TR199801210T2 - 1-(1,2-Çift ikameli piperidinil)-4-(kaynasmis imidazol)piperidin türevleri. - Google Patents

1-(1,2-Çift ikameli piperidinil)-4-(kaynasmis imidazol)piperidin türevleri.

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Publication number
TR199801210T2
TR199801210T2 TR1998/01210T TR9801210T TR199801210T2 TR 199801210 T2 TR199801210 T2 TR 199801210T2 TR 1998/01210 T TR1998/01210 T TR 1998/01210T TR 9801210 T TR9801210 T TR 9801210T TR 199801210 T2 TR199801210 T2 TR 199801210T2
Authority
TR
Turkey
Prior art keywords
alkyl
formula
phenyl
revleri
kayna
Prior art date
Application number
TR1998/01210T
Other languages
English (en)
Inventor
Eduard Janssens Frans
El�Sabeth Leenaerts Joseph
Em�El Mar�A Van Roosbroeck Yves
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR199801210T2 publication Critical patent/TR199801210T2/tr

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
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  • Otolaryngology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bu bulus, (I) formülünün bilesiklerine, N-oksit biçimlerine, farmasötik olarak kabul edilebilir ilave tuzlarina ve bunlarin stereokimyasal sekilde izomerik biçimlerine; bunlarin P antagonistleri maddelerine; hazirlanmalarina, bunlari ihtiva eden bilesimlere ve bunlarin bir tibbi madde olarak kullanimina iliskindir, bu formülde, n,0,1 ya da 2'dir; m,1 ya da 2'dir, bu durumun kosulu olarak, m, 2 oldugunda, n, 1'dir;=Q, =0 ya da NR3'dür; X, bir kovalent bagdir ya da -O-, -S-, -NR3- dür; R1, Ar1,Ar1C1-6 alkil ya da di(Ar1)C1-6 alkildir, burada, her C1-6 alkil grubu istege göre ikame edilmektedir; R2, Ar2, Ar2C1-6 alkil, Het ya da HetC1-6alkildir; R3, hidrojendir ya da C1-6 alkildir; L,(a-2)formülünün bir piperidin türevidir ya da (a-2)formülünün bir spiro piperidin türevidir; Ar1 fenil ya da ikame edilmis fenildir; Ar2, naftalenil; fenil ya da ikame edilmis fenildir; ve Het bir monosiklik ya da bisiklik heterosikldir; her monosiklik ve bisiklik heterosikl istege göre (devami var)
TR1998/01210T 1995-12-27 1996-12-20 1-(1,2-Çift ikameli piperidinil)-4-(kaynasmis imidazol)piperidin türevleri. TR199801210T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95203652 1995-12-27

Publications (1)

Publication Number Publication Date
TR199801210T2 true TR199801210T2 (tr) 1999-10-21

Family

ID=8221024

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01210T TR199801210T2 (tr) 1995-12-27 1996-12-20 1-(1,2-Çift ikameli piperidinil)-4-(kaynasmis imidazol)piperidin türevleri.

Country Status (30)

