BR9910025A - Mesilato de n-(3-etinilfenilamino)-6,7-bis(2-metoxietóxi)-4-quinazo linamina desidratado e monoidratado - Google Patents

Mesilato de n-(3-etinilfenilamino)-6,7-bis(2-metoxietóxi)-4-quinazo linamina desidratado e monoidratado

Info

Publication number
BR9910025A
BR9910025A BR9910025-8A BR9910025A BR9910025A BR 9910025 A BR9910025 A BR 9910025A BR 9910025 A BR9910025 A BR 9910025A BR 9910025 A BR9910025 A BR 9910025A
Authority
BR
Brazil
Prior art keywords
bis
methoxyethoxy
mesylate
quinazo
monohydrated
Prior art date
Application number
BR9910025-8A
Other languages
English (en)
Inventor
Douglas John Meldrum Allen
Timothy Norris
Jeffrey William Raggon
Dinos Paul Santafianos
Ravi Mysore Shanker
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9910025A publication Critical patent/BR9910025A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

Patente de Invenção: <B>"MESILATO DE N-(3-ETINILFENILAMINO)-6,7-BIS(2-METOXIETóXI)-4-QUINAZO LINAMINA DESIDRATADO E MONOIDRATADO''<D>. A presente invenção refere-se às formas anidra e hidratada de mesilato de N-(3-etinilfenil)-6,7-bis(2-metoxietóxi)-4-quinazolinamina. A invenção refere-se ainda às composições farmacêuticas contendo mesilato de N-(3-etinilfenil)-6,7-bis(2-metoxietóxi)-4-quinazolinamina e a métodos de tratamento de distúrbios hiperproliferativos, tais como câncer por administração de mesilato de N-(3-etinilfenil)-6,7-bis(2-metoxietóxi)-4-quinazolinamina.
BR9910025-8A 1998-04-29 1999-04-08 Mesilato de n-(3-etinilfenilamino)-6,7-bis(2-metoxietóxi)-4-quinazo linamina desidratado e monoidratado BR9910025A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8344198P 1998-04-29 1998-04-29
PCT/IB1999/000612 WO1999055683A1 (en) 1998-04-29 1999-04-08 N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate

Publications (1)

Publication Number Publication Date
BR9910025A true BR9910025A (pt) 2000-12-26

Family

ID=22178359

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910025-8A BR9910025A (pt) 1998-04-29 1999-04-08 Mesilato de n-(3-etinilfenilamino)-6,7-bis(2-metoxietóxi)-4-quinazo linamina desidratado e monoidratado

Country Status (42)

Country Link
EP (1) EP1076652B1 (pt)
JP (1) JP4652569B2 (pt)
KR (1) KR100668412B1 (pt)
CN (2) CN1298396A (pt)
AP (1) AP1252A (pt)
AR (1) AR018201A1 (pt)
AT (1) ATE295839T1 (pt)
AU (1) AU759691C (pt)
BR (1) BR9910025A (pt)
CA (1) CA2330447C (pt)
CO (1) CO5060467A1 (pt)
CZ (1) CZ298230B6 (pt)
DE (1) DE69925366T2 (pt)
DZ (1) DZ2777A1 (pt)
EA (1) EA002836B1 (pt)
EG (1) EG24000A (pt)
ES (1) ES2238825T3 (pt)
GT (1) GT199900063A (pt)
HK (1) HK1037180A1 (pt)
HN (1) HN1999000057A (pt)
HU (1) HU227569B1 (pt)
ID (1) ID27198A (pt)
IL (1) IL139172A0 (pt)
MA (1) MA26624A1 (pt)
ME (1) MEP42008A (pt)
MX (1) MXPA00010610A (pt)
MY (1) MY136033A (pt)
NO (1) NO317301B1 (pt)
NZ (1) NZ508154A (pt)
OA (1) OA11769A (pt)
PA (1) PA8471001A1 (pt)
PE (1) PE20000441A1 (pt)
PL (1) PL196940B1 (pt)
RS (1) RS50081B (pt)
SA (1) SA99200216B1 (pt)
TN (1) TNSN99079A1 (pt)
TR (1) TR200003166T2 (pt)
TW (1) TWI248437B (pt)
UA (1) UA60363C2 (pt)
UY (1) UY26099A1 (pt)
WO (1) WO1999055683A1 (pt)
ZA (1) ZA992972B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
YU13200A (sh) 1999-03-31 2002-10-18 Pfizer Products Inc. Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
UA73993C2 (uk) * 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
AU2002350105A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel quinazolines and uses thereof
US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
GB0223854D0 (en) * 2002-10-12 2002-11-20 Astrazeneca Ab Therapeutic treatment
US7148231B2 (en) * 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
MXPA05012939A (es) 2003-05-30 2006-05-17 Astrazeneca Uk Ltd Procedimiento.
BRPI0411126A (pt) 2003-06-10 2006-07-18 Hoffmann La Roche derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
CA2565721C (en) 2004-05-06 2015-10-06 Bioresponse, L.L.C. Diindolymethane formulations for the treatment of leiomyomas
ATE497762T1 (de) 2004-12-30 2011-02-15 Bioresponse Llc Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus
CA2659307A1 (en) 2006-07-28 2008-01-31 Synthon B.V. Crystalline erlotinib
WO2008057253A2 (en) 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
AU2008235274B2 (en) * 2007-04-04 2013-04-18 Cipla Limited Process for preparation of erlotinib and its pharmaceutically acceptable salts
ES2492645T3 (es) 2007-07-11 2014-09-10 Hetero Drugs Limited Un procedimiento mejorado para la preparación de hidrocloruro de erlotinib
WO2009024989A2 (en) 2007-08-17 2009-02-26 Hetero Drugs Limited A novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
KR101132937B1 (ko) * 2008-10-01 2012-04-06 주식회사종근당 Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
US8440823B2 (en) 2009-03-26 2013-05-14 Ranbaxy Laboratories Limited Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
WO2011068404A2 (en) 2009-12-02 2011-06-09 Ultimorphix Technologies B.V. Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
DE202010006543U1 (de) 2010-05-07 2010-09-09 Ratiopharm Gmbh Erlotinibresinat
HU230483B1 (hu) 2011-10-10 2016-07-28 Egis Gyógyszergyár Nyrt. Erlotinib sók
WO2014037961A1 (en) 2012-09-04 2014-03-13 Shilpa Medicare Limited Crystalline erlotinib hydrochloride process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243082A (en) * 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
JP2994165B2 (ja) * 1992-06-26 1999-12-27 ゼネカ・リミテッド キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
ES2332984T3 (es) * 1995-03-30 2010-02-16 Pfizer Products Inc. Derivados de quinazolinas.
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines

Also Published As

Publication number Publication date
DE69925366T2 (de) 2006-03-09
DZ2777A1 (fr) 2003-12-01
NZ508154A (en) 2003-07-25
UY26099A1 (es) 2001-12-28
YU66100A (sh) 2003-07-07
KR100668412B1 (ko) 2007-01-12
MA26624A1 (fr) 2004-12-20
NO317301B1 (no) 2004-10-04
NO20005453D0 (no) 2000-10-27
TNSN99079A1 (fr) 2005-11-10
ZA992972B (en) 2000-10-30
ATE295839T1 (de) 2005-06-15
MY136033A (en) 2008-07-31
IL139172A0 (en) 2001-11-25
SA99200216B1 (ar) 2006-06-04
PL343766A1 (en) 2001-09-10
ES2238825T3 (es) 2005-09-01
PL196940B1 (pl) 2008-02-29
AU759691B2 (en) 2003-04-17
KR20010078710A (ko) 2001-08-21
AP1252A (en) 2004-02-25
PA8471001A1 (es) 2000-09-29
EA200001112A1 (ru) 2001-04-23
JP4652569B2 (ja) 2011-03-16
WO1999055683A1 (en) 1999-11-04
CO5060467A1 (es) 2001-07-30
AR018201A1 (es) 2001-10-31
AU759691C (en) 2004-04-29
PE20000441A1 (es) 2000-05-23
CZ20003974A3 (en) 2001-05-16
MEP42008A (en) 2011-02-10
GT199900063A (es) 2000-10-20
CN101219999A (zh) 2008-07-16
HUP0101818A3 (en) 2002-05-28
EP1076652B1 (en) 2005-05-18
RS50081B (sr) 2009-01-22
UA60363C2 (uk) 2003-10-15
DE69925366D1 (de) 2005-06-23
TR200003166T2 (tr) 2001-02-21
AU2850999A (en) 1999-11-16
CZ298230B6 (cs) 2007-08-01
HU227569B1 (en) 2011-08-29
JP2002513009A (ja) 2002-05-08
HK1037180A1 (en) 2002-02-01
NO20005453L (no) 2000-12-20
MXPA00010610A (es) 2002-07-02
TWI248437B (en) 2006-02-01
HN1999000057A (es) 1999-09-29
EG24000A (en) 2008-03-19
HUP0101818A1 (hu) 2002-03-28
OA11769A (en) 2005-07-25
CN1298396A (zh) 2001-06-06
ID27198A (id) 2001-03-08
EA002836B1 (ru) 2002-10-31
AP9901523A0 (en) 1999-06-30
CA2330447C (en) 2009-06-30
EP1076652A1 (en) 2001-02-21
CA2330447A1 (en) 1999-11-04

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13, 24 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.