CN102973702B - Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof - Google Patents
Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a piglet yellow and white scour treatment compound traditional Chinese medicine composition and a preparation method thereof. The preparation method specifically comprises: carrying out decoction, filtration, concentration and spray drying on Chinese pulsatilla root, tomentose populus ament, coptis chinensis, amur corktree bark and medicine terminalia fruit, then adding western medicine such as mequindox, gentamycin sulfate and sodium salicylate and auxiliary materials such as sucrose and Jiayi powder, and carrying out mixing, crushing, soft material preparation and drying. The piglet yellow and white scour treatment compound traditional Chinese medicine composition has the following characteristics that: significant treatment effects are provided; water drinking and material stirring are adopted to direct take the composition; the composition is subjected to complete metabolism absorption in the body; and the composition has characteristics of good treatment efficacy, easy use, no toxic-side effect, safety and reliability, and is suitable for piglet dysentery treatment, especially for piglet yellow and white scour treatment.
Description
Technical field
The present invention relates to a kind of compound traditional Chinese medicine composite for the treatment of yellow and white dysentery of piglet and preparation method thereof, belong to Veterinary Medicine field.
Background technology
Along with the development of animal husbandry, pig industry is increasing in the scale of livestock, and yellow and white dysentery of piglet is also thereupon visible, and the medicine of clinical treatment yellow and white dysentery of piglet is thereupon visible, and therapeutic effect is not very desirable, and easily recurs, and does not have basic object.
Yellow and white dysentery of piglet is the abbreviation of yellow scour of piglet, Hakuri, usually, within 3 ~ 10 days, be yellow scours after piglet birth, and the Hakuri that is called of being born more than 10 days, and also can judge by observing stool colour, the two is all a kind of acute infectious disease being caused newborn piglet by antibacterial characteristic of disease escherichia coli, if treated not in time, be easy to cause piglet dead, bring huge economic loss to pig farm and raiser.
Yellow scour of piglet (early onset large intestine bar is sick) is also known as newborn piglet colibacillosis, and the one of the newborn piglet caused by dust Xi Shi escherichia coli (E.Coli) is acute, height lethal infectious diseases.After escherichia coli enter intestine of young pigs, facility pili is adsorbed on intestinal mucosa, settles down propagation by this, produces a large amount of enterotoxin, piglet is dewatered and has loose bowels.Be characterized as violent diarrhoea, discharge yellow or yellow-white loose stool and rapid dehydration.Bacillus coli antigen is complicated, has O, H, K tri-kinds of antigens; Serotype is many, has several thousand kinds; The resistance of environment is not strong to external world.Colibacillaryly pathogenicly depend on that it is in the ability of small intestinal adhesion, field planting, propagation and its toxigenic ability, adhesion factor or cilium determine the ability of bacteria planting, once generation bacteria planting, will cause because of the generation of toxin diarrhoea, most important adhesion factor is F4(K88ab, K88ac), F5(K99), F6(987P).Morbidity age in days early, mainly encroaches on 1 ~ 3 age in days piglet, and morbidity is anxious, symptom is obvious, mortality rate is high.Without seasonal, but time cold, sickness rate is higher, and delivery room is moist, and when sanitary condition is bad, sickness rate is higher, and a pig farm is once morbidity is difficult to eradicate.Mainly digestive tract infection, the sow that carries disease germs is Infectious Diseases.
Piglet pujos blancos has another name called Delayed onset escherichia coli, is the diarrhoeal diseases common within age of sucking of piglet.Mainly pass through digestive tract infection.Be characterized as disease piglet milk ejection white or canescence is smelt as of rotten fish loose stool, sickness rate is higher and fatality rate is not very high, but the speed of growth of piglet obviously slows down.The cause of disease is complicated, and still can not affirm completely, it is generally acknowledged pig alteration of intestinal flora, the excessive breeding of escherichia coli is the major reason of primary disease, now confirms, it is one of cause of disease of piglet pujos blancos that pig wheel turns virus.Primary disease is multiple is born in 10 ~ 30 age in days piglets (with 10 ~ 20 age in days morbidities at most, seldom falling ill with the above piglet of 30 age in days within 7 ages in days).The factor of bringing out and aggravate piglet pujos blancos disease is also a lot, and as because sow feeding management is improper, pig house health is bad, the growth of livestock girth of a garment differs, hypogalactia, dense rare change are too large, without seasonal, or weather turns cold suddenly, moisture ascends, overcast and rainy or warming bad, all can bring out the generation of Hakuri.If condition is better, cure and can fully recover very soon in time, mortality rate is lower, and condition is bad, and piglet can be caused to dewater thin and weak death.
Summary of the invention
The object of this invention is to provide a kind of compound traditional Chinese medicine composite for the treatment of yellow and white dysentery of piglet.
The present invention also aims to provide a kind of preparation method for the treatment of the compound traditional Chinese medicine composite of yellow and white dysentery of piglet.
In order to realize above object, the technical solution adopted in the present invention is: compositions of the present invention comprises the raw material of following parts by weight: the Radix Pulsatillae 10 ~ 25 parts, flower of poplar 30 ~ 40 parts, Rhizoma Coptidis 5 ~ 10 parts, Cortex Phellodendri 8 ~ 15 parts, Fructus Chebulae 5 ~ 10 parts, LIJUNJING 3 ~ 5 parts, gentamycin sulfate 1 ~ 2 part, sodium salicylate 2 ~ 3 parts.
Preparation method comprises the following steps:
(1) Radix Pulsatillae 10 ~ 25 parts, flower of poplar 30 ~ 40 parts, Rhizoma Coptidis 5 ~ 10 parts, Cortex Phellodendri 8 ~ 15 parts, Fructus Chebulae's 5 ~ 10 parts of five kinds of medical materials are added 8 ~ 10 times, 6 ~ 8 times soak by water 2 times respectively, first time 1.5 ~ 2h, second time 1 ~ 1.5h, collecting decoction;
(2) filtered by above-mentioned decocting liquid, filtrate is concentrated into thick paste, and relative density is 1.0 ~ 1.2;
(3) in step (2), adding 95% ethanol in thick paste makes alcohol content reach 45 ~ 50%, leaves standstill, again filters, and collects filtrate, reclaims ethanol;
(4) by above-mentioned filtrate spraying dry, add LIJUNJING 3 ~ 5%, gentamycin sulfate 1 ~ 2 part, sodium salicylate 2 ~ 3 parts and adjuvant sucrose and add beneficial powder, pulverizing and sieving, mixing soft material processed, drying.
The effect of main component pharmacological action and drug combination: LIJUNJING is broad spectrum antibiotic, this product mainly suppresses the DNA (deoxyribonucleic acid) (DNA) of thalline to be synthesized.Stronger inhibitory action is had to most antibacterial, stronger to gram negative bacteria effect, also effective to treponema.Be mainly used in the swine dysentery caused by treponema, yellow scour of piglet, Hakuri, diarrhea of pigs etc.; The specially good effects such as gentamycin sulfate for S. aureus L-forms, bacillus pyocyaneus, escherichia coli, dysentery bacterium etc., is mainly used in antibacterial clinically in prescription, treatment escherichia coli; The main chemical composition of flower of poplar is that leaf contains Quercetin, Quercetin 3-β-D-Glucose glycoside, myricetin 3-β-D-galactoside, and luteolin-7-β D-Glucose glycoside, has the specially good effect of removing dampness dysentery relieving; Fructus Chebulae is effective for dysentery bacterium clinically, is good especially with Fructus Chebulae's shell; LIJUNJING combines compatibility with gentamycin sulfate, to the specific effect for the treatment of yellow and white dysentery of piglet tool.
Said composition all uses raw material of Chinese medicine, and to piglet not by any side effect, and granule is easy to use, absorbs fast, does not affect the charge ratio of feedstuff, substantially increase therapeutic effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described.
Embodiment 1
Prescription: Radix Pulsatillae 20g, flower of poplar 35g, Rhizoma Coptidis 8g, Cortex Phellodendri 10g, Fructus Chebulae 7g, LIJUNJING 3g, gentamycin sulfate 2g, sodium salicylate 2g, sucrose 400g, add beneficial powder 450g.
