AR067413A1 - Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer - Google Patents

Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer

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Publication number
AR067413A1
AR067413A1 ARP080102885A ARP080102885A AR067413A1 AR 067413 A1 AR067413 A1 AR 067413A1 AR P080102885 A ARP080102885 A AR P080102885A AR P080102885 A ARP080102885 A AR P080102885A AR 067413 A1 AR067413 A1 AR 067413A1
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AR
Argentina
Prior art keywords
alkyl
phenyl
membered
troliferative
tiperiferative
Prior art date
Application number
ARP080102885A
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English (en)
Original Assignee
Genentech Inc
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genentech Inc, Array Biopharma Inc filed Critical Genentech Inc
Publication of AR067413A1 publication Critical patent/AR067413A1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Reivindicacion 1: Un compuesto de la formula (1) y sus enantiomeros y sales, donde: G es fenilo, naftaleno, un heteroarilo de 5-6 miembros o un heteroarilo bicíclico de 9-10 miembros, donde el fenilo, naftaleno, o heteroarilo de 5-6 miembros o heteroarilo bicíclico de 9-10 miembros están opcionalmente sustituidos con uno a cuatro grupos Ra; R1 y R1a se seleccionan, de manera independiente, de H, Me, Et, -CH=CH2, -CH2OH, CF3, CHF2 o CH2F; R2 es H, -OH, -OMe o F; R2a es H, Me o F, o R2 y R2a son oxo; R3es H, Me, Et, o CF3; R4 es H, heterociclo de 4-6 miembros, ciclopropilmetilo o alquilo C1-4 opcionalmente sustituido con F, -OH o -Oalquilo C1-3; R5 y R5a se seleccionan, de manera independiente, de H y alquilo C1-4; o R5 y R5a junto con el átomo al cual están unidos forman un grupo carbonilo, un cicloalquilo de 5-6 miembros o un heterociclo de 5-6 miembros, donde el heterociclo tiene un heteroátomo de oxigeno; cada Ra es, de manera independiente, halogeno, alquilo C1-6, cicloalquilo C3-6, -O-alquilo C1-6, CF3, -OCF3, Salquilo C1-6, CN, fenilo, -OCH2-fenilo, NH2, -NO2, -NH-alquilo C1-6, -N-(alquilo C1-6)2, piperidina, pirrolidina, pirazol piridina, 2-aminopiridina, CH2F, CHF2, -OCH2F, -OCHF2, -OH, -SO2alquilo C1-6, C(O)NH2, C(O)NHalquilo C1-6 y C(O)N(alquilo C1-6)2 y j es 1 o 2; y cuando j es 2, el carbono de anillo de j opuesto a NR4 puede ser reemplazado con un heteroátomo O.
ARP080102885A 2007-07-05 2008-07-03 Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer AR067413A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94813807P 2007-07-05 2007-07-05
US2008808P 2008-01-09 2008-01-09

Publications (1)

Publication Number Publication Date
AR067413A1 true AR067413A1 (es) 2009-10-07

Family

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Application Number Title Priority Date Filing Date
ARP080102885A AR067413A1 (es) 2007-07-05 2008-07-03 Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer

Country Status (20)

Country Link
US (1) US8618097B2 (es)
EP (1) EP2170863B1 (es)
JP (2) JP5628028B2 (es)
KR (2) KR101650956B1 (es)
CN (2) CN103396409B (es)
AR (1) AR067413A1 (es)
AU (1) AU2008272830B8 (es)
BR (1) BRPI0813999A2 (es)
CA (1) CA2692502C (es)
CO (1) CO6251283A2 (es)
CR (1) CR11229A (es)
EC (1) ECSP109937A (es)
ES (1) ES2551352T3 (es)
HK (1) HK1147255A1 (es)
MA (1) MA31679B1 (es)
NZ (1) NZ582692A (es)
RU (1) RU2486181C2 (es)
SG (1) SG185274A1 (es)
TW (1) TWI450720B (es)
WO (1) WO2009006567A2 (es)

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MA31679B1 (fr) 2010-09-01
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CA2692502A1 (en) 2009-01-08
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