UY26099A1 - Procedimiento para preparar formas anhidras e hidratadas de mesilato de n -(3-etinilfenil)-6,7- bis (2- metoxietoxi)-4- quinazolinaminan - Google Patents

Procedimiento para preparar formas anhidras e hidratadas de mesilato de n -(3-etinilfenil)-6,7- bis (2- metoxietoxi)-4- quinazolinaminan

Info

Publication number
UY26099A1
UY26099A1 UY26099A UY26099A UY26099A1 UY 26099 A1 UY26099 A1 UY 26099A1 UY 26099 A UY26099 A UY 26099A UY 26099 A UY26099 A UY 26099A UY 26099 A1 UY26099 A1 UY 26099A1
Authority
UY
Uruguay
Prior art keywords
bis
mixture
ethynylphenyl
methoxyethoxy
quinazolinamine
Prior art date
Application number
UY26099A
Other languages
English (en)
Spanish (es)
Inventor
Ravi Mysore Shanker
Timothy Norris
Douglas J Allen
Jeffrey William Raggon
Dinos Paul Santafianos
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY26099A1 publication Critical patent/UY26099A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
UY26099A 1998-04-29 2000-04-05 Procedimiento para preparar formas anhidras e hidratadas de mesilato de n -(3-etinilfenil)-6,7- bis (2- metoxietoxi)-4- quinazolinaminan UY26099A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8344198P 1998-04-29 1998-04-29

Publications (1)

Publication Number Publication Date
UY26099A1 true UY26099A1 (es) 2001-12-28

Family

ID=22178359

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26099A UY26099A1 (es) 1998-04-29 2000-04-05 Procedimiento para preparar formas anhidras e hidratadas de mesilato de n -(3-etinilfenil)-6,7- bis (2- metoxietoxi)-4- quinazolinaminan

Country Status (42)

Country Link
EP (1) EP1076652B1 (xx)
JP (1) JP4652569B2 (xx)
KR (1) KR100668412B1 (xx)
CN (2) CN1298396A (xx)
AP (1) AP1252A (xx)
AR (1) AR018201A1 (xx)
AT (1) ATE295839T1 (xx)
AU (1) AU759691C (xx)
BR (1) BR9910025A (xx)
CA (1) CA2330447C (xx)
CO (1) CO5060467A1 (xx)
CZ (1) CZ298230B6 (xx)
DE (1) DE69925366T2 (xx)
DZ (1) DZ2777A1 (xx)
EA (1) EA002836B1 (xx)
EG (1) EG24000A (xx)
ES (1) ES2238825T3 (xx)
GT (1) GT199900063A (xx)
HK (1) HK1037180A1 (xx)
HN (1) HN1999000057A (xx)
HU (1) HU227569B1 (xx)
ID (1) ID27198A (xx)
IL (1) IL139172A0 (xx)
MA (1) MA26624A1 (xx)
ME (1) MEP42008A (xx)
MX (1) MXPA00010610A (xx)
MY (1) MY136033A (xx)
NO (1) NO317301B1 (xx)
NZ (1) NZ508154A (xx)
OA (1) OA11769A (xx)
PA (1) PA8471001A1 (xx)
PE (1) PE20000441A1 (xx)
PL (1) PL196940B1 (xx)
RS (1) RS50081B (xx)
SA (1) SA99200216B1 (xx)
TN (1) TNSN99079A1 (xx)
TR (1) TR200003166T2 (xx)
TW (1) TWI248437B (xx)
UA (1) UA60363C2 (xx)
UY (1) UY26099A1 (xx)
WO (1) WO1999055683A1 (xx)
ZA (1) ZA992972B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
RS49836B (sr) 1999-03-31 2008-08-07 Pfizer Products Inc., Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
AU2002350105A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel quinazolines and uses thereof
US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
GB0223854D0 (en) * 2002-10-12 2002-11-20 Astrazeneca Ab Therapeutic treatment
US7148231B2 (en) 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
WO2005049829A1 (en) 2003-05-30 2005-06-02 Astrazeneca Uk Limited Process
ES2293251T3 (es) 2003-06-10 2008-03-16 F. Hoffmann-La Roche Ag Derivados de 1,3,4-triaza-fenaleno y 1,3,4,6-tetraazafenaleno.
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
WO2005107747A2 (en) 2004-05-06 2005-11-17 Bioresponse, Llc Diindolymethane formulations for the treatment of leiomyomas
CA2593084C (en) 2004-12-30 2014-03-18 Bioresponse, Llc Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
CN101547910A (zh) 2006-07-28 2009-09-30 合成纤维有限公司 结晶埃罗替尼
US8586621B2 (en) 2006-10-27 2013-11-19 Michael A. Zeligs Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
KR20140069232A (ko) * 2007-04-04 2014-06-09 시플라 리미티드 에르로티닙 및 그의 약학적으로 허용가능한 염의 제조방법
EP2162444B1 (en) 2007-07-11 2014-06-04 Hetero Drugs Limited An improved process for the preparation of erlotinib hydrochloride
EP2213665A1 (en) 2007-08-17 2010-08-04 Hetero Drugs Limited Erlotinib hydrochloride
KR101132937B1 (ko) * 2008-10-01 2012-04-06 주식회사종근당 Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
US8440823B2 (en) 2009-03-26 2013-05-14 Ranbaxy Laboratories Limited Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
WO2011068404A2 (en) 2009-12-02 2011-06-09 Ultimorphix Technologies B.V. Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
DE202010006543U1 (de) 2010-05-07 2010-09-09 Ratiopharm Gmbh Erlotinibresinat
HU230483B1 (hu) 2011-10-10 2016-07-28 Egis Gyógyszergyár Nyrt. Erlotinib sók
US9593083B2 (en) 2012-09-04 2017-03-14 Shilpa Medicare Limited Crystalline erlotinib hydrochloride process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243082A (en) * 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
JP2994165B2 (ja) * 1992-06-26 1999-12-27 ゼネカ・リミテッド キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
MX9707453A (es) * 1995-03-30 1997-12-31 Pfizer Derivados de quinazolina.
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines

Also Published As

Publication number Publication date
SA99200216B1 (ar) 2006-06-04
MA26624A1 (fr) 2004-12-20
PE20000441A1 (es) 2000-05-23
AU2850999A (en) 1999-11-16
CN101219999A (zh) 2008-07-16
NO317301B1 (no) 2004-10-04
NZ508154A (en) 2003-07-25
ATE295839T1 (de) 2005-06-15
OA11769A (en) 2005-07-25
MXPA00010610A (es) 2002-07-02
HN1999000057A (es) 1999-09-29
HUP0101818A3 (en) 2002-05-28
ZA992972B (en) 2000-10-30
AP1252A (en) 2004-02-25
EA200001112A1 (ru) 2001-04-23
KR100668412B1 (ko) 2007-01-12
CA2330447A1 (en) 1999-11-04
RS50081B (sr) 2009-01-22
NO20005453D0 (no) 2000-10-27
UA60363C2 (uk) 2003-10-15
GT199900063A (es) 2000-10-20
PA8471001A1 (es) 2000-09-29
CZ20003974A3 (en) 2001-05-16
AU759691C (en) 2004-04-29
TR200003166T2 (tr) 2001-02-21
MEP42008A (en) 2011-02-10
HK1037180A1 (en) 2002-02-01
JP2002513009A (ja) 2002-05-08
NO20005453L (no) 2000-12-20
JP4652569B2 (ja) 2011-03-16
CO5060467A1 (es) 2001-07-30
CZ298230B6 (cs) 2007-08-01
WO1999055683A1 (en) 1999-11-04
KR20010078710A (ko) 2001-08-21
AR018201A1 (es) 2001-10-31
CA2330447C (en) 2009-06-30
TWI248437B (en) 2006-02-01
TNSN99079A1 (fr) 2005-11-10
EG24000A (en) 2008-03-19
EP1076652A1 (en) 2001-02-21
BR9910025A (pt) 2000-12-26
PL196940B1 (pl) 2008-02-29
AU759691B2 (en) 2003-04-17
YU66100A (sh) 2003-07-07
PL343766A1 (en) 2001-09-10
ID27198A (id) 2001-03-08
IL139172A0 (en) 2001-11-25
HU227569B1 (en) 2011-08-29
HUP0101818A1 (hu) 2002-03-28
EP1076652B1 (en) 2005-05-18
AP9901523A0 (en) 1999-06-30
MY136033A (en) 2008-07-31
CN1298396A (zh) 2001-06-06
DE69925366T2 (de) 2006-03-09
DZ2777A1 (fr) 2003-12-01
EA002836B1 (ru) 2002-10-31
ES2238825T3 (es) 2005-09-01
DE69925366D1 (de) 2005-06-23

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Legal Events

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Effective date: 20100304