RU2007149474A - Средство для профилактики и лечения заболеваний печени, содержащее производное пиразолопиримидинона - Google Patents
Средство для профилактики и лечения заболеваний печени, содержащее производное пиразолопиримидинона Download PDFInfo
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- RU2007149474A RU2007149474A RU2007149474/15A RU2007149474A RU2007149474A RU 2007149474 A RU2007149474 A RU 2007149474A RU 2007149474/15 A RU2007149474/15 A RU 2007149474/15A RU 2007149474 A RU2007149474 A RU 2007149474A RU 2007149474 A RU2007149474 A RU 2007149474A
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- pyrazolopyrimidine derivative
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1. Ингибитор фиброза печени, содержащий в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1 ! Химическая формула 1 ! ! 2. Фармацевтическая композиция для профилактики и лечения цирроза печени, содержащая в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1 ! Химическая формула 1 ! ! 3. Ингибитор портальной гипертензии, содержащий в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1 ! Химическая формула 1 ! ! 4. Фармацевтическая композиция для профилактики и лечения осложнения(й), вызванного(ых) портальной гипертензией, содержащая в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1 ! Химическая формула 1 ! ! 5. Фармацевтическая композиция для профилактики и лечения осложнения, вызванного портальной гипертензией, по п.4, где осложнение(я) выбрано из группы, состоящей из варикозных расширений вен пищевода, увеличения селезенки, гиперспленизма, асцита, спонтанного бактериального перитонита, гепаторенального синдрома, гепатопульмонального синдрома или печеночной энцефалопатии.
Claims (5)
1. Ингибитор фиброза печени, содержащий в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1
Химическая формула 1
2. Фармацевтическая композиция для профилактики и лечения цирроза печени, содержащая в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1
Химическая формула 1
3. Ингибитор портальной гипертензии, содержащий в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1
Химическая формула 1
4. Фармацевтическая композиция для профилактики и лечения осложнения(й), вызванного(ых) портальной гипертензией, содержащая в качестве активного ингредиента производное пиразолопиримидинона, представленное следующей химической формулой 1
Химическая формула 1
5. Фармацевтическая композиция для профилактики и лечения осложнения, вызванного портальной гипертензией, по п.4, где осложнение(я) выбрано из группы, состоящей из варикозных расширений вен пищевода, увеличения селезенки, гиперспленизма, асцита, спонтанного бактериального перитонита, гепаторенального синдрома, гепатопульмонального синдрома или печеночной энцефалопатии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20050050033 | 2005-06-10 | ||
| KR10-2005-0050033 | 2005-06-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007149474A true RU2007149474A (ru) | 2009-07-20 |
| RU2369392C2 RU2369392C2 (ru) | 2009-10-10 |
Family
ID=37498629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007149474/15A RU2369392C2 (ru) | 2005-06-10 | 2005-10-21 | Средство для профилактики и лечения заболеваний печени, содержащее производное пиразолопиримидинона |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8796286B2 (ru) |
| EP (1) | EP1888074B1 (ru) |
| JP (1) | JP4879977B2 (ru) |
| KR (1) | KR100914445B1 (ru) |
| CN (1) | CN101193636B (ru) |
| AT (1) | ATE537832T1 (ru) |
| AU (1) | AU2005332719B2 (ru) |
| BR (1) | BRPI0520209A2 (ru) |
| CA (1) | CA2611638C (ru) |
| CY (1) | CY1112637T1 (ru) |
| DK (1) | DK1888074T3 (ru) |
| ES (1) | ES2376628T3 (ru) |
| HK (1) | HK1119596A1 (ru) |
| IL (1) | IL187678A (ru) |
| MX (1) | MX2007015365A (ru) |
| NO (1) | NO20076053L (ru) |
| NZ (1) | NZ564369A (ru) |
| PT (1) | PT1888074E (ru) |
| RU (1) | RU2369392C2 (ru) |
| UA (1) | UA86528C2 (ru) |
| WO (1) | WO2006132460A1 (ru) |
| ZA (1) | ZA200800180B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2101809B1 (en) * | 2006-12-28 | 2011-10-19 | Insect Biotech Co., Ltd. | Pharmaceutical composition containing arazyme for the prevention of liver dysfunction |
| WO2010118367A2 (en) * | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
| AU2011279144A1 (en) * | 2010-07-14 | 2013-01-24 | Cumberland Emerging Technologies, Inc | Methods of treating hepatorenal syndrome and hepatic encephalopathy with thromboxane-A2 receptor antagonists |
| JP6235583B2 (ja) * | 2012-07-11 | 2017-11-22 | ユニバーシティー オブ ミシシッピ メディカル センター | 画像獲得データから肝線維症を検出及びステージ決定する方法 |
| AU2015258805B2 (en) | 2014-05-16 | 2018-05-10 | Cumberland Pharmaceuticals, Inc. | Compositions and methods of treating cardiac fibrosis with ifetroban |
| JP7033454B2 (ja) | 2015-06-30 | 2022-03-10 | カンバーランド ファーマシューティカルズ，インコーポレーテッド | Ａｅｒｄ／喘息におけるトロンボキサン受容体拮抗薬 |
| ES2955158T3 (es) | 2016-05-11 | 2023-11-29 | Cumberland Pharmaceuticals Inc | Composiciones y métodos de tratamiento de la distrofia muscular con antagonistas del receptor de tromboxano-A2 |
| CN110833556A (zh) * | 2018-08-15 | 2020-02-25 | 广西梧州制药（集团）股份有限公司 | 吡唑并嘧啶衍生物在治疗肝纤维化的用途 |
| CN113493459B (zh) * | 2020-04-07 | 2022-12-13 | 广州白云山医药集团股份有限公司白云山制药总厂 | Pde5抑制剂化合物及其制备方法和应用 |
| AU2022325803A1 (en) * | 2021-08-13 | 2024-03-28 | Goldberg, David J. | Methods and compositions for treating fibrotic liver conditions, using udenafil compositions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
| KR100377782B1 (ko) | 2000-06-23 | 2003-03-29 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
| US20030216407A1 (en) * | 2002-01-31 | 2003-11-20 | Pfizer Inc. | Use of PDE5 inhibitors in the treatment of scarring |
| GB0202254D0 (en) * | 2002-01-31 | 2002-03-20 | Pfizer Ltd | Prevention of scarring |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| GB0214784D0 (en) * | 2002-06-26 | 2002-08-07 | Pfizer Ltd | Novel combination |
| AU2003286555A1 (en) | 2002-10-22 | 2004-05-13 | Harbor-Ucla Research And Education Institute | Phosphodiester inhibitors and nitric oxide modulators for treating peyronie's disease, arteriosclerosis and other fibrotic diseases |
| WO2004108662A1 (ja) | 2003-05-15 | 2004-12-16 | Kumiai Chemical Industry Co., Ltd. | フェニルスルホニルカーバメイト誘導体及び農園芸用植物病害防除剤 |
| DE10325813B4 (de) | 2003-06-06 | 2007-12-20 | Universitätsklinikum Freiburg | Prophylaxe und/oder Therapie bei der portalen Hypertonie |
| CA2528975A1 (en) * | 2003-06-10 | 2004-12-16 | Pfizer Inc. | Therapeutic combinations comprising pde inhibitors and vasopressin receptor antagonists for the treatment of dysmenorrhoea |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
-
2005
- 2005-10-21 WO PCT/KR2005/003526 patent/WO2006132460A1/en active Application Filing
- 2005-10-21 BR BRPI0520209-4A patent/BRPI0520209A2/pt not_active IP Right Cessation
- 2005-10-21 CA CA2611638A patent/CA2611638C/en not_active Expired - Fee Related
- 2005-10-21 RU RU2007149474/15A patent/RU2369392C2/ru active
- 2005-10-21 AT AT05808627T patent/ATE537832T1/de active
- 2005-10-21 KR KR1020050099900A patent/KR100914445B1/ko active IP Right Grant
- 2005-10-21 CN CN2005800500656A patent/CN101193636B/zh not_active Expired - Fee Related
- 2005-10-21 JP JP2008515614A patent/JP4879977B2/ja not_active Expired - Fee Related
- 2005-10-21 EP EP05808627A patent/EP1888074B1/en active Active
- 2005-10-21 US US11/916,752 patent/US8796286B2/en active Active
- 2005-10-21 DK DK05808627.3T patent/DK1888074T3/da active
- 2005-10-21 MX MX2007015365A patent/MX2007015365A/es active IP Right Grant
- 2005-10-21 ES ES05808627T patent/ES2376628T3/es active Active
- 2005-10-21 UA UAA200713931A patent/UA86528C2/ru unknown
- 2005-10-21 AU AU2005332719A patent/AU2005332719B2/en not_active Ceased
- 2005-10-21 PT PT05808627T patent/PT1888074E/pt unknown
- 2005-10-21 NZ NZ564369A patent/NZ564369A/en not_active IP Right Cessation
-
2007
- 2007-11-26 NO NO20076053A patent/NO20076053L/no not_active Application Discontinuation
- 2007-11-27 IL IL187678A patent/IL187678A/en not_active IP Right Cessation
-
2008
- 2008-01-08 ZA ZA200800180A patent/ZA200800180B/xx unknown
- 2008-11-27 HK HK08112976.5A patent/HK1119596A1/xx not_active IP Right Cessation
-
2012
- 2012-03-14 CY CY20121100272T patent/CY1112637T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2611638C (en) | 2010-08-24 |
| WO2006132460A1 (en) | 2006-12-14 |
| JP2008543748A (ja) | 2008-12-04 |
| CA2611638A1 (en) | 2006-12-14 |
| PT1888074E (pt) | 2012-03-01 |
| CN101193636A (zh) | 2008-06-04 |
| US8796286B2 (en) | 2014-08-05 |
| US20080207646A1 (en) | 2008-08-28 |
| UA86528C2 (ru) | 2009-04-27 |
| EP1888074B1 (en) | 2011-12-21 |
| KR20060128605A (ko) | 2006-12-14 |
| EP1888074A4 (en) | 2010-06-23 |
| KR100914445B1 (ko) | 2009-08-28 |
| MX2007015365A (es) | 2008-02-12 |
| DK1888074T3 (da) | 2012-01-23 |
| NO20076053L (no) | 2008-02-27 |
| JP4879977B2 (ja) | 2012-02-22 |
| RU2369392C2 (ru) | 2009-10-10 |
| HK1119596A1 (en) | 2009-03-13 |
| ZA200800180B (en) | 2009-01-28 |
| CY1112637T1 (el) | 2016-02-10 |
| AU2005332719B2 (en) | 2010-05-13 |
| BRPI0520209A2 (pt) | 2009-04-22 |
| CN101193636B (zh) | 2011-12-28 |
| ATE537832T1 (de) | 2012-01-15 |
| EP1888074A1 (en) | 2008-02-20 |
| AU2005332719A1 (en) | 2006-12-14 |
| IL187678A (en) | 2013-04-30 |
| NZ564369A (en) | 2010-03-26 |
| IL187678A0 (en) | 2008-11-03 |
| ES2376628T3 (es) | 2012-03-15 |
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