UY36294A - Compuestos y composiciones como inhibidores de quinasa - Google Patents

Compuestos y composiciones como inhibidores de quinasa

Info

Publication number
UY36294A
UY36294A UY0001036294A UY36294A UY36294A UY 36294 A UY36294 A UY 36294A UY 0001036294 A UY0001036294 A UY 0001036294A UY 36294 A UY36294 A UY 36294A UY 36294 A UY36294 A UY 36294A
Authority
UY
Uruguay
Prior art keywords
compounds
compositions
quinasa
inhibitors
quinasa inhibitors
Prior art date
Application number
UY0001036294A
Other languages
English (en)
Inventor
Matthew T Burger
Ramurthy Savithri
Benjamin R Taft
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY36294A publication Critical patent/UY36294A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

La presente invención proporciona un compuesto de Fórmula I , donde X, Y, Z, R1 y R2 son como se describen en el presente documento, y sales de los mismos y usos terapéuticos de estos compuestos para el tratamiento de trastornos asociados con la actividad de la quinasa RAF. La invención proporciona además composiciones farmacéuticas que comprenden estos compuestos, y composiciones que comprenden estos compuestos y un co-agente terapéutico.
UY0001036294A 2014-09-12 2015-09-10 Compuestos y composiciones como inhibidores de quinasa UY36294A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462049469P 2014-09-12 2014-09-12

Publications (1)

Publication Number Publication Date
UY36294A true UY36294A (es) 2016-04-29

Family

ID=54148595

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036294A UY36294A (es) 2014-09-12 2015-09-10 Compuestos y composiciones como inhibidores de quinasa

Country Status (30)

Country Link
US (2) US9573969B2 (es)
EP (1) EP3191472B1 (es)
JP (1) JP6678655B2 (es)
KR (1) KR20170053686A (es)
CN (1) CN107108671B (es)
AP (1) AP2017009830A0 (es)
AR (1) AR101815A1 (es)
AU (1) AU2015313782B2 (es)
BR (1) BR112017004741A2 (es)
CA (1) CA2960971A1 (es)
CL (1) CL2017000541A1 (es)
CO (1) CO2017002292A2 (es)
CR (1) CR20170092A (es)
CU (1) CU20170026A7 (es)
DO (1) DOP2017000066A (es)
EA (1) EA031061B1 (es)
EC (1) ECSP17021897A (es)
ES (1) ES2729243T3 (es)
IL (1) IL250950A0 (es)
MX (1) MX2017003233A (es)
NI (1) NI201700029A (es)
PE (1) PE20171338A1 (es)
PH (1) PH12017500416A1 (es)
SG (1) SG11201701734QA (es)
SV (1) SV2017005405A (es)
TN (1) TN2017000075A1 (es)
TW (1) TWI603977B (es)
UY (1) UY36294A (es)
WO (1) WO2016038581A1 (es)
ZA (1) ZA201701633B (es)

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MX363936B (es) 2013-03-14 2019-04-09 Boehringer Ingelheim Int (bencil-ciano-metil)-amidas del acido 2-aza-biciclo[2.2.1]heptano- 3-carboxilico sustituidas como inhibidores de catepsina c.
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
ES2908042T3 (es) * 2014-01-14 2022-04-27 Takeda Pharmaceuticals Co Heteroarilos y usos de los mismos
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
NZ728684A (en) 2014-09-12 2022-09-30 Boehringer Ingelheim Int Spirocyclic inhibitors of cathepsin c
JP7114575B2 (ja) * 2016-09-19 2022-08-08 ノバルティス アーゲー Ｒａｆ阻害剤及びｅｒｋ阻害剤を含む治療用組合せ
SG11201913249SA (en) * 2017-08-03 2020-02-27 Novartis Ag Therapeutic combination of a third-generation egfr tyrosine kinase inhibitor and a raf inhibitor
EP3941922A4 (en) * 2019-03-22 2022-11-23 Kinnate Biopharma Inc. RAF KINASE INHIBITORS
JP2022532034A (ja) 2019-05-03 2022-07-13 キネート バイオファーマ インク． Ｒａｆキナーゼの阻害剤
MX2022004937A (es) 2019-10-24 2022-07-27 Kinnate Biopharma Inc Inhibidores de las cinasas raf.
US11407737B2 (en) 2020-09-18 2022-08-09 Kinnate Biopharma Inc. Inhibitors of RAF kinases
WO2022066580A1 (en) * 2020-09-23 2022-03-31 Kinnate Biopharma Inc. Raf degrading compounds
WO2022081469A1 (en) 2020-10-12 2022-04-21 Kinnate Biopharma Inc. Inhibitors of raf kinases
KR20240000534A (ko) * 2021-04-23 2024-01-02 킨네이트 바이오파마 인크. Raf 억제제를 이용하는 암의 치료
JP2024517431A (ja) * 2021-04-23 2024-04-22 キネート バイオファーマ インク． （ｓ）－ｎ－（３－（２－（（（ｒ）－１－ヒドロキシプロパン－２－イル）アミノ）－６－モルホリノピリジン－４－イル）－４－メチルフェニル）－３－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびその塩の固体状態での形態
EP4337326A1 (en) * 2021-05-12 2024-03-20 Boehringer Ingelheim International GmbH Pyridine derivatives with n-linked cyclic substituents as cgas inhibitors

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