CN101653441A - Veterinary compound florfenicol injection and preparation method thereof - Google Patents
Veterinary compound florfenicol injection and preparation method thereof Download PDFInfo
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- CN101653441A CN101653441A CN200910018587A CN200910018587A CN101653441A CN 101653441 A CN101653441 A CN 101653441A CN 200910018587 A CN200910018587 A CN 200910018587A CN 200910018587 A CN200910018587 A CN 200910018587A CN 101653441 A CN101653441 A CN 101653441A
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Abstract
The invention relates to a veterinary compound florfenicol injection and a preparation method thereof. The injection comprises the following raw materials: florfenicol, maquindox, trimethoprim, atropine sulfate, organic solvent and water for injection. The veterinary compound florfenicol injection can be used as a special veterinary compound preparation which combines florfenicol with maquindox organically so as to broaden the antibacterial spectrum and increase the targeting to enteric diseases; the veterinary compound florfenicol injection can be used to treat the diseases such as yellow scour of newborn piglets, white diarrhea, calf diarrhea, paratyphoid fever, Avian pasteurellosis, pullorum disease, chicken colibacillosis and the like, has especially good effect for curing serpulina caused by treponema, yellow scour of newborn piglets, white diarrhea, bacteric enteritis, calf diarrhea, paratyphoid fever and the other diseases and has the advantage of easy operation, short treatmentperiod, low drug resistance and the like.
Description
Technical field
The present invention relates to a kind of veterinary compound florfenicol injection, particularly a kind of compound preparation of making by florfenicol, Mequindox, trimethoprim, atropine sulfate and preparation method thereof.
Background technology
In recent years, along with the raising of living standards of the people, Developing of Animal Industry and intensive culture gradually become trend, and the breeding stock of poultry rises year by year, and be also increasing to the demand of side-product, and the vast market space has been quickened aquaculture especially and developed rapidly.But from present China Developing of Animal Industry situation, current Bacillus pasteurii disease, yellow scour of piglet, Hakuri, typhoid fever, paratyphoid fever, spreading unchecked of bacterial enteritis are endangered greatly poultry, also do not have the medicine of comparatively ideal treating both the principal and secondary aspects of a disease now on the market.By some market surveys that effective treatment of this respect is done, find, market press for a kind of efficacy stability, good effect, stability high, easy to use Bacillus pasteurii disease, yellow scour of piglet, Hakuri, typhoid fever, paratyphoid fever, bacterial enteritis are spread unchecked specific medicine.
The antimicrobial spectrum or the antibacterial activity of florfenicol are better than thiamphenicol, multiple gram positive bacteria, gram negative bacteria and mycoplasma etc. there is stronger antibacterial activity, pasteurella haemolytica, pasteurella multocida, Actinobacillus pleuropneumoniae are extremely sensitive to this product, clinical intestinal infection, avian colibacillosis, salmonellosis, the respiratory bacillary that is mainly used in poultry typhoid fever, paratyphoid fever, Hakuri, pneumonia and domestic animal infects, with trimethoprim (TMP) use in conjunction, can strengthen the antibiotic property of florfenicol.
Mequindox (Meqnindox) has another name called LIJUNJING, belongs to synthetic quinoxaline antibacterials, has broad-spectrum antibacterial action, and the effect of gram negative bacteria is better than gram positive bacteria, treponema is also had pretend usefulness.Its antibiotic mechanism is synthetic for the DNA (deoxyribonucleic acid) (DNA) that suppresses thalline.To yellow scour of piglet, Hakuri, calf diarrhea, paratyphoid fever, fowl pasteurellosis, the white scour of chicken, chicken colibacillosis etc. are all effective, are mainly used in swine dysentery due to the treponema, yellow scour of piglet, Hakuri, also be used for bacterial enteritis, also can be used for calf diarrhea, paratyphoid fever.
