SK285362B6 - Kryštalická polymorfná forma I (-)-[[4-(1,4,5,6-tetrahydro-4- metyl-6-oxo-3-pyridazinyl) fenyl]hydrazono]propándinitrilu a spôsoby jej prípravy - Google Patents

Kryštalická polymorfná forma I (-)-[[4-(1,4,5,6-tetrahydro-4- metyl-6-oxo-3-pyridazinyl) fenyl]hydrazono]propándinitrilu a spôsoby jej prípravy Download PDF

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Publication number
SK285362B6
SK285362B6 SK1316-98A SK131698A SK285362B6 SK 285362 B6 SK285362 B6 SK 285362B6 SK 131698 A SK131698 A SK 131698A SK 285362 B6 SK285362 B6 SK 285362B6
Authority
SK
Slovakia
Prior art keywords
methyl
pyridazinyl
tetrahydro
oxo
phenyl
Prior art date
Application number
SK1316-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK131698A3 (en
Inventor
Mika Timmerbacka
Jorma Lehtonen
Veli Pekka Tanninen
Esa Muttonen
Jukka Kaukonen
Riikka HYPP�L�
Reijo B�CKSTR�M
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of SK131698A3 publication Critical patent/SK131698A3/sk
Publication of SK285362B6 publication Critical patent/SK285362B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
SK1316-98A 1996-03-27 1997-03-27 Kryštalická polymorfná forma I (-)-[[4-(1,4,5,6-tetrahydro-4- metyl-6-oxo-3-pyridazinyl) fenyl]hydrazono]propándinitrilu a spôsoby jej prípravy SK285362B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9606474.6A GB9606474D0 (en) 1996-03-27 1996-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative
PCT/FI1997/000196 WO1997035841A2 (en) 1996-03-27 1997-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative

Publications (2)

Publication Number Publication Date
SK131698A3 SK131698A3 (en) 2000-04-10
SK285362B6 true SK285362B6 (sk) 2006-11-03

Family

ID=10791141

Family Applications (3)

Application Number Title Priority Date Filing Date
SK1316-98A SK285362B6 (sk) 1996-03-27 1997-03-27 Kryštalická polymorfná forma I (-)-[[4-(1,4,5,6-tetrahydro-4- metyl-6-oxo-3-pyridazinyl) fenyl]hydrazono]propándinitrilu a spôsoby jej prípravy
SK5035-2005A SK285363B6 (sk) 1996-03-27 1997-03-27 Spôsob optického štiepenia racemického 6-(4-aminofenyl)-4,5- dihydro-5-metyl-3(2H)-pyridazinónu na enantioméry
SK5004-2006A SK285364B6 (sk) 1996-03-27 1997-03-27 Spôsob výroby čistých enantiomérov derivátu pyridazinónu

Family Applications After (2)

Application Number Title Priority Date Filing Date
SK5035-2005A SK285363B6 (sk) 1996-03-27 1997-03-27 Spôsob optického štiepenia racemického 6-(4-aminofenyl)-4,5- dihydro-5-metyl-3(2H)-pyridazinónu na enantioméry
SK5004-2006A SK285364B6 (sk) 1996-03-27 1997-03-27 Spôsob výroby čistých enantiomérov derivátu pyridazinónu

Country Status (23)

