DK2861599T3 - Reversible kovalente pyrrolo- eller pyrazolopyrimidiner, der er nyttige til behandling af cancer og autoimmunsygdomme - Google Patents
Reversible kovalente pyrrolo- eller pyrazolopyrimidiner, der er nyttige til behandling af cancer og autoimmunsygdomme Download PDFInfo
- Publication number
- DK2861599T3 DK2861599T3 DK13731218.7T DK13731218T DK2861599T3 DK 2861599 T3 DK2861599 T3 DK 2861599T3 DK 13731218 T DK13731218 T DK 13731218T DK 2861599 T3 DK2861599 T3 DK 2861599T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazolopyrimidines
- pyrrolo
- auto
- treating cancer
- immune diseases
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661203P | 2012-06-18 | 2012-06-18 | |
| PCT/US2013/045266 WO2013191965A1 (en) | 2012-06-18 | 2013-06-11 | Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2861599T3 true DK2861599T3 (da) | 2020-03-02 |
Family
ID=48692669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13731218.7T DK2861599T3 (da) | 2012-06-18 | 2013-06-11 | Reversible kovalente pyrrolo- eller pyrazolopyrimidiner, der er nyttige til behandling af cancer og autoimmunsygdomme |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20160045503A1 (da) |
| EP (1) | EP2861599B1 (da) |
| JP (1) | JP6189945B2 (da) |
| KR (1) | KR102150432B1 (da) |
| CN (1) | CN104487441B (da) |
| AU (1) | AU2013277582B2 (da) |
| CA (1) | CA2874461C (da) |
| DK (1) | DK2861599T3 (da) |
| ES (1) | ES2776175T3 (da) |
| HK (1) | HK1209103A1 (da) |
| MX (1) | MX368112B (da) |
| WO (1) | WO2013191965A1 (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8962831B2 (en) | 2011-05-17 | 2015-02-24 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| WO2012158795A1 (en) | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| BR112014000653A2 (pt) | 2011-07-13 | 2017-02-14 | Pharmacyclics Inc | inibidores de tirosina quinase de bruton |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| KR20150015021A (ko) | 2012-06-04 | 2015-02-09 | 파마시클릭스, 인코포레이티드 | 브루톤 타이로신 키나아제 저해제의 결정 형태 |
| EP2890691B1 (en) * | 2012-08-31 | 2018-04-25 | Principia Biopharma Inc. | Benzimidazole derivatives as itk inhibitors |
| WO2014039899A1 (en) | 2012-09-10 | 2014-03-13 | Principia Biopharma Inc. | Pyrazolopyrimidine compounds as kinase inhibitors |
| PE20151495A1 (es) | 2012-11-15 | 2015-10-23 | Pharmacyclics Inc | Compuestos de pirrolopirimidina como inhibidores de quinasas |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| MA38961A1 (fr) | 2013-09-30 | 2018-05-31 | Pharmacyclics Llc | Composés 3-phenyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine substitués inhibiteurs de la tyrosine kinase de bruton utilisés pour traiter par exemple les maladies auto-immunes, respiratoires et inflammatoires, cancer, mastocytose et osteoporose |
| BR112016018948B1 (pt) | 2014-02-21 | 2023-01-17 | Principia Biopharma Inc | Uso de composto ou sal farmaceuticamente aceitável, ácido sulfônico ou sal de ácido carboxílico de composto, forma amorfa de sal farmaceuticamente aceitável de composto, composição farmacêutica e respectivo uso |
| CA2942204A1 (en) | 2014-03-12 | 2015-09-17 | Novartis Ag | Combination comprising a btk inhibitor and an akt inhibitor |
| CN105017256A (zh) * | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CA2959602A1 (en) | 2014-08-01 | 2016-02-04 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| WO2016022942A1 (en) | 2014-08-07 | 2016-02-11 | Pharmacyclics Llc | Novel formulations of a bruton's tyrosine kinase inhibitor |
| EP3221320A4 (en) * | 2014-11-19 | 2018-04-25 | Sun Pharmaceutical Industries Ltd | A process for the preparation of ibrutinib |
| MA41197B1 (fr) | 2014-12-18 | 2021-01-29 | Principia Biopharma Inc | Traitement de le pemphigus |
| SG11201705026UA (en) * | 2014-12-24 | 2017-07-28 | Principia Biopharma Inc | Site specific dosing of a btk inhibitor |
| HUE061809T2 (hu) * | 2014-12-24 | 2023-08-28 | Principia Biopharma Inc | Készítmények csípõbél-éhbél szakaszba történõ hatóanyag beadáshoz |
| RU2017133990A (ru) | 2015-03-03 | 2019-04-05 | Фармасайкликс Элэлси | Фармацевтические лекарственные формы ингибитора тирозинкиназы брутона |
| CN106146508A (zh) * | 2015-03-19 | 2016-11-23 | 浙江导明医药科技有限公司 | 优化的联合用药及其治疗癌症和自身免疫疾病的用途 |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| WO2016154998A1 (zh) * | 2015-04-03 | 2016-10-06 | 安润医药科技（苏州）有限公司 | 吡唑并嘧啶衍生物、制备方法、药物组合物及用途 |
| CN106146511A (zh) * | 2015-04-03 | 2016-11-23 | 安润医药科技（苏州）有限公司 | 吡唑并嘧啶衍生物、制备方法、药物组合物及用途 |
| KR102552653B1 (ko) * | 2015-06-03 | 2023-07-07 | 프린시피아 바이오파마, 인코퍼레이티드 | 티로신 키나제 억제제 |
| US20180305350A1 (en) | 2015-06-24 | 2018-10-25 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| WO2017027883A1 (en) * | 2015-08-13 | 2017-02-16 | San Diego State University Research Foundation | Atropisomerism for increased kinase inhibitor selectivity |
| EA201890730A1 (ru) | 2015-09-16 | 2018-10-31 | Локсо Онколоджи, Инк. | Производные пиразолопиримидина в качестве ингибиторов btk для лечения злокачественного новообразования |
| SG10202012498TA (en) | 2015-12-16 | 2021-01-28 | Loxo Oncology Inc | Compounds useful as kinase inhibitors |
| UA123785C2 (uk) | 2016-03-28 | 2021-06-02 | Інсайт Корпорейшн | Сполуки піролотриазину як інгібітори tam |
| WO2017198049A1 (zh) * | 2016-05-16 | 2017-11-23 | 浙江予川医药科技有限公司 | 作为btk抑制剂的吡唑并嘧啶衍生物及其制备方法和药物组合物 |
| MA45547A (fr) | 2016-06-29 | 2019-05-08 | Principia Biopharma Inc | Formulations à libération modifiée à base de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl)pipérazine-1-yl]pent-2-ènenitrile |
| TW201922256A (zh) | 2017-10-27 | 2019-06-16 | 中國大陸商浙江導明醫藥科技有限公司 | 治療淋巴樣惡性疾病之方法 |
| CN110483521B (zh) * | 2018-05-14 | 2022-06-07 | 杭州和正医药有限公司 | 一种可逆共价布鲁顿酪氨酸激酶抑制剂、药物组合物及其应用 |
| KR102300092B1 (ko) * | 2018-11-05 | 2021-09-09 | 가톨릭대학교 산학협력단 | pH 민감성 탄소 나노입자, 이의 제조방법 및 이를 이용한 약물전달 |
| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药（上海）有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| WO2021029467A1 (en) * | 2019-08-14 | 2021-02-18 | Sam Chun Dang Pharm. Co., Ltd. | A solid dosage form for orally administration |
| CN110448557A (zh) * | 2019-09-05 | 2019-11-15 | 黄筱茜 | 抗凝血药达比加群酯的新药用途 |
| TW202142237A (zh) | 2020-01-08 | 2021-11-16 | 美商普林斯匹亞生物製藥公司 | 包含2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)-1h-吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4,4-二甲基戊-2-烯腈之局部醫藥組成物 |
| CA3194724A1 (en) * | 2020-10-05 | 2022-04-14 | Dana-Farber Cancer Institute, Inc. | Potent and selective inhibitors of her2 |
| US11912668B2 (en) | 2020-11-18 | 2024-02-27 | Deciphera Pharmaceuticals, Llc | GCN2 and perk kinase inhibitors and methods of use thereof |
| WO2022137240A1 (en) * | 2020-12-23 | 2022-06-30 | Yeda Research And Development Co. Ltd. | Methacrylamides protein binders and uses thereof |
| KR20230167914A (ko) * | 2022-06-03 | 2023-12-12 | 주식회사 서흥 | 장용성 경질캡슐의 제조를 위한 밴딩 용액과 이를 이용하여 제조한 장용성 경질캡슐 |
| WO2023242597A1 (en) * | 2022-06-16 | 2023-12-21 | Amphista Therapeutics Limited | Bifunctional molecules for targeted protein degradation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2809918A (en) | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
| DE2010416B2 (de) | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
| US4728512A (en) | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
| US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| US20060045822A1 (en) | 2004-09-01 | 2006-03-02 | Board Of Regents, The University Of Texas System | Plasma polymerization for encapsulating particles |
| SI2526934T1 (sl) * | 2006-09-22 | 2016-04-29 | Pharmacyclics Llc | Inhibitorji Bruton tirozin kinaze |
| JP2013510886A (ja) | 2009-11-16 | 2013-03-28 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・カリフオルニア | キナーゼ阻害剤 |
| US9580427B2 (en) * | 2011-05-17 | 2017-02-28 | The Regents Of The University Of California | Kinase inhibitors |
| US8962831B2 (en) * | 2011-05-17 | 2015-02-24 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
-
2013
- 2013-06-11 MX MX2014015346A patent/MX368112B/es active IP Right Grant
- 2013-06-11 KR KR1020157000923A patent/KR102150432B1/ko active IP Right Grant
- 2013-06-11 WO PCT/US2013/045266 patent/WO2013191965A1/en active Application Filing
- 2013-06-11 ES ES13731218T patent/ES2776175T3/es active Active
- 2013-06-11 EP EP13731218.7A patent/EP2861599B1/en active Active
- 2013-06-11 JP JP2015517370A patent/JP6189945B2/ja active Active
- 2013-06-11 DK DK13731218.7T patent/DK2861599T3/da active
- 2013-06-11 US US14/403,744 patent/US20160045503A1/en not_active Abandoned
- 2013-06-11 AU AU2013277582A patent/AU2013277582B2/en active Active
- 2013-06-11 CN CN201380031739.2A patent/CN104487441B/zh active Active
- 2013-06-11 CA CA2874461A patent/CA2874461C/en active Active
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2015
- 2015-10-02 HK HK15109678.3A patent/HK1209103A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX368112B (es) | 2019-09-18 |
| WO2013191965A1 (en) | 2013-12-27 |
| EP2861599B1 (en) | 2019-12-18 |
| JP6189945B2 (ja) | 2017-08-30 |
| US20160045503A1 (en) | 2016-02-18 |
| ES2776175T3 (es) | 2020-08-14 |
| HK1209103A1 (en) | 2016-03-24 |
| CA2874461C (en) | 2021-10-12 |
| AU2013277582B2 (en) | 2017-11-30 |
| AU2013277582A1 (en) | 2015-01-22 |
| CA2874461A1 (en) | 2013-12-27 |
| EP2861599A1 (en) | 2015-04-22 |
| KR102150432B1 (ko) | 2020-09-01 |
| MX2014015346A (es) | 2015-03-05 |
| JP2015519401A (ja) | 2015-07-09 |
| CN104487441B (zh) | 2018-06-01 |
| CN104487441A (zh) | 2015-04-01 |
| KR20150023752A (ko) | 2015-03-05 |
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