CN1872205 (200610031501.1) discloses a kind of medicine for the treatment of disease of alimentary tract of livestock husbandry and birds, its effective active component and weight proportion are: Mequindox 2g～8g, anisodamine hydrochloride 0.2g～1.0g, sodium salicylate 4g～16g, the effective component extracts of Herba Macleayae Cordatae 40g～55g, the effective component extracts of Radix Isatidis 30g～40g, the effective component extracts of Cortex Phellodendri 30g～40g, the effective component extracts of Rhizoma Coptidis 30g～40g.Medicine instant effect of the present invention, good effect, and product-free is residual, and non-evident effect is difficult for producing drug resistance.Utilize Drug therapy baby pig diarrhoea of the present invention, cure rate 〉=97%; Control Pullorum Disease, cure rate 〉=95%; Control newcastle disease, cure rate reaches 〉=and 93%; Control duck viral hepatitis, cure rate reaches 〉=and 92%; Control duck oromeningitis, cure rate reaches 〉=more than 93%; Control the rabbit gastroenteritis, cure rate reaches 〉=and 96%; Control gosling plague, cure rate reaches 〉=and 98%.But owing to the mechanism of action of Mequindox has determined with the onset time of Mequindox slower.Thereby palpus coupling anticholinergic agent, to remove gastrointestinal convulsion, diarrhoea is alleviated rapidly, alleviate poultry pain, be convenient to feed, the enhancing body resistance.
The synergistic factor trimethoprim can strengthen multiple antibiotic effect, and has a broad antifungal spectrum all has antibacterial action to multiple gram positive bacteria and negative bacterium, and its mechanism of action is that overslaugh thalline nucleic acid is synthetic.Trimethoprim (TMP) is mainly discharged from urine.
Atropine sulfate (Atropine Sulfate) is a M cholinoceptor blocking agent, can compete the M cholinoceptor with acetylcholine, thus the M sample effect of blockage of acetylcholine and exogenous cholinomimetic.Heavy dose also can be blocked the N cholinoceptor that is positioned at neuroganglion and skeletal muscle movement soleplate position, and its pharmacological action is extensive.The atropine of therapeutic dose has extremely significant relexation to the gastrointestinal smooth muscle of excess shrinkage or spasm, forces urine to take second place to bladder, a little less than the effect to bronchus and ureter smooth muscle.In addition, also can relax iris sphincter and ciliary muscle show as mydriasis, intraocular pressure rising and regulate paralysis.Salivary gland and sweat gland are to atropic grade sensitivity, and low dose can make salivary gland, broncheal gland and sweat gland (except the horse) secretion reduce, and can reduce gastric secretion than heavy dose.The therapeutic dose atropine then can of short duration decreased heart rate.More heavy dose of atropine can be removed the inhibition of vagus nerve to heart, and antagonism is because of conduction block and the arrhythmia of vagus nerve due to being overexcited.Heavy dose can be accelerated heart rate, promotes the chamber conduction, and can expand periphery and visceral vessel, removes arteriolospasm, microcirculation improvement.Heavy dose of atropine is excited vagus maincenter, respiratory center, zona rolandica and sensory region obviously.This product intramuscular injection easily absorbs, and is distributed in whole body after the absorption rapidly, can be by placental barrier and blood brain barrier.At liver metabolism, through renal excretion, about 30%～50% discharges with urine with original shape.The atropine sulfate effect is similar to anisodamine hydrochloride, but stronger to the effect of cardiovascular, bronchus and gastrointestinal smooth muscle, and price by comparison, hang down about 2 times, thereby have obvious superiority aspect effect and the cost.
Injection means confession injection intravital sterile solution, emulsion or the suspension that medicine is made, and for the sterilized powder or the concentrated solution of facing with preceding wiring solution-forming or suspension.The characteristics of injection mainly show route of administration without digestive system and defence tissue (liver) and directly inject tissue or blood vessel, so drug effect are rapid, is applicable to first aid.But also the curative effect of some injection is extended, to adapt to the needs in the medical treatment.The dosage of injection is accurate, and reliable effect may suffer the influence of Digestive system, food etc., and make the dosage of taking that curative effect can not take place fully unlike endo-medicine.In addition, can make some drugs bring into play localized effect again.
CN1861084 (200610013625.7) discloses a kind of compound florfenicol injection, Preparation method and use.This compound florfenicol injection is made with following method: (1) takes by weighing florfenicol, doxycycline, dimethyl formamide, magnesium dichloride, polyethylene pyrrolidone, trimethoprim, propylene glycol; (2) doxycycline and magnesium dichloride are put into described dimethyl formamide, be stirred to clear and brightly, add florfenicol again and be stirred to clear and bright; (3), add trimethoprim successively, the polyethylene pyrrolidone stirs and makes dissolving with propylene glycol heating; (4) solution that makes of combining step (2) and step (3), stir heating down, the color for the treatment of medicinal liquid is to add injection water to 1000 part after orange red and clear and bright, promptly make a kind of compound florfenicol injection, the present invention adopts compound preparation, and is effective to mycoplasma hyopneumoniae and bacterial pulmonary infection, enlarged antimicrobial spectrum, improve the survival rate of pig, increase the body weight of pig.The principal agent of this injection is a florfenicol, does not have composite effective ingredient such as Mequindox, atropine sulfate.
CN101422464 (200710150006.7) discloses a kind of compound florfenicol injection that porcine mycoplasmal infects for the treatment of, belongs to contain and the pharmaceutical product of effective ingredient, or the infection veterinary drug.Every 100L injection is made by following raw material: florfenicol 5-20kg, dimethyl formamide 10-30L, doxofylline 0.5-5kg, all the other are propylene glycol.The compound preparation of florfenicol and doxofylline associating is adopted in this invention, and is effectively also efficient to mycoplasmal pneumonia of swine, reduces the medication number of times, and treating both the principal and secondary aspects of a disease is alleviated to suffer from and raiseeed the health stress.Can be widely used in the porcine mycoplasmal disease, alleviate porcine mycoplasmal and infect the clinical symptoms that causes, increase the body weight of pig.The principal agent of this injection is a florfenicol, does not have composite effective ingredient such as Mequindox, atropine sulfate, trimethoprim.
Therefore the present invention becomes compound preparation with florfenicol, Mequindox compatibility.The intestinal infection, avian colibacillosis, salmonellosis, the respiratory bacillary that are used for the treatment of poultry typhoid fever, paratyphoid fever, Hakuri, pneumonia and domestic animal infect.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of veterinary compound florfenicol injection and preparation method thereof is provided.
Technical assignment of the present invention specifically is 1, seek suitable double solvents dissolving florfenicol, Mequindox, trimethoprim, and makes them compatible, guarantees the stability of medicinal liquid.2, consider the adaptability of body, determine the pH of medicinal liquid.
A kind of compound florfenicol injection, raw material components is as follows:
Florfenicol 6-15g, Mequindox 5-8g, trimethoprim 1-5g, atropine sulfate 0.03-0.05g, organic solvent 75-80g, water for injection 4-8g; Wherein, florfenicol, Mequindox, trimethoprim, atropine sulfate are all in pure product.
Described organic solvent is benzyl alcohol, N, dinethylformamide and alpha-pyrrolidone, and benzyl alcohol, N, the weight ratio of dinethylformamide and alpha-pyrrolidone is (1-2): (3-5): (3-5);
The preparation method of above-mentioned veterinary compound florfenicol injection, step is as follows:
1) florfenicol, trimethoprim are dissolved in N, in the dinethylformamide, get florfenicol, trimethoprim mixed solution;
2) with Mequindox and alpha-pyrrolidone, the benzyl alcohol mixed dissolution gets Mequindox solution;
3) atropine sulfate is dissolved in an amount of water for injection, gets atropine sulfate solution;
4) florfenicol that step 1) is made, trimethoprim mixed solution, step 2) the atropine sulfate solution that makes of the Mequindox solution that makes and step 3) mixes, stir, the water for injection that adds surplus, transferring pH with lactic acid is 4.8～5.4, with organic membrane filtration of 0.22～0.45 μ m, get filtrate;
5) filtrate that step 4) is made is at 121 ℃, and 0.15MPa sterilization 15-20 minute promptly gets veterinary compound florfenicol injection.
