EA200701810A1 - Производное изоксазолина и новый способ его получения - Google Patents

Производное изоксазолина и новый способ его получения

Info

Publication number
EA200701810A1
EA200701810A1 EA200701810A EA200701810A EA200701810A1 EA 200701810 A1 EA200701810 A1 EA 200701810A1 EA 200701810 A EA200701810 A EA 200701810A EA 200701810 A EA200701810 A EA 200701810A EA 200701810 A1 EA200701810 A1 EA 200701810A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
new method
isoxazoline derivative
isoxazoline
derivative
Prior art date
Application number
EA200701810A
Other languages
English (en)
Other versions
EA013005B1 (ru
Inventor
Хиун Ик Шин
Хиеонг Воок Чои
Тае Хо Хео
Киу Воонг Ли
Дзае Хоон Ли
Ки Соок Парк
Original Assignee
Эл Джи Лайф Сайенсиз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эл Джи Лайф Сайенсиз Лтд. filed Critical Эл Джи Лайф Сайенсиз Лтд.
Publication of EA200701810A1 publication Critical patent/EA200701810A1/ru
Publication of EA013005B1 publication Critical patent/EA013005B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Настоящее изобретение относится к производному изоксазолина, имеющему циклическую карбоксильную кислотную гемикетальную группу формулы (1), предназначенному для применения в качестве ингибитора каспазы, к способу получения его, к фармацевтической композиции на его основе.
EA200701810A 2005-02-26 2006-02-21 Производное изоксазолина и новый способ его получения EA013005B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20050016203 2005-02-26
PCT/KR2006/000576 WO2006090997A1 (en) 2005-02-26 2006-02-21 Isoxazoline derivative and novel process for its preparation

Publications (2)

Publication Number Publication Date
EA200701810A1 true EA200701810A1 (ru) 2008-02-28
EA013005B1 EA013005B1 (ru) 2010-02-26

Family

ID=36927605

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701810A EA013005B1 (ru) 2005-02-26 2006-02-21 Производное изоксазолина и новый способ его получения

Country Status (29)

Country Link
US (1) US8044080B2 (ru)
EP (1) EP1851214B1 (ru)
JP (1) JP4961357B2 (ru)
KR (1) KR100774999B1 (ru)
CN (1) CN101128459B (ru)
AP (1) AP2374A (ru)
AR (1) AR055314A1 (ru)
AU (1) AU2006217293B2 (ru)
BR (1) BRPI0607330B1 (ru)
CA (1) CA2598347C (ru)
DK (1) DK1851214T3 (ru)
EA (1) EA013005B1 (ru)
ES (1) ES2394480T3 (ru)
HK (1) HK1111146A1 (ru)
IL (1) IL185226A0 (ru)
MA (1) MA29311B1 (ru)
MX (1) MX2007010338A (ru)
MY (1) MY149181A (ru)
NO (1) NO341347B1 (ru)
NZ (1) NZ560805A (ru)
PE (1) PE20061076A1 (ru)
PL (1) PL1851214T3 (ru)
PT (1) PT1851214E (ru)
SG (1) SG156689A1 (ru)
SI (1) SI1851214T1 (ru)
TW (1) TWI377205B (ru)
UA (1) UA94395C2 (ru)
WO (1) WO2006090997A1 (ru)
ZA (1) ZA200707202B (ru)

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KR101299720B1 (ko) * 2006-08-16 2013-08-28 주식회사 엘지생명과학 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법
KR20090099886A (ko) * 2008-03-18 2009-09-23 주식회사 엘지생명과학 캐스파제 저해제의 프로드럭
AR072181A1 (es) * 2008-07-11 2010-08-11 Gilead Sciences Inc Metodo de tratamiento y composiciones farmaceuticas que comprenden (r)-n-((2s,3s)-2-(fluorometil)-2-hidroxi-5-oxo-tetrahidrofuran-3-il)-5-isopropil-3-(isoquinolin-1-il)-4,5-dihidroisoxazol-5-carboxamida y uso
TW201012816A (en) * 2008-07-11 2010-04-01 Gilead Sciences Inc Method of treatment and pharmaceutical compositions
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EP2900661B1 (en) * 2012-09-28 2016-10-26 Bayer CropScience AG Quinoline isoxazolin derivatives for plant disease control
JP2017095353A (ja) * 2014-03-27 2017-06-01 日本曹達株式会社 イソオキサゾリン−５−カルボキサミド化合物および有害生物防除剤
TWI764977B (zh) * 2017-01-23 2022-05-21 大陸商正大天晴藥業集團股份有限公司 作爲ｃａｓｐａｓｅ抑制劑的聯環化合物、含有其的藥物組合物及其應用
EP3939976B1 (en) * 2019-04-19 2024-05-01 Lg Chem, Ltd. Prodrug of caspase inhibitor
WO2020222541A1 (ko) * 2019-04-30 2020-11-05 주식회사 엘지화학 캐스파제 저해제의 프로드럭
JP7301448B2 (ja) * 2019-05-31 2023-07-03 エルジー・ケム・リミテッド カスパーゼ阻害剤プロドラッグを含有する注射用組成物及びその調製方法
EP3970699A4 (en) * 2019-05-31 2022-08-10 LG Chem, Ltd. COMPOSITION FOR CASPASE INHIBITOR PRODRUG INJECTION
TW202220655A (zh) * 2020-08-05 2022-06-01 南韓商Ｌｇ化學股份有限公司 半胱天冬酶抑制劑於緩解或治療骨關節炎的用途
CN116568282A (zh) 2020-11-30 2023-08-08 株式会社Lg化学 含有半胱天冬酶抑制剂的注射用组合物及其制备方法
KR20230106073A (ko) * 2022-01-04 2023-07-12 주식회사 이노보테라퓨틱스 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
WO2023140582A1 (ko) * 2022-01-24 2023-07-27 주식회사 엘지화학 이소옥사졸린 유도체를 포함하는 주사용 제제
WO2023163470A1 (ko) * 2022-02-23 2023-08-31 주식회사 엘지화학 이소옥사졸린 유도체를 포함하는 주사용 제제 및 이의 제조방법
KR20230141971A (ko) 2022-03-24 2023-10-10 주식회사 엘지화학 이소옥사졸린 유도체를 포함하는 주사용 제제 및 이의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990079267A (ko) 1998-04-03 1999-11-05 성재갑 이소옥사졸(또는 이소옥사졸린) 구조를 갖는 파네실 전이효소억제제
KR100373375B1 (ko) * 1998-04-03 2003-06-12 주식회사 엘지생명과학 인터루킨-1b-컨버팅효소및아포파인/cpp-32에대한저해제
WO2001021599A1 (en) * 1999-09-17 2001-03-29 Lg Chemical Ltd. Caspase inhibitor
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TWI256952B (en) * 2003-08-27 2006-06-21 Sk Corp Chroman carboxylic acid derivatives for the treatment of diabetes and lipid disorders
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Also Published As

Publication number Publication date
AP2374A (en) 2012-03-07
MY149181A (en) 2013-07-31
CN101128459A (zh) 2008-02-20
ES2394480T3 (es) 2013-02-01
AR055314A1 (es) 2007-08-15
ZA200707202B (en) 2008-10-29
MA29311B1 (fr) 2008-03-03
CA2598347C (en) 2011-08-02
TWI377205B (en) 2012-11-21
PT1851214E (pt) 2012-10-18
EP1851214A1 (en) 2007-11-07
EA013005B1 (ru) 2010-02-26
BRPI0607330A2 (pt) 2009-09-29
US20080262032A1 (en) 2008-10-23
HK1111146A1 (en) 2008-08-01
MX2007010338A (es) 2007-10-11
PE20061076A1 (es) 2006-12-27
EP1851214A4 (en) 2009-10-28
AU2006217293B2 (en) 2012-02-02
DK1851214T3 (da) 2012-10-15
NZ560805A (en) 2010-12-24
KR100774999B1 (ko) 2007-11-09
KR20060094868A (ko) 2006-08-30
WO2006090997A1 (en) 2006-08-31
JP4961357B2 (ja) 2012-06-27
CN101128459B (zh) 2011-10-05
UA94395C2 (ru) 2011-05-10
NO20074895L (no) 2007-11-26
SI1851214T1 (sl) 2012-11-30
AU2006217293A1 (en) 2006-08-31
TW200640918A (en) 2006-12-01
BRPI0607330B1 (pt) 2021-08-03
CA2598347A1 (en) 2006-08-31
IL185226A0 (en) 2008-02-09
SG156689A1 (en) 2009-11-26
US8044080B2 (en) 2011-10-25
EP1851214B1 (en) 2012-09-05
PL1851214T3 (pl) 2013-03-29
NO341347B1 (no) 2017-10-16
JP2008531551A (ja) 2008-08-14

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PD4A Registration of transfer of a eurasian patent in accordance with the succession in title