CN104666878A - Drug formula for preventing and treating chronic PRDC (porcine respiratory disease complex) - Google Patents
Drug formula for preventing and treating chronic PRDC (porcine respiratory disease complex) Download PDFInfo
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Abstract
The invention relates to a drug formula for preventing and treating the chronic PRDC (porcine respiratory disease complex). The drug formula comprises raw materials, namely, valnemulin, enrofloxacin and traditional Chinese medicine powder, wherein the traditional Chinese medicine powder comprises raw materials, namely, codonopsis pilosula, liquorice roots, poria cocos, largehead atractylodes rhizomes, lily bulbs, dwarf lilyturf tubers, purified pinellia tubers, tatarian aster roots, ephedra herbs, thinleaf milkwort roots, common anemarrhena rhizomes, coastal glehnia roots, dried tangerine peels and pumice, the Chinese herbal medicines are distilled with water vapor, an extract is obtained, the extract and fine pumice powder produced through milling by an efficient ball mill are evenly mixed, then dried at the low temperature and packaged in a vacuum manner, and the traditional Chinese medicine powder is prepared. The formula is significant in curative effect on the chronic PRDC, less in traditional Chinese medicine addition amount and good in palatability, takes effect quickly and is high in cure rate according to clinical usage.
Description
Technical field
The present invention relates to field of veterinary, being specifically related to a kind of for preventing and treating the syndromic medicament composing prescription of pig chronic respiratory.
Background technology
The sick syndrome (PRDC) of porcine respiratory is that first the 15th international swine diseases meeting holding at Britain Xia Minghan in 1998 propose, and it is the general name of the respiratory tract disease jointly caused of being interacted by factors such as virus, antibacterial, environmental stress and pig body hypoimmunities.Owing to causing the multiformity of this syndromic cause of disease, make the control of primary disease very difficult.Primary disease has become the No.1 disease affecting global pig industry economic benefit, causes massive losses to pig industry.Porcine respiratory disease is very complicated, clinically mainly contain the two class forms of expression, one is sudden onset, acute onset that can be dead in the treatment situation be not able to do in time, the main pathogen related to is infectious Actinobacillus pleuropneumoniae, streptococcus, pasteurellosis bacillus, toxoplasma, erysipelas bacillus, haemophilus suis, influenza virus, above-mentioned cause of disease actute infection causes this disease, its morbidity is all more anxious, primary treatments is for passing through drug administration by injection, the method effect is better, responsive antibiotic, antimicrobial drug (sulfa) and conventional antipyretic all can control epidemic situation the short time, it is sick that current treatment technology all effectively can treat this kind of sudden porcine respiratory.Equations of The Second Kind respiratory tract disease is very obstinate, and its main manifestations is cough, asthma, rapid breathing, undergrowth, severe patient pulmonary or whole respiratory system generation pathological changes, and then causes serious impact to pig growth, sows farrowing.The cause of disease worked out clinically is mainly the chronic infection of porcine circovirus, Pseudorabies virus, mycoplasma, haemophilus suis etc., and the stealth infection of swine eperythrozoonosis also can cause.Above-mentioned disease adopts existing multiple way control effects all poor, just at present, using maximum is still chemical drugs, as one or more conbined usage in tilmicosin, florfenicol, Tiamulin, sulfanilamide pregnancy, enrofloxacin, tylosin, sharp proceomycin, doxycycline etc., worse and worse, the generation rate of Resistant strain is higher for its antibacterial effect.Meanwhile, life-time service medicine can cause animal body immunologic function degression.
Certainly, also many methods being controlled above-mentioned disease by Chinese medicine are had, but, prior art is just simply added to Chinese medicine inside feedstuff according to comminuting coarsely processing, not only dosage is large, and palatability is poor, and in practice process, effective ingredient plays the non-constant of dynamics, the greatest problem existed when this is the use of current Chinese medicine.
Summary of the invention
For above-mentioned weak point of the prior art, the present invention aim to provide a kind of can the medicament composing prescription of addition that is evident in efficacy to pig chronic respiratory syndrome, Chinese medicine relatively less, good palatability, instant effect.
