CN1020944C - 紧固件 - Google Patents
紧固件 Download PDFInfo
- Publication number
- CN1020944C CN1020944C CN91100552A CN91100552A CN1020944C CN 1020944 C CN1020944 C CN 1020944C CN 91100552 A CN91100552 A CN 91100552A CN 91100552 A CN91100552 A CN 91100552A CN 1020944 C CN1020944 C CN 1020944C
- Authority
- CN
- China
- Prior art keywords
- fastening piece
- ring
- boring
- awl
- expands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Description
Claims (9)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4002687.6 | 1990-01-30 | ||
DEP4011229.2 | 1990-04-06 | ||
DEP4030498.1 | 1990-09-26 | ||
JP2004218895 | 2004-07-27 | ||
JP2004343942 | 2004-11-29 | ||
PCT/JP2005/013716 WO2006011502A1 (ja) | 2004-07-27 | 2005-07-27 | 新規なグルシトール誘導体、そのプロドラッグおよびその塩、ならびにそれらを含有する糖尿病治療薬 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1053827A CN1053827A (zh) | 1991-08-14 |
CN1020944C true CN1020944C (zh) | 1993-05-26 |
Family
ID=35786252
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN91100552A Ceased CN1020944C (zh) | 1990-01-30 | 1991-01-30 | 紧固件 |
CN2005800250928A Expired - Fee Related CN1989132B (zh) | 2004-07-27 | 2005-07-27 | 新的葡萄糖醇衍生物、其前体药物及其盐、以及含有它的糖尿病治疗药 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800250928A Expired - Fee Related CN1989132B (zh) | 2004-07-27 | 2005-07-27 | 新的葡萄糖醇衍生物、其前体药物及其盐、以及含有它的糖尿病治疗药 |
Country Status (12)
Country | Link |
---|---|
US (1) | US7943748B2 (zh) |
EP (1) | EP1803721A4 (zh) |
JP (1) | JPWO2006011502A1 (zh) |
KR (1) | KR20070042191A (zh) |
CN (2) | CN1020944C (zh) |
AU (1) | AU2005265715A1 (zh) |
BR (1) | BRPI0513824A (zh) |
CA (1) | CA2574608A1 (zh) |
MX (1) | MX2007001101A (zh) |
RU (1) | RU2386631C2 (zh) |
TW (1) | TW200617001A (zh) |
WO (1) | WO2006011502A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100441888C (zh) * | 2005-03-16 | 2008-12-10 | 法国I.T.W. | 系留环在承重构件上的固定装置及带有该装置的支架 |
Families Citing this family (43)
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---|---|---|---|---|
EP1609785B1 (en) | 2003-03-14 | 2016-02-03 | Astellas Pharma Inc. | C-glycoside derivatives and salts thereof |
TW200726755A (en) * | 2005-07-07 | 2007-07-16 | Astellas Pharma Inc | A crystalline choline salt of an azulene derivative |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
WO2007140191A2 (en) | 2006-05-23 | 2007-12-06 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
TWI403516B (zh) * | 2006-07-27 | 2013-08-01 | Chugai Pharmaceutical Co Ltd | To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes |
US7858587B2 (en) * | 2006-09-21 | 2010-12-28 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted difluorobenzyl-benzene derivates, medicaments containing such compounds, their use and process for their manufacture |
TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第2型共同運輸體(co-transporter 2)的抑制物與其應用方法 |
KR101100072B1 (ko) * | 2006-12-21 | 2011-12-29 | 고토부키 세이야쿠 가부시키가이샤 | C-글리코시드 유도체의 제조방법 및 이의 합성 중간체 |
US7795228B2 (en) | 2006-12-28 | 2010-09-14 | Theracos, Inc. | Spiroheterocyclic glycosides and methods of use |
US7846945B2 (en) | 2007-03-08 | 2010-12-07 | Lexicon Pharmaceuticals, Inc. | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use |
UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
CL2008003653A1 (es) * | 2008-01-17 | 2010-03-05 | Mitsubishi Tanabe Pharma Corp | Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica. |
CA2935838C (en) | 2008-08-22 | 2018-04-17 | Theracos Sub, Llc | Processes for the preparation of sglt2 inhibitors |
EP2334687B9 (en) * | 2008-08-28 | 2012-08-08 | Pfizer Inc. | Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives |
LT3228320T (lt) | 2008-10-17 | 2020-03-10 | Sanofi-Aventis Deutschland Gmbh | Insulino ir glp-1 agonisto derinys |
CN101830876A (zh) * | 2009-03-12 | 2010-09-15 | 上海恒瑞医药有限公司 | C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用 |
WO2010128152A1 (en) * | 2009-05-07 | 2010-11-11 | Novartis Ag | Fused heterocyclic c-glycosides for the treatment of diabetes |
WO2011048148A2 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Glycoside derivative and uses thereof |
US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
PT2496583E (pt) | 2009-11-02 | 2015-01-14 | Pfizer | Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol |
NZ599848A (en) | 2009-11-13 | 2013-08-30 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin, and methionine |
KR101772372B1 (ko) | 2009-11-13 | 2017-08-29 | 사노피-아벤티스 도이칠란트 게엠베하 | Glp-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
CN102372722A (zh) | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用 |
SG187904A1 (en) * | 2010-08-30 | 2013-04-30 | Sanofi Aventis Deutschland | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
EP2676965B1 (en) | 2011-02-18 | 2017-10-04 | Shanghai Yingli Pharmaceutical Co., Ltd | Aryl glycoside compound, preparation method and use thereof |
WO2012140596A1 (en) | 2011-04-14 | 2012-10-18 | Novartis Ag | Glycoside derivatives and uses thereof |
US8614195B2 (en) | 2011-04-14 | 2013-12-24 | Novartis Ag | Glycoside derivatives and uses thereof |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
CN108079281A (zh) | 2011-08-29 | 2018-05-29 | 赛诺菲-安万特德国有限公司 | 用于2型糖尿病患者中的血糖控制的药物组合 |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
KR20140054800A (ko) * | 2012-10-29 | 2014-05-09 | 주식회사 종근당바이오 | 1-데옥시-1-(2-하이드록시에틸 아미노)-d-글루시톨 및 미글리톨의 제조방법 |
CN103910769B (zh) | 2012-12-31 | 2018-10-02 | 上海璎黎药业有限公司 | 葡萄糖衍生物和脯氨酸的复合物、晶体、制备方法及应用 |
WO2015043473A1 (en) * | 2013-09-25 | 2015-04-02 | Sunshine Lake Pharma Co., Ltd. | Glucopyranosyl derivatives and their uses in medicine |
CN105611920B (zh) | 2013-10-12 | 2021-07-16 | 泰拉科斯萨普有限责任公司 | 羟基-二苯甲烷衍生物的制备 |
AU2015359376B2 (en) | 2014-12-12 | 2021-09-09 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
CN105156426A (zh) * | 2015-10-28 | 2015-12-16 | 苏州道众机械制造有限公司 | 一种膨胀螺栓 |
KR101954188B1 (ko) * | 2017-02-24 | 2019-05-23 | 동아에스티주식회사 | Sglt-2 억제제인 신규 글루코스 유도체 |
US11454128B2 (en) * | 2018-08-06 | 2022-09-27 | General Electric Company | Fairing assembly |
WO2020151620A1 (zh) * | 2019-01-24 | 2020-07-30 | 北京盈科瑞创新药物研究有限公司 | 化合物、其制备方法及其作为药物中间体的应用 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2102591C (en) | 1992-11-12 | 2000-12-26 | Kenji Tsujihara | Hypoglycemic agent |
US5837689A (en) * | 1993-06-16 | 1998-11-17 | Glycomed Incorporated | Sialyl lewis-x mimetics containing naphthyl backbones |
