TR200500707T2 - Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler. - Google Patents
Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.Info
- Publication number
- TR200500707T2 TR200500707T2 TR2005/00707T TR200500707T TR200500707T2 TR 200500707 T2 TR200500707 T2 TR 200500707T2 TR 2005/00707 T TR2005/00707 T TR 2005/00707T TR 200500707 T TR200500707 T TR 200500707T TR 200500707 T2 TR200500707 T2 TR 200500707T2
- Authority
- TR
- Turkey
- Prior art keywords
- replication
- inhibitors
- syncytial virus
- formula
- respiratory system
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000010076 replication Effects 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 210000002345 respiratory system Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Bu bulus, solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler olarak formül (I)e sahip bilesikler, bunlarin ön ilaçlari, N-oksitler, katilma tuzlari, kuaterner aminleri, metal kompleksleri ve streokimyasal izomerik sekiller; bunlarin hazirlanmasi, bunlari ihtiva eden terkipler ve bunlarin ilaç olarak kullanimi ile ilgili olup; burada -a1=a2-a3=a4, formül -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- veya -CH=CH-CH=N- ye sahip bir radikaldir; Q, (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) ve (b-8) formülüne sahip bir radikaldir; G, bir dogrudan bag veya istege bagli olarak sübstitüe edilmis bir C1-10 alkandiildir; R1, istege bagli olarak sübstitüe edilmis bir bisiklik heterohalkadir; ve diger degiskenler tarifnamede tarif edildigi gibidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99202089 | 1999-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200500707T2 true TR200500707T2 (tr) | 2005-04-21 |
Family
ID=8240374
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/03805T TR200103805T2 (tr) | 1999-06-28 | 2000-06-20 | Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler |
TR2005/00707T TR200500707T2 (tr) | 1999-06-28 | 2000-06-20 | Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/03805T TR200103805T2 (tr) | 1999-06-28 | 2000-06-20 | Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler |
Country Status (34)
Country | Link |
---|---|
US (2) | US7071192B1 (tr) |
EP (2) | EP1196410B1 (tr) |
JP (1) | JP2003503403A (tr) |
KR (1) | KR100731273B1 (tr) |
CN (1) | CN1171887C (tr) |
AR (1) | AR024495A1 (tr) |
AT (2) | ATE356121T1 (tr) |
AU (1) | AU774829B2 (tr) |
BG (1) | BG65373B1 (tr) |
BR (1) | BR0011997A (tr) |
CA (1) | CA2376785A1 (tr) |
CZ (1) | CZ20014573A3 (tr) |
DE (2) | DE60033859T2 (tr) |
DK (1) | DK1196410T3 (tr) |
EA (1) | EA004746B1 (tr) |
EE (1) | EE04592B1 (tr) |
ES (2) | ES2283716T3 (tr) |
HK (1) | HK1045998B (tr) |
HR (2) | HRP20010934A2 (tr) |
HU (1) | HUP0201789A3 (tr) |
IL (2) | IL147328A0 (tr) |
MX (1) | MXPA02000117A (tr) |
MY (1) | MY129810A (tr) |
NO (1) | NO321599B1 (tr) |
NZ (1) | NZ515392A (tr) |
PL (1) | PL200694B1 (tr) |
PT (1) | PT1196410E (tr) |
SI (1) | SI1196410T1 (tr) |
SK (1) | SK18952001A3 (tr) |
TR (2) | TR200103805T2 (tr) |
TW (1) | TWI267513B (tr) |
UA (1) | UA75866C2 (tr) |
WO (1) | WO2001000615A1 (tr) |
ZA (1) | ZA200110473B (tr) |
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EP1249450B1 (en) * | 2000-01-17 | 2007-10-10 | Teijin Pharma Limited | Benzimidazole derivatives as human chymase inhibitors |
US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
