AR065718A1 - Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos. - Google Patents
Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos.Info
- Publication number
- AR065718A1 AR065718A1 ARP080101030A ARP080101030A AR065718A1 AR 065718 A1 AR065718 A1 AR 065718A1 AR P080101030 A ARP080101030 A AR P080101030A AR P080101030 A ARP080101030 A AR P080101030A AR 065718 A1 AR065718 A1 AR 065718A1
- Authority
- AR
- Argentina
- Prior art keywords
- het
- aryl
- substituted
- alkyl
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Abstract
Reivindicacion 1: Un compuesto de la formula (1) y las sales farmacéuticamente aceptables del mismo, en donde: R1 es fenilo que puede estar insustituido o sustituido; R2 es het, siendo N cuando menos un heteroátomo del anillo, y el cual puede estarinsustituido o sustituido; L es alquilo inferior, (CH2)1-2-A, A-(CH2)1-2, o CH2-A-CH2, y A es O, S, NH, o N-aIquilo, en donde alquilo inferior puede estar insustituido o sustituido con alquilo inferior, o uno o más átomos de fluor; X es N o CH, ycuando menos un X es N; Y es un enlace, CH2, C(O), o SO2; R3 es arilo o het, el cual está sustituido, Z es H, alquilo inferior, alcoxilo inferior, oxo, C(O)OR6, o -CN; en donde alquilo inferior y alcoxilo inferior pueden estar insustituidos osustituidos con uno o más de halogeno, -OH, -CN, -NH2, u oxo, y dos Z conectados al mismo átomo pueden formar un anillo de cicloalquilo, y m es de 0 a 3, las sustituciones de fenilo, arilo o het de R1, R2, o R3 pueden ser uno o más de alquilo,cicloalquilo, alcoxilo, cicloalcoxilo, halogeno, -CN, oxo, arilo, carbalcoxilo, OCF3, CF3, OH, -C(O)N(R6)2, C(O)R6, -C(O)OR6, -N(R6)2, -NHC(O)R6, -SO2(R6), -SO2N(R6)2, CH2OC(O)N(R6)2, -CH2N(R6)2, -NHC(O)OR6, NHC(O)N(R6)2, -CH2NHC(O)R6,CH2NHC(O)N(R6)2, CH2NHSO2(R6), CHNHC(O)OR6, -OC(O)R6, NHC(O)R6, O-arilo, het, u O-het, en donde alquilo, het, cicloalquilo, cicloalcoxilo, N(R6)2, arilo, carbalcoxilo, y alcoxilo pueden estar insustituidos o sustituidos con uno o más de halogeno, -OCH3, -OCF3, -OH, -NH2, alquilo, OR6, oxo, N(H)0-2-R6, -CN, -C(O)N(R6)2, C(O)R6, C(O)OR6, -N(R6)2, NHC(O)R6, -SO2(R6), -SO2N(R6)2, OSO2R6, -CH2N(R6)2, -CH2NHC(O)R6, -OC(O)R6, arilo, NHC(O)-(R6), O-arilo, het, O-het, o cicloalquilo; R6 es H, alquilo,alquenilo, arilo, het, o dos R6 sobre un átomo pueden formar cicloalquilo, arilo, o het; y alquilo, alquenilo, arilo, het, cicloalquilo, o het pueden estar insustituidos o sustituidos por OH, oxo, alcoxilo, NR6, N-alquilo, acilo, arilo o un grupohet; het es un anillo heterocíclico monocíclico de 5 a 7 miembros, el cual puede ser aromático o no aromático, que contiene de 1 a 4 heteroátomos del anillo seleccionados a partir de N, O, y S; o un sistema de anillos fusionados de 8 a 12 miembrosque incluye cuando menos un anillo heterocíclico de 5 a 7 miembros, el cual puede ser aromático o no aromático, que contiene 1, 2, o 3 heteroátomos de anillo seleccionados a partir de N, O y S, cuyo het está insustituido o sustituido; arilo es unradical aromático que tiene de 6 a 14 átomos de carbono del anillo, y ningun heteroátomo del anillo, en donde este grupo arilo puede ser monocíclico o bicíclico o tricíclico fusionado, que puede estar insustituido o sustituido por uno o mássustituyentes; y n es 0, 1, 2, o 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89499107P | 2007-03-15 | 2007-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065718A1 true AR065718A1 (es) | 2009-06-24 |
Family
