CN104666878B - A kind of medicament composing prescription for preventing pig chronic respiratory syndrome - Google Patents
A kind of medicament composing prescription for preventing pig chronic respiratory syndrome Download PDFInfo
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Abstract
The present invention relates to a kind of medicament composing prescriptions for preventing pig chronic respiratory syndrome, each raw material in the medicament composing prescription is valnemulin, Enrofloxacin, traditional Chinese medicine powder, wherein, the bulk pharmaceutical chemicals of traditional Chinese medicine powder have Radix Codonopsis, Radix Glycyrrhizae, Poria cocos, Rhizoma Atractylodis Macrocephalae, lily, Radix Ophiopogonis, prepared RHIZOMA PINELLIZE without adju-vant, aster, Chinese ephedra, Radix Polygalae, rhizoma anemarrhenae, Radix Glehniae, dried orange peel, float stone, above-mentioned each Chinese herbal medicine obtains extracting solution by steam distillation, the extracting solution mills float stone fine powder obtained after mixing with by efficient ball mill, low temperature drying is vacuum-packed, and traditional Chinese medicine powder is made.The present invention is significant in efficacy to pig chronic respiratory syndrome, Chinese medicine additive amount is less, palatability is good, quick, and by Clinical practice, cure rate is high.
Description
Technical field
The present invention relates to field of veterinary, and in particular to a kind of medicament composing prescription for preventing pig chronic respiratory syndrome.
Background technology
Porcine respiratory disease syndrome (PRDC) is in the 15th international swine disease meeting that Britain Xia Minghan in 1998 is held
It proposes first, it is caused jointly by the interaction of the factors such as virus, bacterium, environmental stress and pig body hypoimmunity
Breathing problem general name.Due to the diversity for the cause of disease for causing the syndrome so that extremely difficult to the prevention of this disease.This
Disease has become the No.1 disease for influencing global pig breeding industry economic benefit, and massive losses are caused to pig breeding industry.Porcine respiratory disease
Extremely complex, clinical there are two main classes the form of expression, one kind is sudden onset, you can dead under the treatment having not enough time to
Acute onset, the main pathogen being related to is infectious Actinobacillus pleuropneumoniae, streptococcus, Pasteurella, toxoplasm, pellet
Bacillus venenosus, haemophilus suis, influenza virus, above-mentioned cause of disease acute infection cause the disease, and morbidity is all relatively more anxious, mainly
Therapy is by drug administration by injection, and this method effect is preferable, sensitive antibiotic, antimicrobial (sulfa) and routine
Antipyretic can control epidemic situation the short time, and current treatment technology can effectively treat this kind of sudden porcine respiratory disease.The
Two class breathing problems are very obstinate, are mainly shown as cough, pant, are short of breath, undergrowth, severe patient lung or whole
Lesion occurs for a respiratory system, and then causes serious influence to pig growth, sows farrowing.The cause of disease master clinically worked out
To be circovirus, Pseudorabies virus, mycoplasma, haemophilus suis etc. chronic infection and swine eperythrozoonosis it is hidden
Shape infection can also cause.Above-mentioned illness is poor using existing a variety of method control effects, just at present, most commonly used
It is still chemicals, as Tilmicosin, Florfenicol, original net medicine, sulfanilamide (SN) pregnancy, Enrofloxacin, tylosin, profit are high mould
One or more of element, fortimicin etc. are used in combination, antibacterial effect worse and worse, the generation rate higher of antibody-resistant bacterium.
Meanwhile drug, which is used for a long time, can cause animal body immune function to decline.
Certainly, also there is the method that above-mentioned illness is much controlled by Chinese medicine, however, the prior art is that Chinese medicine is simple
Be added to inside feed according to comminuting coarsely processing, not only dosage is big, and palatability is poor, and during practice,
Effective ingredient performance dynamics is excessively poor, this is existing greatest problem when current Chinese medicine uses.
Invention content
Shortcoming in for the above-mentioned prior art, the present invention is intended to provide one kind can be to pig chronic respiratory trace integration
Levy the medicament composing prescription that significant in efficacy, Chinese medicine additive amount is relatively fewer, palatability is good, quick.
To achieve the goals above, technical scheme of the present invention：A kind of medicine for preventing pig chronic respiratory syndrome
Object prescription, each raw material and its weight ratio in the medicament composing prescription are valnemulin：Enrofloxacin：Traditional Chinese medicine powder=5-12：8-15：
100-300。
Further, each raw material in the medicament composing prescription and its weight ratio are valnemulin：Enrofloxacin：Traditional Chinese medicine powder=5：
8：100.
Further, the raw material group of the traditional Chinese medicine powder becomes 3 parts of Radix Codonopsis, 2 parts of Radix Glycyrrhizae, 2 parts of Poria cocos, 3 parts of Rhizoma Atractylodis Macrocephalae, lily 3
Part, 2 parts of Radix Ophiopogonis, 2 parts of prepared RHIZOMA PINELLIZE without adju-vant, 2 parts of aster, 1 part of Chinese ephedra, 1 part of Radix Polygalae, 1 part of rhizoma anemarrhenae, 2 parts of Radix Glehniae, 2 parts of dried orange peel, float stone 1
Part.
Further, the preparation method of the traditional Chinese medicine powder is as follows：
Step 1：Radix Codonopsis, Radix Glycyrrhizae, Poria cocos, Rhizoma Atractylodis Macrocephalae, lily, Radix Ophiopogonis, prepared RHIZOMA PINELLIZE without adju-vant, aster, Chinese ephedra, Radix Polygalae, rhizoma anemarrhenae, north is husky
Ginseng, dried orange peel stripping and slicing after adding water infiltration, are distilled by steam distillation and obtain extracting solution；
Step 2：Float stone is milled by fine powder using efficient ball mill；
Step 3：The extracting solution obtained in step 1 is uniformly mixed with the float stone fine powder obtained in step 2, low temperature drying is true
Empty package, it is spare.
Further, application of the medicament composing prescription in the drug for preparing treatment pig chronic respiratory syndrome.
Beneficial effects of the present invention：Each ingredient pharmacological action in medicament composing prescription of the present invention is as follows：
1, valnemulin antibacterial activity is strong, be broad spectrum antibiotic, to mycoplasma, bacterium and conveyor screw, mycoplasma arthritidis,
It is mycoplasma bovirhinis, mycoplasma canis, mycoplasma felis, chicken virus mycoplasma, chicken septic mycoplasma, mycoplasma pneumoniae, streptococcus, golden yellow
Color staphylococcus, Actinobacillus, Pasteurella, Brachyspira hyodysenteriae, colon pili sample conveyor screw etc. have good antibacterial
Activity, it is especially highly sensitive to Mycoplasma and Spirochaeta.Joint Enrofloxacin powder increases to drug-fast bacteria in pig body (such as
Haemophilus parasuis) control, to pig chronic respiratory syndrome the effect of is notable.
2, Radix Codonopsis returns spleen, lung channel, can reinforce vital energy, reinforce the spleen to benefit the lung, promoting the production of body fluid to quench thirst, intelligence development of allaying excitement, increase myocardial blood flow,
It promotes blood circulation and improves function resistance.Rhizoma Atractylodis Macrocephalae returns spleen, stomach, gas, training tonifying spleen and stomach, eliminate dampness and have diuretic effect, solid table stop in energy temperature compensation
Sweat, QI invigorating.Poria cocos returns spleen, the heart, kidney channel, energy clearing damp and promoting diuresis, are good for Pi.The Radix Glycyrrhizae thoughts of returning home, lung, spleen, stomach can invigorate the spleen and benefit qi, moistening lung
Cough-relieving, clearing heat and detoxicating, relieving spasm to stop pain, coordinating the drug actions of a prescription.
