ES8505972A1 - Un procedimiento para preparar derivados de pirimidina - Google Patents
Un procedimiento para preparar derivados de pirimidinaInfo
- Publication number
- ES8505972A1 ES8505972A1 ES530916A ES530916A ES8505972A1 ES 8505972 A1 ES8505972 A1 ES 8505972A1 ES 530916 A ES530916 A ES 530916A ES 530916 A ES530916 A ES 530916A ES 8505972 A1 ES8505972 A1 ES 8505972A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally substituted
- lower alkyl
- hydrogen
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIRIMIDINA DE FORMULA GENERAL (I), Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III) O CON SUS SALES.DE APLICACION COMO AGENTE CARDIOTONICO, COMO AGENTE ANTIHIPERTENSOR, COMO VASODILATADOR CEREBROVASCULAR Y COMO AGENTE ANTI-PLAQUETAS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838308290A GB8308290D0 (en) | 1983-03-25 | 1983-03-25 | Pyrimidinone derivatives |
GB838315542A GB8315542D0 (en) | 1983-06-07 | 1983-06-07 | Pyrimidinone derivatives |
GB838327859A GB8327859D0 (en) | 1983-10-18 | 1983-10-18 | Pyrimidine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES530916A0 ES530916A0 (es) | 1985-06-16 |
ES8505972A1 true ES8505972A1 (es) | 1985-06-16 |
Family
ID=27262023
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530916A Expired ES8505972A1 (es) | 1983-03-25 | 1984-03-23 | Un procedimiento para preparar derivados de pirimidina |
ES538190A Granted ES538190A0 (es) | 1983-03-25 | 1984-11-30 | Un procedimiento para preparar derivados de pirimidina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538190A Granted ES538190A0 (es) | 1983-03-25 | 1984-11-30 | Un procedimiento para preparar derivados de pirimidina |
Country Status (13)
Country | Link |
---|---|
US (3) | US4612376A (es) |
EP (1) | EP0123402B1 (es) |
KR (1) | KR840008333A (es) |
CA (1) | CA1256107A (es) |
DE (1) | DE3473875D1 (es) |
DK (1) | DK160492C (es) |
ES (2) | ES8505972A1 (es) |
FI (1) | FI841128A (es) |
GR (1) | GR81758B (es) |
HU (1) | HU195195B (es) |
NO (1) | NO841168L (es) |
PH (1) | PH22022A (es) |
SU (2) | SU1349698A3 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
US4598149A (en) * | 1984-03-02 | 1986-07-01 | Merck & Co., Inc. | 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents |
US4649142A (en) * | 1984-06-25 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | 3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)-pyrimidinone useful as cardiotonic agent and anti-allergic agent |
US4708958A (en) * | 1986-09-24 | 1987-11-24 | G. D. Searle & Co. | 6-(imidazolyphenyl)-4-iminopyrimidinones useful as hypotensive agents |
US5521315A (en) * | 1993-01-12 | 1996-05-28 | Cell Therapeutics, Inc. | Olefin substituted long chain compounds |
IT1270122B (it) * | 1994-10-04 | 1997-04-28 | Ist Superiore Sanita | 6-benzil-4-ossopirimidine sostituite, processo per la loro preparazione e composizioni farmaceutiche che le contengono |
US6244121B1 (en) * | 1998-03-06 | 2001-06-12 | Applied Materials, Inc. | Sensor device for non-intrusive diagnosis of a semiconductor processing system |
GEP20084540B (en) | 2003-01-14 | 2008-11-25 | Arena Pharm Inc | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
TWI335328B (en) | 2003-07-14 | 2011-01-01 | Arena Pharm Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related hereto |
DOP2006000009A (es) | 2005-01-13 | 2006-08-15 | Arena Pharm Inc | Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina |
JP5113752B2 (ja) | 2005-08-22 | 2013-01-09 | メリオール・ファーマスーティカルズ・ワン・インコーポレイテッド | Lynキナーゼの活性を調節し、関連する疾患を治療するための方法および製剤 |
BRPI0807928A2 (pt) * | 2007-02-20 | 2014-07-08 | Melior Pharmaceuticals I Inc | Métodos para identificar um ativador de lyn quinase, e para tratar diabetes em um humano, kit, e, composição |
US20100197710A1 (en) * | 2007-07-23 | 2010-08-05 | Melior Pharmaceuticals I, Inc. | Methods Of Activating IRS-1 And AKT |
US8552184B2 (en) * | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