ID=39472520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101030A AR065718A1 (es) | 2007-03-15 | 2008-03-13 | Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos. |
Country Status (33)
Country | Link |
---|---|
US (1) | US8536168B2 (es) |
EP (1) | EP2137162B1 (es) |
JP (1) | JP5550352B2 (es) |
KR (1) | KR101473504B1 (es) |
CN (1) | CN101657430B (es) |
AR (1) | AR065718A1 (es) |
AU (1) | AU2008225766B2 (es) |
BR (1) | BRPI0809193A2 (es) |
CA (1) | CA2681162C (es) |
CL (1) | CL2008000754A1 (es) |
CO (1) | CO6220967A2 (es) |
CR (1) | CR11016A (es) |
CU (1) | CU23769B7 (es) |
DK (1) | DK2137162T3 (es) |
DO (1) | DOP2009000217A (es) |
EA (1) | EA016564B1 (es) |
EC (1) | ECSP099636A (es) |
GE (1) | GEP20125487B (es) |
GT (1) | GT200900244A (es) |
IL (1) | IL200654A (es) |
MA (1) | MA31258B1 (es) |
MX (1) | MX2009009873A (es) |
MY (1) | MY156814A (es) |
NI (1) | NI200900168A (es) |
NZ (1) | NZ579402A (es) |
PE (1) | PE20090188A1 (es) |
SG (1) | SG182205A1 (es) |
SM (1) | SMP200900082B (es) |
TN (1) | TN2009000373A1 (es) |
TW (1) | TWI406857B (es) |
UA (1) | UA100684C2 (es) |
WO (1) | WO2008110611A1 (es) |
ZA (1) | ZA200905949B (es) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
MY156814A (en) | 2007-03-15 | 2016-03-31 | Novartis Ag | Organic compounds and their uses |
NZ583495A (en) | 2007-09-20 | 2011-11-25 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
CN104059124A (zh) | 2007-12-27 | 2014-09-24 | 无限药品股份有限公司 | 立体选择性还原的方法 |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
GEP20125664B (en) * | 2008-02-26 | 2012-10-10 | Takeda Pharmaceuticals Co | Condensed heterocyclic derivatives and application thereof |
AU2009241561B2 (en) * | 2008-04-29 | 2013-05-16 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
US20100041663A1 (en) * | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
EP2617414A3 (en) * | 2008-10-01 | 2013-11-06 | Novartis AG | Smoothened antagonism for the treatment of hedgehog pathway-related disorders |
US8404687B2 (en) * | 2008-11-03 | 2013-03-26 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
KR101342184B1 (ko) * | 2008-11-17 | 2013-12-19 | 일라이 릴리 앤드 캄파니 | 사치환된 피리다진 헷지호그 경로 길항제 |
CA2743264C (en) | 2008-11-17 | 2014-02-18 | Julia Marie Clay | Tetrasubstituted pyridazines hedgehog pathway antagonists |
AR077014A1 (es) * | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
WO2011017551A1 (en) | 2009-08-05 | 2011-02-10 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
US20110039850A1 (en) * | 2009-08-12 | 2011-02-17 | Mhairi Copland | Leukemia Treatment |
RU2561055C2 (ru) * | 2009-08-25 | 2015-08-20 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог |
EP2501370A1 (en) * | 2009-11-18 | 2012-09-26 | Novartis AG | Methods and compositions for treating solid tumors and other malignancies |
CN103002738A (zh) | 2010-05-21 | 2013-03-27 | 英特利凯恩有限责任公司 | 用于激酶调节的化学化合物、组合物和方法 |
CA2801074A1 (en) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US9006450B2 (en) * | 2010-07-01 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
CN103298474B (zh) | 2010-11-10 | 2016-06-29 | 无限药品股份有限公司 | 杂环化合物及其用途 |
NZ612909A (en) | 2011-01-10 | 2015-09-25 | Infinity Pharmaceuticals Inc | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
TW201311663A (zh) | 2011-08-29 | 2013-03-16 | Infinity Pharmaceuticals Inc | 雜環化合物及其用途 |
WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
EP2785690B1 (en) * | 2011-12-02 | 2016-07-13 | Boehringer Ingelheim International GmbH | Piperidine derivatives, pharmaceutical compositions and uses thereof |
TWI519515B (zh) | 2011-12-21 | 2016-02-01 | 諾維拉治療公司 | B型肝炎抗病毒劑 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2881057C (en) | 2012-08-28 | 2020-10-27 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
SI2914296T2 (sl) | 2012-11-01 | 2022-01-31 | Infinity Pharmaceuticals, Inc. | Zdravljenje raznih vrst raka z uporabo modulatorjev izooblik PI3-kinaze |
US9844541B2 (en) | 2012-11-29 | 2017-12-19 | Strasspharma, Llc | Methods of modulating follicle stimulating hormone activity |
HUE034820T2 (en) | 2013-02-28 | 2018-02-28 | Janssen Sciences Ireland Uc | Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B |
WO2014151386A1 (en) | 2013-03-15 | 2014-09-25 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
PT2981536T (pt) | 2013-04-03 | 2017-08-09 | Janssen Sciences Ireland Uc | Derivados de n-fenil-carboxamida e sua utilização como medicamentos para o tratamento da hepatite b |
US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
HUE040446T2 (hu) | 2013-05-17 | 2019-03-28 | Janssen Sciences Ireland Uc | Szulfamoiltiofenamid-származékok és gyógyszerként történõ alkalmazásuk hepatitis B kezelésére |
SG11201509842SA (en) | 2013-05-30 | 2015-12-30 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
LT3024819T (lt) | 2013-07-25 | 2018-06-11 | Janssen Sciences Ireland Uc | Pirolamido dariniai, turintys glioksamido pakaitų, ir jų panaudojimas kaip vaistų hepatito b gydymui |
NZ718430A (en) | 2013-10-04 | 2021-12-24 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
NZ717629A (en) | 2013-10-23 | 2021-12-24 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
JP6523303B2 (ja) | 2014-01-17 | 2019-05-29 | ノバルティス アーゲー | Shp2の活性を阻害するための1−ピリダジン/トリアジン−3−イル−ピペラジン/ピペリジン/ピロリジン誘導体およびその組成物 |
JO3517B1 (ar) * | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
JP6473457B2 (ja) * | 2014-01-17 | 2019-02-20 | ノバルティス アーゲー | Shp2の活性を阻害するための1−(トリアジン−3−イル/ピリダジン−3−イル)−ピペリジン/ピペラジン誘導体およびその組成物 |
CA2936947A1 (en) | 2014-02-05 | 2015-08-13 | Novira Therapeutics, Inc. | Combination therapy for treatment of hbv infections |
TW201620893A (zh) | 2014-02-06 | 2016-06-16 | 健生科學愛爾蘭無限公司 | 磺醯胺基吡咯醯胺衍生物及其用作治療b型肝炎之醫藥品的用途 |
AU2015231413B2 (en) | 2014-03-19 | 2020-04-23 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders |
US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
AU2016232801A1 (en) | 2015-03-19 | 2017-10-12 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis B infections |
AU2016271468B2 (en) | 2015-06-04 | 2020-01-02 | Sol-Gel Technologies Ltd. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
JP6878316B2 (ja) | 2015-06-19 | 2021-05-26 | ノバルティス アーゲー | Shp2の活性を阻害するための化合物および組成物 |
CN112625028A (zh) | 2015-06-19 | 2021-04-09 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
EP3310779B1 (en) | 2015-06-19 | 2019-05-08 | Novartis AG | Compounds and compositions for inhibiting the activity of shp2 |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
TW201718496A (zh) | 2015-09-29 | 2017-06-01 | 諾維拉治療公司 | B型肝炎抗病毒劑之晶型 |
US20170231968A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Method for relief of and treatment of pruritus |
US10195283B2 (en) | 2016-03-18 | 2019-02-05 | R.P. Scherer Technologies, Llc | Hydrazinyl-substituted heteroaryl compounds and methods for producing a conjugate |
SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MX2018015625A (es) * | 2016-06-14 | 2019-03-06 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de shp2. |
JP7054681B2 (ja) | 2016-06-24 | 2022-04-14 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 組合せ療法 |
TWI780511B (zh) | 2017-10-27 | 2022-10-11 | 德商百靈佳殷格翰國際股份有限公司 | Trpc 6抑制劑 |
DE102018105524A1 (de) * | 2018-03-09 | 2019-09-12 | Universität Duisburg-Essen | Verwendung von Modulatoren der Sphingosin-1-phosphat-Signaltransduktion |
KR20200131816A (ko) | 2018-03-14 | 2020-11-24 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 캡시드 조립 조절제 투약 요법 |
CA3104808A1 (en) * | 2018-07-02 | 2020-01-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Lactate enhancing compounds and uses thereof |
CN108997224B (zh) * | 2018-08-28 | 2023-04-28 | 韶远科技(上海)有限公司 | 一种2-氯-5-氰基含氮六元杂环化合物的制备方法 |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
KR20210130753A (ko) | 2019-02-22 | 2021-11-01 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Hbv 감염 또는 hbv-유발성 질환의 치료에 유용한 아미드 유도체 |
AR119732A1 (es) | 2019-05-06 | 2022-01-05 | Janssen Sciences Ireland Unlimited Co | Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb |
CN110845426A (zh) * | 2019-11-29 | 2020-02-28 | 都创(上海)医药科技有限公司 | 一种2-氯-5-氰基嘧啶化合物制备方法 |
KR102394110B1 (ko) * | 2020-01-22 | 2022-05-04 | 가톨릭대학교 산학협력단 | 신규 화합물 및 이의 용도 |
EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
CN116199625A (zh) * | 2023-01-19 | 2023-06-02 | 上海昱菘医药科技有限公司 | 一种烟酸酯类化合物的制备方法 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
US3668207A (en) * | 1970-01-22 | 1972-06-06 | Ciba Geigy Corp | 2-amino-4-aryl-quinolines |
DE2643753A1 (de) | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine |
FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
FI70411C (fi) | 1980-12-29 | 1986-09-19 | Pfizer | Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat |
MA20387A1 (fr) * | 1984-03-26 | 1985-10-01 | Janssen Pharmaceutica Nv | Pyridazinamines utiles comme agents anti-viraux et procede pour leur preparation |
EP0157037A3 (en) | 1984-03-29 | 1986-11-05 | Bowmar Instrument Corporation | Long-stroke push-button switch |
US4569934A (en) * | 1984-10-09 | 1986-02-11 | American Cyanamid Company | Imidazo[1,2-b]pyridazines |
CA1307786C (en) * | 1984-12-14 | 1992-09-22 | Keiichi Yokoyama | Quinazoline derivatives and antihypertensive preparations containing same as effective components |
US4760064A (en) * | 1984-12-18 | 1988-07-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds, compositions containing same and processes for preparing same |
JP2544939B2 (ja) | 1987-09-01 | 1996-10-16 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
JPH02193992A (ja) | 1989-01-23 | 1990-07-31 | Kyowa Hakko Kogyo Co Ltd | キナゾリン誘導体 |
JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1―(3―ピリジルメチル)フタラジン誘導体 |
JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
EP0722936B1 (en) | 1994-08-09 | 2004-05-19 | Eisai Co., Ltd. | Fused pyridazine compound |
US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
US5859012A (en) | 1996-04-03 | 1999-01-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5935958A (en) * | 1996-07-01 | 1999-08-10 | Schering Corporation | Muscarinic antagonists |
JP4621351B2 (ja) | 1998-04-20 | 2011-01-26 | アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | カルパインインヒビターとしての複素環式的に置換されたアミド |
ES2221399T3 (es) | 1998-06-30 | 2004-12-16 | Schering Corporation | Antagonistas muscarinicos. |
US6066636A (en) * | 1998-06-30 | 2000-05-23 | Schering Corporation | Muscarinic antagonists |
TR200101939T2 (tr) | 1999-01-28 | 2002-05-21 | Bristol-Myers Squibb Company | Antidepresan heterosiklik bileşikler |
JP2000281660A (ja) | 1999-03-29 | 2000-10-10 | Sumitomo Pharmaceut Co Ltd | キナゾリン誘導体 |
CA2366857C (en) * | 1999-03-30 | 2010-12-14 | Novartis Ag | Phthalazine derivatives for treating inflammatory diseases |
ES2244437T3 (es) * | 1999-05-04 | 2005-12-16 | Schering Corporation | Derivados de piperazina utiles como antagonistas de ccr5. |
ES2165274B1 (es) | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
WO2000074706A1 (en) * | 1999-06-08 | 2000-12-14 | Lorantis Limited | Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway |
FR2803593B1 (fr) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
KR100830859B1 (ko) | 2000-04-27 | 2008-05-21 | 아스텔라스세이야쿠 가부시키가이샤 | 이미다조피리딘 유도체 및 이를 함유하는 의약 조성물 |
DE10043659A1 (de) | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | Arylpiperazinderivate |
ES2172436B1 (es) * | 2000-10-31 | 2004-01-16 | Almirall Prodesfarma Sa | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
WO2002053160A1 (en) | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Method for treating glaucoma ivb |
SE0103754L (sv) | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
JP2004534743A (ja) * | 2001-04-09 | 2004-11-18 | ロランティス リミテッド | ヘッジホッグ |
JP4929547B2 (ja) | 2001-09-03 | 2012-05-09 | コニカミノルタホールディングス株式会社 | アゾメチン化合物、アゾメチン化合物と金属イオン含有化合物との混合物、感熱転写記録材料、カラートナー |
RS50939B (sr) | 2001-10-19 | 2010-08-31 | Ortho-Mcneil Pharmaceutical Inc. | 2-fenil benzimidazoli i imidazo-/4,5/-piridini kao cdsi/chk2 -inhibitori i pomoćna sredstva u hemoterapiji ili terapiji zračenja pri lečenju kancera |
EP1956004B1 (en) * | 2002-03-27 | 2012-06-13 | Glaxo Group Limited | Quinoline derivatives and their use as 5-HT6 ligands |
JP2006509223A (ja) | 2002-10-16 | 2006-03-16 | エレクトロニクス アンド テレコミュニケーションズ リサーチ インスチチュート | 使用者の視覚障害の特徴的症状及び再生嗜好によるビジュアル・コンテンツ適応変換方法及びシステム |
PL378295A1 (pl) | 2003-02-24 | 2006-03-20 | Arena Pharmaceuticals, Inc. | Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu glukozy oraz profilaktyka i leczenie zaburzeń tego metabolizmu |
BRPI0412343A (pt) | 2003-07-30 | 2006-09-05 | Xenon Pharmaceuticals Inc | derivados de piridazina e seu uso como agentes terapêuticos |
DE10337184A1 (de) | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
JP5335191B2 (ja) * | 2003-08-22 | 2013-11-06 | デンドレオン コーポレイション | Trp−p8発現に関連する疾患の処置をするための組成物および方法 |
US8067608B2 (en) | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
AU2005249380C1 (en) | 2004-04-23 | 2012-09-20 | Exelixis, Inc. | Kinase modulators and methods of use |
UA96565C2 (ru) * | 2004-09-02 | 2011-11-25 | Дженентек, Инк. | Пиридильные ингибиторы хеджхоговской передачи сигнала |
GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
DE102005023943A1 (de) | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln |
NZ564222A (en) * | 2005-06-14 | 2011-10-28 | Taigen Biotechnology Co Ltd | Pyrimidine compounds |
US8364148B2 (en) * | 2005-07-07 | 2013-01-29 | Qualcomm Incorporated | Methods and devices for interworking of wireless wide area networks and wireless local area networks or wireless personal area networks |
US8101610B2 (en) * | 2005-11-14 | 2012-01-24 | Genentech, Inc. | Bisamide inhibitors of hedgehog signaling |
EP1963329B1 (en) | 2005-11-30 | 2013-01-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
GB0602335D0 (en) | 2006-02-07 | 2006-03-15 | Remynd Nv | Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
EP1996577B1 (en) * | 2006-03-21 | 2016-02-10 | Merck Sharp & Dohme Corp. | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity |
WO2007127475A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
EP1849781A1 (en) | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments |
EP2015751A2 (en) | 2006-04-28 | 2009-01-21 | Northwestern University | Salts of pyridazine compounds |
JP2009535344A (ja) * | 2006-04-28 | 2009-10-01 | ノースウェスタン ユニバーシティ | 神経炎症性疾患の処置のためのピリダジン化合物を含む処方物 |
US7902199B2 (en) | 2006-07-14 | 2011-03-08 | Schering Corporation | Heterocyclic substituted piperazine compounds with CXCR3 antagonist activity |
GB0623258D0 (en) | 2006-11-22 | 2007-01-03 | Remynd Nv | Thiadiazole derivatives for the treatment of neuro-degenerative diseases |
AP2009004913A0 (en) | 2006-12-14 | 2009-08-31 | Syngenta Ltd | 4-phenyl-pyrane-3,5-diones, 4-phenyl-thiopyrane-3,5-diones and cyclohexanetriones as novel herbicides |
JP2010513520A (ja) | 2006-12-22 | 2010-04-30 | シェーリング コーポレイション | Cxcr3アンタゴニスト活性を有する複素環式化合物 |
TW200900391A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-phenyl-piperidin-1-yl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
MY156814A (en) | 2007-03-15 | 2016-03-31 | Novartis Ag | Organic compounds and their uses |
CA2680583A1 (en) | 2007-03-15 | 2008-09-25 | Schering Corporation | Pyridazinone derivatives useful as glucan synthase inhibitors |
CA2679985A1 (en) | 2007-03-15 | 2008-09-18 | F. Hoffmann-La Roche Ag | Malonamides as orexin antagonists |
EP2188283B1 (en) | 2007-09-07 | 2012-08-15 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
GB0808888D0 (en) * | 2008-05-15 | 2008-06-25 | Syngenta Participations Ag | Insecticidal compounds |
JP5417439B2 (ja) * | 2008-07-03 | 2014-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 5−ht6受容体アンタゴニストとしての置換された6−(1−ピペラジニル)−ピリダジン類 |
WO2010006096A1 (en) * | 2008-07-11 | 2010-01-14 | Smithkline Beecham Corporation | Processes for the preparation of anti-viral compounds and compositions containing them |
US20110301162A1 (en) * | 2008-08-04 | 2011-12-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
US8404687B2 (en) * | 2008-11-03 | 2013-03-26 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
FR2939134A1 (fr) * | 2008-12-01 | 2010-06-04 | Sanofi Aventis | Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
TWI520989B (zh) * | 2015-03-02 | 2016-02-11 | 國立交通大學 | 製備高分子球的方法 |
-
2008
- 2008-03-13 MY MYPI20093757A patent/MY156814A/en unknown
- 2008-03-13 CN CN2008800121920A patent/CN101657430B/zh not_active Expired - Fee Related
- 2008-03-13 MX MX2009009873A patent/MX2009009873A/es active IP Right Grant
- 2008-03-13 KR KR1020097021399A patent/KR101473504B1/ko active IP Right Grant
- 2008-03-13 PE PE2008000477A patent/PE20090188A1/es not_active Application Discontinuation
- 2008-03-13 WO PCT/EP2008/053040 patent/WO2008110611A1/en active Application Filing
- 2008-03-13 DK DK08717784.6T patent/DK2137162T3/en active
- 2008-03-13 CA CA2681162A patent/CA2681162C/en not_active Expired - Fee Related
- 2008-03-13 EP EP08717784.6A patent/EP2137162B1/en active Active
- 2008-03-13 US US12/531,341 patent/US8536168B2/en active Active
- 2008-03-13 NZ NZ579402A patent/NZ579402A/en not_active IP Right Cessation
- 2008-03-13 AU AU2008225766A patent/AU2008225766B2/en not_active Ceased
- 2008-03-13 UA UAA200909484A patent/UA100684C2/uk unknown
- 2008-03-13 BR BRPI0809193-5A patent/BRPI0809193A2/pt active Search and Examination
- 2008-03-13 EA EA200901170A patent/EA016564B1/ru not_active IP Right Cessation
- 2008-03-13 SG SG2012044004A patent/SG182205A1/en unknown
- 2008-03-13 AR ARP080101030A patent/AR065718A1/es unknown
- 2008-03-13 GE GEAP200811474A patent/GEP20125487B/en unknown
- 2008-03-13 JP JP2009553152A patent/JP5550352B2/ja not_active Expired - Fee Related
- 2008-03-14 CL CL200800754A patent/CL2008000754A1/es unknown
- 2008-03-14 TW TW097109177A patent/TWI406857B/zh not_active IP Right Cessation
-
2009
- 2009-08-27 ZA ZA200905949A patent/ZA200905949B/xx unknown
- 2009-08-31 IL IL200654A patent/IL200654A/en not_active IP Right Cessation
- 2009-09-08 CR CR11016A patent/CR11016A/es unknown
- 2009-09-11 TN TNP2009000373A patent/TN2009000373A1/fr unknown
- 2009-09-11 NI NI200900168A patent/NI200900168A/es unknown
- 2009-09-14 CO CO09098892A patent/CO6220967A2/es active IP Right Grant
- 2009-09-14 GT GT200900244A patent/GT200900244A/es unknown
- 2009-09-14 DO DO2009000217A patent/DOP2009000217A/es unknown
- 2009-09-15 CU CU20090159A patent/CU23769B7/es active IP Right Grant
- 2009-09-15 EC EC2009009636A patent/ECSP099636A/es unknown
- 2009-09-24 MA MA32227A patent/MA31258B1/fr unknown
- 2009-10-15 SM SM200900082T patent/SMP200900082B/it unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR065718A1 (es) | Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos. | |
AR077147A1 (es) | Compuestos biciclicos y triciclicos como inhibidores de kat ii | |
AR058984A1 (es) | Derivados de ciclohexil piperazinil metanona | |
AR069849A1 (es) | Derivados de heteroarilo como antagonistas de receptor de orexina | |
AR050953A1 (es) | Compuestos de sulfonamida inhibidores de los receptores de cck1/cck2 duales | |
AR059984A1 (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa -iv para el tratamiento o prevencion de diabetes | |
AR065322A1 (es) | 2-aminooxazolinas comoligandos de taar1 | |
AR060807A1 (es) | Derivados de arilaminopiridina heteroaril - susutituidos como inhibidores de mek | |
ES2655391T3 (es) | Inhibidores isoindolinona de fosfatidilinositol 3-quinasa | |
CO6140056A2 (es) | Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa | |
AR048789A1 (es) | Derivados de oxazol y sus composiciones como moduladores de receptor activado de proliferador de peroxisoma (ppar) | |
PE20080841A1 (es) | Derivados de quinazolinona e isoquinolinona y su uso para el tratamiento o prevencion de trastornos relacionados con el estres o la depresion | |
AR067413A1 (es) | Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer | |
AR084457A1 (es) | Derivados de biciclo[3,2,1]octilamida | |
AR081075A1 (es) | Derivados de imidazo[1,2-c]pirimidina, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de enfermedades autoinmunes e inflamatorias. | |
AR076098A1 (es) | Derivados de benzofurano | |
CO6160296A2 (es) | Derivados de acido benzoazepin-oxi-acetico como agonistas de receptores activados por proliferador de peroxisona delta usados para incrementar la lipoproteina de alta densidad-colesterol-colesterol reducir la lipoproteina de baja densidad-colesterol | |
AR076008A1 (es) | Derivados de hidroximetil-isoxazol moduladores de receptores gaba a, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos para el tratamiento del alzheimer y otros trastornos cognitivos. | |
AR040626A1 (es) | Derivados de quinolina utiles como ligandos del receptor del neuropeptido y (npy) | |
CO6321168A2 (es) | Nuevos derivados de 2-amidotiadiazol | |
AR070274A1 (es) | Derivados arilamida diazepinopirimidona sustituidos utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas y otras, provocadas por la actividad anormal de quinasas gsk3beta, medicamentos que los contienen y proceso de preparacion e intermediarios. | |
EA201390022A8 (ru) | Конденсированные гетероциклические соединения в качестве ингибиторов фосфодиэстераз (фдэ) | |
PE20120900A1 (es) | Compuestos heterociclicos de fenoximetilo | |
AR049954A1 (es) | Derivados de azepina sustituidos como moduladores de los receptores de la serotonina | |
AR066421A1 (es) | Compuestos derivados de piridona |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |