole, 14 to 40 mass parts of sulfamic acid, 5 to 35 mass parts of sodium bicarbonate and 13 to 29 mass parts of glucose in a mixing machine, and grinding. By the method, medicines can be applied in multiple ways, can be mixed with other materials and can be orally taken by drinking water; the method is high in medicine absorption speed and bioavailability; the metronidazole can be quickly distributed to most tissues, organs and body fluid of a whole body; blood concentration can reach a peak point within a short time; and the dosage of a medicine is a half of that of a mixing material in the water drinking process to ensure that the same effect can be achieved.
Description
Technical field
The invention belongs to the veterinary medicament preparation field, specifically is a kind of method for preparing of water solublity metronidazole.
Technical background
Metronidazole tool wide spectrum anaerobe resistant and protozoacidal effect, effective to the genital disease that treatment animal reproductive system disease and some infectious disease cause.Various anaerobic infections also there is excellent curative, and is difficult for forming Resistant strain, dysbacteriosis and superinfection, share no antagonism with common antibiotics.So the use on veterinary drug is very extensive.
In recent years, the many veterinary drugs of China manufacturer is studied the application aspect the veterinary drug of metronidazole.At present, existing more corresponding products in domestic market.It is metronidazole to be mixed with relevant adjuvant make the lower powder product of content, is stirred in feedstuff then and supplies animal to use.But because the dosage of this product in feedstuff be less,, cause the many administrations of animal that have and the animals administer of poisoning, having is few and do not have therapeutical effect, bring certain harm and loss to breed so often take place to mix inhomogeneous.
Summary of the invention
The technical problem that the present invention will solve is: overcome water insoluble can only be stirred in the feedstuff of present metronidazole product and use and can not be through the shortcoming of water way administration.
The present invention realizes through following technical scheme: a kind of method for preparing of water solublity metronidazole; It is characterized in that: according to the following ratio of mass percent: metronidazole: 50-70 part; Sulfamic acid: 14-40 part, sodium bicarbonate: 5-35 part, glucose: 13-29 part; Be configured, in mixer, pulverize behind the mix homogeneously then.
The invention has the beneficial effects as follows: route of administration is many, but both spice also can drink water, oral.Safety, through the water way administration, drug level is even, and intoxicating phenomenon can not take place in animal.Medicine absorbs fast, and bioavailability is high, can be distributed to rapidly in the most histoorgan of whole body and the body fluid, and the short time, interior blood drug level reached the peak, and drug dose is that a half-value dose of spice can reach effect same during drinking-water.
The specific embodiment:
Embodiment 1
Weigh title according to mass ratio and go 50 parts metronidazole, 14 parts of sulfamic acids, titles to remove 7 parts sodium bicarbonate, 29 parts glucose, in mixer, mix and stirred 1 hour, be crushed to 80-100 orders, packing gets final product.(25 kilograms/barrel)
Embodiment 2
Weigh title according to mass ratio and go 60 parts metronidazole, 18 parts of sulfamic acids, titles to remove 9 parts sodium bicarbonate, 13 parts glucose, in mixer, mix and stirred 1 hour, be crushed to 80-100 orders, packing gets final product.(25 kilograms/barrel)
Embodiment 3
Weigh title according to mass ratio and go 70 parts metronidazole, 20 parts of sulfamic acids, titles to remove 10 parts sodium bicarbonate, 13 parts glucose, in mixer, mix and stirred 1 hour, be crushed to 80-100 orders, packing gets final product.(25 kilograms/barrel)
The product of the present invention's preparation can be used for preventing and treating the Animal diseases that taken place by infusorian, anti-ameba, outer anaerobic infection.
The detailed directions consumption is following: get the product of embodiment 1 preparation, the ratio that every gram is converted water 10-20 kilogram is dissolved in confession animal drinking-water in the water.
The also available spice mode of crossing is used:
Fowl: mix and raise: get embodiment 2 product 1g spices 4-5kg, one day 1-2 times, logotype 3-5 days.
For oral administration: as to get the each amount of embodiment 3 products and calculate pig 10mg, cattle 60mg, dog 25mg, one day 2 times, logotype 3-5 days with every kg body weight.
Effect: therapeutic effect is good.
Claims (1)
1. the method for preparing of a water solublity metronidazole is characterized in that: according to the following ratio of mass percent: metronidazole: 50-70 part, sulfamic acid: 14-40 part; Sodium bicarbonate: 5-35 part; Glucose: 13-29 part, be configured, in mixer, pulverize behind the mix homogeneously then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101745116A CN102697734A (en) | 2012-05-31 | 2012-05-31 | Method for preparing water-soluble metronidazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101745116A CN102697734A (en) | 2012-05-31 | 2012-05-31 | Method for preparing water-soluble metronidazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102697734A true CN102697734A (en) | 2012-10-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101745116A Pending CN102697734A (en) | 2012-05-31 | 2012-05-31 | Method for preparing water-soluble metronidazole |
Country Status (1)
| Country | Link |
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| CN (1) | CN102697734A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1246334A (en) * | 1998-08-31 | 2000-03-08 | 曾泳铭 | Drug for treating animal coccidiosis |
| CN101953871A (en) * | 2010-10-14 | 2011-01-26 | 山东省农业科学院畜牧兽医研究所 | Antibacterial medicament for animals and preparation method and application thereof |
-
2012
- 2012-05-31 CN CN2012101745116A patent/CN102697734A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1246334A (en) * | 1998-08-31 | 2000-03-08 | 曾泳铭 | Drug for treating animal coccidiosis |
| CN101953871A (en) * | 2010-10-14 | 2011-01-26 | 山东省农业科学院畜牧兽医研究所 | Antibacterial medicament for animals and preparation method and application thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20121003 |
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| RJ01 | Rejection of invention patent application after publication |