WO2002048147A2 (en) | 2000-12-15 | 2002-06-20 | Glaxo Group Limited | Pyrazolopyridines |
AU2002239348A1 (en) | 2000-12-15 | 2002-06-24 | Glaxo Group Limited | Pyrazolopyridine derivatives |
US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
AU2002248531A1 (en) | 2001-03-08 | 2002-09-24 | Smithkline Beecham Corporation | Pyrazolopyriadine derivatives |
US7034030B2 (en) | 2001-03-30 | 2006-04-25 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapeutic compounds |
ATE332301T1 (de) | 2001-04-10 | 2006-07-15 | Smithkline Beecham Corp | Antivirale pyrazolopyridin verbindungen |
ES2242028T3 (es) | 2001-04-27 | 2005-11-01 | Smithkline Beecham Corporation | Derivados de pirazolo(1,5-a)piridina. |
US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
HUP0400266A2 (hu) | 2001-06-21 | 2004-08-30 | Smithkline Beecham Corp. | Imidazo[1,2-a]piridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk herpeszvírus-fertőzések megelőzésére vagy kezelésére |
JP2005508955A (ja) | 2001-10-05 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | ヘルペスウイルス感染の治療で使用されるためのイミダゾ−ピリジン誘導体 |
US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
AU2002357740A1 (en) | 2001-12-11 | 2003-06-23 | Smithkline Beecham Corporation | Pyrazolo-pyridine derivatives as antiherpes agents |
US7244847B2 (en) * | 2002-02-06 | 2007-07-17 | Isis Pharmaceuticals, Inc. | Benzimidazole compounds |
WO2004014316A2 (en) | 2002-08-09 | 2004-02-19 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
AU2003258177A1 (en) | 2002-08-09 | 2004-02-25 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
WO2004033454A1 (en) | 2002-10-03 | 2004-04-22 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridine derivatives |
CA2541618C (en) * | 2003-10-30 | 2011-12-13 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
WO2005058874A1 (en) * | 2003-12-18 | 2005-06-30 | Tibotec Pharmaceuticals Ltd. | 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication |
AR046771A1 (es) * | 2003-12-18 | 2005-12-21 | Tibotec Pharm Ltd | Derivados piperidina-amino-bencimidazol como inhibidores de la replicacion del virus sincitial respiratorio |
CN1894236B (zh) * | 2003-12-18 | 2011-08-17 | 泰博特克药品有限公司 | 作为呼吸道合胞病毒复制抑制剂的氨基-苯并咪唑类衍生物 |
ES2326813T3 (es) * | 2003-12-18 | 2009-10-20 | Tibotec Pharmaceuticals Ltd. | Derivados de amino-bencimidazoles como inhibidores de la replicacion del virus respiratorio sincitial. |
US8044073B2 (en) | 2003-12-18 | 2011-10-25 | Tibotec Pharmaceuticals | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
AR046959A1 (es) | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
CA2600507C (en) * | 2005-03-17 | 2013-10-22 | Tibotec Pharmaceuticals Ltd. | 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication |
CA2612263C (en) | 2005-06-20 | 2015-04-14 | Tibotec Pharmaceuticals Ltd. | 1-(2-amino-3-(substituted alkyl)-3h-benzimidazolylmethyl)-3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
AU2006260970B2 (en) * | 2005-06-20 | 2012-07-05 | Janssen Sciences Ireland Uc | Heterocyclylaminoalkyl substituted benzimidazoles |
CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
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JP5487692B2 (ja) | 2009-04-10 | 2014-05-07 | 国立大学法人京都大学 | 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法 |
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AU2010266570A1 (en) * | 2009-06-30 | 2012-01-19 | Siga Technologies, Inc. | Treatment and prevention of Dengue virus infections |