3, lily, Radix Ophiopogonis, Radix Glehniae and rhizoma anemarrhenae moisten the lung and nourish yin in the present invention, are monarch drug in a prescription；Aster and Radix Polygalae preventing phlegm from forming and stopping coughing, it is old
Skin, prepared RHIZOMA PINELLIZE without adju-vant, Chinese ephedra and float stone is eliminating dampness and eliminating phlegm, antiasthmatic-antitussive, are altogether ministerial drug；It is adjuvant to coordinate above-mentioned Poria cocos, Radix Glycyrrhizae.All medicines
It shares, gathers the work(of moistening lung for removing phlegm, cough-relieving, Yin-nourishing and Qi-supplementing altogether.It is chronic to pig to exhale by traditional Chinese medicine powder finished product made from the Chinese prescription
The effect of trace integration sign has both treatment and prevention is inhaled, feeding in feed can be added separately to, it is without side-effects.
4, the herbal raw material in the present invention is extracted by distillation, and the active ingredient concentration of extracting solution significantly improves, drug
Effect be not fully exerted, compared with the prior art in using original Chinese medicine crush after be added feed in directly feeding side
Method, Traditional Chinese Medicine dosage significantly reduce.Since the sugar in Chinese medical extract has hygroscopicity, finally by Chinese medicine extract and ground pumice
It is uniformly mixed, low temperature drying vacuum packaging, traditional Chinese medicine powder obtained will not be condensed into blocks because of moisture absorption, can uniformly be mixed with feed
It closes, palatability is good, gives full play to drug effect after feeding in animal body.
5, the present invention improves animal body function based on Chinese medicine, bacillary mycoplasma cause of disease is controlled with Western medicine, by big
Experimental exploring is measured, chosen in raw material and achieves best preparation in dosage, by the incidence control of pig chronic respiratory syndrome
System is 20% hereinafter, 8% can be reduced to.
Specific implementation mode
With reference to specific embodiment, present invention be described in more detail.
The clinical effectiveness experiment of the present invention is as follows：
Experimental method：Its No respiratory disease or the lighter child care pig of the state of an illness are determined by clinical examinations, by 100 by body
It is randomly divided into four groups, every group 25 again.
A groups are blank control group, do not give drug therapy；
B group spice final concentrations (in terms of the net content of each component)：The wonderful woods 50PPM of Buddhist nun difficult to understand, Enrofloxacin 80PPM, traditional Chinese medicine powder
1000PPM is added to mixing in feed, continuous feeding 10 days as one therapeutic course；
C group spice final concentrations (in terms of the net content of each component)：The wonderful woods 80PPM of Buddhist nun difficult to understand, Enrofloxacin 120PPM, traditional Chinese medicine powder
2000PPM is added to mixing in feed, continuous feeding 10 days as one therapeutic course；
D group spice final concentrations (in terms of the net content of each component)：The wonderful woods 120PPM of Buddhist nun difficult to understand, Enrofloxacin 150PPM, Chinese medicine
Powder 3000PPM is added to mixing in feed, continuous feeding 10 days as one therapeutic course.
After feeding starts, per day entry affected pig body situation of change, feeding effect is counted after 12 days.
Experimental result statistics such as following table：
It is analyzed to fruit：A groups, respiratory tract incidence 32%, coat gloss is low, and feeding is general.
B groups, respiratory tract incidence 20%, coat gloss is general, and feeding is good.
C groups, respiratory tract incidence 8%, coat gloss is preferable, and feeding is good.
D groups, respiratory tract incidence 8%, coat gloss is preferable, and feeding is general.
D group feed intakes decline, it should related with the palatability of drug.Incidence, appearance luster, the feed intake etc. of comprehensive pig
Factor, recommends to feed intake by B group of formula for the common state of an illness, on Clinical practice, recommends to press for the serious state of an illness, on Clinical practice
C group of formula feeds intake, and each component content in the present invention is higher, and drug effect is better, and the incidence of pig chronic respiratory syndrome is lower,
But palatability can also reduce, and when use should consider various influence factors.
