CN101389624B - 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 - Google Patents
3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 Download PDFInfo
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Abstract
Description
化合物 | I-2 | I-3 | I-4 | I-5 | I-9 | I-14 | I-19 | I-21 | I-26 | I-34 | I-36 | I-40 | I-44 |
IC50nmol/L | 76 | 5.3 | 5.6 | 9 | 30 | 79 | 31 | 27 | 9.1 | 11 | 6.3 | 82 | 6.8 |
化合物 | I-45 | I-46 | I-49 | I-51 | I-53 | I-55 | I-56 | I-57 | I-60 | I-68 | I-71 | I-74 | I-77 |
IC50nmol/L | 8.0 | 11 | 12 | 54 | 13 | 19 | 17 | 13 | 14 | 43 | 34 | 13 | 25 |
Claims (16)
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CN200780006890.5A CN101389624B (zh) | 2006-12-04 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
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CN200610098202.X | 2006-12-04 | ||
CNA200610098202XA CN101195601A (zh) | 2006-12-04 | 2006-12-04 | 2-二氢吲哚酮衍生物及其制备方法和用途 |
CN200610161220.8 | 2006-12-15 | ||
CNA2006101612208A CN101200446A (zh) | 2006-12-15 | 2006-12-15 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
CN200780006890.5A CN101389624B (zh) | 2006-12-04 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
PCT/CN2007/071161 WO2008067756A1 (fr) | 2006-12-04 | 2007-12-03 | Dérivés de 3-pyrrolo-cyclohexylène-2-dihydro-indolinone et utilisations de ceux-ci |
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CN201210162848.5A Division CN102702068B (zh) | 2007-12-03 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
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CN101389624B true CN101389624B (zh) | 2012-10-03 |
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CN200780006890.5A Expired - Fee Related CN101389624B (zh) | 2006-12-04 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
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CN102532118B (zh) * | 2010-12-24 | 2014-04-09 | 沈阳药科大学 | 含有吲哚酮的4-噻唑烷酮类衍生物及其应用 |
CN102675183B (zh) * | 2011-03-11 | 2014-07-16 | 南京优科生物医药研究有限公司 | 一种药物中间体的大规模制备方法 |
CN102675184A (zh) * | 2011-03-15 | 2012-09-19 | 江苏先声药物研究有限公司 | 一种酪氨酸激酶抑制剂的盐形式 |
CN103664738B (zh) * | 2012-09-12 | 2016-07-13 | 南京优科生物医药研究有限公司 | 一种羧酰胺化合物l-苹果酸盐的结晶多晶型物 |
CN104876851A (zh) * | 2015-05-15 | 2015-09-02 | 南京大学 | 一类含吲哚-3羧酸骨架的哌嗪类衍生物的制备方法及在抗癌药物中的应用 |
CN114213396B (zh) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | 一种吲哚-2-酮类化合物及其制备方法与用途 |
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CN101195601A (zh) | 2008-06-11 |
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