SA520411112B1 - عملية محسّنة لتحضير مشتقات أمينو بيريميدين - Google Patents
عملية محسّنة لتحضير مشتقات أمينو بيريميدينInfo
- Publication number
- SA520411112B1 SA520411112B1 SA520411112A SA520411112A SA520411112B1 SA 520411112 B1 SA520411112 B1 SA 520411112B1 SA 520411112 A SA520411112 A SA 520411112A SA 520411112 A SA520411112 A SA 520411112A SA 520411112 B1 SA520411112 B1 SA 520411112B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- preparing
- improved process
- aminopyrimidine derivatives
- protein kinases
- present
- Prior art date
Links
- 150000005005 aminopyrimidines Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108060006633 protein kinase Proteins 0.000 abstract 2
- 102000001301 EGF receptor Human genes 0.000 abstract 1
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/22—Tin compounds
- C07F7/2284—Compounds with one or more Sn-N linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
يوفر الاختراع الحالي عملية محسّنة لتحضير مشتقات أمينو بيريميدين أو أملاح منه مقبولة صيدلانيًا تتميز بنشاط تثبيطي انتقائي ضد كينازات البروتين، وخاصة ضد كينازات البروتين لمستقبلات عوامل النمو البشروية الطافرة. ويوفر الاختراع الحالي أيضًا مركبات وسيطة جديدة مفيدة للعملية المذكورة ولعمليات من أجل تحضيرها.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20170096212 | 2017-07-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
SA520411112B1 true SA520411112B1 (ar) | 2022-02-21 |
Family
ID=65040211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA520411112A SA520411112B1 (ar) | 2017-07-28 | 2020-01-21 | عملية محسّنة لتحضير مشتقات أمينو بيريميدين |
Country Status (31)
Country | Link |
---|---|
US (4) | US10889578B2 (ar) |
EP (1) | EP3658552B1 (ar) |
JP (2) | JP7228562B2 (ar) |
KR (1) | KR20190013553A (ar) |
CN (2) | CN116987112A (ar) |
AU (2) | AU2018308038B2 (ar) |
BR (1) | BR112020001278A2 (ar) |
CA (1) | CA3070069C (ar) |
CO (1) | CO2020000374A2 (ar) |
DK (1) | DK3658552T3 (ar) |
EA (1) | EA202090383A1 (ar) |
ES (1) | ES2962961T3 (ar) |
FI (1) | FI3658552T3 (ar) |
HR (1) | HRP20231191T1 (ar) |
HU (1) | HUE063533T2 (ar) |
IL (2) | IL271973B (ar) |
LT (1) | LT3658552T (ar) |
MA (1) | MA49700B1 (ar) |
MD (1) | MD3658552T2 (ar) |
MX (1) | MX2022008743A (ar) |
NZ (1) | NZ761156A (ar) |
PH (1) | PH12020500059A1 (ar) |
PL (1) | PL3658552T3 (ar) |
PT (1) | PT3658552T (ar) |
RS (1) | RS64654B1 (ar) |
SA (1) | SA520411112B1 (ar) |
SG (1) | SG11201913517UA (ar) |
SI (1) | SI3658552T1 (ar) |
UA (1) | UA125317C2 (ar) |
WO (1) | WO2019022485A1 (ar) |
ZA (1) | ZA202001250B (ar) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI3658552T3 (fi) | 2017-07-28 | 2023-11-16 | Yuhan Corp | Menetelmä n-(5-((4-(4-((dimetyyliamino)metyyli)-3-fenyyli-1h-pyratsol-1-yyli)pyrimidin-2-yyli)amino)-4-metoksi-2-morfolinofenyyli)akryyliamidin valmistamiseksi saattamalla vastaava amiini reagoimaan 3-halopropionyylikloridin kanssa |
WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
US11850248B2 (en) * | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
US11780824B2 (en) * | 2020-12-16 | 2023-10-10 | Scinopharm Taiwan, Ltd. | Process for preparing osimertinib or a salt thereof |
Family Cites Families (29)
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US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
ATE370123T1 (de) | 2001-11-27 | 2007-09-15 | Wyeth Corp | 3-cyanochinoline als inhibitoren von egf-r- und her2-kinasen |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
JP2008520612A (ja) | 2004-11-24 | 2008-06-19 | ノバルティス アクチエンゲゼルシャフト | JAK阻害剤およびBcr−Abl、Flt−3、FAKまたはRAFキナーゼ阻害剤のうち少なくとも1個の組合せ |
US20060270600A1 (en) | 2005-05-26 | 2006-11-30 | Eisuke Mekada | Anti-cancer agents |
TW200736232A (en) | 2006-01-26 | 2007-10-01 | Astrazeneca Ab | Pyrimidine derivatives |
EP2684874B1 (en) | 2006-10-23 | 2017-05-17 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors |
TW200840581A (en) | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
WO2008124085A2 (en) | 2007-04-03 | 2008-10-16 | Exelixis, Inc. | Methods of using combinations of mek and jak-2 inhibitors |
KR20110025224A (ko) | 2008-06-27 | 2011-03-09 | 아빌라 테라퓨틱스, 인크. | 헤테로아릴 화합물 및 이의 용도 |
NZ599826A (en) | 2009-10-12 | 2014-08-29 | Myrexis Inc | Amino-pyrimidine compounds as inhibitors of ikk epsilon and/or tbk1 |
KR101663637B1 (ko) | 2009-11-13 | 2016-10-07 | 제노스코 | 키나아제 억제제 |
CA2782684C (en) | 2009-12-04 | 2018-09-04 | Mustapha Haddach | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
EA022623B1 (ru) | 2010-10-06 | 2016-02-29 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Производные бензимидазола в качестве ингибиторов pi3-киназ |
ES2635713T3 (es) | 2010-11-01 | 2017-10-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
WO2012082689A1 (en) | 2010-12-13 | 2012-06-21 | Array Biopharma Inc. | SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS |
CN105348266B (zh) * | 2011-07-27 | 2018-04-10 | 阿斯利康(瑞典)有限公司 | 取代的3‑氯‑n‑[3‑(嘧啶‑2‑基氨基)苯基]丙酰胺或其盐 |
WO2013096642A1 (en) | 2011-12-23 | 2013-06-27 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
PL2797927T3 (pl) | 2011-12-30 | 2019-12-31 | Hanmi Pharm. Co., Ltd. | Pochodne tieno[3,2-d]pirymidyny wykazujące działanie hamujące kinazy białkowe |
CN104860891B (zh) | 2014-02-25 | 2017-06-30 | 上海海雁医药科技有限公司 | 芳氨基嘧啶类化合物及其应用以及由其制备的药物组合物和药用组合物 |
CN106687457B (zh) | 2014-05-13 | 2020-01-10 | 阿里亚德医药股份有限公司 | 用于激酶抑制的杂芳基化合物 |
CN111875585B (zh) | 2014-06-12 | 2023-06-23 | 上海艾力斯医药科技股份有限公司 | 一类激酶抑制剂 |
PT3207035T (pt) * | 2014-10-13 | 2020-02-19 | Yuhan Corp | Compostos e composições para modular actividades da cinase do mutante de egfr |
CN104788427B (zh) | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
AR102263A1 (es) | 2015-10-14 | 2017-02-15 | Yuhan Corp | Compuestos y composiciones para la modulación de las actividades quinasa del receptor de egf mutante |
DE102017212159A1 (de) | 2017-07-14 | 2019-01-17 | Krones Aktiengesellschaft | Verfahren und Vorrichtung zur Handhabung von Stückgütern, Artikeln und/oder Gebinden |
PT3658547T (pt) | 2017-07-28 | 2023-10-20 | Yuhan Corp | Processo de preparação de n -(5 -(4 -(4 -formil -3- fenil- 1h -pirazol- 1 -il)pirimidin -2- ilamino) -4 -metoxi 2- morfolinofenil) acrilamida |
FI3658552T3 (fi) | 2017-07-28 | 2023-11-16 | Yuhan Corp | Menetelmä n-(5-((4-(4-((dimetyyliamino)metyyli)-3-fenyyli-1h-pyratsol-1-yyli)pyrimidin-2-yyli)amino)-4-metoksi-2-morfolinofenyyli)akryyliamidin valmistamiseksi saattamalla vastaava amiini reagoimaan 3-halopropionyylikloridin kanssa |
CN108826170A (zh) | 2018-06-26 | 2018-11-16 | 深圳市远润欣电子有限公司 | 局部全般照明的模式、控制方法及台灯 |
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2018
- 2018-07-25 FI FIEP18837360.9T patent/FI3658552T3/fi active
- 2018-07-25 WO PCT/KR2018/008379 patent/WO2019022485A1/en active Application Filing
- 2018-07-25 MA MA49700A patent/MA49700B1/fr unknown
- 2018-07-25 MX MX2022008743A patent/MX2022008743A/es unknown
- 2018-07-25 SI SI201830998T patent/SI3658552T1/sl unknown
- 2018-07-25 SG SG11201913517UA patent/SG11201913517UA/en unknown
- 2018-07-25 LT LTEPPCT/KR2018/008379T patent/LT3658552T/lt unknown
- 2018-07-25 CA CA3070069A patent/CA3070069C/en active Active
- 2018-07-25 BR BR112020001278-5A patent/BR112020001278A2/pt unknown
- 2018-07-25 IL IL271973A patent/IL271973B/en unknown
- 2018-07-25 AU AU2018308038A patent/AU2018308038B2/en active Active
- 2018-07-25 PT PT188373609T patent/PT3658552T/pt unknown
- 2018-07-25 KR KR1020180086376A patent/KR20190013553A/ko active IP Right Grant
- 2018-07-25 CN CN202310702453.8A patent/CN116987112A/zh active Pending
- 2018-07-25 JP JP2020504203A patent/JP7228562B2/ja active Active
- 2018-07-25 RS RS20230834A patent/RS64654B1/sr unknown
- 2018-07-25 HR HRP20231191TT patent/HRP20231191T1/hr unknown
- 2018-07-25 HU HUE18837360A patent/HUE063533T2/hu unknown
- 2018-07-25 UA UAA202001303A patent/UA125317C2/uk unknown
- 2018-07-25 ES ES18837360T patent/ES2962961T3/es active Active
- 2018-07-25 DK DK18837360.9T patent/DK3658552T3/da active
- 2018-07-25 PL PL18837360.9T patent/PL3658552T3/pl unknown
- 2018-07-25 MD MDE20200593T patent/MD3658552T2/ro unknown
- 2018-07-25 EP EP18837360.9A patent/EP3658552B1/en active Active
- 2018-07-25 CN CN201880048638.9A patent/CN111315742B/zh active Active
- 2018-07-25 EA EA202090383A patent/EA202090383A1/ru unknown
- 2018-07-25 NZ NZ761156A patent/NZ761156A/en unknown
- 2018-07-25 US US16/633,684 patent/US10889578B2/en active Active
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2020
- 2020-01-07 PH PH12020500059A patent/PH12020500059A1/en unknown
- 2020-01-15 CO CONC2020/0000374A patent/CO2020000374A2/es unknown
- 2020-01-21 SA SA520411112A patent/SA520411112B1/ar unknown
- 2020-02-27 ZA ZA2020/01250A patent/ZA202001250B/en unknown
- 2020-12-08 US US17/115,037 patent/US11286253B2/en active Active
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2022
- 2022-03-25 US US17/704,718 patent/US11708362B2/en active Active
- 2022-04-24 IL IL292429A patent/IL292429B2/en unknown
- 2022-05-03 AU AU2022202936A patent/AU2022202936B2/en active Active
- 2022-11-18 JP JP2022184867A patent/JP2023027091A/ja active Pending
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2023
- 2023-06-02 US US18/328,267 patent/US20230312545A1/en active Pending
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