CN104739960A - Intestine and stomach antibacterial drug composition, and intestine and stomach antibacterial drug containing intestine and stomach antibacterial drug composition and preparation thereof - Google Patents
Intestine and stomach antibacterial drug composition, and intestine and stomach antibacterial drug containing intestine and stomach antibacterial drug composition and preparation thereof Download PDFInfo
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Abstract
The present invention relates to an intestine and stomach antibacterial drug composition, and an intestine and stomach antibacterial drug containing the intestine and stomach antibacterial drug composition and preparation thereof. The drug composition comprises, by weight, 100-300 parts of coptis chinensis, 50-150 parts of rheum palmatum, and 50-150 parts of licorice root. The intestine and stomach antibacterial drug comprises the drug composition, a pharmaceutically acceptable carrier and other drug auxiliary agents. The three traditional Chinese medicines such as coptis chinensis, rheum palmatum and licorice root are subjected to extraction processing to obtain an extract, and the extract and the drug auxiliary agents are mixed according to a certain ratio to prepare the intestine and stomach antibacterial drug. According to the intestine and stomach antibacterial drug composition and the intestine and stomach antibacterial drug of the present invention, the existing formula of the Sihuang dysentery stopping granules is simplified, the production cost is reduced, the clinical treatment efficacy is good, and the intestine and stomach antibacterial drug preparation prepared from the intestine and stomach antibacterial drug composition provides the same treatment effect compared with the existing Sihuang dysentery stopping granules.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of the intestines and stomach antibacterial combination, containing the intestines and stomach antibacterials of said composition and preparation thereof.
Background technology
A kind of preparation being conventionally used to the treatment of damp-heat dysentery and chicken colibacillosis is four yellow Zhili granules, said preparation by Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae 6 taste Chinese medicine through extract be processed into extractum after, the granule be mixed according to a certain percentage with sucrose, dextrin, there is effect of clearing away heat-fire, dysentery relieving, the clinical treatment being mainly used in damp-heat dysentery and chicken colibacillosis, as the escherichia coli of chicken, pasteurellosis bacillus, Salmonella infects and viral disease secondary infection causes damp-heat dysentery, Hakuri, yellow-white dysentery, water sample dysentery etc.; The spurting watery diarrhea etc. that the viral diseases such as the diarrhoea that swine escherichia coli, Salmonella cause, HUANGBAI(sic) dysentery, Transmissible Gastroenteritis, epidemic diarrhea, rotavirus diarrhea cause.The curative effect definite because of it and good reputation, be successively included in 2005 editions, 2010 editions People's Republic of China's veterinary drug allusion quotations.But four yellow Zhili granule complicated components, non-principal component is more, and difficult quality controls, and limits four yellow Zhili granule application clinically to a certain extent.
Chinese patent CN102008585B discloses a kind of four yellow dysentery relieving effervescent granules and preparation method thereof, be prepared from by the stock and adjunct of following weight portion: Rhizoma Coptidis 200, Cortex Phellodendri 200, Radix Et Rhizoma Rhei 100, Radix Scutellariae 200, Radix Isatidis 200, Radix Glycyrrhizae 100, sodium bicarbonate 108 ~ 132, fumaric acid 90 ~ 110, diluent 549 ~ 671, correctives 18 ~ 22.The method simultaneously adopting soda acid separately to granulate prepares effervescent granule.The present invention adopts sodium bicarbonate as alkaline agent, fumaric acid is as acidizer, and add other adjuvant and prepare four yellow dysentery relieving effervescent granules and can reduce supplementary product consumption, preparation technology is simple, easy-formation, not easily moisture absorption, rate of effervescence is fast, effervescent is effective, and melting is good, after effervescent medicinal liquid clarity good, without breeze foreign body etc.Also there is complicated component in said preparation, non-principal component is more, quality problem rambunctious.
Therefore, current Problems existing needs a kind of composition of research and development simple, and quality is easy to control, and eutherapeutic the intestines and stomach antibiotic preparation.
Summary of the invention
Technical problem to be solved by this invention is for the deficiencies in the prior art, provides a kind of the intestines and stomach antibacterial combination, and it is made up of Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Glycyrrhizae 3 taste Chinese medicine.Present invention also offers a kind of the intestines and stomach antibacterials, it is made up of the pharmaceutical adjuvant such as aforementioned pharmaceutical compositions and pharmaceutically acceptable carrier.These the intestines and stomach antibacterials be by Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Glycyrrhizae 3 taste Chinese medicine through extract be processed into extractum after, be mixed according to a certain percentage with pharmaceutical adjuvant.The intestines and stomach antibacterial combination of the present invention and the intestines and stomach antibacterials simplify existing four yellow Zhili granule prescriptions, reduce production cost, and clinical efficacy are good.
For this reason, first aspect present invention provides a kind of the intestines and stomach antibacterial combination, with parts by weight, composed of the following components:
Rhizoma Coptidis 100 ~ 300 parts,
Radix Et Rhizoma Rhei 50 ~ 150 parts, and
50 ~ 150 parts, Radix Glycyrrhizae.
The present invention second aspect provides a kind of the intestines and stomach antibacterials, and its pharmaceutical composition provided by first aspect present invention and pharmaceutical adjuvant form, and wherein, described pharmaceutical adjuvant comprises the pharmaceutically acceptable carrier of 200 ~ 300 parts by weight.
According to the present invention, described pharmaceutically acceptable carrier comprises soluble starch, dextrin, glucose or sucrose.
In one embodiment of the invention, described pharmaceutical adjuvant also comprises the saccharin sodium counting 8 ~ 12 parts by weight.
In another embodiment of the present invention, described the intestines and stomach antibacterials are graininess.
Third aspect of the present invention provides a kind of preparation method of the intestines and stomach antibacterials according to right the present invention second aspect, and it comprises:
Steps A, preparation Rhizoma Coptidis-Radix Et Rhizoma Rhei-GANGCAO GAO: soak Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae and carry out first time decoct, then filter, obtain Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae mix decoction liquor I, add water and carry out second time in residue medicinal residues and decoct, then filter, obtain Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae mixing decoction liquor II, merge mixing decoction liquor I and II, filter, leave standstill, by supernatant concentrating under reduced pressure, to obtain final product;
Step B, prepares the intestines and stomach antibacterials: in Rhizoma Coptidis-Radix Et Rhizoma Rhei-Radix Glycyrrhizae extractum, add pharmaceutical adjuvant, spray-dried granulation, sieves, and to obtain final product.
According to the present invention, the described Rhizoma Coptidis-relative density of Radix Et Rhizoma Rhei-Radix Glycyrrhizae extractum under 20 DEG C of conditions is 1.32 ~ 1.35.
In a specific embodiment of the present invention, in step, according to Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Glycyrrhizae gross weight 8 times soak Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae 4h, carry out first time decoction, filter, obtain Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae mixing decoction liquor I, 1h is decocted with water according to 8 times of residue medicinal residues weight, filter, obtain Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae mixing decoction liquor II, merge mixing decoction liquor I and II, filter, leave standstill, by supernatant concentrating under reduced pressure, obtained Rhizoma Coptidis-Radix Et Rhizoma Rhei-GANGCAO GAO.
In another detailed description of the invention of the present invention, in stepb, in Rhizoma Coptidis-Radix Et Rhizoma Rhei-GANGCAO GAO, add pharmaceutically acceptable carrier and saccharin sodium, spray-dried granulation, cross 16 mesh sieves, obtained the intestines and stomach antibacterials.
The present invention the 4th aspect provides the application of a kind of pharmaceutical composition according to the present invention first aspect in the medicine for the preparation for the treatment of damp-heat dysentery and chicken colibacillosis.
Term described in the present invention " extractum " refers to the extract of Chinese medicine extraction liquid after concentrated, because be paste, institute thinks extractum.
Term described in the present invention " decoction " refers to that atmospheric boiling extracts the method for Chinese medicine ingredients.
The intestines and stomach antibacterial combination provided by the present invention is made up of Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Glycyrrhizae 3 taste Chinese medicine.The pharmaceutical adjuvant compositions such as the intestines and stomach antibacterials of the present invention pharmaceutical composition provided by the present invention and pharmaceutically acceptable carrier.These the intestines and stomach antibacterials be by Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Glycyrrhizae 3 taste Chinese medicine through extract be processed into extractum after, be mixed according to a certain percentage with pharmaceutical adjuvant.The intestines and stomach antibacterial combination of the present invention and the intestines and stomach antibacterials simplify existing four yellow Zhili granule prescriptions, reduce production cost, and clinical efficacy are good.The intestines and stomach antibacterial combination is made the intestines and stomach antibacterial medicine preparation suitable with existing four yellow Zhili granule therapeutic effect.
Detailed description of the invention
For making the present invention easier to understand, describe the present invention in detail below in conjunction with embodiment, these embodiments only play illustrative effect, are not limited to range of application of the present invention, NM specific experiment method in the following example, conveniently experimental technique carries out usually.
Embodiment of the present invention Rhizoma Coptidis used, Radix Et Rhizoma Rhei, licorice medicinal materials and saccharin sodium source: Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, be purchased from Bozhou Chigusa Pharmaceutical Factory; Saccharin sodium, content 99.1%, Jingde, Zhengzhou chemical products company limited.Embodiment
Embodiment 1:
A kind of Chinese medicine compound antimicrobial drug, comprises the component of following parts by weight: Rhizoma Coptidis 200, Radix Et Rhizoma Rhei 100, Radix Glycyrrhizae 100, soluble starch 250g.Its preparation method is as follows:
1,200g Rhizoma Coptidis, 100g Radix Et Rhizoma Rhei, 100g Radix Glycyrrhizae is taken, by the water soaking 4h of 8 times amount medical material weight, heating decocts, first time 2h, second time medicinal residues add the soak by water 1h of 8 times amount medical material weight, merge decoction liquor, filter, leave standstill, getting relative density when supernatant is evaporated to 20 DEG C is the thick paste of 1.32 ~ 1.35.
2, add in thick paste, 250g soluble starch, spray-dried granulation, cross 16 mesh sieves, to obtain final product.
Embodiment 2:
A kind of Chinese medicine compound antimicrobial drug, comprises the component of following parts by weight: Rhizoma Coptidis 100, Radix Et Rhizoma Rhei 50, Radix Glycyrrhizae 50, glucose 200.Its preparation method is as follows:
1,100g Rhizoma Coptidis, 50g Radix Et Rhizoma Rhei, 50g Radix Glycyrrhizae is taken, by the water soaking 4h of 8 times amount medical material weight, heating decocts, first time 2h, second time medicinal residues add the soak by water 1h of 8 times amount medical material weight, merge decoction liquor, filter, leave standstill, getting relative density when supernatant is evaporated to 20 DEG C is the thick paste of 1.32 ~ 1.35.
2, in thick paste, add 200g glucose, spray-dried granulation, cross 16 mesh sieves, to obtain final product.
Embodiment 3:
A kind of Chinese medicine compound antimicrobial drug, comprises the component of following parts by weight: Rhizoma Coptidis 300, Radix Et Rhizoma Rhei 150, Radix Glycyrrhizae 150, dextrin 100, sucrose 200g.Its preparation method is as follows:
1,300g Rhizoma Coptidis, 150g Radix Et Rhizoma Rhei, 150g Radix Glycyrrhizae is taken, by the water soaking 4h of 8 times amount medical material weight, heating decocts, first time 2h, second time medicinal residues add the soak by water 1h of 8 times amount medical material weight, merge decoction liquor, filter, leave standstill, getting relative density when supernatant is evaporated to 20 DEG C is the thick paste of 1.32 ~ 1.35.
2, add in thick paste, 300g dextrin, sucrose 200g, spray-dried granulation, cross 16 mesh sieves, to obtain final product.
Embodiment 4: Chinese medicine compound antimicrobial drug is to the clinical effect trial of artificial challenge's colibacillosis
Control drug: four yellow granulation granules, self-control.
Four yellow Zhili granule preparation methoies:
(1) Rhizoma Coptidis 200g, Cortex Phellodendri 200g, Radix Et Rhizoma Rhei 100g, Radix Scutellariae 200g, Radix Isatidis 200g, Radix Glycyrrhizae 100g is taken respectively, join in 8000ml purified water and soak 4h, decoct 2 times, first time 2h, the purified water that second time medicinal residues add 8 times of medical material weight decocts 1h, merges decoction liquor, filters, leave standstill, get supernatant and be evaporated to the thick paste that relative density is 1.31 ~ 1.35.
(2) add the sucrose of the dextrin of 2 times of thick paste quality, 25% thick paste quality in thick paste, mix homogeneously, makes soft material, and 16 mesh sieves are granulated, and dry under 70 ~ 80 DEG C of conditions, granulate, to obtain final product.
Choose 20 age in days SPF chicken 180, be divided into 6 groups at random, often organize 30, often group is weighed.The grouping of experimental animal and dosage regimen are in table 1.
Table 1
| Group | Number of animals/only | First body weight/g | Dosage regimen |
| 1st group: embodiment 1 | 30 | 191.4 | Infect, 1mg/ml concentrates drinking-water, is used in conjunction 5d |
| 2nd group: embodiment 2 | 30 | 178.9 | Infect, 1mg/ml concentrates drinking-water, is used in conjunction 5d |
| 3rd group: embodiment 3 | 30 | 184.2 | Infect, 1mg/ml concentrates drinking-water, is used in conjunction 5d |
| 4th group: drug control group | 30 | 176.5 | Infect, 1mg/ml concentrates drinking-water, is used in conjunction 5d |
| 5th group: positive controls | 30 | 185.2 | Infect, not administration |
| 6th group: normal healthy controls group | 30 | 187.8 | Do not infect, not administration |
1st ~ 5 groups of chicken cervical region subcutaneous injection escherichia coli (chickenE coliO2 reference culture, China Veterinery Drug Inspection Office provides) culture fluid (bacterial concentration 5 × 108CFU/ml) 0.5ml.1st ~ 4 groups start administration when there is symptom after counteracting toxic substances, prohibit water 2h, be used in conjunction 5d before medication.After counteracting toxic substances, every day observes the clinical symptoms such as each group of the chicken mental status, appetite, breathing, and record morbidity and death condition, cut open inspection and to die of illness chicken, observe lesion degree, make bacteria distribution and cultivate, determine the cause of the death, continue observation after drug withdrawal 14 days.
Index of assessment of curative effect is as follows:
Cure: duration of test, after drinking water administration, escherichia coli disease symptoms fades away, and the mental status, appetite, breathing etc. recover normal.Cure rate=healing chicken number/morbidity chicken number.
Effective: duration of test, after drinking water administration, the symptoms such as diarrhoea alleviate, and the mental status, appetite, breathing etc. progressively recover normal.Effective percentage=effectively chicken number/morbidity chicken number.
Dead: death appears escherichia coli disease symptoms and in duration of test, and cuing open inspection has typical characteristics of lesion, and pathological material of disease can isolate escherichia coli, be judged to be to infect this bacterium dead.Mortality rate=dead chicken number/test chicken number.
Weightening finish: on-test and at the end of weigh chicken body weight respectively, calculate average weight gain and body weight increase rate.With normal healthy controls group chicken at the average weight gain of duration of test for 100%, calculate the body weight increase rate of other each group chickens.
Add up each group of sickness rate, mortality rate, effective percentage, cure rate and body weight increase rate, X 2 test is carried out to mortality rate, effective percentage, cure rate, t inspection is carried out to body weight increase rate.
Blank group chicken is good in duration of test spirit, and appetite is normal, No respiratory, bowel symptoms, cuts open inspection without pathological changes after off-test.Start after 1st ~ 5 groups of chicken counteracting toxic substances 5h to occur to be afraid of cold, flock together, lassitude, search for food reduce or do not eat, the symptom such as diarrhoea, sickness rate reaches about 90%, acute death chicken is there is successively after counteracting toxic substances 12h, inspection is cutd open to dead chicken and finds the typical colibacillosis pathological changes such as caecum, duodenal hemorrhage, make a definite diagnosis chicken ehec infection.Concrete result of the test is in table 2.
Table 2
Conclusion: compared with positive controls, 1st ~ 4 groups of chicken mortality rates are starkly lower than positive controls, and effective percentage, cure rate are apparently higher than positive controls, and difference is extremely remarkable; 1st ~ 3 groups of chicken mortality rates lower than drug control group, effective percentage, cure rate higher than drug control group, no significant difference.
Body weight increase rate statistical result is in table 3.
Table 3
Conclusion, 1st ~ 4 groups of chicken body weight increase rate apparently higher than positive controls, significant difference; Without significant difference between 1st ~ 4 groups.
Conclusions illustrates that Chinese medicine compound antimicrobial drug prepared by the present invention is suitable with four yellow Zhili granule therapeutic effect.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. a intestines and stomach antibacterial combination, with parts by weight, composed of the following components:
Rhizoma Coptidis 100 ~ 300 parts,
Radix Et Rhizoma Rhei 50 ~ 150 parts, and
50 ~ 150 parts, Radix Glycyrrhizae.
2. the intestines and stomach antibacterials, it is made up of pharmaceutical composition as claimed in claim 1 and pharmaceutical adjuvant, and wherein, described pharmaceutical adjuvant comprises the pharmaceutically acceptable carrier of 200 ~ 300 parts by weight.
3. the intestines and stomach antibacterials according to claim 2, is characterized in that, described pharmaceutically acceptable carrier comprises soluble starch, dextrin, glucose or sucrose.
4. the intestines and stomach antibacterials according to Claims 2 or 3, is characterized in that, described pharmaceutical adjuvant also comprises the saccharin sodium counting 8 ~ 12 parts by weight.
5. according to the intestines and stomach antibacterials in claim 2 ~ 4 described in any one, it is characterized in that, described the intestines and stomach antibacterials are graininess.
6., according to a preparation method for the intestines and stomach antibacterials in claim 2 ~ 5 described in any one, it comprises:
Steps A, preparation Rhizoma Coptidis-Radix Et Rhizoma Rhei-GANGCAO GAO: soak Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae and carry out first time decoct, then filter, obtain Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae mix decoction liquor I, add water and carry out second time in residue medicinal residues and decoct, then filter, obtain Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae mixing decoction liquor II, merge mixing decoction liquor I and II, filter, leave standstill, by supernatant concentrating under reduced pressure, to obtain final product;
Step B, prepares the intestines and stomach antibacterials: in Rhizoma Coptidis-Radix Et Rhizoma Rhei-Radix Glycyrrhizae extractum, add pharmaceutical adjuvant, spray-dried granulation, sieves, and to obtain final product.
7. preparation method according to claim 6, is characterized in that, the described Rhizoma Coptidis-relative density of Radix Et Rhizoma Rhei-Radix Glycyrrhizae extractum under 20 DEG C of conditions is 1.32 ~ 1.35.
8. the application of pharmaceutical composition according to claim 1 in the medicine for the preparation for the treatment of damp-heat dysentery and chicken colibacillosis.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622989A (en) * | 2015-01-15 | 2015-05-20 | 西安医学院 | Traditional Chinese medicine compound sterilizing agent and preparation method thereof |
| CN108186752A (en) * | 2018-03-22 | 2018-06-22 | 山西福瑞沃农大生物技术工程有限公司 | A kind of herbal medicine for treating fowl bacterial diarrhea and preparation method thereof |
| CN110954645A (en) * | 2019-09-09 | 2020-04-03 | 山东琪康生物技术有限公司 | Detection method of high-quality Sihuang dysentery stopping granules |
| CN115154427A (en) * | 2022-08-15 | 2022-10-11 | 保定冀中药业有限公司 | Preparation method for improving damp-heat diarrhea effect of Sihuang diarrhea-stopping granules |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622989A (en) * | 2015-01-15 | 2015-05-20 | 西安医学院 | Traditional Chinese medicine compound sterilizing agent and preparation method thereof |
| CN108186752A (en) * | 2018-03-22 | 2018-06-22 | 山西福瑞沃农大生物技术工程有限公司 | A kind of herbal medicine for treating fowl bacterial diarrhea and preparation method thereof |
| CN110954645A (en) * | 2019-09-09 | 2020-04-03 | 山东琪康生物技术有限公司 | Detection method of high-quality Sihuang dysentery stopping granules |
| CN110954645B (en) * | 2019-09-09 | 2020-09-29 | 山东琪康生物技术有限公司 | Detection method of high-quality Sihuang dysentery stopping granules |
| CN115154427A (en) * | 2022-08-15 | 2022-10-11 | 保定冀中药业有限公司 | Preparation method for improving damp-heat diarrhea effect of Sihuang diarrhea-stopping granules |
| CN115154427B (en) * | 2022-08-15 | 2023-07-11 | 保定冀中药业有限公司 | Preparation method for improving effect of Sihuang dysentery stopping particles in treating damp-heat dysentery |
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