Embodiment
On November 20th, 2014, Hebei Hengshui pig farm, the scale with 300 sows, main problem are respiratory tract disease
Disease is continuous and unbroken, and it is even more serious to enter the winter.We select model case 80, Symptomatic 120 of atypia to press group with Buddhist nun difficult to understand
Wonderful woods 80PPM, Enrofloxacin 120PPM, traditional Chinese medicine powder 2000PPM are added to mixing in feed, continuous feeding 10 days as one therapeutic course.
5 days feeding times are increased to model case.The results show that dead 2 of model case group, 63 clinical observations are asymptomatic,
Remission 15,95% or more effective percentage, 79% or more cure rate.And further only feed traditional Chinese medicine powder 1 week, all alleviate.
Atypical case is all normal, and the speed of growth is accelerated.
It is provided for the embodiments of the invention technical solution above to be described in detail, specific case used herein
The principle and embodiment of the embodiment of the present invention are expounded, the explanation of above example is only applicable to help to understand this
The principle of inventive embodiments；Meanwhile for those of ordinary skill in the art, embodiment according to the present invention, in specific embodiment party
There will be changes in formula and application range, in conclusion the content of the present specification should not be construed as limiting the invention.
Claims (4)
1. a kind of pharmaceutical composition for preventing pig chronic respiratory syndrome, which is characterized in that in the pharmaceutical composition
Each raw material and its weight ratio are valnemulin：Enrofloxacin：Traditional Chinese medicine powder=5-12:8-15:100-300, the original of the traditional Chinese medicine powder
Material group becomes 3 parts of Radix Codonopsis, 2 parts of Radix Glycyrrhizae, 2 parts of Poria cocos, 3 parts of Rhizoma Atractylodis Macrocephalae, 3 parts of lily, 2 parts of Radix Ophiopogonis, 2 parts of prepared RHIZOMA PINELLIZE without adju-vant, 2 parts of aster, fiber crops
1 part yellow, 1 part of Radix Polygalae, 1 part of rhizoma anemarrhenae, 2 parts of Radix Glehniae, 2 parts of dried orange peel, 1 part of float stone.
2. pharmaceutical composition as described in claim 1, which is characterized in that each raw material in the pharmaceutical composition and its weight ratio
For valnemulin：Enrofloxacin：Traditional Chinese medicine powder=5：8：100.
3. pharmaceutical composition as described in claim 1, which is characterized in that the preparation method of the traditional Chinese medicine powder is as follows：
Step 1：By Radix Codonopsis, Radix Glycyrrhizae, Poria cocos, Rhizoma Atractylodis Macrocephalae, lily, Radix Ophiopogonis, prepared RHIZOMA PINELLIZE without adju-vant, aster, Chinese ephedra, Radix Polygalae, rhizoma anemarrhenae, Radix Glehniae,
Dried orange peel stripping and slicing after adding water infiltration, is distilled by steam distillation and obtains extracting solution；
Step 2：Float stone is milled by fine powder using efficient ball mill；
Step 3：The extracting solution obtained in step 1 is uniformly mixed with the float stone fine powder obtained in step 2, low temperature drying vacuum packet
Dress, it is spare.
4. application of the pharmaceutical composition described in claim 1 in the drug for preparing treatment pig chronic respiratory syndrome.
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| CN108030906A (en) * | 2017-12-29 | 2018-05-15 | 湖南惠生农业科技开发股份有限公司 | A kind of Chinese medicine composition for preventing porcine respiratory disease and feed and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953871A (en) * | 2010-10-14 | 2011-01-26 | 山东省农业科学院畜牧兽医研究所 | Antibacterial medicament for animals and preparation method and application thereof |
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2015
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953871A (en) * | 2010-10-14 | 2011-01-26 | 山东省农业科学院畜牧兽医研究所 | Antibacterial medicament for animals and preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中草药在防治猪呼吸道病综合症（PRDC）中的应用研究;沈华伟;《动物科学与动物医学》;20041130;第21卷(第11期);第148页 * |
| 中西药结合对猪呼吸道病综合征的防治;张立新 等;《养猪》;20071231(第6期);第54-56页 * |
| 猪呼吸道病的中草药疗法;陈家红 等;《养殖技术顾问》;20121231(第5期);第50-51页 * |
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