AU2002217999A1 - Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides - Google Patents

Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides

Info

Publication number
AU2002217999A1
AU2002217999A1 AU2002217999A AU1799902A AU2002217999A1 AU 2002217999 A1 AU2002217999 A1 AU 2002217999A1 AU 2002217999 A AU2002217999 A AU 2002217999A AU 1799902 A AU1799902 A AU 1799902A AU 2002217999 A1 AU2002217999 A1 AU 2002217999A1
Authority
AU
Australia
Prior art keywords
kinases
quinazolinylpiperazin
production
carboxylic acid
phosphorylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002217999A
Inventor
James Kanter
Anjali Pandey
James Robinson
Robert M. Scarborough Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COR Therapeutics Inc
Original Assignee
COR Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COR Therapeutics Inc filed Critical COR Therapeutics Inc
Publication of AU2002217999A1 publication Critical patent/AU2002217999A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.
AU2002217999A 2000-11-01 2001-11-01 Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides Abandoned AU2002217999A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24465500P 2000-11-01 2000-11-01
US60/244,655 2000-11-01
US25985901P 2001-01-08 2001-01-08
US60/259,859 2001-01-08
PCT/US2001/045400 WO2002036587A2 (en) 2000-11-01 2001-11-01 Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides

Publications (1)

Publication Number Publication Date
AU2002217999A1 true AU2002217999A1 (en) 2002-05-15

Family

ID=26936702

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002217999A Abandoned AU2002217999A1 (en) 2000-11-01 2001-11-01 Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides

Country Status (7)

Country Link
US (4) US6951937B2 (en)
EP (1) EP1330444B1 (en)
JP (1) JP4564713B2 (en)
AT (1) ATE502928T1 (en)
AU (1) AU2002217999A1 (en)
DE (1) DE60144284D1 (en)
WO (1) WO2002036587A2 (en)

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AU2005274852B2 (en) * 2004-07-19 2011-12-08 The Johns Hopkins University FLT3 inhibitors for immune suppression
EP1904459A1 (en) * 2005-07-20 2008-04-02 Millennium Pharmaceuticals, Inc. New crystal forms of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide
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BRPI0810800A2 (en) * 2007-05-02 2014-10-29 Portola Pharm Inc [4- (6-Fluoro-7-methylamino-2,4-dioxy-1,4-dihydro-2H-quinazolin-3-yl) -phenyl] -5-chlorine-thiophen-2-yl-s salts , FORMS AND METHODS RELATED TO THEM.
US20100273808A1 (en) * 2008-11-21 2010-10-28 Millennium Pharmaceticals, Inc. Lactate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders
CN103242245B (en) * 2013-05-22 2015-05-20 苏州明锐医药科技有限公司 Preparation method of tandutinib
WO2015009889A1 (en) 2013-07-18 2015-01-22 Concert Pharmaceuticals, Inc. Deuterated intedanib derivatives and their use for the treatment of proliferative disorders
CN104193688A (en) * 2014-09-04 2014-12-10 埃斯特维华义制药有限公司 Synthetic method for erlotinib intermediate
CN104496915B (en) * 2014-12-19 2017-05-03 华侨大学 Synthetic method of quinazolinone aromatic compound

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Also Published As

Publication number Publication date
DE60144284D1 (en) 2011-05-05
US20020091130A1 (en) 2002-07-11
EP1330444B1 (en) 2011-03-23
WO2002036587A2 (en) 2002-05-10
ATE502928T1 (en) 2011-04-15
EP1330444A2 (en) 2003-07-30
JP4564713B2 (en) 2010-10-20
US20060167011A1 (en) 2006-07-27
US7709640B2 (en) 2010-05-04
WO2002036587A3 (en) 2002-08-22
USRE43098E1 (en) 2012-01-10
US20100240893A1 (en) 2010-09-23
US8536184B2 (en) 2013-09-17
US6951937B2 (en) 2005-10-04
JP2004513126A (en) 2004-04-30

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