AR098517A1 - Compuestos derivados de octahidro-ciclobuta[1,2-c;3,4-c]dipirrol-2-ilo - Google Patents
Compuestos derivados de octahidro-ciclobuta[1,2-c;3,4-c]dipirrol-2-iloInfo
- Publication number
- AR098517A1 AR098517A1 ARP140104399A ARP140104399A AR098517A1 AR 098517 A1 AR098517 A1 AR 098517A1 AR P140104399 A ARP140104399 A AR P140104399A AR P140104399 A ARP140104399 A AR P140104399A AR 098517 A1 AR098517 A1 AR 098517A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- phenyl
- pyridinyl
- thiophenyl
- alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
Abstract
Composiciones que incluyen los compuestos y métodos de uso de los compuestos. Útiles en el tratamiento o profilaxis de estados patológicos inflamatorios, del sistema respiratorio, fibróticas, etc. Reivindicación 1: Compuestos de la fórmula (1) en la que: R¹ es quinolinilo sustituido, 1,2,3,4-tetrahidroquinolinilo sustituido, isoquinolinilo sustituido, 1,2,3,4-tetrahidroiso-quinolinilo sustituido, 9H-carbazolilo sustituido, cromanilo sustituido, indolilo sustituido, naftilo sustituido, oxazolilo sustituido, fenilo sustituido, fenilalquilo sustituido, fenilcicloalquilo sustituido, fenoxialquilo sustituido, fenilalcoxi sustituido, fenilalquenilo sustituido, fenilalquinilo sustituido, piridazinilo sustituido, piridazinilalquilo sustituido, piridazinilalquenilo sustituido, piridazinilalquinilo sustituido, piridinilo sustituido, piridinilalquilo sustituido, piridinilalquenilo sustituido, piridinilalquinilo sustituido, piridinonilo sustituido, piridinonilalquilo sustituido, piridinonilalquenilo sustituido, piridinonilalquinilo sustituido, tiofenilo sustituido, tiofenilalquilo sustituido, tiofenilalquenilo sustituido, tiofenilalquinilo sustituido, tetralinilo sustituido o tetralinonilo sustituido, dichos quinolinilo sustituido, 1,2,3,4-tetrahidroquinolinilo sustituido, isoquinolinilo sustituido, 1,2,3,4-tetrahidroisoquinolinilo sustituido, 9H-carbazolilo sustituido, cromanilo sustituido, indolilo sustituido, naftilo sustituido, oxazolilo sustituido, fenilo sustituido, fenilalquilo sustituido, fenilcicloalquilo sustituido, fenoxialquilo sustituido, fenilalcoxi sustituido, fenilalquenilo sustituido, fenilalquinilo sustituido, piridazinilo sustituido, piridazinilalquilo sustituido, piridazinilalquenilo sustituido, piridazinilalquinilo sustituido, piridinilo sustituido, piridinilalquilo sustituido, piridinilalquenilo sustituido, piridinilalquinilo sustituido, piridinonilo sustituido, piridinonilalquilo sustituido, piridinonilalquenilo sustituido, piridinonilalquinilo sustituido, tiofenilo sustituido, tiofenilalquilo sustituido, tiofenilalquenilo sustituido, tiofenilalquinilo sustituido, tetralinilo sustituido y tetralinonilo sustituido están sustituidos por R⁶, R⁷ y R⁸; Y es -C(O)- O -S(O)₂-; R² es piridinilo sustituido, fenilo sustituido o se elige entre los sistemas de anillo de fórmula (2), (3) y (4), dichos piridinilo sustituido y fenilo sustituido están sustituidos por un aminosulfonilo sustituido, dicho aminosulfonilo sustituido está sustituido sobre el átomo de nitrógeno por uno o dos sustituyentes elegidos con independencia entre H, alquilo, cicloalquilo, cicloalquilalquilo, hidroxialquilo y alcoxialquilo; R³, R⁴ y R⁵ se eligen con independencia entre H, alquilo, halógeno, haloalquilo y alcoxi; R⁶, R⁷ y R⁸ se eligen con independencia entre H, halógeno, ciano, cianoalquilo, alquilo, hidroxialquilo, haloalquilo, hidroxihaloalquilo, cicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, cicloalcoxi, cicloalcoxialquilo, cicloalquilalcoxialquilo, alcoxi, alcoxialquilo, haloalcoxi, alcoxihaloalquilo, alcoxialcoxi, alcoxialcoxialquilo, alquilsulfonilo, furanilo, tetrahidropiranilo, fenilo, fenilo sustituido, fenilalcoxi, fenilalcoxi sustituido, piridinilo, piridinilo sustituido, pirrolilo, pirrolilo sustituido, pirrolidinilo y sustituido pirrolidinilo, dichos fenilo sustituido, fenilalcoxi sustituido, piridinilo sustituido, pirrolilo sustituido y pirrolidinilo sustituido están sustituidos de una a tres veces por halógeno; o las sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13194475 | 2013-11-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR098517A1 true AR098517A1 (es) | 2016-06-01 |
Family
ID=49726473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140104399A AR098517A1 (es) | 2013-11-26 | 2014-11-25 | Compuestos derivados de octahidro-ciclobuta[1,2-c;3,4-c]dipirrol-2-ilo |
Country Status (32)
Country | Link |
---|---|
US (3) | US20160264586A1 (es) |
EP (1) | EP3074400B1 (es) |
JP (1) | JP6496730B2 (es) |
KR (1) | KR20160087900A (es) |
CN (1) | CN105764905B (es) |
AR (1) | AR098517A1 (es) |
AU (1) | AU2014356583B2 (es) |
CA (1) | CA2923523A1 (es) |
CL (1) | CL2016001266A1 (es) |
CR (1) | CR20160171A (es) |
DK (1) | DK3074400T3 (es) |
EA (1) | EA201691044A1 (es) |
ES (1) | ES2656198T3 (es) |
HK (1) | HK1223921A1 (es) |
HR (1) | HRP20180029T1 (es) |
HU (1) | HUE036117T2 (es) |
IL (1) | IL244519A0 (es) |
LT (1) | LT3074400T (es) |
MA (1) | MA38982A1 (es) |
MX (1) | MX2016005186A (es) |
MY (1) | MY187449A (es) |
NO (1) | NO3074400T3 (es) |
PE (1) | PE20160845A1 (es) |
PH (1) | PH12016500643A1 (es) |
PL (1) | PL3074400T3 (es) |
PT (1) | PT3074400T (es) |
RS (1) | RS56776B1 (es) |
SI (1) | SI3074400T1 (es) |
TW (1) | TW201605861A (es) |
UA (1) | UA118201C2 (es) |
WO (1) | WO2015078803A1 (es) |
ZA (1) | ZA201601726B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201407534PA (en) | 2012-06-13 | 2014-12-30 | Hoffmann La Roche | New diazaspirocycloalkane and azaspirocycloalkane |
IN2015DN00960A (es) | 2012-09-25 | 2015-06-12 | Hoffmann La Roche | |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
MY187449A (en) | 2013-11-26 | 2021-09-22 | Hoffmann La Roche | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
JP6554481B2 (ja) | 2014-03-26 | 2019-07-31 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | オートタキシン(atx)及びリゾホスファチジン酸(lpa)産生の阻害剤としての縮合[1,4]ジアゼピン化合物 |
HUE046820T2 (hu) | 2014-03-26 | 2020-03-30 | Hoffmann La Roche | Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
CR20180058A (es) | 2015-09-04 | 2018-02-26 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
KR20180054830A (ko) * | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서의 이환형 화합물 |
MX2018001890A (es) | 2015-09-24 | 2018-06-20 | Hoffmann La Roche | Compuestos biciclicos como inhibidores de autotaxina (atx). |
MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
CN107922415B (zh) | 2015-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 新的作为双重atx/ca抑制剂的二环化合物 |
CN108456208B (zh) * | 2017-02-22 | 2021-04-16 | 广州市恒诺康医药科技有限公司 | 氮杂螺环类化合物及其制备方法和应用 |
WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
CR20190423A (es) | 2017-03-16 | 2019-11-01 | Hoffmann La Roche | Nuevos compuestos biciclícos como inhibidores dobles de atx/ca |
FR3079742B1 (fr) | 2018-04-06 | 2023-01-13 | Keranova | Appareil de traitement d’un tissu incluant des systemes optiques originaux de deviation et de focalisation d’un faisceau l.a.s.e.r. |
Family Cites Families (138)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1252898B (de) | 1965-06-12 | 1967-10-26 | Bayer Ag | Verfahren zur Herstellung von Copolymerisaten des Trioxans |
US5240928A (en) | 1989-07-03 | 1993-08-31 | Merck & Co., Inc. | Substituted quinazolinones as angiotensin II antagonists |
DE3930262A1 (de) | 1989-09-11 | 1991-03-21 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
KR910009330B1 (ko) | 1989-10-23 | 1991-11-11 | 재단법인 한국화학연구소 | 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법 |
CA2037630C (en) | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
US5470975A (en) | 1990-10-16 | 1995-11-28 | E.R. Squibb & Sons, Inc. | Dihydropyrimidine derivatives |
US5290780A (en) | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
US5238942A (en) | 1991-05-10 | 1993-08-24 | Merck & Co., Inc. | Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists |
DE4121214A1 (de) | 1991-06-27 | 1993-01-14 | Bayer Ag | 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate |
US5202322A (en) | 1991-09-25 | 1993-04-13 | Merck & Co., Inc. | Quinazolinone and pyridopyrimidine a-II antagonists |
US5532243A (en) | 1992-02-14 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Antipsychotic nitrogen-containing bicyclic compounds |
US5358951A (en) | 1993-04-23 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones |
DE4407047A1 (de) | 1994-03-03 | 1995-09-07 | Merck Patent Gmbh | Acetamide |
US20010016657A1 (en) | 1997-03-18 | 2001-08-23 | Smithkline Beecham P.L.C. | Substituted isoquinoline derivatives and their use as anticonvulsants |
KR20010040693A (ko) | 1998-02-04 | 2001-05-15 | 나가사까 겐지로 | N-아실 환상 아민유도체 |
JP2001039950A (ja) | 1999-07-30 | 2001-02-13 | Banyu Pharmaceut Co Ltd | N−アシル環状アミン誘導体 |
DE60005545D1 (de) | 1999-10-27 | 2003-10-30 | Millennium Pharm Inc | Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation |
CA2440803A1 (en) | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
US7667053B2 (en) | 2002-04-12 | 2010-02-23 | Merck & Co., Inc. | Bicyclic amides |
GB0303852D0 (en) | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
WO2005023762A1 (en) | 2003-09-04 | 2005-03-17 | Abbott Laboratories | Pyrrolidine-2-carbonitrile derivatives and their use as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
SE0302811D0 (sv) | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
US7226951B2 (en) | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
KR100610731B1 (ko) | 2004-02-24 | 2006-08-09 | 한국과학기술연구원 | T-형 칼슘 채널 차단제로서 유용한 3,4-디히드로퀴나졸린유도체 및 그의 제조 방법 |
EP1720545B1 (en) | 2004-03-03 | 2014-10-29 | ChemoCentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
EP1761542B1 (en) | 2004-06-09 | 2008-01-02 | F.Hoffmann-La Roche Ag | Octahydropyrrolo[3,4-c]pyrrole derivatives an their use as antiviral agents |
RU2401833C2 (ru) | 2004-08-10 | 2010-10-20 | Янссен Фармацевтика Н.В. | Производные 1, 2, 4-триазин-6-она, ингибирующие вич |
US7410949B2 (en) | 2005-01-18 | 2008-08-12 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof |
GB0504019D0 (en) | 2005-02-26 | 2005-04-06 | Astrazeneca Ab | Amide derivatives |
MX2007013469A (es) | 2005-04-28 | 2008-01-22 | Wyeth Corp | Forma ii polimorfa de tanaproget. |
US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
TW200800999A (en) | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
WO2007049771A1 (ja) | 2005-10-28 | 2007-05-03 | Ono Pharmaceutical Co., Ltd. | 塩基性基を含有する化合物およびその用途 |
ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
JP2007176809A (ja) | 2005-12-27 | 2007-07-12 | Hideaki Natsukari | 複素環置換アミド化合物、その製造法および医薬組成物 |
WO2007103719A2 (en) | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
JP2008031064A (ja) | 2006-07-27 | 2008-02-14 | Astellas Pharma Inc | ジアシルピペラジン誘導体 |
AU2007296634B2 (en) | 2006-09-11 | 2012-09-20 | Merck Sharp & Dohme B.V. | Quinazolinone and isoquinolinone acetamide derivatives |
US7638526B2 (en) | 2006-09-15 | 2009-12-29 | Schering Corporation | Azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism |
US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
TWI454262B (zh) | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
US7915299B2 (en) | 2006-11-15 | 2011-03-29 | High Point Pharmaceuticals, Llc | 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
AU2008233929A1 (en) | 2007-03-29 | 2008-10-09 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
EP2152711B1 (de) | 2007-04-27 | 2010-11-24 | Sanofi-Aventis | 2 -heteroaryl- pyrrolo [3, 4-c]pyrrol- derivate und deren verwendung als scd inhibitoren |
WO2009019286A1 (en) | 2007-08-07 | 2009-02-12 | Abbott Gmbh & Co. Kg | Quinoline compounds suitable for treating disorders that respond to modulation of the serotonin 5-ht6 receptor |
DE102007047737A1 (de) | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
US20090155176A1 (en) | 2007-10-19 | 2009-06-18 | Sarcode Corporation | Compositions and methods for treatment of diabetic retinopathy |
PE20091017A1 (es) | 2007-10-31 | 2009-07-16 | Janssen Pharmaceutica Nv | Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa |
JP2009161449A (ja) | 2007-12-28 | 2009-07-23 | Lion Corp | Ppar活性促進剤並びに美容用飲食品、皮膚外用剤及び医薬 |
EP2301936A1 (en) | 2008-06-19 | 2011-03-30 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
EP2328898B1 (de) | 2008-09-09 | 2014-12-24 | Sanofi | 2-heteroaryl-pyrrolo[3,4-c]pyrrol- derivate und ihre verwendung als scd inhibitoren |
TW201020247A (en) | 2008-11-06 | 2010-06-01 | Gruenenthal Gmbh | Substituierte disulfonamide |
JP5373104B2 (ja) | 2008-11-17 | 2013-12-18 | エフ.ホフマン−ラ ロシュ アーゲー | Crth2アンタゴニスト又は部分アゴニストとして使用されるナフチル酢酸 |
DE102008059578A1 (de) | 2008-11-28 | 2010-06-10 | Merck Patent Gmbh | Benzo-Naphtyridin Verbindungen |
CN102216299B (zh) | 2008-12-01 | 2015-02-11 | 默克专利有限公司 | 作为自体毒素抑制剂的2,5-二氨基取代的吡啶并[4,3-d]嘧啶化合物 |
TW201035102A (en) | 2009-03-04 | 2010-10-01 | Gruenethal Gmbh | Sulfonylated tetrahydroazolopyrazines and their use as medicinal products |
EP2404918B1 (en) | 2009-03-05 | 2016-11-30 | Daiichi Sankyo Company, Limited | Pyridine derivative as ppary inhibitor |
US20120010186A1 (en) | 2009-03-23 | 2012-01-12 | Merck Frosst Canada Ltd. | Heterocyclic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
EA201101396A1 (ru) * | 2009-04-02 | 2012-09-28 | Мерк Патент Гмбх | Ингибиторы аутотаксина |
CN102369186B (zh) | 2009-04-02 | 2014-07-09 | 默克专利有限公司 | 作为自分泌运动因子抑制剂的哌啶和哌嗪衍生物 |
ES2527788T3 (es) | 2009-04-02 | 2015-01-30 | Merck Patent Gmbh | Compuestos heterocíclicos como inhibidores de autotaxina |
FR2945534B1 (fr) | 2009-05-12 | 2012-11-16 | Sanofi Aventis | DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
CA2763099A1 (en) | 2009-05-22 | 2010-11-25 | Exelixis, Inc. | Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases |
WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
DE102009033392A1 (de) | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
WO2011017350A2 (en) | 2009-08-04 | 2011-02-10 | Amira Pharmaceuticals, Inc. | Compounds as lysophosphatidic acid receptor antagonists |
UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
MX2012007935A (es) | 2010-01-07 | 2012-08-15 | Du Pont | Compuestos heterociclicos fungicidas. |
WO2011115813A1 (en) | 2010-03-18 | 2011-09-22 | Abbott Laboratories | Lactam acetamides as calcium channel blockers |
HUE025774T2 (en) | 2010-03-19 | 2016-05-30 | Pfizer | 2,3-Dihydro-1H-inden-1-yl-2,7-diazaspiro [3.6] nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor |
CA2794211A1 (en) | 2010-03-26 | 2011-09-29 | Wolfgang Staehle | Benzonaphthyridinamines as autotaxin inhibitors |
GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
EP2575794A2 (en) | 2010-06-04 | 2013-04-10 | B.S.R.C. "Alexander Fleming" | Autotaxin pathway modulation and uses thereof |
CN102958853A (zh) | 2010-06-29 | 2013-03-06 | 奥林巴斯株式会社 | 光学元件制造方法以及光学元件制造装置 |
EP2606031B1 (en) | 2010-08-20 | 2017-09-27 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
CA2809892C (en) | 2010-09-02 | 2019-05-28 | Merck Patent Gmbh | Pyrazolopyridinone derivatives as lpa receptor antagonists |
US8999985B2 (en) | 2010-12-02 | 2015-04-07 | Shanghai De Novo Pharmatech Co Ltd. | Substituted phthalazin-1(2H)-ones, preparation processes and medical uses thereof |
CN103298460B (zh) | 2010-12-14 | 2016-06-01 | 电泳有限公司 | 酪蛋白激酶1δ(CK1δ)抑制剂 |
US9260416B2 (en) | 2011-05-27 | 2016-02-16 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
ES2609579T3 (es) | 2011-08-29 | 2017-04-21 | VIIV Healthcare UK (No.5) Limited | Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH |
WO2013054185A1 (en) * | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
JPWO2013065712A1 (ja) | 2011-10-31 | 2015-04-02 | 東レ株式会社 | ジアザスピロウレア誘導体及びその医薬用途 |
US8809552B2 (en) | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
WO2013079223A1 (en) | 2011-12-02 | 2013-06-06 | Phenex Pharmaceuticals Ag | Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rorϒ, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚o-甲基轉移酶活性抑制化合物 |
SG11201407534PA (en) * | 2012-06-13 | 2014-12-30 | Hoffmann La Roche | New diazaspirocycloalkane and azaspirocycloalkane |
PT3176170T (pt) | 2012-06-13 | 2019-02-05 | Incyte Holdings Corp | Compostos tricíclicos substituídos como inibidores de fgfr |
CA2871388A1 (en) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | 5-azaindazole compounds and methods of use |
EA028364B1 (ru) | 2012-07-27 | 2017-11-30 | Биоген Айдек Ма Инк. | Аутотаксин-модулирующие соединения |
US9550798B2 (en) | 2012-07-27 | 2017-01-24 | Biogen Ma Inc. | Compounds that are S1P modulating agents and/or ATX modulating agents |
AR092211A1 (es) | 2012-09-24 | 2015-04-08 | Merck Patent Ges Mit Beschränkter Haftung | Derivados de hidropirrolopirrol |
MX357035B (es) | 2012-09-25 | 2018-06-25 | Bayer Pharma AG | Combinacion de regorafenib y acido acetilsalicilico para el tratamiento del cancer. |
IN2015DN00960A (es) | 2012-09-25 | 2015-06-12 | Hoffmann La Roche | |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
DK2912019T3 (da) | 2012-10-25 | 2021-05-25 | Tetra Discovery Partners Llc | Heteroarylhæmmere af pde4 |
DK2938598T3 (en) | 2012-12-31 | 2017-02-13 | Cadila Healthcare Ltd | Substituted phthalazine-1 (2H) -one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1 |
US20160002247A1 (en) | 2013-03-01 | 2016-01-07 | The University Of Tokyo | 8-substituted imidazopyrimidinone derivative having autotaxin inhibitory activity |
TWI593692B (zh) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
UY35395A (es) | 2013-03-12 | 2014-10-31 | Abbvie Inc | Inhibidores de bromodominios tetracíclicos |
CN105209428A (zh) | 2013-03-12 | 2015-12-30 | 奥克塞拉有限公司 | 用于治疗眼科疾病和病症的取代的3-苯基丙胺衍生物 |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
TW201446768A (zh) | 2013-03-15 | 2014-12-16 | Biogen Idec Inc | S1p及/或atx調節劑 |
AU2014291711B2 (en) | 2013-07-18 | 2017-02-02 | Novartis Ag | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
PT3057959T (pt) | 2013-10-17 | 2018-06-04 | Vertex Pharma | Inibidores de adn-pk |
CN105793253B (zh) | 2013-11-22 | 2019-08-23 | 法玛克亚公司 | 自分泌运动因子抑制剂化合物 |
AR098475A1 (es) | 2013-11-26 | 2016-06-01 | Bayer Cropscience Ag | Compuestos pesticidas y usos |
MY187449A (en) | 2013-11-26 | 2021-09-22 | Hoffmann La Roche | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
HUE046820T2 (hu) | 2014-03-26 | 2020-03-30 | Hoffmann La Roche | Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként |
PL3122732T3 (pl) | 2014-03-26 | 2018-08-31 | Basf Se | Podstawione związki [1,2,4]triazolowe i imidazolowe jako fungicydy |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
JP6554481B2 (ja) | 2014-03-26 | 2019-07-31 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | オートタキシン(atx)及びリゾホスファチジン酸(lpa)産生の阻害剤としての縮合[1,4]ジアゼピン化合物 |
MX2016013049A (es) | 2014-04-04 | 2017-04-27 | X-Rx Inc | Inhibidores de autotaxina espirociclicos sustituidos. |
WO2016031987A1 (ja) | 2014-08-29 | 2016-03-03 | 国立大学法人東京大学 | オートタキシン阻害活性を有するピリミジノン誘導体 |
WO2016061160A1 (en) | 2014-10-14 | 2016-04-21 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ror-gamma |
AU2016217851A1 (en) | 2015-02-15 | 2017-08-03 | F. Hoffmann-La Roche Ag | 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as TRPA1 antagonists |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
CN104927727B (zh) | 2015-07-06 | 2017-01-11 | 香山红叶建设有限公司 | 一种玻璃幕墙用结构密封胶及其制备方法 |
PL415078A1 (pl) | 2015-09-04 | 2017-03-13 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków |
CR20180058A (es) | 2015-09-04 | 2018-02-26 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
KR20180054830A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서의 이환형 화합물 |
EP3353328A4 (en) | 2015-09-24 | 2019-06-12 | Ionis Pharmaceuticals, Inc. | MODULATORS OF KRAS EXPRESSION |
CN107922415B (zh) | 2015-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 新的作为双重atx/ca抑制剂的二环化合物 |
MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
MX2018001890A (es) * | 2015-09-24 | 2018-06-20 | Hoffmann La Roche | Compuestos biciclicos como inhibidores de autotaxina (atx). |
WO2017087858A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
WO2017087863A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
WO2017091673A2 (en) | 2015-11-25 | 2017-06-01 | Dana-Farber Cancer Institute, Inc. | Bivalent bromodomain inhibtors and uses thereof |
CN108290858B (zh) | 2015-12-01 | 2021-07-06 | 日本农药株式会社 | 3h-吡咯并吡啶化合物或其n-氧化物、或它们的盐类及含有该化合物的农业园艺用杀虫剂及其使用方法 |
WO2017139978A1 (zh) | 2016-02-19 | 2017-08-24 | 吴伟东 | 手机app更新方法及*** |
CR20190423A (es) | 2017-03-16 | 2019-11-01 | Hoffmann La Roche | Nuevos compuestos biciclícos como inhibidores dobles de atx/ca |
WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
EA201992215A1 (ru) | 2017-03-20 | 2020-02-06 | Форма Терапьютикс, Инк. | Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr) |
-
2014
- 2014-11-24 MY MYPI2016701851A patent/MY187449A/en unknown
- 2014-11-24 LT LTEP14805527.0T patent/LT3074400T/lt unknown
- 2014-11-24 AU AU2014356583A patent/AU2014356583B2/en not_active Ceased
- 2014-11-24 SI SI201430553T patent/SI3074400T1/en unknown
- 2014-11-24 HU HUE14805527A patent/HUE036117T2/hu unknown
- 2014-11-24 KR KR1020167016752A patent/KR20160087900A/ko not_active Application Discontinuation
- 2014-11-24 MX MX2016005186A patent/MX2016005186A/es unknown
- 2014-11-24 EP EP14805527.0A patent/EP3074400B1/en active Active
- 2014-11-24 WO PCT/EP2014/075360 patent/WO2015078803A1/en active Application Filing
- 2014-11-24 JP JP2016534720A patent/JP6496730B2/ja not_active Expired - Fee Related
- 2014-11-24 EA EA201691044A patent/EA201691044A1/ru unknown
- 2014-11-24 DK DK14805527.0T patent/DK3074400T3/en active
- 2014-11-24 PE PE2016000678A patent/PE20160845A1/es unknown
- 2014-11-24 UA UAA201606880A patent/UA118201C2/uk unknown
- 2014-11-24 CN CN201480064141.8A patent/CN105764905B/zh active Active
- 2014-11-24 NO NO14805527A patent/NO3074400T3/no unknown
- 2014-11-24 PT PT148055270T patent/PT3074400T/pt unknown
- 2014-11-24 ES ES14805527.0T patent/ES2656198T3/es active Active
- 2014-11-24 MA MA38982A patent/MA38982A1/fr unknown
- 2014-11-24 RS RS20180041A patent/RS56776B1/sr unknown
- 2014-11-24 CA CA2923523A patent/CA2923523A1/en not_active Abandoned
- 2014-11-24 PL PL14805527T patent/PL3074400T3/pl unknown
- 2014-11-25 TW TW103140878A patent/TW201605861A/zh unknown
- 2014-11-25 AR ARP140104399A patent/AR098517A1/es unknown
-
2016
- 2016-03-09 IL IL244519A patent/IL244519A0/en unknown
- 2016-03-14 ZA ZA2016/01726A patent/ZA201601726B/en unknown
- 2016-04-07 PH PH12016500643A patent/PH12016500643A1/en unknown
- 2016-04-14 CR CR20160171A patent/CR20160171A/es unknown
- 2016-05-25 CL CL2016001266A patent/CL2016001266A1/es unknown
- 2016-05-25 US US15/164,122 patent/US20160264586A1/en not_active Abandoned
- 2016-10-19 HK HK16112055.9A patent/HK1223921A1/zh unknown
-
2018
- 2018-01-08 HR HRP20180029TT patent/HRP20180029T1/hr unknown
- 2018-06-04 US US15/997,341 patent/US10849881B2/en active Active
-
2020
- 2020-09-28 US US17/034,323 patent/US20210015792A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR098517A1 (es) | Compuestos derivados de octahidro-ciclobuta[1,2-c;3,4-c]dipirrol-2-ilo | |
AR123048A2 (es) | Moduladores de p2x7 | |
AR119651A1 (es) | Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington | |
AR092645A1 (es) | Derivados biciclicos inhibidores de autotaxina (atx) | |
AR108388A2 (es) | Compuestos de oxazol sustituidos con indazol como inhibidores de pi3-quinasas | |
AR088423A1 (es) | Ligadores p1 ciclicos como inhibidores del factor xia | |
AR108875A1 (es) | COMPUESTOS HETEROCÍCLICOS COMO INHIBIDORES DE PI3K-g | |
ES2620668T3 (es) | Derivados de amidas y sulfonamidas amido espirocíclicas | |
AR096979A1 (es) | Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
AR099823A1 (es) | Compuestos bicíclicos de 7 eslabones | |
AR099824A1 (es) | Compuestos bicíclicos | |
AR090220A1 (es) | Inhibidores de serina/treonina cinasa | |
AR103561A1 (es) | Fenilpiridinas herbicidas | |
AR091424A1 (es) | Compuestos triciclicos sustituidos como inhibidores de receptores del factor de crecimiento del fibroplasto (fgfr) | |
AR106595A1 (es) | COMPUESTOS HETEROCÍCLICOS COMO INHIBIDORES DE PI3K-g | |
AR095079A1 (es) | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo | |
ES2618703T3 (es) | Nuevos compuestos diazaspirocicloalcano y azaspirocicloalcano | |
AR091156A1 (es) | Nucleosidos de espirooxetano de uracilo | |
AR097571A1 (es) | Compuestos espirocíclicos como inhibidores de la triptofano hidroxilasa | |
AR095570A1 (es) | Derivados de urea | |
AR107042A1 (es) | Inhibidores de la tirosina quinasa de bruton y métodos de su uso | |
AR096532A1 (es) | Inhibidores de quinasa | |
AR097279A1 (es) | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx | |
AR099914A1 (es) | Derivados de indol y de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
AR083694A1 (es) | USO DE COMPUESTOS FARMACEUTICOS ACTIVOS PARA EL TRATAMIENTO DE ESTADOS PATOLOGICOS DEL SISTEMA NERVIOSO CENTRAL, COMPOSICION FARMACEUTICA, MODULADOR ALOSTERICO NEGATIVO DEL GABA A a5, METODO |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |