SI2710005T1 - Zaviralci tirozinske kinaze - Google Patents
Zaviralci tirozinske kinazeInfo
- Publication number
- SI2710005T1 SI2710005T1 SI201230743A SI201230743A SI2710005T1 SI 2710005 T1 SI2710005 T1 SI 2710005T1 SI 201230743 A SI201230743 A SI 201230743A SI 201230743 A SI201230743 A SI 201230743A SI 2710005 T1 SI2710005 T1 SI 2710005T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tyrosine kinase
- kinase inhibitors
- inhibitors
- tyrosine
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486944P | 2011-05-17 | 2011-05-17 | |
| US201161514892P | 2011-08-03 | 2011-08-03 | |
| US201161556336P | 2011-11-07 | 2011-11-07 | |
| US201261618152P | 2012-03-30 | 2012-03-30 | |
| EP12722662.9A EP2710005B1 (en) | 2011-05-17 | 2012-05-16 | Tyrosine kinase inhibitors |
| PCT/US2012/038092 WO2012158764A1 (en) | 2011-05-17 | 2012-05-16 | Tyrosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2710005T1 true SI2710005T1 (sl) | 2017-03-31 |
Family
ID=46147109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201230743A SI2710005T1 (sl) | 2011-05-17 | 2012-05-16 | Zaviralci tirozinske kinaze |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8962831B2 (sl) |
| EP (1) | EP2710005B1 (sl) |
| JP (1) | JP5974084B2 (sl) |
| KR (1) | KR102027598B1 (sl) |
| CN (1) | CN103534258B (sl) |
| AU (3) | AU2012255860C1 (sl) |
| CA (1) | CA2836410C (sl) |
| EA (1) | EA025496B1 (sl) |
| ES (1) | ES2604191T3 (sl) |
| HR (1) | HRP20170017T1 (sl) |
| HU (1) | HUE033019T2 (sl) |
| MX (1) | MX347040B (sl) |
| PL (1) | PL2710005T3 (sl) |
| PT (1) | PT2710005T (sl) |
| SI (1) | SI2710005T1 (sl) |
| WO (1) | WO2012158764A1 (sl) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| US20110224235A1 (en) | 2008-07-16 | 2011-09-15 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
| CA3007787C (en) | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| BR112013029508B1 (pt) * | 2011-05-17 | 2022-05-03 | Principia Biopharma, Inc. | Composto, composição farmacêutica, e, uso do referido composto |
| US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| CA2836410C (en) | 2011-05-17 | 2019-08-20 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| WO2013010136A2 (en) | 2011-07-13 | 2013-01-17 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| MY187999A (en) | 2012-06-04 | 2021-11-08 | Pharmacyclics Llc | Crystalline forms of a bruton's tyrosine kinase inhibitor |
| DK2861599T3 (da) * | 2012-06-18 | 2020-03-02 | Principia Biopharma Inc | Reversible kovalente pyrrolo- eller pyrazolopyrimidiner, der er nyttige til behandling af cancer og autoimmunsygdomme |
| WO2014018567A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| US9573958B2 (en) | 2012-08-31 | 2017-02-21 | Principia Biopharma, Inc. | Benzimidazole derivatives as ITK inhibitors |
| KR102203990B1 (ko) * | 2012-09-10 | 2021-01-18 | 프린시피아 바이오파마, 인코퍼레이티드 | 키나제 저해제로서의 피라졸로피리미딘 화합물 |
| WO2014078578A1 (en) * | 2012-11-15 | 2014-05-22 | Pharmacyclics, Inc. | Pyrrolopyrimidine compounds as kinase inhibitors |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| JP6204568B2 (ja) | 2013-04-25 | 2017-09-27 | ベイジーン，リミテッド | タンパク質キナーゼ阻害剤としての縮合複素環化合物 |
| GB201309085D0 (en) | 2013-05-20 | 2013-07-03 | Redx Pharma Ltd | Compounds |
| JP6139782B2 (ja) * | 2013-05-21 | 2017-05-31 | チャンスー メドリューション リミテッド | 置換ピラゾロピリミジン化合物、及びその薬学的に許容される塩、並びにこれらの溶媒和物、立体異性体、及び互変異性体、並びにこれらを含む医薬組成物 |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
| CN112552401B (zh) | 2013-09-13 | 2023-08-25 | 广州百济神州生物制药有限公司 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
| US9624224B2 (en) | 2013-09-30 | 2017-04-18 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| PT3107544T (pt) | 2014-02-21 | 2021-01-05 | Principia Biopharma Inc | Sais e forma sólida de um inibidor de btk |
| JP2017509336A (ja) | 2014-03-20 | 2017-04-06 | ファーマサイクリックス エルエルシー | ホスホリパーゼｃガンマ２及び耐性に関連した変異 |
| CN105017256A (zh) * | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CN110156892B (zh) | 2014-07-03 | 2023-05-16 | 百济神州有限公司 | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 |
| WO2016019233A1 (en) | 2014-08-01 | 2016-02-04 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| US9545407B2 (en) | 2014-08-07 | 2017-01-17 | Pharmacyclics Llc | Formulations of a bruton's tyrosine kinase inhibitor |
| CN105399756B (zh) * | 2014-09-05 | 2019-06-25 | 广东东阳光药业有限公司 | Btk抑制剂及其用途 |
| EP3233103B1 (en) | 2014-12-18 | 2020-10-14 | Principia Biopharma Inc. | Treatment of pemphigus |
| CN105820168B (zh) * | 2015-01-09 | 2018-12-04 | 上海医药工业研究院 | 一种依鲁替尼中间体的制备方法 |
| CN104557945B (zh) * | 2015-01-27 | 2017-08-04 | 安润医药科技（苏州）有限公司 | 依鲁替尼合成方法 |
| TW202315634A (zh) | 2015-03-03 | 2023-04-16 | 美商製藥公司 | 布魯東氏（ｂｒｕｔｏｎ’ｓ）酪胺酸激酶抑制劑之醫藥調配物 |
| CN106146508A (zh) * | 2015-03-19 | 2016-11-23 | 浙江导明医药科技有限公司 | 优化的联合用药及其治疗癌症和自身免疫疾病的用途 |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| CN106146512B (zh) * | 2015-04-09 | 2018-07-17 | 北京睿创康泰医药研究院有限公司 | 依鲁替尼的制备方法 |
| CN104844580B (zh) * | 2015-04-17 | 2017-10-20 | 中国药科大学 | 嘧啶类化合物、其制备方法及医药用途 |
| CN106188062A (zh) * | 2015-05-08 | 2016-12-07 | 苏州鹏旭医药科技有限公司 | 依鲁替尼的制备方法、依鲁替尼的中间体及中间体的制备方法 |
| KR102552653B1 (ko) * | 2015-06-03 | 2023-07-07 | 프린시피아 바이오파마, 인코퍼레이티드 | 티로신 키나제 억제제 |
| WO2016210165A1 (en) * | 2015-06-24 | 2016-12-29 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| WO2017027883A1 (en) | 2015-08-13 | 2017-02-16 | San Diego State University Research Foundation | Atropisomerism for increased kinase inhibitor selectivity |
| CA2997051C (en) * | 2015-09-01 | 2020-03-24 | Taiho Pharmaceutical Co., Ltd. | Novel pyrazolo[3,4-d]pyrimidine compound or salt thereof |
| KR20180109842A (ko) | 2015-09-16 | 2018-10-08 | 록쏘 온콜로지, 인코포레이티드 | 화합물 |
| CA3008488C (en) | 2015-12-16 | 2023-10-10 | Loxo Oncology, Inc. | Compounds useful as kinase inhibitors |
| CN107021963A (zh) | 2016-01-29 | 2017-08-08 | 北京诺诚健华医药科技有限公司 | 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用 |
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| CN115054586A (zh) | 2016-06-29 | 2022-09-16 | 普林斯匹亚生物制药公司 | 改性的释放制剂 |
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| KR20220124752A (ko) | 2020-01-08 | 2022-09-14 | 프린시피아 바이오파마, 인코퍼레이티드 | 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)-1h-피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4,4-디메틸펜트-2-엔니트릴의 결정 형태 |
| CA3175788A1 (en) | 2020-04-22 | 2021-10-28 | Claire LANGRISH | Treatment of acute respiratory distress syndrome and other disorders involving cytokine storm using btk inhibitors |
| CN111481671A (zh) * | 2020-05-26 | 2020-08-04 | 华中科技大学同济医学院附属协和医院 | 酪氨酸激酶抑制剂在制备***性红斑狼疮脑病药物中的应用 |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
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- 2012-05-16 MX MX2013013294A patent/MX347040B/es active IP Right Grant
- 2012-05-16 EA EA201391528A patent/EA025496B1/ru not_active IP Right Cessation
- 2012-05-16 WO PCT/US2012/038092 patent/WO2012158764A1/en active Application Filing
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- 2012-05-16 HU HUE12722662A patent/HUE033019T2/en unknown
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| US8962831B2 (en) | 2015-02-24 |
| MX2013013294A (es) | 2014-04-25 |
| PL2710005T3 (pl) | 2017-07-31 |
| KR102027598B1 (ko) | 2019-10-01 |
| AU2015243110A1 (en) | 2015-11-05 |
| CA2836410C (en) | 2019-08-20 |
| AU2012255860B2 (en) | 2015-07-23 |
| EP2710005A1 (en) | 2014-03-26 |
| EA201391528A1 (ru) | 2014-09-30 |
| CN103534258A (zh) | 2014-01-22 |
| JP5974084B2 (ja) | 2016-08-23 |
| CA2836410A1 (en) | 2012-11-22 |
| MX347040B (es) | 2017-04-10 |
| WO2012158764A1 (en) | 2012-11-22 |
| US20140094459A1 (en) | 2014-04-03 |
| CN103534258B (zh) | 2016-09-14 |
| AU2012255860A1 (en) | 2013-04-18 |
| KR20140058438A (ko) | 2014-05-14 |
| US20150353557A1 (en) | 2015-12-10 |
| JP2014517838A (ja) | 2014-07-24 |
| AU2012255860C1 (en) | 2015-12-10 |
| EP2710005B1 (en) | 2016-10-05 |
| EA025496B1 (ru) | 2016-12-30 |
| HRP20170017T1 (hr) | 2017-02-24 |
| PT2710005T (pt) | 2016-11-16 |
| ES2604191T3 (es) | 2017-03-03 |
| AU2015243110B2 (en) | 2018-05-24 |
| HUE033019T2 (en) | 2017-11-28 |
| AU2018208715A1 (en) | 2018-08-16 |
| BR112013028846A2 (pt) | 2020-01-21 |
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