Preferably, the described N of step 1), dinethylformamide and step 2) described in alpha-pyrrolidone and the weight ratio of benzyl alcohol be (3-5): (3-5): (1-2).
Preferably, the pH of filtrate is 5.0～5.2 in the described step 5).
More than each raw material components be medical commercially available prod.
Beneficial effect of the present invention is as follows:
The present invention is with florfenicol, the Mequindox compatibility becomes compound preparation, antimicrobial spectrum had both been widened in the combination of the two, strengthened targeting again to intestinal tract disease, add trimethoprim (TMP), make florfenicol, the Mequindox antibacterial activity strengthens 4～6 times, at the treatment yellow scour of piglet, Hakuri, calf diarrhea, paratyphoid fever, fowl pasteurellosis, the white scour of chicken, chicken colibacillosis etc., swine dysentery due to the treponema, yellow scour of piglet, Hakuri, bacterial enteritis, calf diarrhea, there is specially good effect aspects such as paratyphoid fever, have easy to use, short treating period, advantages such as drug resistance is low.
The mechanism of action of the present invention is as follows:
1, determines that double solvents is used to dissolve florfenicol, Mequindox, trimethoprim (TMP), and can make them compatible, guarantee the stability of medicinal liquid.
2, add trimethoprim (TMP), make florfenicol, Mequindox antibacterial activity strengthen 4～6 times.
3, consider the adaptability of body, determine pH4.8～5.4 of medicinal liquid, preferred pH is 5.0～5.2.
Its prescription of the present invention and production technology be domestic initiation only, its scientific formulation forms through a large amount of screenings, and through secular study on the stability, stablizing of proof character ten minutes, be subjected to the influence of exterior ambient environment little, after the administration, long action time, local irriate effect is little, and easy to use, curative effect is reliable, has than vast market prospect.
The specific embodiment
Below in conjunction with embodiment technical scheme of the present invention is illustrated in detail.
Each raw material is described as follows among the embodiment: florfenicol, and Zhejiang Haixiang Pharmaceutical Co., Ltd. sells; Mequindox, the leading scientific and technological pharmaceutcal corporation, Ltd in Henan sells; Trimethoprim, the holy nation in Shouguang City bio tech ltd is sold; Atropine sulfate, Pu Rui pharmaceutical Co. Ltd in Henan sells.
Embodiment 1
A kind of veterinary compound florfenicol injection contains following component, is weight portion:
Florfenicol 10g, Mequindox 5g, trimethoprim 1g, atropine sulfate 0.04g, N, dinethylformamide 50g, alpha-pyrrolidone 15g, benzyl alcohol 15g, water for injection 4g;
This veterinary compound florfenicol injection adopts the following steps preparation:
1) with florfenicol 10g and trimethoprim 1.2g and N, dinethylformamide 50g mixed dissolution gets florfenicol and trimethoprim mixed solution 61.2g;
2) with Mequindox 5g and alpha-pyrrolidone 15g, benzyl alcohol 15g mixed dissolution, Mequindox solution 35g;
3) atropine sulfate 0.04g is dissolved in the 2g water for injection, gets atropine sulfate solution 2.04g.
4) with florfenicol, the mixed solution 61.2g of trimethoprim, the step 2 of step 1) gained) the Mequindox solution 35g of gained and the atropine sulfate solution 2.04g of step 3) gained mix, add surplus water for injection, stir, adjust pH is 5.1, with organic membrane filtration of 0.22-0.45 μ m, get filtrate;
5) filtrate that step 4) is made is at 121 ℃, and 0.15MPa sterilized 20 minutes, and surveying pH value is 5.1, promptly gets veterinary compound florfenicol injection.
