UA71994C2 - Glucopyranosyloxypyrazole derivatives, a pharmaceutical composition containing these derivatives and intermediate compounds for the preparation thereof - Google Patents

Glucopyranosyloxypyrazole derivatives, a pharmaceutical composition containing these derivatives and intermediate compounds for the preparation thereof Download PDF

Info

Publication number: UA71994C2
Authority: UA; Ukraine
Prior art keywords: methyl; glucopyranosyloxy; pyrazole; acetyl; tetra
Prior art date: 1999-08-31

Application number

UA2002032522A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Kissei Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-31

Filing date

2000-08-24

Publication date

2005-01-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17153879&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA71994(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-08-24 Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical

2005-01-17 Publication of UA71994C2 publication Critical patent/UA71994C2/uk

Links

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239000008194 pharmaceutical composition Substances 0.000 title description 5
238000002360 preparation method Methods 0.000 title description 4
125000000217 alkyl group Chemical group 0.000 abstract description 34
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230000002401 inhibitory effect Effects 0.000 abstract description 8
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238000005481 NMR spectroscopy Methods 0.000 description 71
238000000034 method Methods 0.000 description 63
-1 methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy, tert-butoxy, pentyloxy, isopentyloxy, neopentyloxy, tertpentyloxy group Chemical group 0.000 description 35
239000002904 solvent Substances 0.000 description 33
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XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
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IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

UA2002032522A 1999-08-31 2000-08-24 Glucopyranosyloxypyrazole derivatives, a pharmaceutical composition containing these derivatives and intermediate compounds for the preparation thereof UA71994C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP24680099		1999-08-31
PCT/JP2000/005678 WO2001016147A1 (fr)	1999-08-31	2000-08-24	Derives de glucopyranosyloxypyrazole, compositions medicinales renfermant lesdits derives et produits intermediaires obtenus au cours de leur production

Publications (1)

Publication Number	Publication Date
UA71994C2 true UA71994C2 (en)	2005-01-17

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UA2002032522A UA71994C2 (en)	1999-08-31	2000-08-24	Glucopyranosyloxypyrazole derivatives, a pharmaceutical composition containing these derivatives and intermediate compounds for the preparation thereof

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US (4)	US6972283B2 (zh)
EP (1)	EP1213296B1 (zh)
JP (1)	JP3989730B2 (zh)
KR (1)	KR100591585B1 (zh)
CN (1)	CN1145635C (zh)
AT (1)	ATE264337T1 (zh)
AU (1)	AU782330B2 (zh)
BG (1)	BG65388B1 (zh)
BR (1)	BRPI0013667B8 (zh)
CA (1)	CA2382480C (zh)
CZ (1)	CZ303372B6 (zh)
DE (1)	DE60009929T2 (zh)
DK (1)	DK1213296T3 (zh)
ES (1)	ES2216937T3 (zh)
HK (1)	HK1050369A1 (zh)
HU (1)	HU229581B1 (zh)
IL (2)	IL148384A0 (zh)
MX (1)	MXPA02002271A (zh)
NO (1)	NO322703B1 (zh)
NZ (1)	NZ517439A (zh)
PL (1)	PL203124B1 (zh)
PT (1)	PT1213296E (zh)
RU (1)	RU2232767C2 (zh)
SK (1)	SK286600B6 (zh)
TR (1)	TR200201082T2 (zh)
TW (1)	TW579378B (zh)
UA (1)	UA71994C2 (zh)
WO (1)	WO2001016147A1 (zh)
ZA (1)	ZA200201991B (zh)

