PL2758394T3 - Związki heteroarylowe jako ligandy receptora 5-HT4 - Google Patents

Związki heteroarylowe jako ligandy receptora 5-HT4

Info

Publication number
PL2758394T3
PL2758394T3 PL12716662T PL12716662T PL2758394T3 PL 2758394 T3 PL2758394 T3 PL 2758394T3 PL 12716662 T PL12716662 T PL 12716662T PL 12716662 T PL12716662 T PL 12716662T PL 2758394 T3 PL2758394 T3 PL 2758394T3
Authority
PL
Poland
Prior art keywords
receptor ligands
heteroaryl compounds
heteroaryl
compounds
ligands
Prior art date
Application number
PL12716662T
Other languages
English (en)
Inventor
Ramakrishna Nirogi
Abdul Rasheed Mohammed
Suresh Yarlagadda
Srinivasa Rao Ravella
Anil Karbhari Shinde
Ramasastri Kambhampati
Praveen Kumar Roayapalley
Pradeep Jayarajan
Gopinadh Bhyrapuneni
Sriramachandra Murthy Patnala
Jyothsna Ravula
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of PL2758394T3 publication Critical patent/PL2758394T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
PL12716662T 2011-09-19 2012-01-05 Związki heteroarylowe jako ligandy receptora 5-HT4 PL2758394T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3203CH2011 2011-09-19
EP12716662.7A EP2758394B1 (en) 2011-09-19 2012-01-05 Heteroaryl compounds as 5-ht4 receptor ligands
PCT/IN2012/000011 WO2013042135A1 (en) 2011-09-19 2012-01-05 Heteroaryl compounds as 5-ht4 receptor ligands

Publications (1)

Publication Number Publication Date
PL2758394T3 true PL2758394T3 (pl) 2015-08-31

Family

ID=46001349

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12716662T PL2758394T3 (pl) 2011-09-19 2012-01-05 Związki heteroarylowe jako ligandy receptora 5-HT4

Country Status (26)

Country Link
US (2) US9079894B2 (pl)
EP (1) EP2758394B1 (pl)
JP (1) JP5714729B2 (pl)
KR (1) KR101551481B1 (pl)
CN (1) CN103380131B (pl)
AP (1) AP3307A (pl)
AU (1) AU2012311057B2 (pl)
BR (1) BR112014001083B8 (pl)
CA (1) CA2823548C (pl)
CY (1) CY1116173T1 (pl)
DK (1) DK2758394T3 (pl)
EA (1) EA022374B1 (pl)
ES (1) ES2531885T3 (pl)
HK (1) HK1187340A1 (pl)
HR (1) HRP20150229T1 (pl)
IL (1) IL231305A0 (pl)
ME (1) ME02107B (pl)
MX (1) MX337721B (pl)
PL (1) PL2758394T3 (pl)
PT (1) PT2758394E (pl)
RS (1) RS53940B1 (pl)
SG (1) SG2014003560A (pl)
SI (1) SI2758394T1 (pl)
SM (1) SMT201500087B (pl)
WO (1) WO2013042135A1 (pl)
ZA (1) ZA201309100B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833507A1 (en) * 2011-06-07 2012-12-13 Dainippon Sumitomo Pharma Co., Ltd. Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof
CN105120851A (zh) * 2013-04-05 2015-12-02 Abc生物科学公司 用于医疗用途,具体为用于治疗与氧化应激相关的疾病或者炎症和用于保存或者洗涤器官的barettin及其衍生物
EA029951B1 (ru) 2013-12-16 2018-06-29 Сувен Лайф Сайенсиз Лимитед Соединения индазола в качестве агонистов 5-ht-рецептора
DK3180333T3 (da) * 2014-08-16 2020-09-28 Suven Life Sciences Ltd Fremgangsmåde til storstilet fremstilling af 1-isopropyl-3-{5- [1-(3-methoxypropyl)piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1h-indazoloxalat
KR101966576B1 (ko) * 2015-02-13 2019-04-05 수벤 라이프 사이언시스 리미티드 5-ht4 수용체 작용제로서 아미드 화합물
CN107540568A (zh) * 2017-08-25 2018-01-05 许昌恒生制药有限公司 一种乙氧酰胺苯甲酯的制备方法
BR112021007365A2 (pt) * 2018-10-18 2021-07-20 Suven Life Sciences Limited novos usos de um agonista do receptor 5-ht4
AU2020282759A1 (en) 2019-05-31 2021-12-23 Ikena Oncology, Inc. TEAD inhibitors and uses thereof
CN110746450A (zh) * 2019-09-17 2020-02-04 济南康和医药科技有限公司 一种贝前列素钠关键中间体的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492919A (en) * 1991-08-03 1996-02-20 Smithkline Beecham P.L.C. 5-HT4 receptor antagonists
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
EE03487B1 (et) * 1995-11-09 2001-08-15 Synthlabo 5-fenüül-3-(piperidin-4-üül)-1,3,4-oksadiasol-2(3H)-ooni derivaadid kasutamiseks 5-HT4 - või H3- retseptorite ligandidena
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
EP1689742B1 (en) 2003-11-24 2010-03-17 Pfizer, Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
DK1856110T3 (da) * 2005-02-22 2011-08-15 Pfizer Oxyindol derivater som 5HT4-receptor agonister
EP1856114B1 (en) 2005-02-25 2014-08-20 Pfizer Inc. Benzisoxazole derivatives
JP5075818B2 (ja) 2005-07-22 2012-11-21 ファイザー株式会社 5ht4受容体アゴニストとしてのインダゾールカルボキサミド誘導体
KR101121240B1 (ko) * 2005-12-23 2012-06-12 에프. 호프만-라 로슈 아게 아릴-아이속사졸-4-일-옥사다이아졸 유도체
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US20080255203A1 (en) * 2007-04-12 2008-10-16 Abbott Laboratories Heterocyclic compounds and their methods of use
WO2010102958A1 (en) * 2009-03-09 2010-09-16 Glaxo Group Limited 4-oxadiazol-2 -yl- indazoles as inhibitors of p13 kinases

Also Published As

Publication number Publication date
US9079894B2 (en) 2015-07-14
JP5714729B2 (ja) 2015-05-07
EP2758394A1 (en) 2014-07-30
BR112014001083A2 (pt) 2019-10-01
EA201391056A1 (ru) 2013-12-30
EP2758394B1 (en) 2015-02-18
US20150283125A1 (en) 2015-10-08
JP2014509320A (ja) 2014-04-17
ZA201309100B (en) 2014-08-27
AP3307A (en) 2015-06-30
SG2014003560A (en) 2014-11-27
BR112014001083B1 (pt) 2022-02-01
BR112014001083B8 (pt) 2022-06-14
US9636335B2 (en) 2017-05-02
MX2013014577A (es) 2014-03-31
IL231305A0 (en) 2014-04-30
SMT201500087B (it) 2015-05-05
RS53940B1 (en) 2015-08-31
CA2823548A1 (en) 2013-03-28
PT2758394E (pt) 2015-04-22
WO2013042135A8 (en) 2013-08-15
AP2013007301A0 (en) 2013-12-31
US20140187581A1 (en) 2014-07-03
MX337721B (es) 2016-03-16
CN103380131A (zh) 2013-10-30
CA2823548C (en) 2015-10-27
AU2012311057A1 (en) 2013-08-01
KR20130109228A (ko) 2013-10-07
HRP20150229T1 (hr) 2015-04-10
SI2758394T1 (sl) 2015-05-29
AU2012311057B2 (en) 2015-09-17
CN103380131B (zh) 2015-12-02
WO2013042135A1 (en) 2013-03-28
HK1187340A1 (zh) 2014-04-04
NZ619776A (en) 2015-04-24
DK2758394T3 (en) 2015-04-20
CY1116173T1 (el) 2017-02-08
ES2531885T3 (es) 2015-03-20
ME02107B (me) 2015-10-20
KR101551481B1 (ko) 2015-09-08
BR112014001083A8 (pt) 2021-08-24
EA022374B1 (ru) 2015-12-30

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