Country Link
US (1) US6251894B1 (tr)
EP (1) EP0843679B1 (tr)
JP (1) JP4097043B2 (tr)
KR (1) KR100485147B1 (tr)
CN (1) CN1066733C (tr)
AR (2) AR005278A1 (tr)
AT (1) ATE208392T1 (tr)
AU (1) AU716071B2 (tr)
BR (1) BR9612307A (tr)
CA (1) CA2238817C (tr)
CY (1) CY2271B1 (tr)
CZ (1) CZ295861B6 (tr)
DE (1) DE69616802T2 (tr)
DK (1) DK0843679T3 (tr)
EA (1) EA001374B1 (tr)
ES (1) ES2167619T3 (tr)
HK (1) HK1011206A1 (tr)
HU (1) HU229766B1 (tr)
IL (2) IL124641A (tr)
MY (1) MY117680A (tr)
NO (1) NO310916B1 (tr)
NZ (1) NZ325845A (tr)
PL (1) PL183767B1 (tr)
PT (1) PT843679E (tr)
SI (1) SI0843679T1 (tr)
SK (1) SK283540B6 (tr)
TR (1) TR199801210T2 (tr)
TW (1) TW382017B (tr)
WO (1) WO1997024356A1 (tr)
ZA (1) ZA9610889B (tr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
ATE233104T1 (de) * 1997-09-18 2003-03-15 Janssen Pharmaceutica Nv Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika
CA2355939C (en) * 1998-12-19 2010-12-14 Janssen Pharmaceutica N.V. Antihistaminic spiro compounds
WO2001030348A1 (en) * 1999-10-25 2001-05-03 Janssen Pharmaceutica N.V. Use of substance p antagonists for influencing the circadian timing system
CA2448735C (en) 2001-06-12 2008-10-28 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
PL209953B1 (pl) * 2001-11-23 2011-11-30 Janssen Pharmaceutica Nv Zastosowanie pochodnej benzimidazo [2,1-b] [3] benzazepiny
EP1457493A4 (en) * 2001-12-10 2005-11-30 Kyorin Seiyaku Kk CONDENSED, BICYCLIC PYRIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS
ATE295845T1 (de) * 2002-01-16 2005-06-15 Janssen Pharmaceutica Nv Prucaloprid-n-oxid
WO2003062245A1 (fr) * 2002-01-18 2003-07-31 Kyorin Pharmaceutical Co., Ltd. Derives de pyrimidine fusionnes bicycliques
JPWO2003080626A1 (ja) 2002-03-26 2005-07-21 杏林製薬株式会社 タキキニン受容体拮抗剤としての縮合二環式ピリジン誘導体
JO2696B1 (en) 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
US7514424B2 (en) * 2002-12-23 2009-04-07 Janssen Pharmaceutica N.V. Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
ES2346147T3 (es) 2005-03-03 2010-10-11 Janssen Pharmaceutica Nv Derivados de oxa-diaza-espiro-(5.5)-undecanona sustituidos y su uso como antagonistas de las neuroquininas.
EP1858896B1 (en) 2005-03-08 2010-08-18 Janssen Pharmaceutica NV Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists
AU2008278273A1 (en) * 2007-07-19 2009-01-22 Adelaide Research & Innovation Pty Ltd Method for reducing intracranial pressure
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
CA3091944A1 (en) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
AU8902591A (en) * 1990-10-10 1992-05-20 Schering Corporation Substituted imidazobenzazepines and imidazopyridoazepines
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
PT708776E (pt) * 1993-07-13 2001-06-29 Janssen Pharmaceutica Nv Imidazoazepinas anti-alergicas
US5814636A (en) 1994-07-15 1998-09-29 Meiji Seika Kabushiki Kaisha Compounds with platelet aggregation inhibitor activity
NZ321575A (en) 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

Also Published As

Publication number Publication date
HU229766B1 (hu) 2014-06-30
CZ186598A3 (cs) 1998-11-11
IL124641A (en) 2001-11-25
IL124642A (en) 2002-08-14
PL183767B1 (pl) 2002-07-31
ES2167619T3 (es) 2002-05-16
DE69616802D1 (de) 2001-12-13
ATE208392T1 (de) 2001-11-15
CA2238817A1 (en) 1997-07-10
DE69616802T2 (de) 2002-07-04
HUP9903948A3 (hu) 2000-04-28
DK0843679T3 (da) 2002-02-25
PT843679E (pt) 2002-04-29
AR005278A1 (es) 1999-04-28
HK1011206A1 (en) 1999-07-09
KR19990076715A (ko) 1999-10-15
EA199800603A1 (ru) 1998-12-24
TW382017B (en) 2000-02-11
HUP9903948A2 (hu) 2000-03-28
EP0843679A1 (en) 1998-05-27
AR051817A2 (es) 2007-02-14
IL124641A0 (en) 1998-12-06
NO982405L (no) 1998-08-19
ZA9610889B (en) 1998-06-23
JP2000506503A (ja) 2000-05-30
AU716071B2 (en) 2000-02-17
IL124642A0 (en) 1998-12-06
NO310916B1 (no) 2001-09-17
SK283540B6 (sk) 2003-09-11
CN1066733C (zh) 2001-06-06
US6251894B1 (en) 2001-06-26
BR9612307A (pt) 1999-07-13
KR100485147B1 (ko) 2005-09-13
CA2238817C (en) 2006-10-17
CN1206417A (zh) 1999-01-27
EA001374B1 (ru) 2001-02-26
EP0843679B1 (en) 2001-11-07
JP4097043B2 (ja) 2008-06-04
SI0843679T1 (en) 2002-06-30
AU1308697A (en) 1997-07-28
PL327136A1 (en) 1998-11-23
SK83098A3 (en) 1999-01-11
NO982405D0 (no) 1998-05-27
CZ295861B6 (cs) 2005-11-16
WO1997024356A1 (en) 1997-07-10
MY117680A (en) 2004-07-31
NZ325845A (en) 1999-06-29
CY2271B1 (en) 2003-07-04

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