PL2909188T3 - Nowy sposób wytwarzania związków do stosowania w leczeniu raka - Google Patents

Nowy sposób wytwarzania związków do stosowania w leczeniu raka

Info

Publication number
PL2909188T3
PL2909188T3 PL13780303T PL13780303T PL2909188T3 PL 2909188 T3 PL2909188 T3 PL 2909188T3 PL 13780303 T PL13780303 T PL 13780303T PL 13780303 T PL13780303 T PL 13780303T PL 2909188 T3 PL2909188 T3 PL 2909188T3
Authority
PL
Poland
Prior art keywords
cancer
treatment
novel process
making compounds
compounds
Prior art date
Application number
PL13780303T
Other languages
English (en)
Inventor
Sriram Naganathan
Nathan GUZ
Matthew PFEIFFER
C. Gregory Sowell
Tracy Bostick
Jason Yang
Amit Srivastava
Original Assignee
Exelixis, Inc.
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis, Inc., Genentech, Inc. filed Critical Exelixis, Inc.
Publication of PL2909188T3 publication Critical patent/PL2909188T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
PL13780303T 2012-10-12 2013-10-14 Nowy sposób wytwarzania związków do stosowania w leczeniu raka PL2909188T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261713104P 2012-10-12 2012-10-12
PCT/US2013/064866 WO2014059422A1 (en) 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer
EP13780303.7A EP2909188B1 (en) 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
PL2909188T3 true PL2909188T3 (pl) 2018-08-31

Family

ID=49474740

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13780303T PL2909188T3 (pl) 2012-10-12 2013-10-14 Nowy sposób wytwarzania związków do stosowania w leczeniu raka

Country Status (31)

Country Link
US (4) US9771347B2 (pl)
EP (1) EP2909188B1 (pl)
JP (2) JP6300042B2 (pl)
KR (1) KR102204520B1 (pl)
CN (2) CN108948043B (pl)
AU (1) AU2013328929B2 (pl)
BR (1) BR112015008113B1 (pl)
CA (1) CA2889466C (pl)
CL (1) CL2015000926A1 (pl)
CR (2) CR20200237A (pl)
EA (1) EA030613B1 (pl)
ES (1) ES2671502T3 (pl)
GE (1) GEP201706690B (pl)
HK (2) HK1213567A1 (pl)
HR (1) HRP20180670T1 (pl)
IL (1) IL238116B (pl)
IN (1) IN2015DN03928A (pl)
MA (1) MA38085B1 (pl)
MX (2) MX2015004660A (pl)
MY (1) MY186549A (pl)
NZ (1) NZ706723A (pl)
PE (3) PE20191818A1 (pl)
PH (1) PH12015500785A1 (pl)
PL (1) PL2909188T3 (pl)
SA (1) SA515360271B1 (pl)
SG (1) SG11201502795VA (pl)
SI (1) SI2909188T1 (pl)
TR (1) TR201807861T4 (pl)
UA (1) UA115455C2 (pl)
WO (1) WO2014059422A1 (pl)
ZA (1) ZA201502349B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201807861T4 (tr) 2012-10-12 2018-06-21 Exelixis Inc Kanser tedavisinde kullanım için bileşikler yapmak için yeni işlem.
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
CA2987912C (en) 2015-06-30 2023-01-24 Genentech, Inc. Immediate-release tablets containing a drug and processes for forming the tablets
CN105330643B (zh) * 2015-12-09 2017-12-05 苏州明锐医药科技有限公司 卡比替尼的制备方法
CN106045969B (zh) * 2016-05-27 2019-04-12 湖南欧亚药业有限公司 一种卡比替尼的合成方法
JP2019524820A (ja) 2016-08-12 2019-09-05 ジェネンテック， インコーポレイテッド Ｍｅｋ阻害剤、ｐｄ−１軸阻害剤及びｖｅｇｆ阻害剤での組合せ療法
JP2019534251A (ja) 2016-09-29 2019-11-28 ジェネンテック， インコーポレイテッド Ｍｅｋ阻害剤、ｐｄ−１軸阻害剤、及びタキサンを用いた併用療法
WO2020187674A1 (en) 2019-03-15 2020-09-24 Sandoz Ag Crystalline (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemisuccinate
JP2024509269A (ja) 2021-03-09 2024-02-29 ジェネンテック， インコーポレイテッド 脳がんの治療における使用のためのベルバラフェニブ
WO2022216719A1 (en) 2021-04-06 2022-10-13 Genentech, Inc. Combination therapy with belvarafenib and cobimetinib or with belvarafenib, cobimetinib, and atezolizumab

