PE20200342A1 - Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue - Google Patents
Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengueInfo
- Publication number
- PE20200342A1 PE20200342A1 PE2019002416A PE2019002416A PE20200342A1 PE 20200342 A1 PE20200342 A1 PE 20200342A1 PE 2019002416 A PE2019002416 A PE 2019002416A PE 2019002416 A PE2019002416 A PE 2019002416A PE 20200342 A1 PE20200342 A1 PE 20200342A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- indoline derivatives
- viral replication
- dengue viral
- derivatives substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Referido a un compuesto de formula I, incluida cualquiera de sus formas estereoquimicamente isomericas; donde A es a-1 o a-2; R1 es Cl, R2 es H, R3 es H, A es (a-1), R4 es pentafluorosulfanilo, R5 es H, Z es carbono, y R6 es H; o R1 es Cl, R2 es H, R3 es H, A es (a-1), R4 es trifluorometilo, R5 es H, Z es carbono, y R6 es metilo; entre otros. Estos compuestos son derivados de indolina sustituidos, siendo util para la prevencion o el tratamiento de infecciones virales por dengue. Tambien se refiere a procesos para la preparacion de dichos compuestos, compuestos intermedios y composiciones farmaceuticas de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17172247 | 2017-05-22 | ||
| PCT/EP2018/063029 WO2018215316A1 (en) | 2017-05-22 | 2018-05-18 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20200342A1 true PE20200342A1 (es) | 2020-02-14 |
Family
ID=58745159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019002416A PE20200342A1 (es) | 2017-05-22 | 2018-05-18 | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US11053196B2 (es) |
| EP (1) | EP3630724B1 (es) |
| JP (1) | JP7179773B2 (es) |
| KR (1) | KR102625991B1 (es) |
| CN (1) | CN110753682B (es) |
| AR (1) | AR111820A1 (es) |
| AU (1) | AU2018274101C1 (es) |
| BR (1) | BR112019024311A2 (es) |
| CA (1) | CA3061026C (es) |
| CL (1) | CL2019003309A1 (es) |
| CO (1) | CO2019013042A2 (es) |
| CR (1) | CR20190531A (es) |
| DK (1) | DK3630724T3 (es) |
| EA (1) | EA039702B1 (es) |
| EC (1) | ECSP19083621A (es) |
| ES (1) | ES2884157T3 (es) |
| HR (1) | HRP20210724T1 (es) |
| HU (1) | HUE054379T2 (es) |
| IL (1) | IL270727B2 (es) |
| LT (1) | LT3630724T (es) |
| MX (1) | MX2019013878A (es) |
| PE (1) | PE20200342A1 (es) |
| PH (1) | PH12019502577A1 (es) |
| SI (1) | SI3630724T1 (es) |
| TW (1) | TWI771420B (es) |
| UA (1) | UA125970C2 (es) |
| UY (1) | UY37741A (es) |
| WO (1) | WO2018215316A1 (es) |
| ZA (1) | ZA201907713B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CR20180495A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Deribados de indol sustituidos como inhibidores de replicación viral del dengue |
| EP3436436B1 (en) | 2016-03-31 | 2022-05-11 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3013408A1 (en) | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110691773B (zh) | 2017-05-22 | 2023-06-23 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| ES2941946T3 (es) * | 2018-06-19 | 2023-05-26 | Novartis Ag | Derivados de tetrahidrotienopiridina n-sustituidos y usos de los mismos |
| JOP20210172A1 (ar) | 2018-12-27 | 2023-01-30 | Les Laboratoires Servier Sas | مثبطات أزا-غير متجانسة ثنائية الحلقة لـ mat2a وطرق الاستخدام لعلاج السرطان |
| WO2023278564A1 (en) | 2021-07-02 | 2023-01-05 | Mirati Therapeutics, Inc. | Aminopyridine-based mta-cooperative prmt5 inhibitors |
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| CR20180495A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Deribados de indol sustituidos como inhibidores de replicación viral del dengue |
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2018
- 2018-05-18 KR KR1020197037345A patent/KR102625991B1/ko active IP Right Grant
- 2018-05-18 SI SI201830306T patent/SI3630724T1/sl unknown
- 2018-05-18 US US16/614,715 patent/US11053196B2/en active Active
- 2018-05-18 JP JP2019564452A patent/JP7179773B2/ja active Active
- 2018-05-18 CR CR20190531A patent/CR20190531A/es unknown
- 2018-05-18 EA EA201992784A patent/EA039702B1/ru unknown
- 2018-05-18 AU AU2018274101A patent/AU2018274101C1/en active Active
- 2018-05-18 UA UAA201912061A patent/UA125970C2/uk unknown
- 2018-05-18 DK DK18729051.5T patent/DK3630724T3/da active
- 2018-05-18 BR BR112019024311-9A patent/BR112019024311A2/pt active Search and Examination
- 2018-05-18 WO PCT/EP2018/063029 patent/WO2018215316A1/en active Application Filing
- 2018-05-18 PE PE2019002416A patent/PE20200342A1/es unknown
- 2018-05-18 MX MX2019013878A patent/MX2019013878A/es unknown
- 2018-05-18 TW TW107116922A patent/TWI771420B/zh active
- 2018-05-18 CN CN201880033731.2A patent/CN110753682B/zh active Active
- 2018-05-18 CA CA3061026A patent/CA3061026C/en active Active
- 2018-05-18 HU HUE18729051A patent/HUE054379T2/hu unknown
- 2018-05-18 EP EP18729051.5A patent/EP3630724B1/en active Active
- 2018-05-18 ES ES18729051T patent/ES2884157T3/es active Active
- 2018-05-18 LT LTEP18729051.5T patent/LT3630724T/lt unknown
- 2018-05-18 IL IL270727A patent/IL270727B2/en unknown
- 2018-05-22 AR ARP180101352A patent/AR111820A1/es unknown
- 2018-05-22 UY UY0001037741A patent/UY37741A/es unknown
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2019
- 2019-11-18 PH PH12019502577A patent/PH12019502577A1/en unknown
- 2019-11-18 CL CL2019003309A patent/CL2019003309A1/es unknown
- 2019-11-21 ZA ZA2019/07713A patent/ZA201907713B/en unknown
- 2019-11-22 EC ECSENADI201983621A patent/ECSP19083621A/es unknown
- 2019-11-22 CO CONC2019/0013042A patent/CO2019013042A2/es unknown
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2021
- 2021-05-10 HR HRP20210724TT patent/HRP20210724T1/hr unknown
- 2021-05-28 US US17/334,432 patent/US11702387B2/en active Active
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