BR0109828A - Composto, processo para a prepapação do mesmo ou de um sal deste, composição farmacêutica, uso do composto ou de um sal deste farmaceuticamente aceitável, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento - Google Patents

Composto, processo para a prepapação do mesmo ou de um sal deste, composição farmacêutica, uso do composto ou de um sal deste farmaceuticamente aceitável, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento

Info

Publication number
BR0109828A
BR0109828A BR0109828-4A BR0109828A BR0109828A BR 0109828 A BR0109828 A BR 0109828A BR 0109828 A BR0109828 A BR 0109828A BR 0109828 A BR0109828 A BR 0109828A
Authority
BR
Brazil
Prior art keywords
sup
compound
salt
producing
treatment
Prior art date
Application number
BR0109828-4A
Other languages
English (en)
Inventor
Laurent Francois And Hennequin
Elaine Sophie Elizabeth Stokes
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0109828A publication Critical patent/BR0109828A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTO, PROCESSO PARA A PREPARAçãO DO MESMO OU DE UM SAL DESTE, COMPOSIçãO FARMACêUTICA, USO DO COMPOSTO OU DE UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL, E, MéTODO PARA A PRODUçãO DE UM EFEITO ANTIANGIOGêNICO E/OU REDUTOR DA PERMEABILIDADE VASCULAR EM UM ANIMAL DE SANGUE QUENTE EM NECESSIDADE DE TAL TRATAMENTO". A invenção diz respeito aos compostos da fórmula (I): em que o anel A é fenila ou anel heterocíclico de 5 ou de 6 membros como definido aqui, Z é -O-, -NH- ou -S-; m é um número inteiro de 0 a 5 inclusive; R^ 1^ é hidrogênio, hidróxi, halógeno, nitro, trifluorometila, ciano, alquila C~ 1-3~, alcóxi C~ 1-3~, alquiltio C~ 1-3~ou -NR^ 5^R^ 6^ (em que R^ 5^ ou R^ 6^ que podem ser os mesmos ou diferentes são hidrogênio ou alquila C~ 1-3~);R^ 2^ é hidrogênio, hidróxi, halógeno, alquila C~ 1-3~, alcóxi C~ 1-3~, trifluorometila, amino ou nitro; R^ 3^ é hidróxi, halógeno, alquila C~ 1-3~, alcóxi C~ 1-3~, alcanoilóxi C~ 1-3~, trifluorometila, ciano, amino ou nitro; contanto que quando o anel A for um anel heterocíclico de 5 ou de 6 membros, pelo menos um R3 é hidróxi ou halógeno; X^ 1^ é -O-, -CH^ 2^-, -S-, -SO-, -SO~ 2~-, -NR^ 7^-, -NR^ 7^CO-, -CONR^ 7^, SO^ 2^NR^ 7^- ou -NR^ 7^SO^ 2^- , (em que R^ 7^ é hidrogênio, alquila C~ 1-3~, ou alcóxi C~ 1-3~ alquila C~ 2-3~); e R^ 4^ é selecionado e um número de grupos definidos aqui que compreendem uma cadeia de alquileno C~ 2-5~, alquenileno C~ 3-5~ ou alquinileno C~ 3-5~ em que cada grupo metileno (outro que não o <244>-carbono) é opcionalmente substituído por um substituinte independentemente selecionado de hidróxi, halógeno, amino e alcanoilóxi C~ 1-4~; as condições são como definidas aqui. A invenção também diz respeito a composições farmacêuticas que compreendem um composto da fórmula (I), ao uso de um composto da fórmula (I) na fabricação de um medicamento para uso na produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente e a um método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento. OS compostos são úteis em estados de doenças, tais como o câncer, a artrite reumatóide e a psoríase.
BR0109828-4A 2000-04-07 2001-04-03 Composto, processo para a prepapação do mesmo ou de um sal deste, composição farmacêutica, uso do composto ou de um sal deste farmaceuticamente aceitável, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento BR0109828A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP00400967 2000-04-07
EP00400968 2000-04-07
EP00401034 2000-04-13
EP00401033 2000-04-13
PCT/GB2001/001514 WO2001077085A1 (en) 2000-04-07 2001-04-03 Quinazoline compounds

Publications (1)

Publication Number Publication Date
BR0109828A true BR0109828A (pt) 2002-12-17

Family

ID=27440054

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109828-4A BR0109828A (pt) 2000-04-07 2001-04-03 Composto, processo para a prepapação do mesmo ou de um sal deste, composição farmacêutica, uso do composto ou de um sal deste farmaceuticamente aceitável, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento

Country Status (20)

Country Link
US (2) US7160889B2 (pt)
EP (1) EP1274692B1 (pt)
JP (2) JP4970689B2 (pt)
KR (1) KR100858069B1 (pt)
CN (1) CN1240688C (pt)
AT (1) ATE334973T1 (pt)
AU (1) AU779695B2 (pt)
BR (1) BR0109828A (pt)
CA (1) CA2403365A1 (pt)
CY (1) CY1107539T1 (pt)
DE (1) DE60121931T2 (pt)
DK (1) DK1274692T3 (pt)
ES (1) ES2267748T3 (pt)
IL (2) IL151626A0 (pt)
MX (1) MXPA02009891A (pt)
NO (1) NO324471B1 (pt)
NZ (1) NZ521421A (pt)
PT (1) PT1274692E (pt)
SI (1) SI1274692T1 (pt)
WO (1) WO2001077085A1 (pt)

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US7160889B2 (en) 2007-01-09
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NO324471B1 (no) 2007-10-29
US20030191308A1 (en) 2003-10-09
CA2403365A1 (en) 2001-10-18
NO20024763D0 (no) 2002-10-03
ATE334973T1 (de) 2006-08-15
EP1274692B1 (en) 2006-08-02
JP4970689B2 (ja) 2012-07-11
SI1274692T1 (sl) 2006-12-31
EP1274692A1 (en) 2003-01-15
NO20024763L (no) 2002-11-19
JP2003530387A (ja) 2003-10-14
JP2012136537A (ja) 2012-07-19
CY1107539T1 (el) 2013-03-13
DE60121931T2 (de) 2007-03-01
IL151626A0 (en) 2003-04-10
CN1240688C (zh) 2006-02-08
AU779695B2 (en) 2005-02-10
AU4850701A (en) 2001-10-23
KR20020084295A (ko) 2002-11-04
KR100858069B1 (ko) 2008-09-22
WO2001077085A1 (en) 2001-10-18
DK1274692T3 (da) 2006-10-30
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NZ521421A (en) 2004-09-24
PT1274692E (pt) 2006-11-30

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