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1563587A (en) * 1924-09-20 1925-12-01 Raney Murray Method of preparing catalytic material
US1628190A (en) * 1926-05-14 1927-05-10 Raney Murray Method of producing finely-divided nickel
US1915473A (en) * 1930-12-31 1933-06-27 Raney Murray Method of preparing catalytic material
US4510139A (en) 1984-01-06 1985-04-09 Sterling Drug Inc. Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity
US5155110A (en) 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
EP0754684A4 (en) 1994-04-01 1998-05-13 Shionogi & Co OXIME DERIVATIVES AND BACTERICIDE CONTAINING IT AS ACTIVE INGREDIENTS
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
US6251943B1 (en) 1997-02-28 2001-06-26 Warner-Lambert Company Method of treating or preventing septic shock by administering a MEK inhibitor
PT993439E (pt) 1997-07-01 2004-12-31 Warner Lambert Co Derivados de acido 4-bromo ou 4-iodofenilaminobenzidroxamico e sua utilizacao como inibidores de mek
US6310060B1 (en) * 1998-06-24 2001-10-30 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
ES2274572T3 (es) * 1997-07-01 2007-05-16 Warner-Lambert Company Llc Derivados de acido 2-(4-bromo- o 4-yodo-fenilamino) benzoico y su uso como inhibidor de mek.
US6974878B2 (en) 2001-03-21 2005-12-13 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
JP2002532414A (ja) 1998-12-15 2002-10-02 ワーナー−ランバート・カンパニー 移植片拒絶反応を防止するためのｍｅｋ阻害剤の使用
JP2002532415A (ja) 1998-12-16 2002-10-02 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤による関節炎の治療
NZ512859A (en) 1998-12-22 2004-06-25 Warner Lambert Co Combination chemotherapy
KR20000047461A (ko) 1998-12-29 2000-07-25 성재갑 트롬빈 억제제
JP2002534380A (ja) 1999-01-07 2002-10-15 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤による喘息の治療
WO2000040237A1 (en) 1999-01-07 2000-07-13 Warner-Lambert Company Antiviral method using mek inhibitors
CA2348236A1 (en) 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
ES2247859T3 (es) 1999-01-13 2006-03-01 Warner-Lambert Company Llc Benzoheterociclos y su uso como inhibidores de mek.
JP2002534446A (ja) 1999-01-13 2002-10-15 ワーナー−ランバート・カンパニー ４′ヘテロアリールジアリールアミン
PL348870A1 (en) 1999-01-13 2002-06-17 Warner Lambert Co 1-heterocycle substituted diarylamines
CA2349832A1 (en) 1999-01-13 2000-07-20 Warner-Lambert Company Benzenesulfonamide derivatives and their use as mek inhibitors
CA2374052A1 (en) 1999-07-16 2001-01-25 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
WO2001005393A2 (en) 1999-07-16 2001-01-25 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
WO2001005390A2 (en) 1999-07-16 2001-01-25 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
JP2003504399A (ja) 1999-07-16 2003-02-04 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤を用いる慢性疼痛の治療方法
MX226123B (es) 1999-09-17 2005-02-07 Millennium Pharm Inc Benzamidas e inhibidores del factor xa relacionadas.
MXPA02008103A (es) 2000-03-15 2002-11-29 Warner Lambert Co Diarilaminas sustituidas con 5-amida como inhibidores mek.
AR033517A1 (es) 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
EE05450B1 (et) 2000-07-19 2011-08-15 Warner-Lambert Company 4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine
BR0113520A (pt) * 2000-08-25 2003-06-24 Warner Lambert Co Processo de preparação de ácidos n-aril-antranìlicos e seus derivados
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
NZ518726A (en) 2001-05-09 2004-06-25 Warner Lambert Co Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
US20040039208A1 (en) * 2001-07-20 2004-02-26 Chen Michael Huai Gu Process for making n-aryl-anthranilic acids and their derivatives
DE10141266A1 (de) 2001-08-21 2003-03-06 Syntec Ges Fuer Chemie Und Tec Elektrolumineszierende Derivate der 2,5-Diamino-terephthalsäure und deren Verwendung in organischen Leuchtdioden
US7085492B2 (en) 2001-08-27 2006-08-01 Ibsen Photonics A/S Wavelength division multiplexed device
KR20050038583A (ko) 2001-10-31 2005-04-27 화이자 프로덕츠 인크. 하지 불안 증후군 치료에서의 니코틴성 아세틸콜린 수용체아고니스트
BR0307060A (pt) 2002-01-23 2004-10-26 Warner Lambert Co ésteres hidroxamato do ácido n-(fenil 4-substituìdo)-antranìlico
DOP2003000556A (es) 2002-01-23 2003-10-31 Warner Lambert Co Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico.
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
PA8569201A1 (es) 2002-03-13 2004-05-21 Array Biopharma Inc "derivados de bencimidazol n3 alquilado como inhibidores de mek" "n3 alkylated benzimimidazole derivatives as mek inhibitors"
PT3000810T (pt) 2002-03-13 2017-10-25 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
EP1515727A4 (en) 2002-06-11 2009-04-08 Merck & Co Inc INHIBITORS OF P38 KINASE (HALO-BENZO CARBONYL) HETEROBICYCLIC
GB0214268D0 (en) 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
WO2004004644A2 (en) 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
US20050004186A1 (en) 2002-12-20 2005-01-06 Pfizer Inc MEK inhibiting compounds
RU2357957C2 (ru) 2003-03-03 2009-06-10 Эррэй Биофарма, Инк. Ингибиторы р38 и способы их применения
TW200505834A (en) 2003-03-18 2005-02-16 Sankyo Co Sulfamide derivative and the pharmaceutical composition thereof
JP2005162727A (ja) 2003-03-18 2005-06-23 Sankyo Co Ltd スルファミド誘導体及びその医薬組成物
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
MXPA05013227A (es) 2003-06-20 2006-03-09 Celltech R&D Ltd Derivados de tienopiridona como inhibidores de cinasa.
WO2005000818A1 (en) 2003-06-27 2005-01-06 Warner-Lambert Company Llc 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
US20050049276A1 (en) 2003-07-23 2005-03-03 Warner-Lambert Company, Llc Imidazopyridines and triazolopyridines
MXPA06000921A (es) 2003-07-24 2006-03-30 Warner Lambert Co Derivados de benzamidazoles como inhibidores de mek.
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
EP1674452A4 (en) 2003-09-19 2007-10-10 Chugai Pharmaceutical Co Ltd NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND ITS USE AS MEK INHIBITOR
US7772234B2 (en) 2003-11-19 2010-08-10 Array Biopharma Inc. Bicyclic inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
ATE384058T1 (de) 2003-12-08 2008-02-15 Hoffmann La Roche Thiazolderivate
TWI361066B (en) 2004-07-26 2012-04-01 Chugai Pharmaceutical Co Ltd 5-substituted-2-phenylamino benzamides as mek inhibitors
DK1802579T3 (da) * 2004-10-20 2014-01-20 Merck Serono Sa Derivater af 3-arylaminopyridin
WO2006061712A2 (en) 2004-12-10 2006-06-15 Pfizer Inc. Use of mek inhibitors in treating abnormal cell growth
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
JP5129143B2 (ja) 2005-10-07 2013-01-23 エグゼリクシス， インコーポレイテッド Ｍｅｋインヒビターおよびその使用方法
EP2056829B9 (en) 2006-08-16 2012-09-26 Exelixis, Inc. Using pi3k and mek modulators in treatments of cancer
PL2101759T3 (pl) * 2006-12-14 2019-05-31 Exelixis Inc Sposoby stosowania inhibitorów MEK
TR201807861T4 (tr) 2012-10-12 2018-06-21 Exelixis Inc Kanser tedavisinde kullanım için bileşikler yapmak için yeni işlem.
AU2014381760B2 (en) 2014-02-07 2018-08-02 Sumitomo Chemical Company, Limited Method for producing (R)-1,1,3-trimethyl-4-aminoindane
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona

Also Published As

Publication number Publication date
CN104837826A (zh) 2015-08-12
MA38085B1 (fr) 2018-11-30
US20190185447A1 (en) 2019-06-20
AU2013328929B2 (en) 2018-01-04
CN104837826B (zh) 2018-07-27
UA115455C2 (uk) 2017-11-10
PE20151494A1 (es) 2015-11-06
HRP20180670T1 (hr) 2018-07-13
PH12015500785B1 (en) 2015-06-15
PH12015500785A1 (en) 2015-06-15
ES2671502T3 (es) 2018-06-06
US20200392104A1 (en) 2020-12-17
EA030613B1 (ru) 2018-08-31
BR112015008113A2 (pt) 2017-07-04
HK1213567A1 (zh) 2016-07-08
EP2909188A1 (en) 2015-08-26
JP2015533175A (ja) 2015-11-19
US20150210668A1 (en) 2015-07-30
ZA201502349B (en) 2019-12-18
JP2018052973A (ja) 2018-04-05
SG11201502795VA (en) 2015-05-28
US20170349569A1 (en) 2017-12-07
CR20200237A (es) 2020-07-26
US9771347B2 (en) 2017-09-26
MA38085A1 (fr) 2018-08-31
US11414396B2 (en) 2022-08-16
IL238116B (en) 2018-06-28
PE20200387A1 (es) 2020-02-24
CR20150245A (es) 2015-11-19
EA201590700A1 (ru) 2015-09-30
MX2015004660A (es) 2015-08-07
GEP201706690B (en) 2017-06-26
IN2015DN03928A (pl) 2015-10-02
EP2909188B1 (en) 2018-03-07
WO2014059422A1 (en) 2014-04-17
CN108948043A (zh) 2018-12-07
MY186549A (en) 2021-07-26
JP6300042B2 (ja) 2018-03-28
HK1213878A1 (zh) 2016-07-15
CL2015000926A1 (es) 2015-08-28
PE20191818A1 (es) 2019-12-27
MX2020005533A (es) 2020-10-12
TR201807861T4 (tr) 2018-06-21
CA2889466C (en) 2021-09-14
CN108948043B (zh) 2021-05-04
KR20150067339A (ko) 2015-06-17
SI2909188T1 (en) 2018-07-31
SA515360271B1 (ar) 2016-05-19
KR102204520B1 (ko) 2021-01-20
NZ706723A (en) 2018-07-27
BR112015008113B1 (pt) 2022-05-24
CA2889466A1 (en) 2014-04-17
US10793541B2 (en) 2020-10-06
US10239858B2 (en) 2019-03-26
AU2013328929A1 (en) 2015-04-30

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