EA200700601A1 - Производные фениламинопиримидина как ингибиторы bcr-abl - Google Patents

Производные фениламинопиримидина как ингибиторы bcr-abl

Info

Publication number
EA200700601A1
EA200700601A1 EA200700601A EA200700601A EA200700601A1 EA 200700601 A1 EA200700601 A1 EA 200700601A1 EA 200700601 A EA200700601 A EA 200700601A EA 200700601 A EA200700601 A EA 200700601A EA 200700601 A1 EA200700601 A1 EA 200700601A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
phenylaminopyrimidine
bcr
abl inhibitors
phenylaminopyrimidines
Prior art date
Application number
EA200700601A
Other languages
English (en)
Other versions
EA013328B1 (ru
Inventor
Амала Кишан Компелла
Бхуджанга Рао Адибхатла Кали Сатьа
Сринивас Рачаконда
Кхадгапатхи Подили
Наннапанени Венкайах Чоудари
Original Assignee
Натко Фарма Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Натко Фарма Лимитед filed Critical Натко Фарма Лимитед
Publication of EA200700601A1 publication Critical patent/EA200700601A1/ru
Publication of EA013328B1 publication Critical patent/EA013328B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к промежуточным соединениям, применимым для получения производных фениламинопиримидинов и к производным фениламинопиримидинов, содержащим их фармацевтическим композициям и способам их получения, в частности, изобретение относится к производным фениламинопиримидинов формулы IЭти соединения можно применять при лечении хронической миелоидной лейкемии.
EA200700601A 2004-09-09 2005-07-19 Производные фениламинопиримидина как ингибиторы bcr-abl EA013328B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN908CH2004 2004-09-09
PCT/IN2005/000243 WO2006027795A1 (en) 2004-09-09 2005-07-19 Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase

Publications (2)

Publication Number Publication Date
EA200700601A1 true EA200700601A1 (ru) 2008-02-28
EA013328B1 EA013328B1 (ru) 2010-04-30

Family

ID=35395645

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700601A EA013328B1 (ru) 2004-09-09 2005-07-19 Производные фениламинопиримидина как ингибиторы bcr-abl

Country Status (26)

Country Link
US (2) US7910598B2 (ru)
EP (2) EP2295424B1 (ru)
JP (1) JP5184887B2 (ru)
KR (1) KR100948453B1 (ru)
CN (1) CN101068805B (ru)
AP (1) AP2470A (ru)
AU (1) AU2005281299B2 (ru)
BR (1) BRPI0515081B8 (ru)
CA (1) CA2591321C (ru)
CY (1) CY1113617T1 (ru)
DK (1) DK1786799T3 (ru)
EA (1) EA013328B1 (ru)
ES (1) ES2390227T3 (ru)
HK (1) HK1110588A1 (ru)
HR (1) HRP20070146B1 (ru)
IL (1) IL181811A (ru)
MA (1) MA28922B1 (ru)
MX (1) MX2007002819A (ru)
NO (1) NO337598B1 (ru)
NZ (1) NZ554361A (ru)
PL (1) PL1786799T3 (ru)
PT (1) PT1786799E (ru)
SI (1) SI1786799T1 (ru)
UA (1) UA94570C2 (ru)
WO (1) WO2006027795A1 (ru)
ZA (2) ZA200701942B (ru)

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US6667300B2 (en) * 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
LT2612862T (lt) 2004-05-13 2017-01-25 Icos Corporation Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai
US7939541B2 (en) 2004-09-09 2011-05-10 Natco Pharma Limited Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
CA2591321C (en) 2004-09-09 2013-09-24 Natco Pharma Limited Phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase
US8735415B2 (en) 2004-09-09 2014-05-27 Natco Pharma Limited Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
US20110190328A1 (en) * 2004-09-09 2011-08-04 Natco Pharma Limited Acid addition salts of (3,5-bis trifluoromethyl)-n-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
WO2008031534A1 (en) * 2006-09-11 2008-03-20 Syngenta Participations Ag Insecticidal compounds
RU2009120882A (ru) * 2006-11-03 2010-12-10 Айрм Ллк (Bm) Соединения и композиции, как ингибиторы протеинкиназы
NZ577611A (en) * 2006-12-14 2012-01-12 Bayer Schering Pharma Ag Dihydropyridine derivatives useful as protein kinase inhibitors
EP2148874B1 (en) * 2007-05-04 2012-02-08 Irm Llc Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors
AU2008247442B2 (en) * 2007-05-04 2013-01-10 Irm Llc Compounds and compositions as c-kit and PDGFR kinase inhibitors
US8288540B2 (en) 2007-08-22 2012-10-16 Irm Llc 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
AU2008289037B2 (en) 2007-08-22 2012-03-01 Novartis Ag 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors
EP2265599B1 (en) * 2008-03-04 2013-11-20 Natco Pharma Limited Crystal form of phenylaminopyrimidine derivative
US8067422B2 (en) 2008-03-04 2011-11-29 Natco Pharma Limited Crystal form of phenylamino pyrimidine derivatives
WO2012004801A1 (en) * 2010-07-07 2012-01-12 Hetero Research Foundation Process for imatinib mesylate
GB2488788B (en) * 2011-03-07 2013-07-10 Natco Pharma Ltd Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response
EA026152B1 (ru) 2011-09-01 2017-03-31 Новартис Аг СОЕДИНЕНИЯ И КОМПОЗИЦИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ с-kit
US9061028B2 (en) 2012-02-15 2015-06-23 Natco Pharma Limited Process for the preparation of Nilotinib
EP2861589B1 (en) * 2012-06-15 2017-05-17 Basf Se Multicomponent crystals comprising dasatinib and selected cocrystal formers
CN108495620B (zh) 2015-12-18 2021-09-03 纳科制药有限公司 包含苯基氨基嘧啶衍生物的药物组合物
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2022016021A1 (en) 2020-07-15 2022-01-20 Third Harmonic Bio, Inc. Crystalline forms of a selective c-kit kinase inhibitor
WO2022109595A1 (en) 2020-11-19 2022-05-27 Third Harmonic Bio, Inc. Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same
CN113125689B (zh) * 2021-03-29 2022-02-22 创芯国际生物科技(广州)有限公司 一种新型mtt细胞活力检测试剂盒及其应用

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US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
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Also Published As

Publication number Publication date
EP1786799B1 (en) 2012-07-04
US20080306100A1 (en) 2008-12-11
EP2295424A1 (en) 2011-03-16
WO2006027795A1 (en) 2006-03-16
AU2005281299B2 (en) 2012-03-15
CA2591321C (en) 2013-09-24
AP2007003944A0 (en) 2007-04-30
CA2591321A1 (en) 2006-03-16
ZA200701942B (en) 2008-10-29
HRP20070146B1 (hr) 2015-12-04
MX2007002819A (es) 2007-08-14
NO337598B1 (no) 2016-05-09
JP2008512448A (ja) 2008-04-24
NZ554361A (en) 2009-03-31
EA013328B1 (ru) 2010-04-30
UA94570C2 (en) 2011-05-25
BRPI0515081B1 (pt) 2021-05-04
SI1786799T1 (sl) 2012-12-31
JP5184887B2 (ja) 2013-04-17
KR20070106681A (ko) 2007-11-05
ES2390227T3 (es) 2012-11-07
PL1786799T3 (pl) 2012-12-31
US8183253B2 (en) 2012-05-22
HK1110588A1 (en) 2008-07-18
EP2295424B1 (en) 2015-10-14
IL181811A0 (en) 2007-07-04
IL181811A (en) 2013-07-31
PT1786799E (pt) 2012-09-18
BRPI0515081B8 (pt) 2021-05-25
EP1786799A1 (en) 2007-05-23
NO20071521L (no) 2007-06-11
CN101068805B (zh) 2013-04-03
ZA200703123B (en) 2008-10-29
AU2005281299A1 (en) 2006-03-16
MA28922B1 (fr) 2007-10-01
AP2470A (en) 2012-09-17
CN101068805A (zh) 2007-11-07
BRPI0515081A (pt) 2008-07-08
CY1113617T1 (el) 2016-06-22
KR100948453B1 (ko) 2010-03-17
HRP20070146A2 (en) 2007-08-31
US20070232633A1 (en) 2007-10-04
US7910598B2 (en) 2011-03-22
DK1786799T3 (da) 2012-10-01

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