US5830873A (en) | 1994-05-11 | 1998-11-03 | Tanabe Seiyaku Co., Ltd. | Propiophenone derivative and a process for preparing the same |
JP2814950B2 (ja) | 1994-05-11 | 1998-10-27 | 田辺製薬株式会社 | 血糖降下剤 |
JP3034192B2 (ja) | 1995-11-07 | 2000-04-17 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
JP3006513B2 (ja) | 1995-11-07 | 2000-02-07 | 田辺製薬株式会社 | 医薬組成物 |
JP3065235B2 (ja) | 1995-11-07 | 2000-07-17 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
ES2176600T3 (es) | 1996-12-26 | 2002-12-01 | Tanabe Seiyaku Co | Derivado de la propiofenona y procedimientos para su preparacion. |
JP2000080041A (ja) | 1998-03-09 | 2000-03-21 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
UA71994C2 (en) | 1999-08-31 | 2005-01-17 | Kissei Pharmaceutical | Glucopyranosyloxypyrazole derivatives, a pharmaceutical composition containing these derivatives and intermediate compounds for the preparation thereof |
PH12000002657B1 (en) * | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US6627611B2 (en) | 2000-02-02 | 2003-09-30 | Kotobuki Pharmaceutical Co Ltd | C-glycosides and preparation of thereof as antidiabetic agents |
JP4456768B2 (ja) | 2000-02-02 | 2010-04-28 | 壽製薬株式会社 | C−配糖体を含有する薬剤 |
WO2001068660A1 (fr) | 2000-03-17 | 2001-09-20 | Kissei Pharmaceutical Co., Ltd. | Derives glucopyranosyloxybenzylbenzene, preparations medicinales les contenant et intermediaires pour la preparation desdits derives |
US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
US6555519B2 (en) | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
PL205607B1 (pl) | 2000-09-29 | 2010-05-31 | Kissei Pharmaceutical | Pochodna glukopiranozyloksybenzylobenzenu, kompozycja farmaceutyczna zawierająca tą pochodną oraz zastosowanie tej pochodnej do wytwarzania kompozycji farmaceutycznej |
EP1338603B1 (en) | 2000-11-02 | 2010-01-20 | Ajinomoto Co., Inc. | Novel pyrazole derivatives and diabetes remedies containing the same |
JP4212891B2 (ja) | 2000-11-30 | 2009-01-21 | キッセイ薬品工業株式会社 | グルコピラノシルオキシベンジルベンゼン誘導体、それを含有する医薬組成物およびその製造中間体 |
CZ305971B6 (cs) | 2000-12-28 | 2016-06-01 | Kissei Pharmaceutical Co., Ltd. | Deriváty glukopyranosyloxypyrazolu a jejich použití v léčivech |
TWI255817B (en) | 2001-02-14 | 2006-06-01 | Kissei Pharmaceutical | Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof |
US7087579B2 (en) | 2001-02-26 | 2006-08-08 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and medicinal use thereof |
JP4147111B2 (ja) | 2001-02-27 | 2008-09-10 | キッセイ薬品工業株式会社 | グルコピラノシルオキシピラゾール誘導体およびその医薬用途 |
US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US6774112B2 (en) * | 2001-04-11 | 2004-08-10 | Bristol-Myers Squibb Company | Amino acid complexes of C-aryl glucosides for treatment of diabetes and method |
CA2445346C (en) | 2001-04-27 | 2010-04-06 | Ajinomoto Co., Inc. | N-substituted pyrazole-o-glycoside derivatives and therapeutic agent for diabetes containing the same |
CA2448741C (en) | 2001-05-30 | 2010-06-22 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate therefor |
US7271153B2 (en) | 2001-06-20 | 2007-09-18 | Kissei Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic derivatives, medicinal compositions containing the same, medicinal uses thereof, and intermediates therefor |
JP4115105B2 (ja) | 2001-07-02 | 2008-07-09 | 協和醗酵工業株式会社 | ピラゾール誘導体 |
JPWO2003011880A1 (ja) | 2001-07-31 | 2004-11-18 | キッセイ薬品工業株式会社 | グルコピラノシルオキシベンジルベンゼン誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
WO2003020737A1 (en) | 2001-09-05 | 2003-03-13 | Bristol-Myers Squibb Company | O-pyrazole glucoside sglt2 inhibitors and method of use |
AU2003231517A1 (en) | 2002-04-26 | 2003-11-10 | Ajinomoto Co., Inc. | Preventive/remedy for diabetes |
DE10231370B4 (de) | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
TWI254635B (en) * | 2002-08-05 | 2006-05-11 | Yamanouchi Pharma Co Ltd | Azulene derivative and salt thereof |
EP1528066A4 (en) | 2002-08-09 | 2007-05-02 | Taisho Pharmaceutical Co Ltd | ARYL-t-THIO-B-GLUCOPYRANOSIDE DERIVATIVES AND DIABETES CONTAINING THEM |
DE10258008B4 (de) | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
DE10258007B4 (de) | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
AU2003289440A1 (en) | 2002-12-25 | 2004-07-22 | Kissei Pharmaceutical Co., Ltd. | Nitrogen-containing heterocycic derivatives, medicinal compositions containing the same and medicinal use thereof |
EP1609785B1 (en) * | 2003-03-14 | 2016-02-03 | Astellas Pharma Inc. | C-glycoside derivatives and salts thereof |
MXPA06001274A (es) | 2003-08-01 | 2006-04-11 | Tanabe Seiyaku Co | Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio. |
-
1991
- 1991-01-30 CN CN91100552A patent/CN1020944C/zh not_active Ceased
-
2005
- 2005-07-22 TW TW094124936A patent/TW200617001A/zh unknown
- 2005-07-27 CN CN2005800250928A patent/CN1989132B/zh not_active Expired - Fee Related
- 2005-07-27 CA CA002574608A patent/CA2574608A1/en not_active Abandoned
- 2005-07-27 JP JP2006527817A patent/JPWO2006011502A1/ja not_active Withdrawn
- 2005-07-27 WO PCT/JP2005/013716 patent/WO2006011502A1/ja active Application Filing
- 2005-07-27 MX MX2007001101A patent/MX2007001101A/es unknown
- 2005-07-27 AU AU2005265715A patent/AU2005265715A1/en not_active Abandoned
- 2005-07-27 EP EP05767034A patent/EP1803721A4/en not_active Withdrawn
- 2005-07-27 BR BRPI0513824-8A patent/BRPI0513824A/pt not_active IP Right Cessation
- 2005-07-27 KR KR1020077004673A patent/KR20070042191A/ko not_active Application Discontinuation
- 2005-07-27 RU RU2007107076/04A patent/RU2386631C2/ru not_active IP Right Cessation
- 2005-07-27 US US11/658,765 patent/US7943748B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100441888C (zh) * | 2005-03-16 | 2008-12-10 | 法国I.T.W. | 系留环在承重构件上的固定装置及带有该装置的支架 |
Also Published As
Publication number | Publication date |
---|---|
RU2007107076A (ru) | 2008-09-10 |
US7943748B2 (en) | 2011-05-17 |
BRPI0513824A (pt) | 2008-05-20 |
US20080319047A1 (en) | 2008-12-25 |
JPWO2006011502A1 (ja) | 2008-05-01 |
EP1803721A4 (en) | 2009-05-20 |
AU2005265715A1 (en) | 2006-02-02 |
CA2574608A1 (en) | 2006-02-02 |
EP1803721A1 (en) | 2007-07-04 |
CN1989132A (zh) | 2007-06-27 |
KR20070042191A (ko) | 2007-04-20 |
RU2386631C2 (ru) | 2010-04-20 |
WO2006011502A1 (ja) | 2006-02-02 |
CN1989132B (zh) | 2010-06-09 |
MX2007001101A (es) | 2007-03-15 |
CN1053827A (zh) | 1991-08-14 |
TW200617001A (en) | 2006-06-01 |
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