MXPA05013227A - Derivados de tienopiridona como inhibidores de cinasa. - Google Patents

Derivados de tienopiridona como inhibidores de cinasa.

Info

Publication number
MXPA05013227A
MXPA05013227A MXPA05013227A MXPA05013227A MXPA05013227A MX PA05013227 A MXPA05013227 A MX PA05013227A MX PA05013227 A MXPA05013227 A MX PA05013227A MX PA05013227 A MXPA05013227 A MX PA05013227A MX PA05013227 A MXPA05013227 A MX PA05013227A
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
derivatives
thienopyridone derivatives
thienopyridone
inhibitors
Prior art date
Application number
MXPA05013227A
Other languages
English (en)
Inventor
Barry John Langham
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0314492A external-priority patent/GB0314492D0/en
Priority claimed from GB0329485A external-priority patent/GB0329485D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of MXPA05013227A publication Critical patent/MXPA05013227A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se describe una serie de derivaos de tieno[2,3-b]piridin-6(7H)-ona, sustituidos en la posicion 2 por una porcion pirrolidin-1-ilo enlazada a carbonilo o sulfonilo o porcion relacionada, los cuales son inhibidores de p38 MAP cinasa, y son en consecuencia de utilizad en medicina, por ejemplo en el tratamiento y/o prevencion de trastornos inmunes o inflamatorios.
MXPA05013227A 2003-06-20 2004-06-18 Derivados de tienopiridona como inhibidores de cinasa. MXPA05013227A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0314492A GB0314492D0 (en) 2003-06-20 2003-06-20 Chemical compounds
GB0329485A GB0329485D0 (en) 2003-12-19 2003-12-19 Chemical compounds
PCT/GB2004/002621 WO2004113347A1 (en) 2003-06-20 2004-06-18 Thienopyridone derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
MXPA05013227A true MXPA05013227A (es) 2006-03-09

Family

ID=33542685

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013227A MXPA05013227A (es) 2003-06-20 2004-06-18 Derivados de tienopiridona como inhibidores de cinasa.

Country Status (12)

Country Link
US (1) US7521460B2 (es)
EP (1) EP1641804A1 (es)
JP (1) JP2007516161A (es)
KR (1) KR20060021905A (es)
AU (1) AU2004249495A1 (es)
BR (1) BRPI0410653A (es)
CA (1) CA2528602A1 (es)
EA (1) EA010297B1 (es)
IL (1) IL172132A0 (es)
MX (1) MXPA05013227A (es)
NO (1) NO20060279L (es)
WO (1) WO2004113347A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
EP1638979A1 (en) * 2003-06-20 2006-03-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
AU2004285752A1 (en) * 2003-10-24 2005-05-12 Ucb Pharma S.A. Thieno-pyridinone derivatives as kinase inhibitors
EP2591784B1 (en) 2005-05-10 2016-09-14 Intermune, Inc. Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system
CA3052368A1 (en) * 2005-10-07 2007-04-19 Exelixis, Inc. Azetidines as mek inhibitors
EP2426134A3 (en) * 2005-11-23 2012-07-04 Intermune, Inc. Method of modulating stress-activated protein kinase system
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
US8633201B2 (en) 2006-04-07 2014-01-21 Boehringer Ingelheim International Gmbh Thienopyrimidines having Mnk1/Mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
US20100179185A1 (en) * 2006-11-30 2010-07-15 Ucb Pharma, S.A. Novel Aminothienopyridinone Derivatives Processes for Preparing Them and Pharmaceutical Compositions Thereof
CN105106199A (zh) 2006-12-14 2015-12-02 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
WO2008124085A2 (en) * 2007-04-03 2008-10-16 Exelixis, Inc. Methods of using combinations of mek and jak-2 inhibitors
GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
EP2240494B1 (en) 2008-01-21 2016-03-30 UCB Biopharma SPRL Thieno-pyridine derivatives as mek inhibitors
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
GB0811304D0 (en) 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
AU2009286734A1 (en) 2008-08-26 2010-03-04 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
CA2791114A1 (en) 2010-02-26 2011-09-01 Boehringer Ingelheim International Gmbh Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
CN102858782A (zh) 2010-02-26 2013-01-02 贝林格尔.英格海姆国际有限公司 用于药物组合物的具有Mnk1/Mnk2 抑制活性的4-[环烷基氧基(杂)芳基氨基]噻吩并[2,3-d]嘧啶
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
CA2806670A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
MY186549A (en) 2012-10-12 2021-07-26 Exelixis Inc Novel process for making compounds for use in the treatment of cancer
EP2922854B1 (en) * 2012-11-21 2022-05-04 Zoetis Services LLC Synthesis of spirocyclic isoxazoline derivatives
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2015002729A2 (en) 2013-06-13 2015-01-08 Biomatrica, Inc. Cell stabilization
MX2016012808A (es) 2014-04-02 2017-01-05 Intermune Inc Piridinonas anti-fibroticas.
US10064404B2 (en) 2014-06-10 2018-09-04 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
KR102589056B1 (ko) 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048863A (en) * 1994-04-19 2000-04-11 Takeda Chemical Industries, Ltd. Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
AU4429799A (en) * 1998-06-12 1999-12-30 Vertex Pharmaceuticals Incorporated Inhibitors of p38
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
EP1638979A1 (en) * 2003-06-20 2006-03-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
AU2004285752A1 (en) * 2003-10-24 2005-05-12 Ucb Pharma S.A. Thieno-pyridinone derivatives as kinase inhibitors

Also Published As

Publication number Publication date
WO2004113347A1 (en) 2004-12-29
NO20060279L (no) 2006-03-20
AU2004249495A1 (en) 2004-12-29
BRPI0410653A (pt) 2006-07-04
CA2528602A1 (en) 2004-12-29
JP2007516161A (ja) 2007-06-21
EP1641804A1 (en) 2006-04-05
IL172132A0 (en) 2006-04-10
EA010297B1 (ru) 2008-08-29
US20070099894A1 (en) 2007-05-03
EA200600064A1 (ru) 2006-08-25
US7521460B2 (en) 2009-04-21
KR20060021905A (ko) 2006-03-08

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