EP2462123B1 (en) * | 2009-08-04 | 2013-10-02 | Merck Sharp & Dohme Corp. | 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors |
CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
WO2011150300A1 (en) | 2010-05-28 | 2011-12-01 | Melior Pharmaceuticals I, Inc. | Prevention of pancreatic beta cell degeneration |
PE20131371A1 (es) | 2010-09-22 | 2013-11-25 | Arena Pharm Inc | Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con este |
US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
EP3187492A4 (en) * | 2014-08-29 | 2018-05-09 | The University of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
NZ734220A (en) | 2015-01-06 | 2022-01-28 | Arena Pharm Inc | Methods of treating conditions related to the s1p1 receptor |
IL285890B (en) | 2015-06-22 | 2022-07-01 | Arena Pharm Inc | Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid |
US11534424B2 (en) | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
CA3059432A1 (en) | 2017-04-10 | 2018-10-18 | Melior Pharmaceuticals I, Inc. | Compositions comprising a lyn kinase activator and a trpms agonist |
CN109053589A (zh) * | 2018-09-30 | 2018-12-21 | 浙江师范大学 | 4-亚胺基四氢嘧啶-2-酮类化合物的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1296371A (es) * | 1969-02-26 | 1972-11-15 | ||
AU1108070A (en) * | 1969-03-06 | 1971-08-12 | Imperial Chemical Industries Limited | Pyrimidine derivatives |
GB1336138A (en) * | 1969-12-10 | 1973-11-07 | Ici Ltd | Process for the production of pyrimidine derivatives |
US3923807A (en) * | 1973-09-10 | 1975-12-02 | Takeda Chemical Industries Ltd | 6-Aminouracil derivatives |
JPS5053381A (es) * | 1973-09-20 | 1975-05-12 | ||
US4208366A (en) * | 1978-10-31 | 1980-06-17 | E. I. Du Pont De Nemours And Company | Process for preparing a nonwoven web |
DE2847693A1 (de) * | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
-
1984
- 1984-03-12 US US06/588,902 patent/US4612376A/en not_active Expired - Fee Related
- 1984-03-14 EP EP84301741A patent/EP0123402B1/en not_active Expired
- 1984-03-14 DE DE8484301741T patent/DE3473875D1/de not_active Expired
- 1984-03-14 PH PH30400A patent/PH22022A/en unknown
- 1984-03-14 GR GR74104A patent/GR81758B/el unknown
- 1984-03-20 KR KR1019840001414A patent/KR840008333A/ko not_active Application Discontinuation
- 1984-03-21 FI FI841128A patent/FI841128A/fi not_active Application Discontinuation
- 1984-03-21 CA CA000450076A patent/CA1256107A/en not_active Expired
- 1984-03-23 NO NO841168A patent/NO841168L/no unknown
- 1984-03-23 DK DK166884A patent/DK160492C/da active IP Right Grant
- 1984-03-23 HU HU841170A patent/HU195195B/hu not_active IP Right Cessation
- 1984-03-23 SU SU843718401A patent/SU1349698A3/ru active
- 1984-03-23 ES ES530916A patent/ES8505972A1/es not_active Expired
- 1984-11-30 ES ES538190A patent/ES538190A0/es active Granted
-
1985
- 1985-03-28 SU SU853892541A patent/SU1436872A3/ru active
-
1986
- 1986-06-05 US US06/870,826 patent/US4746664A/en not_active Expired - Fee Related
-
1988
- 1988-03-25 US US07/173,584 patent/US4824851A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO841168L (no) | 1984-09-26 |
ES8601922A1 (es) | 1985-11-01 |
KR840008333A (ko) | 1984-12-14 |
CA1256107A (en) | 1989-06-20 |
US4824851A (en) | 1989-04-25 |
SU1436872A3 (ru) | 1988-11-07 |
SU1349698A3 (ru) | 1987-10-30 |
US4746664A (en) | 1988-05-24 |
DK160492C (da) | 1991-08-26 |
EP0123402B1 (en) | 1988-09-07 |
FI841128A (fi) | 1984-09-26 |
EP0123402A3 (en) | 1985-09-18 |
ES530916A0 (es) | 1985-06-16 |
PH22022A (en) | 1988-05-13 |
DK166884D0 (da) | 1984-03-23 |
DK160492B (da) | 1991-03-18 |
US4612376A (en) | 1986-09-16 |
FI841128A0 (fi) | 1984-03-21 |
DE3473875D1 (en) | 1988-10-13 |
ES538190A0 (es) | 1985-11-01 |
GR81758B (es) | 1984-12-12 |
DK166884A (da) | 1984-09-26 |
HU195195B (en) | 1988-04-28 |
EP0123402A2 (en) | 1984-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |