AR074822A1 - Compuestos heterociclicos de pirazina utiles como inhibidores de proteinquinasas atr, composiciones farmaceuticas que los comprenden y uso de los mismos en el tratamiento del cancer - Google Patents

Compuestos heterociclicos de pirazina utiles como inhibidores de proteinquinasas atr, composiciones farmaceuticas que los comprenden y uso de los mismos en el tratamiento del cancer

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Publication number
AR074822A1
AR074822A1 ARP090105005A ARP090105005A AR074822A1 AR 074822 A1 AR074822 A1 AR 074822A1 AR P090105005 A ARP090105005 A AR P090105005A AR P090105005 A ARP090105005 A AR P090105005A AR 074822 A1 AR074822 A1 AR 074822A1
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AR
Argentina
Prior art keywords
aliphatic
alkyl
halo
optionally substituted
nitrogen
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ARP090105005A
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English (en)
Inventor
Philip Reaper
Alistair Rutherford
Jean-Damien Charrier
David Kay
Steven Durrant
Somhairle Maccormick
Ronald Knegtel
Michael Mortimore
Stephen Young
Donnell Michael O
Joanne Pinder
Anisa Nizarali Virani
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Vertex Pharma
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Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR074822A1 publication Critical patent/AR074822A1/es

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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S507/00—Earth boring, well treating, and oil field chemistry
    • Y10S507/939—Corrosion inhibitor

Abstract

Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo; caracterizado porque Y es una cadena alifática de C1-10 donde hasta tres unidades de metileno de la cadena alifática opcionalmente son reemplazados por O, NR0, S, C(O), o S(O)2; el anillo A es un anillo heteroarilo de 5 miembros seleccionado entre el grupo de fórmulas (2); J3 es H o alquilo de C1-4 donde 1 unidad de metileno del grupo alquilo opcionalmente puede ser reemplazada por O, NR0, N(alquilo de C1-4), o S y opcionalmente sustituido con 1 - 3 halo; Q es un anillo aromático monocíclico de 5 - 6 miembros que contiene 0 - 4 heteroátomos seleccionados independientemente entre nitrógeno, oxigeno o azufre; o un anillo aromático bicíclico de 8 - 10 miembros que contiene 0 - 6 heteroátomos seleccionados independientemente entre nitrógeno, oxígeno o azufre; R5 es H; un anillo monocíclico de 3 - 7 miembros completamente saturado, parcialmente saturado o aromático que contiene 0 - 4 heteroátomos seleccionados independientemente entre nitrógeno, oxigeno o azufre; un anillo bicíclico de 8 - 10 miembros, completamente saturado, parcialmente saturado o aromático que contiene 0 - 6 heteroátomos seleccionados independientemente entre nitrógeno, oxigeno o azufre; R5 está opcionalmente sustituido con 1-5 grupos J5; L es una cadena alquilo de C1-4 donde hasta dos unidades de metileno de la cadena alquilo, opcionalmente, son reemplazadas por O, NR6, S, -C(O)-, -SO-, o -SO2-; R0 es H o alquilo de C1-6 donde una unidad de metileno de la cadena alquilo puede ser, opcionalmente. reemplazada por O, NH, N(alquilo C1-4), o S; R1 es H o alquilo de C1-6; R2 es H, alquilo de C1-6, -(alquilo de C2-6)-Z o un anillo cíclico de 4 - 8 miembros que contiene 0 - 2 átomos de nitrógeno; donde dicho anillo está ligado mediante un átomo de carbono y está opcionalmente sustituido con una presencia de JZ; o R1 y R2, tomados junto con el átomo al que están ligados, forman un anillo heterocíclico de 4 - 8 miembros que contiene 1 - 2 heteroátomos seleccionados entre oxigeno, nitrógeno o azufre; donde dicho anillo heterocíclico está opcionalmente sustituido con una presencia de JZ1; JZ1 es halo, CN, un grupo alifático de C1-8, -(X)t-CN, o -(X)r-Z; donde dichas hasta dos unidades de metileno de dicho grupo alifático C1-8 pueden ser, opcionalmente, reemplazadas por O, NR, S, P(O), C(O), S(O), o S(O)2; donde dicho grupo alifático de C1-8 está opcionalmente sustituido con halo, CN, o NO2; X es alquilo de C1-4; cada t, r y m es, independientemente, 0 ó 1; Z es-NR3R4; R3 es H o alquilo de C1-2; R4 es H o alquilo de C1-6; o R3 y R4, tomados junto con el átomo al que están ligados, forman un anillo heterocíclico de 4 - 8 miembros que contiene 1 - 2 heteroátomos seleccionados entre oxigeno, nitrógeno o azufre; donde dicho anillo está opcionalmente sustituido con una presencia de JZ; R6 es H, o alquilo de C1-6; JZ es, independientemente, NH2, NH(alifático de C1-4), N(alifático de C1-4)2, halógeno, alifático de C1-4, OH, O(alifático de C1-4), NO2, CN, CO2H, CO(alifático de C1-4), CO2(alifático de C1-4), O(haloalifático de C1-4), o haloalifático de C1-4; J5 es halo, oxo, CN, NO2, X'-R, o -(X1)p-Q4; X1 es un grupo alifático de C1-10 donde 1-3 unidades de metileno de dicho grupo alifático de C1-10 opcionalmente son reemplazadas por -NR'-, -O-, -S-, C(=NR'), C(O), S(O)2, o S(O); donde X1 está opcional e independientemente sustituido con 1 - 4 presencias de NH2, NH(alifático de C1-4), N(alifático de C1-4)2, halógeno, alifático de C1-4, OH, O(alifático de C1-4), NO2, CN, CO2H, CO2(alifático de C1-4), C(O)NH2, C(O)NH(alifático de C1-4), C(O)N(alifático de C1-4)2, SO(alifático de C1-4), SO2(alifático de C1-4), SO2NH(alifático de C1-4), SO2NH(alifático de C1-4), NHC(O)(alifático de C1-4), N(alifático de C1-4)C(O)(alifático de C1-4), donde dicho grupo alifático de C1-4 está opcionalmente sustituido con 1 - 3 presencias de halo; Q4 es un anillo monocíclico de 3 - 8 miembros saturado o insaturado que tiene 0 - 4 heteroátomos seleccionados independientemente entre nitrógeno, oxigeno o azufre, o un anillo bicíclico de 8 - 10 miembros saturado o insaturado que tiene 0 - 6 heteroátomos seleccionados independientemente entre nitrógeno, oxígeno o azufre; cada Q4 está opcionalmente sustituido con 1 - 5 JQ4; JQ4 es halo, CN, o alquilo de C1-4 donde hasta 2 unidades de metileno opcionalmente son reemplazadas por O, NR*, S, C(O). S(O), o S(O)2; R es H o alquilo de C1-4 donde dicho grupo alquilo de C1-4 está opcionalmente sustituido con 1-4 halo; J2 es halo; CN; un anillo monocíclico de 5 - 6 miembros aromático o no aromático que tiene 0 - 3 heteroátomos seleccionados entre oxígeno, nitrógeno o azufre; o un grupo alifático de C1-10 donde hasta 2 unidades de metileno opcionalmente son reemplazadas por O, NR'', C(O), S, S(O), o S(O)2 donde dicho grupo alifático de C1-10 está opcionalmente sustituido con 1 - 3 halo o CN; y dicho anillo monocíclico está opcionalmente sustituido con 1 - 3 presencias de halo; CN; un grupo cicloalquilo de C3-6; un heterociclilo de 3 - 7 miembros que contiene 0 - 2 heteroátomos seleccionados entre oxígeno, nitrógeno o azufre; o un grupo alquilo de C1-4 donde hasta una unidad de metileno de la cadera alquilo está opcionalmente reemplazada con O, NR'' o S; y donde dicho grupo alquilo de C1-4 está opcionalmente sustituido con 1 - 3 halo; q es 0, 1 ó 2; p es 0 ó 1; R', R'' y R* son, cada uno, independientemente H, alquilo de C1-4, o está ausente; donde dicho alquilo de C1-4 está opcionalmente sustituido con 1 - 4 halo.
ARP090105005A 2008-12-19 2009-12-21 Compuestos heterociclicos de pirazina utiles como inhibidores de proteinquinasas atr, composiciones farmaceuticas que los comprenden y uso de los mismos en el tratamiento del cancer AR074822A1 (es)

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US13942908P 2008-12-19 2008-12-19
US13942408P 2008-12-19 2008-12-19
US13942608P 2008-12-19 2008-12-19
US13942008P 2008-12-19 2008-12-19
US18179409P 2009-05-28 2009-05-28
US21910009P 2009-06-22 2009-06-22

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