To achieve these goals, technical scheme of the present invention: a kind of for preventing and treating the syndromic medicament composing prescription of pig chronic respiratory, each raw material in this medicament composing prescription and weight ratio thereof are valnemulin: enrofloxacin: Chinese medicine powder=5-12:8-15:100-300.
Further, each raw material in this medicament composing prescription and weight ratio thereof are valnemulin: enrofloxacin: Chinese medicine powder=5:8:100.
Further, the raw material of described Chinese medicine powder consists of Radix Codonopsis 3 parts, 2 parts, Radix Glycyrrhizae, 2 parts, Poria, the Rhizoma Atractylodis Macrocephalae 3 parts, Bulbus Lilii 3 parts, Radix Ophiopogonis 2 parts, Rhizoma Pinelliae 2 parts, Radix Asteris 2 parts, 1 part, Herba Ephedrae, Radix Polygalae 1 part, the Rhizoma Anemarrhenae 1 part, Radix Glehniae 2 parts, Pericarpium Citri Reticulatae 2 parts, Pumex 1 part.
Further, the preparation method of described Chinese medicine powder is as follows:
Step 1: by Radix Codonopsis, Radix Glycyrrhizae, Poria, the Rhizoma Atractylodis Macrocephalae, Bulbus Lilii, Radix Ophiopogonis, Rhizoma Pinelliae, Radix Asteris, Herba Ephedrae, Radix Polygalae, the Rhizoma Anemarrhenae, Radix Glehniae, Pericarpium Citri Reticulatae stripping and slicing, after adding water infiltration, obtains extracting solution by steam distillation distillation;
Step 2: adopt efficient ball mill that Pumex is milled into fine powder;
Step 3: the extracting solution obtained in step 1 is mixed homogeneously with the Pumex fine powder obtained in step 2, cold drying vacuum packaging, for subsequent use.
Further, the application of this medicament composing prescription in the syndromic medicine of preparation treatment pig chronic respiratory.
Beneficial effect of the present invention: each composition pharmacological action in medicament composing prescription of the present invention is as follows:
1, valnemulin antibacterial activity is strong, for broad spectrum antibiotic, have good antibacterial activity to mycoplasma, antibacterial and spirillum, mycoplasma arthritidis, mycoplasma bovirhinis, mycoplasma canis, mycoplasma felis, chicken virus mycoplasma, chicken septic mycoplasma, mycoplasma pneumoniae, streptococcus, staphylococcus aureus, Actinobacillus, pasteurellosis bacillus, Brachyspira hyodysenteriae, colon pili sample spirillum etc., particularly to Mycoplasma and Spirochaetes extremely sensitive.Associating enrofloxacin powder, increases the control to fastbacteria (as haemophilus parasuis) in pig body, syndromic evident in efficacy to pig chronic respiratory.
2, Radix Codonopsis returns spleen, lung meridian, can strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the mind calming and mentality promoting, increase myocardial flow, blood circulation promoting raising function resistance.The Rhizoma Atractylodis Macrocephalae returns spleen, stomach warp, gas, training tonifying the spleen and stomach, dampness diuretic, strengthening superficial resistance to stop perspiration, QI invigorating in energy temperature compensation.Poria returns spleen, the heart, kidney channel, energy promoting diuresis to eliminate damp pathogen, strong Pi.Radix Glycyrrhizae GUIXIN, lung, spleen, stomach warp, can invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
3, Bulbus Lilii, Radix Ophiopogonis, Radix Glehniae and Rhizoma Anemarrhenae nourishing lung-YIN in the present invention, be monarch drug; Radix Asteris and Radix Polygalae preventing phlegm from forming and stopping coughing, Pericarpium Citri Reticulatae, Rhizoma Pinelliae, Herba Ephedrae and Pumex drying dampness to eliminate phlegm, antiasthmatic-antitussive are ministerial drug altogether; Coordinate above-mentioned Poria, Radix Glycyrrhizae is adjuvant.All medicines share, and gather the merit of moistening the lung and resolving phlegm, cough-relieving, YIN nourishing and QI supplementing altogether.By the Chinese medicine powder finished product that this Chinese prescription is obtained, pig chronic respiratory syndrome is had concurrently to effect for the treatment of and prevention, feeding in feedstuff can be added separately to, have no side effect.
4, the herbal raw material in the present invention is through distillation extraction, the effective ingredient concentration of extracting solution significantly improves, the effect of medicine is not fully exerted, and add the method for direct feeding in feedstuff after pulverizing compared to using original Chinese crude drug in prior art, Traditional Chinese Medicine dosage obviously reduces.Because the sugar in Chinese medicine extract has hygroscopicity, finally Chinese medicine extraction liquid is mixed homogeneously with pumice, cold drying vacuum packaging, obtained Chinese medicine powder can not condense because of moisture absorption in bulk, can with feedstuff Homogeneous phase mixing, good palatability, gives full play to drug effect after feeding in animal body.
5, the present invention is based on Chinese medicine, improves animal body function, controls bacillary mycoplasma cause of disease with Western medicine, explored by great many of experiments, raw material choose with consumption on achieve best preparation, syndromic for pig chronic respiratory sickness rate is controlled below 20%, can 8% be reduced to.
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment.
Clinical effectiveness experiment of the present invention is as follows:
Experimental technique: determine its No respiratory disease or the lighter nursery pig of the state of an illness by 100 through clinical examination, be divided into four groups at random by body weight, often organize 25.
A group is blank group, does not give Drug therapy;
B group spice final concentration (net content in each component): the wonderful woods 50PPM of Buddhist nun difficult to understand, enrofloxacin 80PPM, Chinese medicine powder 1000PPM, adds in feedstuff and mixes, and continuous feeding 10 days is a course for the treatment of;
C group spice final concentration (net content in each component): the wonderful woods 80PPM of Buddhist nun difficult to understand, enrofloxacin 120PPM, Chinese medicine powder 2000PPM, adds in feedstuff and mixes, and continuous feeding 10 days is a course for the treatment of;
D group spice final concentration (net content in each component): the wonderful woods 120PPM of Buddhist nun difficult to understand, enrofloxacin 150PPM, Chinese medicine powder 3000PPM, adds in feedstuff and mixes, and continuous feeding 10 days is a course for the treatment of.
Feed after starting, every day entry affected pig health situation of change, added up feeding effect after 12 days.
Experimental result statistics is as following table:
Give fruit analysis: A group, respiratory tract sickness rate 32%, coat gloss is low, searches for food general.
B group, respiratory tract sickness rate 20%, coat gloss is general, searches for food good.
C group, respiratory tract sickness rate 8%, coat gloss is better, searches for food good.
D group, respiratory tract sickness rate 8%, coat gloss is better, searches for food general.
D group feed intake declines, should be relevant with the palatability of medicine.The factor such as sickness rate, appearance luster, feed intake of comprehensive pig, for the common state of an illness, Clinical practice is recommended feed intake by B group of formula, for the serious state of an illness, Clinical practice is recommended feed intake by C group of formula, each constituent content in the present invention is higher, drug effect is better, the syndromic sickness rate of pig chronic respiratory is lower, but palatability also can reduce, and should consider various influence factor during use.
Embodiment
On November 20th, 2014, pig farm, Hengshui, Hebei, has the scale of 300 sows, and subject matter is that respiratory tract disease is continuous and unbroken, and enters the winter even more serious.We select model case 80, Symptomatic 120 of atypia, and all by the group wonderful woods 80PPM of Buddhist nun difficult to understand, enrofloxacin 120PPM, Chinese medicine powder 2000PPM, add in feedstuff and mix, continuous feeding 10 days is a course for the treatment of.Model case is added to the feeding time of 5 days.Result shows, and dead 2 of model case group, 63 clinical observations are asymptomatic, remission 15, effective percentage more than 95%, cure rate more than 79%.And the Chinese medicine powder 1 week of only throwing something and feeding further, all alleviate.Atypical case is all normal, and the speed of growth is accelerated.