Concrete preparation process is as follows:
(1) get the Radix Pulsatillae, flower of poplar, Rhizoma Coptidis, Cortex Phellodendri, Fructus Chebulae's five kinds of medical materials add 9 times, 6 times soak by water 2 times, first time 1.6h, second time 1.5h, collecting decoction respectively;
(2) filtered by above-mentioned decocting liquid, it is the thick paste of 1.0 that filtrate is concentrated into relative density at 70 DEG C;
(3) in step (2), adding 95% ethanol in thick paste makes alcohol content reach 50%, leaves standstill, and filters, filtrate recycling ethanol;
(4) by above-mentioned filtrate spraying dry, add LIJUNJING, gentamycin sulfate, sodium salicylate and adjuvant, pulverize and sieve, mix soft material processed, dry.
Embodiment 2
Prescription: Radix Pulsatillae 25g, flower of poplar 40g, Rhizoma Coptidis 10g, Cortex Phellodendri 15g, Fructus Chebulae 10g, LIJUNJING 5g, gentamycin sulfate 1g, sodium salicylate 2.5g, sucrose 450g, add beneficial powder 400g.
Concrete preparation process is as follows:
(1) get the Radix Pulsatillae, flower of poplar, Rhizoma Coptidis, Cortex Phellodendri, Fructus Chebulae's five kinds of medical materials add 10 times, 7 times soak by water 2 times, first time 1.5h, second time 1.2h, collecting decoction respectively;
(2) filtered by above-mentioned decocting liquid, it is the thick paste of 1.1 that filtrate is concentrated into relative density at 70 DEG C;
(3) in step (2), adding 95% ethanol in thick paste makes alcohol content reach 48%, leaves standstill, and filters, filtrate recycling ethanol;
(4) by above-mentioned filtrate spraying dry, add LIJUNJING, gentamycin sulfate, sodium salicylate and adjuvant, pulverize and sieve, mix soft material processed, dry.
Embodiment 3
Prescription: Radix Pulsatillae 10g, flower of poplar 30g, Rhizoma Coptidis 5g, Cortex Phellodendri 8g, Fructus Chebulae 5g, LIJUNJING 4g, gentamycin sulfate 1.5g, sodium salicylate 3g, sucrose 420g, adds beneficial powder 420g
Concrete preparation process is as follows:
(1) get the Radix Pulsatillae, flower of poplar, Rhizoma Coptidis, Cortex Phellodendri, Fructus Chebulae's five kinds of medical materials add 8 times of soak by water 2 times, first time 2h, second time 1h, collecting decoction respectively;
(2) filtered by above-mentioned decocting liquid, it is the thick paste of 1.2 that filtrate is concentrated into relative density at 70 DEG C;
(3) in step (2), adding 95% ethanol in thick paste makes alcohol content reach 45%, leaves standstill, and filters, filtrate recycling ethanol;
(4) by above-mentioned filtrate spraying dry, add LIJUNJING, gentamycin sulfate, sodium salicylate and adjuvant, pulverize and sieve, mix soft material processed, dry.
Animal experiment
40 sodium selenites, body weight 9.5-10.5kg, male and female has concurrently, be divided into contrast, blank, test, city's medicine group 4 groups at random, 10/group, 4 groups of test pig adapt to two days later in new feeding environment, contrast, test group, city's medicine group every pig artificial vaccination pathogenic bacteria 5mL coli-infection pig, blank group inoculation normal saline, freely drinks water and searches for food, carrying out clinical treatment according to operation instruction of the present invention.
Table 1 animal test results statistical table
Experimental group can be found out compared with matched group with city's medicine group, and street drug and Chinese medicine of the present invention all can resist coli-infection well, but are obviously better than antibiotic therapy group with Chinese medicine preparation therapeutic effect, and cure rate is respectively 100% and 89%.
Claims (7)
1. be used for the treatment of a compound traditional Chinese medicine composite for yellow and white dysentery of piglet, it is characterized in that: be made up of the raw material of following parts by weight: the Radix Pulsatillae 10 ~ 25 parts, flower of poplar 30 ~ 40 parts, Rhizoma Coptidis 5 ~ 10 parts, Cortex Phellodendri 8 ~ 15 parts, Fructus Chebulae 5 ~ 10 parts, LIJUNJING 3 ~ 5 parts, gentamycin sulfate 1 ~ 2 part, sodium salicylate 2 ~ 3 parts.
2. a kind of compound traditional Chinese medicine composite being used for the treatment of yellow and white dysentery of piglet as claimed in claim 1, is characterized in that: product forms is acceptable dosage form on oral liquid, powder, tablet, granule, injection or other pharmaceutics.
3. a kind of compound traditional Chinese medicine composite being used for the treatment of yellow and white dysentery of piglet as claimed in claim 2, is characterized in that: product forms is granule.
4. be used for the treatment of a preparation method for the compound traditional Chinese medicine composite of yellow and white dysentery of piglet as claimed in claim 3, it is characterized in that: comprise the following steps:
(1) Radix Pulsatillae 10 ~ 25 parts, flower of poplar 30 ~ 40 parts, Rhizoma Coptidis 5 ~ 10 parts, Cortex Phellodendri 8 ~ 15 parts, Fructus Chebulae's 5 ~ 10 parts of five kinds of medical materials are added 8 ~ 10 times, 6 ~ 8 times soak by water 2 times respectively, first time 1.5 ~ 2h, second time 1 ~ 1.5h, collecting decoction;
(2) filtered by above-mentioned decocting liquid, filtrate is concentrated into thick paste;
(3) in step (2), add ethanol in thick paste, make alcohol content reach 45 ~ 50%, leave standstill, again filter, collect filtrate, reclaim ethanol;
(4) by above-mentioned filtrate spraying dry, add LIJUNJING 3 ~ 5 parts, gentamycin sulfate 1 ~ 2 part, sodium salicylate 2 ~ 3 parts and adjuvant, pulverize and sieve, mix soft material processed, dry.
5. be used for the treatment of the preparation method of the compound traditional Chinese medicine composite of yellow and white dysentery of piglet as claimed in claim 4, it is characterized in that: the relative density that filtrate is concentrated into thick paste is 1.0 ~ 1.2 at 70 DEG C.
6. be used for the treatment of the preparation method of the compound traditional Chinese medicine composite of yellow and white dysentery of piglet as claimed in claim 4, it is characterized in that: ethanol used is 95% ethanol.
7. be used for the treatment of the preparation method of the compound traditional Chinese medicine composite of yellow and white dysentery of piglet as claimed in claim 4, it is characterized in that: adjuvant is sucrose and adds beneficial powder, and addition is respectively: 400 ~ 450 parts and 400 ~ 450 parts.
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| CN104274539A (en) * | 2013-07-01 | 2015-01-14 | 牙韩温 | Herbal medicine for treating poultry white scour |
| CN103385928A (en) * | 2013-07-10 | 2013-11-13 | 吉林大学 | Compound medical preparation for curing diarrhea of young livestock and applications thereof |
| CN103404729B (en) * | 2013-08-09 | 2015-02-04 | 青岛根源生物技术集团有限公司 | Composite microecologics capable of improving growth rate of stichopus japonicus and application of composite microecologics |
| CN103585338A (en) * | 2013-11-27 | 2014-02-19 | 镇江天和生物技术有限公司 | Five-medicine oral liquid for dysentery stopping, and preparation method thereof |
| CN104288436A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Veterinary injection with effects of astringing intestine to stop diarrhea and preparation method of veterinary injection |
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| JP2006333842A (en) * | 2005-06-06 | 2006-12-14 | Unitika Ltd | Compounding agent for fodder |
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Address after: 451162 Zhengzhou economic comprehensive experimentation area, Zhengzhou air port, Henan, Xingang Province Patentee after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451162 Xingang, Henan, Zhengzhou, Hong Kong airport on the eastern side of the road on the eastern side of Zhengzhou Patentee before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |