PE20071020A1 - Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa - Google Patents
Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasaInfo
- Publication number
- PE20071020A1 PE20071020A1 PE2007000237A PE2007000237A PE20071020A1 PE 20071020 A1 PE20071020 A1 PE 20071020A1 PE 2007000237 A PE2007000237 A PE 2007000237A PE 2007000237 A PE2007000237 A PE 2007000237A PE 20071020 A1 PE20071020 A1 PE 20071020A1
- Authority
- PE
- Peru
- Prior art keywords
- glycine
- derivative compounds
- naphthyridin
- dihydro
- oxo
- Prior art date
Links
- -1 GLYCINE DERIVATIVE COMPOUNDS Chemical class 0.000 title abstract 4
- 108010049175 N-substituted Glycines Proteins 0.000 title abstract 2
- 102000004079 Prolyl Hydroxylases Human genes 0.000 title 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 abstract 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE GLICINA N-SUSTITUIDOS DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C10), ALQUENILO(C2-C10), CICLOALQUILO(C3-C8), ENTRE OTROS; R2 ES NR6R7 U OR8, DONDE R6 Y R7 SON CADA UNO H, ALQUILO(C1-C10), ALQUENILO(C2-C10), HETEROCICLOALQUILO(C3-C8), ENTRE OTROS; R8 ES H, UN CATION O ALQUILO(C1-C10) OPCIONALMENTE SUSTITUIDO CON CICLOALQUILO(C3-C8), HETEROCICLOALQUILO(C3-C8), ARILO(C6-C14) O HETEROARILO; X, Y, W Y Z SON CADA UNO CR9 O N, DONDE R9 ES H, NITRO, CN, HALOGENO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-{[1-(2-CICLOPROPILETIL)-4-HIDROXI-2-OXO-1,2-DIHIDRO-1,8-NAFTIRIDIN-3-IL]CARBONIL}GLICINA, N-{[4-HIDROXI-1-(3-METILBUTIL)-2-OXO-1,2-DIHIDRO-1,8-NAFTIRIDIN-3-IL]CARBONIL}GLICINA, N-{[1-(3,3-DIMETILBUTIL)-4-HIDROXI-2-OXO-1,2-DIHIDRO-1,8-NAFTIRIDIN-3-IL]CARBONIL}GLICINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE PROLIL HIDROXILASAS QUE REGULAN EL FACTOR INDUCIBLE POR HIPOXIA (HIF) SIENDO UTILES EN EL TRATAMIENTO DE ANEMIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77973706P | 2006-03-07 | 2006-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20071020A1 true PE20071020A1 (es) | 2007-12-11 |
Family
ID=38475787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000237A PE20071020A1 (es) | 2006-03-07 | 2007-03-05 | Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa |
Country Status (7)
Country | Link |
---|---|
US (2) | US7897612B2 (es) |
EP (1) | EP1991227A2 (es) |
JP (1) | JP2009529536A (es) |
AR (1) | AR059733A1 (es) |
PE (1) | PE20071020A1 (es) |
TW (1) | TW200808793A (es) |
WO (1) | WO2007103905A2 (es) |
Families Citing this family (68)
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KR101229647B1 (ko) * | 2004-09-03 | 2013-02-05 | 메르크 세로노 에스.에이. | 피리딘 메틸렌 아조리디논 및 포스포이노시타이드 저해제의용도 |
US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
LT3357911T (lt) | 2006-06-26 | 2022-08-10 | Akebia Therapeutics Inc. | Prolilo hidroksilazės inhibitoriai ir naudojimo būdai |
AU2007334321B2 (en) * | 2006-12-18 | 2012-03-08 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
AU2007334323B2 (en) | 2006-12-18 | 2011-03-10 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
WO2008130527A1 (en) * | 2007-04-18 | 2008-10-30 | Merck & Co., Inc. | Novel 1,8-naphthyridine compounds |
ES2442847T3 (es) * | 2007-04-18 | 2014-02-13 | Amgen, Inc | Quinolonas y azaquinolonas que inhiben la prolil hidroxilasa |
US7569726B2 (en) | 2007-04-18 | 2009-08-04 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
EP2150251B9 (en) | 2007-05-04 | 2013-02-27 | Amgen, Inc | Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity |
EP2155746A2 (en) * | 2007-05-04 | 2010-02-24 | Amgen, Inc | Diazaquinolones that inhibit prolyl hydroxylase activity |
US8962530B2 (en) * | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
WO2009039322A1 (en) * | 2007-09-19 | 2009-03-26 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
WO2009039321A1 (en) * | 2007-09-19 | 2009-03-26 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
WO2009039323A1 (en) * | 2007-09-19 | 2009-03-26 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
WO2009049112A1 (en) * | 2007-10-10 | 2009-04-16 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
JP2011508725A (ja) * | 2007-11-30 | 2011-03-17 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | プロリルヒドロキシラーゼ阻害剤 |
CN101932324A (zh) * | 2007-11-30 | 2010-12-29 | 葛兰素史密斯克莱有限责任公司 | 脯氨酰羟化酶抑制剂 |
WO2009073669A1 (en) | 2007-12-03 | 2009-06-11 | Fibrogen, Inc. | Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions |
WO2009086044A1 (en) * | 2007-12-19 | 2009-07-09 | Smith Kline Beecham Corporation | Prolyl hydroxylase inhibitors |
EP2252619B1 (en) | 2008-01-11 | 2013-10-09 | Fibrogen, Inc. | Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity |
WO2009100250A1 (en) * | 2008-02-05 | 2009-08-13 | Fibrogen, Inc. | Chromene derivatives and use thereof as hif hydroxylase activity inhibitors |
EP2257170B1 (en) * | 2008-02-25 | 2012-12-26 | Merck Sharp & Dohme Corp. | Tetrahydrofuropyridones |
EP2257171B1 (en) * | 2008-02-25 | 2016-02-10 | Merck Sharp & Dohme Corp. | Tetrahydro-1h-pyrrolo-fused pyridones |
WO2009134754A1 (en) | 2008-04-28 | 2009-11-05 | Janssen Pharmaceutica Nv | Benzoimidazole glycinamides as prolyl hydroxylase inhibitors |
JP2011519858A (ja) * | 2008-04-30 | 2011-07-14 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | プロリルヒドロキシラ−ゼ阻害剤 |
GB0809262D0 (en) * | 2008-05-21 | 2008-06-25 | Isis Innovation | Assay |
CN102264740B (zh) | 2008-08-20 | 2014-10-15 | 菲布罗根有限公司 | 一种吡咯[1,2-b]哒嗪衍生物及其作为hif调节剂的用途 |
JP2012500850A (ja) * | 2008-08-25 | 2012-01-12 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | プロリルヒドロキシラーゼ阻害剤 |
WO2010056767A1 (en) * | 2008-11-14 | 2010-05-20 | Fibrogen, Inc. | Thiochromene derivatives as hip hydroxylase inhibitors |
WO2010059552A1 (en) * | 2008-11-18 | 2010-05-27 | Glaxosmithkline Llc | Prolyl hydroxylase inhibitors |
CA2748411A1 (fr) | 2008-12-29 | 2010-07-08 | Sanofi | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
FR2940652B1 (fr) * | 2008-12-29 | 2011-02-11 | Sanofi Aventis | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique |
SI2382215T1 (sl) * | 2008-12-29 | 2020-06-30 | Sanofi | Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba |
ES2548250T3 (es) | 2009-02-10 | 2015-10-15 | Janssen Pharmaceutica, N.V. | Quinazolinonas como inhibidores de prolilhidroxilasa |
ES2702524T3 (es) * | 2009-07-15 | 2019-03-01 | Beijing Betta Pharmaceuticals Co Ltd | Compuestos como miméticos de hipoxia, y composiciones, y usos de estos |
AU2010271732B2 (en) * | 2009-07-17 | 2016-08-25 | Japan Tobacco Inc. | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
AU2010314976B2 (en) | 2009-11-06 | 2014-03-06 | Aerpio Therapeutics Inc. | Prolyl hydroxylase inhibitors |
EP2603502B1 (en) | 2010-08-13 | 2014-07-30 | Janssen Pharmaceutica, N.V. | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors |
US9290453B2 (en) | 2010-12-23 | 2016-03-22 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as CRTH2 receptor modulators |
JP5952829B2 (ja) | 2010-12-23 | 2016-07-13 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Crth2受容体調節剤としてのキノキサリン類およびアザ−キノキサリン類 |
CN103608346B (zh) * | 2011-02-02 | 2016-06-15 | 菲布罗根有限公司 | 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物 |
GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
AU2012268400C1 (en) | 2011-06-06 | 2016-12-22 | Akebia Therapeutics Inc. | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
NO2686520T3 (es) | 2011-06-06 | 2018-03-17 | ||
GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
BR112014009910B1 (pt) | 2011-10-25 | 2020-06-30 | Janssen Pharmaceutica N.V. | sal di-hidrato de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico, composição farmacêuticae pomada tópica |
ES2718495T3 (es) | 2012-12-21 | 2019-07-02 | Celgene Quanticel Res Inc | Inhibidores de la histona desmetilasa |
US9394300B2 (en) | 2012-12-24 | 2016-07-19 | Cadila Healthcare Limited | Quinolone derivatives |
CA3151685A1 (en) | 2013-06-13 | 2014-12-18 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
US20150164991A1 (en) * | 2013-11-01 | 2015-06-18 | Vanderbilt University | Method and Kit for Evaluating and Monitoring a Treatment Program for Anemia |
KR102495018B1 (ko) | 2013-11-15 | 2023-02-06 | 아케비아 테라퓨틱스 인코포레이티드 | {[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노}아세트산의 고체형, 이의 조성물 및 용도 |
ES2862648T3 (es) | 2014-06-25 | 2021-10-07 | Celgene Quanticel Res Inc | Inhibidores de la histona desmetilasa |
ES2898476T3 (es) | 2014-09-02 | 2022-03-07 | Sunshine Lake Pharma Co Ltd | Compuesto de quinolona y uso del mismo |
WO2016045127A1 (en) | 2014-09-28 | 2016-03-31 | Merck Sharp & Dohme Corp. | Inhibitors of hif prolyl hydroxylase |
WO2016118858A1 (en) | 2015-01-23 | 2016-07-28 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
CN106146491B (zh) * | 2015-03-27 | 2017-12-12 | 沈阳三生制药有限责任公司 | 被芳基或杂芳基取代的5‑羟基‑1,7‑萘啶化合物、其制备方法及其制药用途 |
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SI3277270T1 (sl) | 2015-04-01 | 2022-04-29 | Akebia Therapeutics, Inc. | Sestavki in postopki za zdravljenje anemije |
EP3370518B1 (en) | 2015-10-14 | 2023-08-23 | X-Therma, Inc. | Compositions and methods for reducing ice crystal formation |
CN108069957B (zh) * | 2016-11-09 | 2022-11-04 | 广东东阳光药业有限公司 | 脯氨酰羟化酶抑制剂及其用途 |
WO2019068613A1 (en) | 2017-10-02 | 2019-04-11 | Boehringer Ingelheim International Gmbh | NOVEL [1,6] NAPHTHYRIDINE COMPOUNDS AND DERIVATIVES AS CDK8 / CDK19 INHIBITORS |
CA3097219A1 (en) | 2018-05-09 | 2019-11-14 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
CN110878096A (zh) * | 2018-09-05 | 2020-03-13 | 石药集团中奇制药技术(石家庄)有限公司 | 一种1,7-萘啶类衍生物及其制备方法和用途 |
US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
CN115835909A (zh) | 2020-05-05 | 2023-03-21 | 泰昂治疗公司 | ***素受体2型(cb2)调节剂和其用途 |
EP4342885A1 (en) | 2022-09-20 | 2024-03-27 | Basf Se | N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides |
WO2024061665A1 (en) | 2022-09-20 | 2024-03-28 | Basf Se | N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1644336T3 (da) * | 2003-06-06 | 2011-05-09 | Fibrogen Inc | Nitrogenholdige heteroarylforbindelser og deres anvendelse til forøgelse af endogent erythropoietin |
MXPA06009132A (es) * | 2004-02-11 | 2007-03-26 | Smithkline Beecham Corp | Inhibidores de integrasa de vih. |
-
2007
- 2007-03-05 PE PE2007000237A patent/PE20071020A1/es not_active Application Discontinuation
- 2007-03-05 TW TW096107424A patent/TW200808793A/zh unknown
- 2007-03-05 AR ARP070100894A patent/AR059733A1/es not_active Application Discontinuation
- 2007-03-06 US US12/281,677 patent/US7897612B2/en not_active Expired - Fee Related
- 2007-03-06 JP JP2008558499A patent/JP2009529536A/ja active Pending
- 2007-03-06 US US11/682,362 patent/US20070213335A1/en not_active Abandoned
- 2007-03-06 EP EP07757957A patent/EP1991227A2/en not_active Withdrawn
- 2007-03-06 WO PCT/US2007/063359 patent/WO2007103905A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1991227A2 (en) | 2008-11-19 |
US20070213335A1 (en) | 2007-09-13 |
WO2007103905A2 (en) | 2007-09-13 |
AR059733A1 (es) | 2008-04-23 |
WO2007103905A3 (en) | 2008-10-30 |
JP2009529536A (ja) | 2009-08-20 |
TW200808793A (en) | 2008-02-16 |
US20090082357A1 (en) | 2009-03-26 |
US7897612B2 (en) | 2011-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |