EA200201271A1 - Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 - Google Patents

Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1

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Publication number
EA200201271A1
EA200201271A1 EA200201271A EA200201271A EA200201271A1 EA 200201271 A1 EA200201271 A1 EA 200201271A1 EA 200201271 A EA200201271 A EA 200201271A EA 200201271 A EA200201271 A EA 200201271A EA 200201271 A1 EA200201271 A1 EA 200201271A1
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EA
Eurasian Patent Office
Prior art keywords
hydroxysteroid
type
degydrogenase
inhibitors
beta
Prior art date
Application number
EA200201271A
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English (en)
Other versions
EA005274B1 (ru
Inventor
Тьерд Барф
Рикард Эмонд
Гвидо Курц
Йерк Валлгорда
Марианне Нильссон
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Биовитрум Аб
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Application filed by Биовитрум Аб filed Critical Биовитрум Аб
Publication of EA200201271A1 publication Critical patent/EA200201271A1/ru
Publication of EA005274B1 publication Critical patent/EA005274B1/ru

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Настоящее изобретение относится к соединениям формулы (II), а также к фармацевтическим композициям, содержащим указанные соединения, способам их получения, а также к применению соединений в медицине и для получения лекарственного средства, которое действует на фермент человека 11-β-гидроксистероиддегидрогеназу типа 1.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201271A 2000-05-22 2001-05-22 Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 EA005274B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0001899A SE0001899D0 (sv) 2000-05-22 2000-05-22 New compounds
PCT/SE2001/001155 WO2001090090A1 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Publications (2)

Publication Number Publication Date
EA200201271A1 true EA200201271A1 (ru) 2003-04-24
EA005274B1 EA005274B1 (ru) 2004-12-30

Family

ID=20279781

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201271A EA005274B1 (ru) 2000-05-22 2001-05-22 Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1

Country Status (24)

Country Link
US (7) US7618961B2 (ru)
EP (4) EP1283832B1 (ru)
JP (4) JP2003534337A (ru)
KR (4) KR20030016271A (ru)
CN (4) CN1249039C (ru)
AR (1) AR033534A1 (ru)
AT (2) ATE443055T1 (ru)
AU (6) AU6283101A (ru)
BR (1) BR0111099A (ru)
CA (4) CA2408144C (ru)
DE (3) DE1283831T1 (ru)
EA (1) EA005274B1 (ru)
ES (1) ES2333846T3 (ru)
HK (1) HK1056878A1 (ru)
HU (1) HUP0302435A3 (ru)
IL (4) IL152670A0 (ru)
MX (1) MXPA02011632A (ru)
NO (4) NO323779B1 (ru)
NZ (4) NZ522591A (ru)
PE (1) PE20020100A1 (ru)
PL (1) PL360137A1 (ru)
SE (1) SE0001899D0 (ru)
WO (5) WO2001090092A1 (ru)
ZA (4) ZA200209359B (ru)

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GB0107383D0 (en) * 2001-03-23 2001-05-16 Univ Edinburgh Lipid profile modulation
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US20030130279A1 (en) * 2001-11-22 2003-07-10 Guido Kurz Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
AU2002353717B2 (en) * 2001-11-22 2006-08-03 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7074788B2 (en) 2001-11-22 2006-07-11 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
BR0214343A (pt) 2001-11-22 2004-09-14 Biovitrum Ab Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1
RS44304A (en) * 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EP1583530A4 (en) 2002-01-16 2008-07-23 Univ Virginia ALLOSTERIC ACTIVATORS 2-AMINOTHIAZOLES FROM ADENOSINE A1 RECEPTORS
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