SA520411120B1 - مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات - Google Patents
مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركباتInfo
- Publication number
- SA520411120B1 SA520411120B1 SA520411120A SA520411120A SA520411120B1 SA 520411120 B1 SA520411120 B1 SA 520411120B1 SA 520411120 A SA520411120 A SA 520411120A SA 520411120 A SA520411120 A SA 520411120A SA 520411120 B1 SA520411120 B1 SA 520411120B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- preparing
- same
- aminopyrimidine derivatives
- intermediates useful
- novel intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
يوفر الاختراع الحالي عملية محسّنة لتحضير مشتقات أمينو بيريميدين أو أملاح منه مقبولة صيدلانيًا تتميز بنشاط تثبيطي انتقائي ضد كينازات البروتين، وخاصة ضد كينازات البروتين لمستقبلات عوامل النمو البشروية الطافرة. ويوفر الاختراع الحالي أيضًا مركبات وسيطة جديدة مفيدة للعملية المذكورة ولعمليات من أجل تحضيرها.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170096220 | 2017-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA520411120B1 true SA520411120B1 (ar) | 2022-08-25 |
Family
ID=65040817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA520411120A SA520411120B1 (ar) | 2017-07-28 | 2020-01-22 | مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10858353B2 (ar) |
| EP (1) | EP3658553B1 (ar) |
| JP (1) | JP7216704B2 (ar) |
| KR (1) | KR20190013554A (ar) |
| CN (1) | CN111032650A (ar) |
| AU (1) | AU2018308039B2 (ar) |
| BR (1) | BR112020001396A2 (ar) |
| CA (1) | CA3069408A1 (ar) |
| CO (1) | CO2020000595A2 (ar) |
| DK (1) | DK3658553T3 (ar) |
| EA (1) | EA038856B1 (ar) |
| ES (1) | ES2923278T3 (ar) |
| HR (1) | HRP20220848T1 (ar) |
| HU (1) | HUE059501T2 (ar) |
| IL (1) | IL271974B (ar) |
| LT (1) | LT3658553T (ar) |
| MA (1) | MA49703A (ar) |
| PH (1) | PH12020500070A1 (ar) |
| PL (1) | PL3658553T3 (ar) |
| PT (1) | PT3658553T (ar) |
| RS (1) | RS63497B1 (ar) |
| SA (1) | SA520411120B1 (ar) |
| SG (1) | SG11201913520YA (ar) |
| SI (1) | SI3658553T1 (ar) |
| UA (1) | UA125664C2 (ar) |
| WO (1) | WO2019022486A1 (ar) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20210304A1 (ar) | 2019-05-14 | 2023-01-30 | Janssen Biotech Inc | علاجات مركبة باستخدام الأجسام المضادة ثنائية النوعية المضادة لمستقبل عامل نمو البشرة (EGFR)/ مستقبل عامل نمو خلايا الكبد (c-Met) ومثبطات كيناز التيروسين الخاصة بمستقبل عامل نمو البشرة (EGFR) من الجيل الثالث |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8629132B2 (en) * | 2009-11-13 | 2014-01-14 | Genosco | Kinase inhibitors |
| CN105461695B (zh) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
| MX2017003181A (es) * | 2014-10-13 | 2017-07-20 | Yuhan Corp | Compuestos y composiciones para modular actividades de quinasa de mutante de receptor del factor de crecimiento epidermico. |
| CN104788427B (zh) * | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
| EP3312179B1 (en) * | 2015-04-29 | 2019-07-10 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Fused-ring or tricyclic aryl pyrimidine compound used as kinase inhibitor |
| US10329257B2 (en) * | 2015-08-13 | 2019-06-25 | The Broad Institute, Inc. | Compositions and methods for treating tuberculosis |
| SG11201913556SA (en) | 2017-07-28 | 2020-02-27 | Yuhan Corp | Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same |
-
2018
- 2018-07-25 MA MA049703A patent/MA49703A/fr unknown
- 2018-07-25 US US16/633,695 patent/US10858353B2/en active Active
- 2018-07-25 BR BR112020001396-0A patent/BR112020001396A2/pt unknown
- 2018-07-25 KR KR1020180086377A patent/KR20190013554A/ko active IP Right Grant
- 2018-07-25 CA CA3069408A patent/CA3069408A1/en active Pending
- 2018-07-25 WO PCT/KR2018/008381 patent/WO2019022486A1/en active Application Filing
- 2018-07-25 DK DK18838173.5T patent/DK3658553T3/da active
- 2018-07-25 ES ES18838173T patent/ES2923278T3/es active Active
- 2018-07-25 CN CN201880049025.7A patent/CN111032650A/zh active Pending
- 2018-07-25 IL IL271974A patent/IL271974B/en unknown
- 2018-07-25 SI SI201830722T patent/SI3658553T1/sl unknown
- 2018-07-25 EA EA202090385A patent/EA038856B1/ru unknown
- 2018-07-25 SG SG11201913520YA patent/SG11201913520YA/en unknown
- 2018-07-25 PT PT188381735T patent/PT3658553T/pt unknown
- 2018-07-25 PL PL18838173.5T patent/PL3658553T3/pl unknown
- 2018-07-25 HR HRP20220848TT patent/HRP20220848T1/hr unknown
- 2018-07-25 LT LTEPPCT/KR2018/008381T patent/LT3658553T/lt unknown
- 2018-07-25 EP EP18838173.5A patent/EP3658553B1/en active Active
- 2018-07-25 JP JP2020503944A patent/JP7216704B2/ja active Active
- 2018-07-25 HU HUE18838173A patent/HUE059501T2/hu unknown
- 2018-07-25 UA UAA202001305A patent/UA125664C2/uk unknown
- 2018-07-25 AU AU2018308039A patent/AU2018308039B2/en active Active
- 2018-07-25 RS RS20220706A patent/RS63497B1/sr unknown
-
2020
- 2020-01-09 PH PH12020500070A patent/PH12020500070A1/en unknown
- 2020-01-20 CO CONC2020/0000595A patent/CO2020000595A2/es unknown
- 2020-01-22 SA SA520411120A patent/SA520411120B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20200207750A1 (en) | 2020-07-02 |
| HUE059501T2 (hu) | 2022-11-28 |
| EP3658553A1 (en) | 2020-06-03 |
| CA3069408A1 (en) | 2019-01-31 |
| RS63497B1 (sr) | 2022-09-30 |
| EP3658553A4 (en) | 2021-04-21 |
| WO2019022486A1 (en) | 2019-01-31 |
| UA125664C2 (uk) | 2022-05-11 |
| KR20190013554A (ko) | 2019-02-11 |
| JP7216704B2 (ja) | 2023-02-01 |
| CO2020000595A2 (es) | 2020-05-05 |
| IL271974B (en) | 2022-08-01 |
| PT3658553T (pt) | 2022-09-23 |
| LT3658553T (lt) | 2022-09-12 |
| JP2020528437A (ja) | 2020-09-24 |
| BR112020001396A2 (pt) | 2020-08-11 |
| ES2923278T3 (es) | 2022-09-26 |
| PL3658553T3 (pl) | 2022-10-10 |
| DK3658553T3 (da) | 2022-07-25 |
| CN111032650A (zh) | 2020-04-17 |
| MA49703A (fr) | 2021-04-21 |
| PH12020500070A1 (en) | 2020-12-07 |
| SG11201913520YA (en) | 2020-02-27 |
| EA038856B1 (ru) | 2021-10-28 |
| US10858353B2 (en) | 2020-12-08 |
| EA202090385A1 (ru) | 2020-09-09 |
| AU2018308039A1 (en) | 2020-01-30 |
| AU2018308039B2 (en) | 2022-04-14 |
| EP3658553B1 (en) | 2022-06-15 |
| SI3658553T1 (sl) | 2022-10-28 |
| IL271974A (en) | 2020-02-27 |
| HRP20220848T1 (hr) | 2022-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020500093A1 (en) | Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same | |
| SA520411112B1 (ar) | عملية محسّنة لتحضير مشتقات أمينو بيريميدين | |
| ZA202202097B (en) | Amino pyrimidine ssao inhibitors | |
| AU2018271990A1 (en) | Covalent inhibitors of KRAS | |
| WO2017108723A3 (en) | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | |
| MX2019009501A (es) | Compuestos de amino piridina utiles como inhibidores de ssao. | |
| SG10201902206QA (en) | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof | |
| SG11201906435SA (en) | Pyrimidine compound and pharmaceutical use thereof | |
| PH12017550004B1 (en) | Heterocyclic derivatives and use thereof | |
| MX2019000536A (es) | Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1. | |
| EP4234547A3 (en) | Pharmaceutical salts of pyrimidine derivatives and method of treating disorders | |
| SA520411120B1 (ar) | مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات | |
| MX2021007247A (es) | Derivados de rapamicina. | |
| WO2018075598A8 (en) | SYNTHESIS OF EZH2 INHIBITORS | |
| AU2018375456A1 (en) | Thieno(3,2-d)pyrimidine compound having inhibitory activity for protein kinase | |
| WO2018229796A3 (en) | PROCESS FOR THE PREPARATION OF BETRIXABAN CHLORHYDRATE AND BETRIXABAN MALEATE SALT | |
| UA124942C2 (uk) | Спосіб одержання енантіомерів пірліндолу та їхніх солей | |
| AU2019248350A8 (en) | Process for making sarecycline hydrochloride |