Embodiment 2
A kind of veterinary compound florfenicol injection contains following component, is weight portion:
Florfenicol 6g, Mequindox 8g, trimethoprim 3g, atropine sulfate 0.03g, N, dinethylformamide 30g, alpha-pyrrolidone 25g, benzyl alcohol 20g, water for injection 8g;
Preparation process is with embodiment 1.
Embodiment 3
A kind of veterinary compound florfenicol injection contains following component, is weight portion:
Florfenicol 15g, Mequindox 6g, trimethoprim 5g, atropine sulfate 0.05g, N, dinethylformamide 45g, alpha-pyrrolidone 15g, benzyl alcohol 10g, water for injection 4g;
Preparation process is with embodiment 1.
Embodiment 4
The clinical experiment of embodiment 1 veterinary compound florfenicol injection is as follows:
Test method:
The test data of this veterinary compound florfenicol injection is as follows: controlled animal by the body weight per kilogram, veterinary compound florfenicol injection 0.1ml/kgl of injection in first day, used medicine drinking-water in second day instead, continue treatment three days, the configuration of medicine drinking-water is to get veterinary compound florfenicol injection 100ml, convert water 100kg, press the dosage of animal per kg body weight 0.1ml compound florfenicol injection and drink water for animal pharmaceuticals every day, detect according to a conventional method then.
The result of the test of embodiment 1 veterinary compound florfenicol injection is as follows:
Table 1 embodiment 1 clinical therapeutic efficacy
Table 2 embodiment 1 and florfenicol injection clinical treatment comparative test result
Experimental example:
Da Zhang town, Shenxian County Jiang feeds 6000 of meat chickens, and 7 age in days sudden onset show as the young poly-heap of disease, near thermal source, lethargy draws white be clamminess loose stool or yellow loose stool, and pollutes perianal fine hair, the feather pine is disorderly suffered from diarrhoea, and doubts to be the salmonellal Hakuri of chickling.After using injection (the every 1kg body weight injection 0.1ml) injection once of the embodiment of the invention 1, the chicken group mental status is clearly better, suffering from diarrhoea obviously alleviates, used medicine drinking-water in second day instead, continue treatment, (configuration of medicine drinking-water is to get veterinary compound florfenicol injection 100ml, converts water 100kg, pressing the dosage of animal per kg body weight 0.1ml compound florfenicol injection drinks water for animal pharmaceuticals every day,) after three days, basic rehabilitation, cure rate reaches 99.50%.
Safety testing result: the no abnormal death of injection back chicken.Observed 30 days, the chicken after the administration grows fine, and does not have any disease dead 5 of matched group takes place.
Show by above experiment, injection of the present invention has significant curative effect to the intestinal infection of poultry typhoid fever, paratyphoid fever, Hakuri, pneumonia and domestic animal, chicken colibacillosis, salmonellosis, respiratory bacillary infection etc. in clinical treatment, especially to just, case onset in mid-term is rapid; Other bacterial disease diseases of poultry also there is good curative effect.
Contrast therapy result shows that the cure rate of injection for treating baby pig diarrhoea of the present invention, chicken colibacillosis, calf paratyphoid fever is better than the florfenicol injection group for all being higher than matched group.Safety test proves that the present invention does not show toxic and side effects.
Embodiment 5
The stability test of product is as follows:
Stability testing method: the compound florfenicol injection among the embodiment 1-3 places (40 ± 2 ℃ of calorstats by commercially available back, 75 ± 5%) accelerated test six months under the condition, when producing, deposit one month, deposit two months, deposited three months and deposited each sampling in six months once, its character, pH value, content are detected;
The stability test result: all kinds of indexs of product, see following table for details.
Embodiment 1:
| Holding time | Character | The pH value | Florfenicol content (labelled amount %) | Mequindox content (labelled amount %) | Trimethoprim content (labelled amount %) | Atropine sulfate (labelled amount %) |
| 0 month | Yellow clear liquid | ??5.1 | ??102.1％ | ??100.7％ | ??101.3％ | ??100.2％ |
| 1 month | Yellow clear liquid | ??5.1 | ??102.1％ | ??100.6％ | ??101.3％ | ??99.9％ |
| 2 months | Yellow clear liquid | ??5.1 | ??101.7％ | ??100.3％ | ??101.0％ | ??99.6％ |
| 3 months | Yellow clear liquid | ??5.1 | ??101.3％ | ??100.0％ | ??100.7％ | ??99.3％ |
| 6 months | Yellow clear liquid | ??5.1 | ??100.5％ | ??99.4％ | ??100.1％ | ??98.7％ |
Embodiment 2:
| Holding time | Character | The pH value | Florfenicol content (labelled amount %) | Mequindox content (labelled amount %) | Trimethoprim content (labelled amount %) | Atropine sulfate (labelled amount %) |
| 0 month | Yellow clear liquid | ??5.0 | ??103.2％ | ??99.7％ | ??100.4％ | ??99.2％ |
| 1 month | Yellow clear liquid | ??5.0 | ??103.2％ | ??99.7％ | ??100.2％ | ??99.0％ |
| 2 months | Yellow clear liquid | ??5.0 | ??102.9％ | ??99.5％ | ??100.0％ | ??98.7％ |
| 3 months | Yellow clear liquid | ??5.0 | ??102.6％ | ??99.1％ | ??99.7％ | ??98.2％ |
| 6 months | Yellow clear liquid | ??5.0 | ??101.7％ | ??98.5％ | ??99.1％ | ??97.8％ |
Embodiment 3:
| Holding time | Character | The pH value | Florfenicol content (labelled amount %) | Mequindox content (labelled amount %) | Trimethoprim content (labelled amount %) | Atropine sulfate (labelled amount %) |
| 0 month | Yellow clear liquid | ??5.2 | ??99.1％ | ??100.1％ | ??100.9％ | ??101.1％ |
| 1 month | Yellow clear liquid | ??5.2 | ??99.1％ | ??99.9％ | ??100.9％ | ??101.0％ |
| 2 months | Yellow clear liquid | ??5.2 | ??98.7％ | ??99.8％ | ??100.7％ | ??100.8％ |
| 3 months | Yellow clear liquid | ??5.2 | ??98.5％ | ??99.5％ | ??100.3％ | ??100.7％ |
| 6 months | Yellow clear liquid | ??5.2 | ??97.6％ | ??98.8％ | ??99.7％ | ??100.2％ |
From above data as can be seen, after through 6 months product accelerated test, product colour does not have significant change, and all within prescribed limit, pH does not have significant change, and within prescribed limit, the variation of product content is all within prescribed limit.The result shows, at 40 ± 2 ℃, under 75 ± 5% conditions, pH value is between 8.5～8.9 the time, and character, pH value, content are all up to specification, illustrate that this product is very stable under this experimental condition.Can be decided to be 2 years effect duration.
Claims (4)
1, a kind of veterinary compound florfenicol injection is characterized in that, raw material components is as follows:
Florfenicol 6-15g, Mequindox 5-8g, trimethoprim 1-5g, atropine sulfate 0.03-0.05g, organic solvent 75-80g, water for injection 4-8g;
Described organic solvent is N, dinethylformamide, alpha-pyrrolidone and benzyl alcohol, and N, the weight ratio of dinethylformamide, alpha-pyrrolidone and benzyl alcohol is (3-5): (3-5): (1-2).
2, the preparation method of the described veterinary compound florfenicol injection of claim 1 is characterized in that, step is as follows:
1) florfenicol, trimethoprim are dissolved in N, in the dinethylformamide, get florfenicol, trimethoprim mixed solution;
2), get Mequindox solution with Mequindox and alpha-pyrrolidone and benzyl alcohol mixed dissolution;
3) atropine sulfate is dissolved in an amount of water for injection, gets atropine sulfate solution;
4) florfenicol that step 1) is made, trimethoprim mixed solution, step 2) the atropine sulfate solution that makes of the Mequindox solution that makes and step 3) mixes, stir, the water for injection that adds surplus, with the lactic acid adjust pH is 4.8～5.4, with organic membrane filtration of 0.22～0.45 μ m, get filtrate;
5) filtrate that step 4) is made is at 121 ℃, and 0.15MPa sterilization 15-20 minute promptly gets veterinary compound florfenicol injection.
3, the preparation method of veterinary compound florfenicol injection as claimed in claim 2, it is characterized in that, N described in the step 1), dinethylformamide, step 2) described in alpha-pyrrolidone and the weight ratio of benzyl alcohol be (3-5): (3-5): (1-2).
4, the preparation method of veterinary compound florfenicol injection as claimed in claim 2 is characterized in that, adjust pH is 5.0～5.2 in the described step 4).
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| CN102274228A (en) * | 2011-06-29 | 2011-12-14 | 河南牧翔动物药业有限公司 | Compound trimethoprim and sodium succinate florfenicol nanoemulsion preparation and preparation thereof |
| CN102283842A (en) * | 2011-08-24 | 2011-12-21 | 西北农林科技大学 | Compound mequindox florfenicol nanoemulsion antibacterial drug and preparation method thereof |
| CN103432153A (en) * | 2013-08-13 | 2013-12-11 | 潍坊富邦药业有限公司 | Novel prescription of injection for treating infectious pleuropneumonia of livestock and preparation technology thereof |
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| CN102274228A (en) * | 2011-06-29 | 2011-12-14 | 河南牧翔动物药业有限公司 | Compound trimethoprim and sodium succinate florfenicol nanoemulsion preparation and preparation thereof |
| CN102274228B (en) * | 2011-06-29 | 2012-09-05 | 河南牧翔动物药业有限公司 | Compound trimethoprim and sodium succinate florfenicol nanoemulsion preparation and preparation thereof |
| CN102283842A (en) * | 2011-08-24 | 2011-12-21 | 西北农林科技大学 | Compound mequindox florfenicol nanoemulsion antibacterial drug and preparation method thereof |
| CN103432153A (en) * | 2013-08-13 | 2013-12-11 | 潍坊富邦药业有限公司 | Novel prescription of injection for treating infectious pleuropneumonia of livestock and preparation technology thereof |
| CN103432153B (en) * | 2013-08-13 | 2015-04-22 | 潍坊富邦药业有限公司 | Novel prescription of injection for treating infectious pleuropneumonia of livestock and preparation technology thereof |
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| CN108836942A (en) * | 2018-09-26 | 2018-11-20 | 四川兴华药业有限责任公司 | A kind of compound mequindox injection and preparation method thereof for treating grice diarrhoea |
| CN110893170A (en) * | 2019-12-04 | 2020-03-20 | 北京立时达药业有限公司 | Single-component mequindox injection and preparation method thereof |
| CN110893170B (en) * | 2019-12-04 | 2021-09-24 | 北京立时达药业有限公司 | Single-component mequindox injection and preparation method thereof |
| CN111494312A (en) * | 2020-05-20 | 2020-08-07 | 山东省健牧生物药业有限公司 | Oral liquid for preventing and treating chicken colibacillosis and preparation method thereof |
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Assignee: Shandong Enkang Pharmaceutical Co., Ltd. Assignor: Chen Jianbo Contract record no.: 2011370000380 Denomination of invention: Veterinary compound florfenicol injection and preparation method thereof License type: Exclusive License Open date: 20100224 Record date: 20110822 |
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