Country Link
US (1) US6180789B1 (cs)
EP (3) EP2143715B1 (cs)
JP (3) JP4179630B2 (cs)
AT (3) ATE465154T1 (cs)
AU (1) AU715887B2 (cs)
BR (1) BR9708353A (cs)
CA (1) CA2250062C (cs)
CZ (3) CZ294964B6 (cs)
DE (2) DE69733748T2 (cs)
DK (2) DK0894087T3 (cs)
ES (3) ES2343525T3 (cs)
GB (1) GB9606474D0 (cs)
HU (1) HU227541B1 (cs)
MX (1) MXPA98007851A (cs)
NO (1) NO312193B1 (cs)
NZ (1) NZ332010A (cs)
PL (3) PL189963B1 (cs)
PT (3) PT2143715E (cs)
SI (2) SI0894087T1 (cs)
SK (3) SK285362B6 (cs)
TR (1) TR199801921T2 (cs)
WO (1) WO1997035841A2 (cs)
ZA (1) ZA972729B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI105389B (fi) * 1998-04-23 2000-08-15 Orion Yhtymae Oyj Menetelmä levosimendaaniannon siedettävyyden seuraamiseksi
FI104718B (fi) 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) * 1998-06-19 1999-05-18 Orion Corporation Use of a pyridazinone derivative
FI109659B (fi) 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
EP1943248A2 (en) * 2006-08-03 2008-07-16 Teva Pharmaceutical Industries Ltd. Solifenacin base forms and preparation thereof
JP5747030B2 (ja) * 2009-07-14 2015-07-08 シプラ・リミテッド レボシメンダンの製造方法及びその方法で用いる中間体
JP5482926B2 (ja) * 2011-02-28 2014-05-07 株式会社リコー 伝送管理装置
CN103554033A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
EP3424908A1 (en) * 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Process for preparation of levosimendan
US11760730B2 (en) * 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
US4946842A (en) 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
MXPA98007851A (es) 2006-06-07
EP2143715A1 (en) 2010-01-13
DE69739858D1 (de) 2010-06-02
US6180789B1 (en) 2001-01-30
JP4179630B2 (ja) 2008-11-12
JP2008179645A (ja) 2008-08-07
JP2011236251A (ja) 2011-11-24
CA2250062C (en) 2006-11-14
PT894087E (pt) 2005-09-30
HUP9904150A3 (en) 2000-11-28
EP2143715B1 (en) 2011-09-21
ATE465154T1 (de) 2010-05-15
AU2162697A (en) 1997-10-17
NO312193B1 (no) 2002-04-08
DK2143715T3 (da) 2011-12-05
WO1997035841A3 (en) 1998-01-22
JP5277295B2 (ja) 2013-08-28
PL189963B1 (pl) 2005-10-31
PL329068A1 (en) 1999-03-15
TR199801921T2 (xx) 1998-12-21
SK285363B6 (sk) 2006-11-03
SI2143715T1 (sl) 2012-01-31
PT2143715E (pt) 2011-10-11
NO984487D0 (no) 1998-09-25
ES2243988T3 (es) 2005-12-01
JP4825825B2 (ja) 2011-11-30
GB9606474D0 (en) 1996-06-05
HUP9904150A2 (hu) 2000-09-28
ATE299867T1 (de) 2005-08-15
CZ304198A3 (cs) 1999-03-17
DE69733748D1 (de) 2005-08-25
DK0894087T3 (da) 2005-09-19
JP2000515492A (ja) 2000-11-21
CZ295001B6 (cs) 2005-05-18
DE69733748T2 (de) 2006-04-20
ES2343525T3 (es) 2010-08-03
SI0894087T1 (en) 2005-10-31
NO984487L (no) 1998-11-26
CZ294964B6 (cs) 2005-04-13
EP1619186A1 (en) 2006-01-25
HU227541B1 (en) 2011-08-29
CZ295002B6 (cs) 2005-05-18
NZ332010A (en) 2000-02-28
EP0894087A2 (en) 1999-02-03
AU715887B2 (en) 2000-02-10
PL190573B1 (pl) 2005-12-30
PL190574B1 (pl) 2005-12-30
WO1997035841A2 (en) 1997-10-02
PT1619186E (pt) 2010-06-04
ATE525361T1 (de) 2011-10-15
ES2370760T3 (es) 2011-12-22
BR9708353A (pt) 1999-08-03
SK131698A3 (en) 2000-04-10
SK285364B6 (sk) 2006-11-03
CA2250062A1 (en) 1997-10-02
EP1619186B1 (en) 2010-04-21
EP0894087B1 (en) 2005-07-20
ZA972729B (en) 1997-10-30

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Expiry date: 20170327