BR112022009390A2 - Síntese melhorada de composto inibidor de kras g12c - Google Patents

Síntese melhorada de composto inibidor de kras g12c

Info

Publication number
BR112022009390A2
BR112022009390A2 BR112022009390A BR112022009390A BR112022009390A2 BR 112022009390 A2 BR112022009390 A2 BR 112022009390A2 BR 112022009390 A BR112022009390 A BR 112022009390A BR 112022009390 A BR112022009390 A BR 112022009390A BR 112022009390 A2 BR112022009390 A2 BR 112022009390A2
Authority
BR
Brazil
Prior art keywords
inhibitor compound
improved synthesis
kras
kras inhibitor
synthesis
Prior art date
Application number
BR112022009390A
Other languages
English (en)
Inventor
T Parsons Andrew
Beaver Matthew
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112022009390A2 publication Critical patent/BR112022009390A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Abstract

SÍNTESE MELHORADA DE COMPOSTO INIBIDOR DE KRAS G12C. A presente divulgação se relaciona com um processo melhorado, eficiente, escalonável para preparar compostos intermediários, tais como 2,2',2''-(1,3,5,2,4,6-trioxatriborinano-2,4,6-tri-il)tris(3-fluorofenol), úteis para a síntese de compostos, tais como Composto 9, para o tratamento de cânceres mutados KRAS G12C.
BR112022009390A 2019-11-14 2020-11-13 Síntese melhorada de composto inibidor de kras g12c BR112022009390A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962935502P 2019-11-14 2019-11-14
PCT/US2020/060421 WO2021097212A1 (en) 2019-11-14 2020-11-13 Improved synthesis of kras g12c inhibitor compound

Publications (1)

Publication Number Publication Date
BR112022009390A2 true BR112022009390A2 (pt) 2022-08-09

Family

ID=73790234

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022009390A BR112022009390A2 (pt) 2019-11-14 2020-11-13 Síntese melhorada de composto inibidor de kras g12c

Country Status (14)

Country Link
US (1) US20230192681A1 (pt)
EP (1) EP4058453A1 (pt)
JP (1) JP2023501528A (pt)
KR (1) KR20220101125A (pt)
CN (1) CN114728960A (pt)
AR (1) AR120457A1 (pt)
AU (1) AU2020381492A1 (pt)
BR (1) BR112022009390A2 (pt)
CA (1) CA3158188A1 (pt)
CL (1) CL2022001258A1 (pt)
IL (1) IL292315A (pt)
MX (1) MX2022005708A (pt)
TW (1) TW202132296A (pt)
WO (1) WO2021097212A1 (pt)

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* Cited by examiner, † Cited by third party
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JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
CN114144414A (zh) 2019-05-21 2022-03-04 美国安进公司 固态形式
WO2021244555A1 (zh) * 2020-06-02 2021-12-09 上海喆邺生物科技有限公司 一种手性中间体及其制备方法
AR124105A1 (es) 2020-11-20 2023-02-15 Amgen Inc Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona
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WO2023172858A1 (en) 2022-03-07 2023-09-14 Amgen Inc. A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法

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