BR112014018728A8 - Compostos de purinonas como inibidores de quinase - Google Patents
Compostos de purinonas como inibidores de quinaseInfo
- Publication number
- BR112014018728A8 BR112014018728A8 BR112014018728A BR112014018728A BR112014018728A8 BR 112014018728 A8 BR112014018728 A8 BR 112014018728A8 BR 112014018728 A BR112014018728 A BR 112014018728A BR 112014018728 A BR112014018728 A BR 112014018728A BR 112014018728 A8 BR112014018728 A8 BR 112014018728A8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- disclosed
- conditions
- purinones
- kinase inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Abstract
COMPOSTOS DE PURINONA, SUA COMPOSIÇÃO FARMACÊUTICA E SEU USO. São aqui revelados compostos que formam ligações covalentes com tirosina-quinase de Bruton (Btk). Também são descritos inibidores irreversíveis de Btk. Além disso, inibidores reversíveis de Btk também são descritos. Também são reveladas composições farmacêuticas que incluem os compostos. Métodos de utilização dos inibidores de Btk são revelados, isoladamente ou em combinação com outros agentes terapêuticos, para o tratamento de doenças ou condições autoimunes, doenças ou condições heteroimunes, câncer, incluindo linfoma, e doenças ou condições inflamatórias.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261593146P | 2012-01-31 | 2012-01-31 | |
US201261637765P | 2012-04-24 | 2012-04-24 | |
US13/460,524 US8501724B1 (en) | 2012-01-31 | 2012-04-30 | Purinone compounds as kinase inhibitors |
PCT/US2013/023918 WO2013116382A1 (en) | 2012-01-31 | 2013-01-30 | Purinone compounds as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014018728A2 BR112014018728A2 (pt) | 2017-06-20 |
BR112014018728A8 true BR112014018728A8 (pt) | 2017-07-11 |
Family
ID=48870746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014018728A BR112014018728A8 (pt) | 2012-01-31 | 2013-01-30 | Compostos de purinonas como inibidores de quinase |
Country Status (14)
Country | Link |
---|---|
US (3) | US8501724B1 (pt) |
EP (2) | EP2809672A4 (pt) |
JP (3) | JP6095075B2 (pt) |
KR (2) | KR101841325B1 (pt) |
CN (2) | CN104640861B (pt) |
AU (3) | AU2013215166B2 (pt) |
BR (1) | BR112014018728A8 (pt) |
CA (2) | CA2863140C (pt) |
HK (1) | HK1203489A1 (pt) |
IL (1) | IL261282A (pt) |
MX (1) | MX2014009219A (pt) |
PH (1) | PH12014501815A1 (pt) |
RU (2) | RU2655388C2 (pt) |
WO (1) | WO2013116382A1 (pt) |
Families Citing this family (55)
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AU2009270856B2 (en) | 2008-07-16 | 2013-07-25 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors |
EP2575818A4 (en) | 2010-06-03 | 2013-11-06 | Pharmacyclics Inc | USE OF INHIBITORS OF BRUTON TYROSINE KINASE (BTK) |
US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
EP2710005B1 (en) | 2011-05-17 | 2016-10-05 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
KR20140048968A (ko) | 2011-07-13 | 2014-04-24 | 파마시클릭스, 인코포레이티드 | 브루톤형 티로신 키나제의 억제제 |
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CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN113527300B (zh) * | 2020-06-04 | 2023-02-03 | 广州百霆医药科技有限公司 | 布鲁顿酪氨酸蛋白激酶抑制剂 |
WO2022242740A1 (zh) * | 2021-05-21 | 2022-11-24 | 杭州领业医药科技有限公司 | Tolebrutinib盐及其晶型、其制备方法、其药物组合物和用途 |
WO2023155760A1 (zh) * | 2022-02-16 | 2023-08-24 | 贝达药业股份有限公司 | 一种药物组合物及所含活性成分化合物的制备方法 |
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WO2008060301A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia , Llc | 7-substituted purine derivatives for immunosuppression |
US20080119496A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
ES2562215T3 (es) | 2007-03-28 | 2016-03-03 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton |
NZ603643A (en) * | 2010-05-31 | 2014-07-25 | Ono Pharmaceutical Co | Purinone derivative |
US8501724B1 (en) * | 2012-01-31 | 2013-08-06 | Pharmacyclics, Inc. | Purinone compounds as kinase inhibitors |
US9637487B2 (en) * | 2013-07-02 | 2017-05-02 | Pharmacyclics Llc | Purinone compounds as kinase inhibitors |
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