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CN1020944C (zh)	1990-01-30	1993-05-26	阿图尔-费希尔股份公司费希尔厂	紧固件
PH12000002657B1 (en) *	1999-10-12	2006-02-21	Bristol Myers Squibb Co	C-aryl glucoside SGLT2 inhibitors
NZ521369A (en) *	2000-03-17	2004-07-30	Kissei Pharmaceutical	Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
JP4591781B2 (ja) *	2000-11-02	2010-12-01	味の素株式会社	新規ピラゾール誘導体及びそれらを含有する糖尿病治療薬
AU2002210990A1 (en)	2000-11-02	2002-05-15	Ajinomoto Co. Inc.	Novel pyrazole derivatives and diabetes remedies containing the same
CA2429833A1 (en) *	2000-11-30	2002-06-06	Kissei Pharmaceutical Co., Ltd.	Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
PL209375B1 (pl) *	2000-12-28	2011-08-31	Kissei Pharmaceutical	Pochodne glukopiranozyloksypirazolu, kompozycja farmaceutyczna zawierająca takie pochodne i zastosowanie tych pochodnych do wytwarzania kompozycji farmaceutycznej
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- 2000-08-24 PT PT00954963T patent/PT1213296E/pt unknown
- 2000-08-24 RU RU2002107975/04A patent/RU2232767C2/ru active
- 2000-08-24 EP EP00954963A patent/EP1213296B1/en not_active Expired - Lifetime
- 2000-08-31 TW TW089117757A patent/TW579378B/zh not_active IP Right Cessation
2002
- 2002-02-26 IL IL148384A patent/IL148384A/en active IP Right Grant
- 2002-02-27 BG BG106451A patent/BG65388B1/bg unknown
- 2002-02-27 NO NO20020968A patent/NO322703B1/no not_active IP Right Cessation
- 2002-03-11 ZA ZA200201991A patent/ZA200201991B/en unknown
2003
- 2003-04-09 HK HK03102515A patent/HK1050369A1/xx not_active IP Right Cessation
2004
- 2004-01-20 US US10/759,138 patent/US6972283B2/en not_active Expired - Lifetime
- 2004-11-03 US US10/979,154 patent/US20050137143A1/en not_active Abandoned
2005
- 2005-07-27 US US11/189,832 patent/US7056892B2/en not_active Expired - Lifetime
- 2005-07-28 US US11/191,024 patent/US7115575B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL364800A1 (en)	2004-12-13
ZA200201991B (en)	2003-05-28
PT1213296E (pt)	2004-08-31
DE60009929T2 (de)	2005-03-31
DK1213296T3 (da)	2004-08-16
TR200201082T2 (tr)	2002-07-22
US20050137143A1 (en)	2005-06-23
SK2872002A3 (en)	2003-01-09
US7115575B2 (en)	2006-10-03
NO20020968L (no)	2002-04-26
EP1213296B1 (en)	2004-04-14
NZ517439A (en)	2003-03-28
US7056892B2 (en)	2006-06-06
HU229581B1 (en)	2014-02-28
CZ303372B6 (cs)	2012-08-22
IL148384A (en)	2009-06-15
HK1050369A1 (en)	2003-06-20
CA2382480A1 (en)	2001-03-08
BRPI0013667B1 (pt)	2016-06-14
NO322703B1 (no)	2006-11-27
JP3989730B2 (ja)	2007-10-10
DE60009929D1 (de)	2004-05-19
HUP0203190A3 (en)	2003-04-28
BRPI0013667B8 (pt)	2021-05-25
ES2216937T3 (es)	2004-11-01
US20050261206A1 (en)	2005-11-24
TW579378B (en)	2004-03-11
EP1213296A1 (en)	2002-06-12
RU2232767C2 (ru)	2004-07-20
BG106451A (en)	2002-09-30
IL148384A0 (en)	2002-09-12
MXPA02002271A (es)	2002-10-31
KR20020033781A (ko)	2002-05-07
CN1377363A (zh)	2002-10-30
NO20020968D0 (no)	2002-02-27
AU782330B2 (en)	2005-07-21
EP1213296A4 (en)	2002-09-04
SK286600B6 (sk)	2009-02-05
US20040147729A1 (en)	2004-07-29
KR100591585B1 (ko)	2006-06-20
BG65388B1 (bg)	2008-05-30
PL203124B1 (pl)	2009-08-31
CA2382480C (en)	2008-09-30
US6972283B2 (en)	2005-12-06
CZ2002665A3 (cs)	2002-06-12
CN1145635C (zh)	2004-04-14
AU6727500A (en)	2001-03-26
BR0013667A (pt)	2002-06-11
HUP0203190A2 (hu)	2003-01-28
US20050261205A1 (en)	2005-11-24
ATE264337T1 (de)	2004-04-15
WO2001016147A1 (fr)	2001-03-08

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