Above the technical scheme that the embodiment of the present invention provides is described in detail, apply specific case herein to set forth the principle of the embodiment of the present invention and embodiment, the explanation of above embodiment is only applicable to the principle helping to understand the embodiment of the present invention; Meanwhile, for one of ordinary skill in the art, according to the embodiment of the present invention, detailed description of the invention and range of application all will change, and in sum, this description should not be construed as limitation of the present invention.
Claims (5)
1. for preventing and treating the syndromic medicament composing prescription of pig chronic respiratory, it is characterized in that, each raw material in this medicament composing prescription and weight ratio thereof are valnemulin: enrofloxacin: Chinese medicine powder=5-12:8-15:100-300.
2. as claimed in claim 1 a kind of for preventing and treating the syndromic medicament composing prescription of pig chronic respiratory, it is characterized in that, each raw material in this medicament composing prescription and weight ratio thereof are valnemulin: enrofloxacin: Chinese medicine powder=5:8:100.
3. the one as described in any one of claim 1 or 2 is for preventing and treating the syndromic medicament composing prescription of pig chronic respiratory, it is characterized in that, the raw material of described Chinese medicine powder consists of Radix Codonopsis 3 parts, 2 parts, Radix Glycyrrhizae, 2 parts, Poria, the Rhizoma Atractylodis Macrocephalae 3 parts, Bulbus Lilii 3 parts, Radix Ophiopogonis 2 parts, Rhizoma Pinelliae 2 parts, Radix Asteris 2 parts, 1 part, Herba Ephedrae, Radix Polygalae 1 part, the Rhizoma Anemarrhenae 1 part, Radix Glehniae 2 parts, Pericarpium Citri Reticulatae 2 parts, Pumex 1 part.
4. as claimed in claim 3 a kind of for preventing and treating the syndromic medicament composing prescription of pig chronic respiratory, it is characterized in that, the preparation method of described Chinese medicine powder is as follows:
Step 1: by Radix Codonopsis, Radix Glycyrrhizae, Poria, the Rhizoma Atractylodis Macrocephalae, Bulbus Lilii, Radix Ophiopogonis, Rhizoma Pinelliae, Radix Asteris, Herba Ephedrae, Radix Polygalae, the Rhizoma Anemarrhenae, Radix Glehniae, Pericarpium Citri Reticulatae stripping and slicing, after adding water infiltration, obtains extracting solution by steam distillation distillation;
Step 2: adopt efficient ball mill that Pumex is milled into fine powder;
Step 3: the extracting solution obtained in step 1 is mixed homogeneously with the Pumex fine powder obtained in step 2, cold drying vacuum packaging, for subsequent use.
5. one as claimed in claim 4 is for preventing and treating the syndromic medicament composing prescription of pig chronic respiratory, it is characterized in that, the application of this medicament composing prescription in the syndromic medicine of preparation treatment pig chronic respiratory.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030906A (en) * | 2017-12-29 | 2018-05-15 | 湖南惠生农业科技开发股份有限公司 | A kind of Chinese medicine composition for preventing porcine respiratory disease and feed and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953871A (en) * | 2010-10-14 | 2011-01-26 | 山东省农业科学院畜牧兽医研究所 | Antibacterial medicament for animals and preparation method and application thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953871A (en) * | 2010-10-14 | 2011-01-26 | 山东省农业科学院畜牧兽医研究所 | Antibacterial medicament for animals and preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张立新 等: "中西药结合对猪呼吸道病综合征的防治", 《养猪》 * |
| 沈华伟: "中草药在防治猪呼吸道病综合症（PRDC）中的应用研究", 《动物科学与动物医学》 * |
| 陈家红 等: "猪呼吸道病的中草药疗法", 《养殖技术顾问》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030906A (en) * | 2017-12-29 | 2018-05-15 | 湖南惠生农业科技开发股份有限公司 | A kind of Chinese medicine composition for preventing porcine respiratory disease and feed and preparation method thereof |
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