CN101389624A - 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 - Google Patents
3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 Download PDFInfo
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Abstract
本发明涉及具有式(I)结构的3－吡咯并环己亚基－2－二氢吲哚酮衍生物或其药学上可接受的盐，以及其用途；另外，本发明还涉及合成该类化合物的式(II)中间体。生物学实验表明，此类化合物或其药学上可接受的盐对蛋白激酶活性具有调节作用，可以抑制多种酪氨酸激酶的活性，同时对多种肿瘤细胞的增殖具有抑制作用。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200780006890.5A CN101389624B (zh) | 2006-12-04 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200610098202.X | 2006-12-04 | ||
| CNA200610098202XA CN101195601A (zh) | 2006-12-04 | 2006-12-04 | 2-二氢吲哚酮衍生物及其制备方法和用途 |
| CN200610161220.8 | 2006-12-15 | ||
| CNA2006101612208A CN101200446A (zh) | 2006-12-15 | 2006-12-15 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
| CN200780006890.5A CN101389624B (zh) | 2006-12-04 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
| PCT/CN2007/071161 WO2008067756A1 (fr) | 2006-12-04 | 2007-12-03 | Dérivés de 3-pyrrolo-cyclohexylène-2-dihydro-indolinone et utilisations de ceux-ci |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210162848.5A Division CN102702068B (zh) | 2007-12-03 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
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| CN101389624A true CN101389624A (zh) | 2009-03-18 |
| CN101389624B CN101389624B (zh) | 2012-10-03 |
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| CN200780006890.5A Expired - Fee Related CN101389624B (zh) | 2006-12-04 | 2007-12-03 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102532118B (zh) * | 2010-12-24 | 2014-04-09 | 沈阳药科大学 | 含有吲哚酮的4-噻唑烷酮类衍生物及其应用 |
| CN102675183B (zh) * | 2011-03-11 | 2014-07-16 | 南京优科生物医药研究有限公司 | 一种药物中间体的大规模制备方法 |
| CN102675184A (zh) * | 2011-03-15 | 2012-09-19 | 江苏先声药物研究有限公司 | 一种酪氨酸激酶抑制剂的盐形式 |
| CN103664738B (zh) * | 2012-09-12 | 2016-07-13 | 南京优科生物医药研究有限公司 | 一种羧酰胺化合物l-苹果酸盐的结晶多晶型物 |
| CN104876851A (zh) * | 2015-05-15 | 2015-09-02 | 南京大学 | 一类含吲哚-3羧酸骨架的哌嗪类衍生物的制备方法及在抗癌药物中的应用 |
| CN114213396B (zh) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | 一种吲哚-2-酮类化合物及其制备方法与用途 |
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| CN101195601A (zh) | 2008-06-11 |
| CN101389624B (zh) | 2012-10-03 |
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