BR112014001018A2 (pt) | 2011-07-15 | 2017-01-10 | Shionogi & Co | derivado de azabenzimidazol tendo atividade de ativação de ampk |
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-
2000
- 2000-06-20 JP JP2001507023A patent/JP2003503403A/ja not_active Withdrawn
- 2000-06-20 AT AT03102464T patent/ATE356121T1/de not_active IP Right Cessation
- 2000-06-20 KR KR1020017015284A patent/KR100731273B1/ko not_active IP Right Cessation
- 2000-06-20 ES ES03102464T patent/ES2283716T3/es not_active Expired - Lifetime
- 2000-06-20 SI SI200030358T patent/SI1196410T1/xx unknown
- 2000-06-20 AT AT00936899T patent/ATE259796T1/de not_active IP Right Cessation
- 2000-06-20 BR BR0011997-0A patent/BR0011997A/pt not_active Application Discontinuation
- 2000-06-20 WO PCT/EP2000/005677 patent/WO2001000615A1/en active Application Filing
- 2000-06-20 DK DK00936899T patent/DK1196410T3/da active
- 2000-06-20 US US10/019,376 patent/US7071192B1/en not_active Expired - Fee Related
- 2000-06-20 EP EP00936899A patent/EP1196410B1/en not_active Expired - Lifetime
- 2000-06-20 CA CA002376785A patent/CA2376785A1/en not_active Abandoned
- 2000-06-20 TR TR2001/03805T patent/TR200103805T2/tr unknown
- 2000-06-20 HU HU0201789A patent/HUP0201789A3/hu unknown
- 2000-06-20 PL PL352385A patent/PL200694B1/pl not_active IP Right Cessation
- 2000-06-20 EP EP03102464A patent/EP1400519B1/en not_active Expired - Lifetime
- 2000-06-20 PT PT00936899T patent/PT1196410E/pt unknown
- 2000-06-20 DE DE60033859T patent/DE60033859T2/de not_active Expired - Fee Related
- 2000-06-20 AU AU52222/00A patent/AU774829B2/en not_active Ceased
- 2000-06-20 NZ NZ515392A patent/NZ515392A/xx unknown
- 2000-06-20 UA UA2002010361A patent/UA75866C2/uk unknown
- 2000-06-20 EE EEP200100694A patent/EE04592B1/xx not_active IP Right Cessation
- 2000-06-20 SK SK1895-2001A patent/SK18952001A3/sk unknown
- 2000-06-20 TR TR2005/00707T patent/TR200500707T2/tr unknown
- 2000-06-20 DE DE60008382T patent/DE60008382T2/de not_active Expired - Fee Related
- 2000-06-20 ES ES00936899T patent/ES2215670T3/es not_active Expired - Lifetime
- 2000-06-20 EA EA200200086A patent/EA004746B1/ru not_active IP Right Cessation
- 2000-06-20 MX MXPA02000117A patent/MXPA02000117A/es active IP Right Grant
- 2000-06-20 CZ CZ20014573A patent/CZ20014573A3/cs unknown
- 2000-06-20 CN CNB008095302A patent/CN1171887C/zh not_active Expired - Fee Related
- 2000-06-20 IL IL14732800A patent/IL147328A0/xx active IP Right Grant
- 2000-06-26 TW TW089112479A patent/TWI267513B/zh not_active IP Right Cessation
- 2000-06-27 MY MYPI20002914A patent/MY129810A/en unknown
- 2000-06-27 AR ARP000103222A patent/AR024495A1/es unknown
-
2001
- 2001-12-19 HR HR20010934A patent/HRP20010934A2/hr not_active Application Discontinuation
- 2001-12-20 ZA ZA200110473A patent/ZA200110473B/xx unknown
- 2001-12-26 IL IL147328A patent/IL147328A/en not_active IP Right Cessation
- 2001-12-27 NO NO20016370A patent/NO321599B1/no unknown
-
2002
- 2002-01-08 BG BG106288A patent/BG65373B1/bg unknown
- 2002-10-21 HK HK02107623.8A patent/HK1045998B/zh not_active IP Right Cessation
-
2005
- 2005-10-11 US US11/247,392 patent/US7407969B2/en not_active Expired - Fee Related
-
2008
- 2008-08-12 HR HR20080390A patent/HRP20080390A2/xx not_active Application Discontinuation
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