PT2758394E - Compostos heteroarilo como ligandos de recetores 5-ht4 - Google Patents

Compostos heteroarilo como ligandos de recetores 5-ht4 Download PDF

Info

Publication number
PT2758394E
PT2758394E PT127166627T PT12716662T PT2758394E PT 2758394 E PT2758394 E PT 2758394E PT 127166627 T PT127166627 T PT 127166627T PT 12716662 T PT12716662 T PT 12716662T PT 2758394 E PT2758394 E PT 2758394E
Authority
PT
Portugal
Prior art keywords
receptor ligands
heteroaryl compounds
heteroaryl
compounds
ligands
Prior art date
Application number
PT127166627T
Other languages
English (en)
Inventor
Ramakrishna Nirogi
Abdul Rasheed Mohammed
Suresh Yarlagadda
Srinivasa Rao Ravella
Anil Karbhari Shinde
Ramasastri Kambhampati
Praveen Kumar Roayapalley
Pradeep Jayarajan
Gopinadh Bhyrapuneni
Sriramachandra Murthy Patnala
Jyothsna Ravula
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of PT2758394E publication Critical patent/PT2758394E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
PT127166627T 2011-09-19 2012-01-05 Compostos heteroarilo como ligandos de recetores 5-ht4 PT2758394E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3203CH2011 2011-09-19

Publications (1)

Publication Number Publication Date
PT2758394E true PT2758394E (pt) 2015-04-22

Family

ID=46001349

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127166627T PT2758394E (pt) 2011-09-19 2012-01-05 Compostos heteroarilo como ligandos de recetores 5-ht4

Country Status (26)

Country Link
US (2) US9079894B2 (pt)
EP (1) EP2758394B1 (pt)
JP (1) JP5714729B2 (pt)
KR (1) KR101551481B1 (pt)
CN (1) CN103380131B (pt)
AP (1) AP3307A (pt)
AU (1) AU2012311057B2 (pt)
BR (1) BR112014001083B8 (pt)
CA (1) CA2823548C (pt)
CY (1) CY1116173T1 (pt)
DK (1) DK2758394T3 (pt)
EA (1) EA022374B1 (pt)
ES (1) ES2531885T3 (pt)
HK (1) HK1187340A1 (pt)
HR (1) HRP20150229T1 (pt)
IL (1) IL231305A0 (pt)
ME (1) ME02107B (pt)
MX (1) MX337721B (pt)
PL (1) PL2758394T3 (pt)
PT (1) PT2758394E (pt)
RS (1) RS53940B1 (pt)
SG (1) SG2014003560A (pt)
SI (1) SI2758394T1 (pt)
SM (1) SMT201500087B (pt)
WO (1) WO2013042135A1 (pt)
ZA (1) ZA201309100B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833507A1 (en) * 2011-06-07 2012-12-13 Dainippon Sumitomo Pharma Co., Ltd. Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof
JP2016523813A (ja) * 2013-04-05 2016-08-12 エービーシー バイオサイエンス エーエス 医学的使用、特に酸化ストレスまたは炎症に関連する疾患の治療、および臓器の保存または洗浄のための、バレッチンおよびその誘導体
NZ720879A (en) * 2013-12-16 2017-05-26 Suven Life Sciences Ltd Indazole compounds as 5-ht4 receptor agonists
HUE052083T2 (hu) * 2014-08-16 2021-04-28 Suven Life Sciences Ltd Eljárás 1-izopropil-3-{5-[1-(3-metoxi-propil)-piperidin-4-il]-[1,3,4]oxadiazol-2-il}-1H-indazol-oxalát nagyüzemi termelésére
NZ734400A (en) * 2015-02-13 2018-03-23 Suven Life Sciences Ltd Amide compounds as 5-ht4 receptor agonists
CN107540568A (zh) * 2017-08-25 2018-01-05 许昌恒生制药有限公司 一种乙氧酰胺苯甲酯的制备方法
WO2020079630A1 (en) * 2018-10-18 2020-04-23 Suven Life Sciences Limited New uses of a 5-ht4 receptor agonist
EP3976192A1 (en) 2019-05-31 2022-04-06 Ikena Oncology, Inc. Tead inhibitors and uses thereof
CN110746450A (zh) * 2019-09-17 2020-02-04 济南康和医药科技有限公司 一种贝前列素钠关键中间体的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06509574A (ja) * 1991-08-03 1994-10-27 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 5−ht↓4レセプターアンタゴニスト
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
TR199800827T2 (xx) * 1995-11-09 1999-02-22 Synthelabo 5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri.
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
DK1689742T3 (da) 2003-11-24 2010-05-17 Pfizer Quinoloncarboxylsyreforbindelser med 5-HT-receptor-agonistisk aktivitet
EP1856110B1 (en) * 2005-02-22 2011-06-22 Pfizer Inc. Oxyindole derivatives as 5ht4 receptor agonists
CA2598516C (en) 2005-02-25 2010-05-11 Pfizer Inc. Benzisoxazole derivatives
ATE449092T1 (de) 2005-07-22 2009-12-15 Pfizer Indazolcarbonsäureamidderivate als agonisten des 5ht4-rezeptors
KR101121240B1 (ko) * 2005-12-23 2012-06-12 에프. 호프만-라 로슈 아게 아릴-아이속사졸-4-일-옥사다이아졸 유도체
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US20080255203A1 (en) * 2007-04-12 2008-10-16 Abbott Laboratories Heterocyclic compounds and their methods of use
ES2542551T3 (es) * 2009-03-09 2015-08-06 Glaxo Group Limited 4-Oxadiazol-2-il-indazoles como inhibidores de PI3 cinasas

Also Published As

Publication number Publication date
KR101551481B1 (ko) 2015-09-08
PL2758394T3 (pl) 2015-08-31
AP3307A (en) 2015-06-30
JP5714729B2 (ja) 2015-05-07
BR112014001083B8 (pt) 2022-06-14
SI2758394T1 (sl) 2015-05-29
BR112014001083B1 (pt) 2022-02-01
US20150283125A1 (en) 2015-10-08
WO2013042135A8 (en) 2013-08-15
EA201391056A1 (ru) 2013-12-30
AU2012311057B2 (en) 2015-09-17
US9079894B2 (en) 2015-07-14
EA022374B1 (ru) 2015-12-30
CN103380131B (zh) 2015-12-02
EP2758394A1 (en) 2014-07-30
IL231305A0 (en) 2014-04-30
SMT201500087B (it) 2015-05-05
CA2823548C (en) 2015-10-27
ES2531885T3 (es) 2015-03-20
SG2014003560A (en) 2014-11-27
CA2823548A1 (en) 2013-03-28
MX337721B (es) 2016-03-16
BR112014001083A2 (pt) 2019-10-01
NZ619776A (en) 2015-04-24
DK2758394T3 (en) 2015-04-20
EP2758394B1 (en) 2015-02-18
ME02107B (me) 2015-10-20
HRP20150229T1 (hr) 2015-04-10
KR20130109228A (ko) 2013-10-07
CY1116173T1 (el) 2017-02-08
HK1187340A1 (zh) 2014-04-04
BR112014001083A8 (pt) 2021-08-24
US9636335B2 (en) 2017-05-02
ZA201309100B (en) 2014-08-27
WO2013042135A1 (en) 2013-03-28
MX2013014577A (es) 2014-03-31
RS53940B1 (en) 2015-08-31
AP2013007301A0 (en) 2013-12-31
AU2012311057A1 (en) 2013-08-01
US20140187581A1 (en) 2014-07-03
JP2014509320A (ja) 2014-04-17
CN103380131A (zh) 2013-10-30

Similar Documents

Publication Publication Date Title
IL286152A (en) Modified imidazopyridinyl-aminopyridine compounds
GB201106799D0 (en) Novel compounds
GB201107325D0 (en) Novel compounds
AP3307A (en) Heteroaryl compounds as 5-HT4 receptor ligands
EP2670746A4 (en) BICYCLIC HETEROARYL COMPOUNDS AS GPR119 RECEPTOR AGONISTS
HK1187613A1 (en) Compounds as histamine h3 receptor ligands h3
EP2717694A4 (en) NEW COMPOUNDS
HK1180955A1 (en) Heterocyclyl compounds as histamine h3 receptor ligands h3
HUP1100731A2 (en) Complex forming compounds
TH1401001203B (th) สารประกอบเฮเทอโรเอริลในฐานะที่เป็น 5-ht4 รีเซปเตอร์ลิแกนด์
TH148768B (th) สารประกอบเฮเทอโรเอริลในฐานะที่เป็น 5-ht4 รีเซปเตอร์ลิแกนด์
GB201111409D0 (en) Novel compounds
GB201111410D0 (en) Novel compounds
GB201111308D0 (en) Novel compounds
GB201111229D0 (en) Novel compounds
GB201109514D0 (en) Novel compounds
GB201109508D0 (en) Novel compounds
GB201106801D0 (en) Novel compounds
GB201104138D0 (en) Novel compounds
GB201103283D0 (en) Novel compounds
GB201103073D0 (en) Novel compounds
GB201101640D0 (en) Novel compounds
GB201101085D0 (en) Novel compounds