BR112018070073A2 - receptores de antígeno quimérico e célula t e métodos de uso - Google Patents

receptores de antígeno quimérico e célula t e métodos de uso

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Publication number
BR112018070073A2
BR112018070073A2 BR112018070073-8A BR112018070073A BR112018070073A2 BR 112018070073 A2 BR112018070073 A2 BR 112018070073A2 BR 112018070073 A BR112018070073 A BR 112018070073A BR 112018070073 A2 BR112018070073 A2 BR 112018070073A2
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BR
Brazil
Prior art keywords
chimeric antigen
methods
receptor
cell receptors
tcr
Prior art date
Application number
BR112018070073-8A
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English (en)
Inventor
Wiltzius Jed
Original Assignee
Kite Pharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma, Inc. filed Critical Kite Pharma, Inc.
Publication of BR112018070073A2 publication Critical patent/BR112018070073A2/pt

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70589—CD45
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2510/00—Genetically modified cells

Abstract

a invenção fornece um receptor quimérico de antígeno (car) ou um receptor de célula t (tcr) compreendendo o domínio extracelular descrito aqui. alguns aspectos da invenção referem-se a um polinucleotídeo que codifica um receptor de antígeno quimérico (car) ou um receptor de célula t (tcr) compreendendo o domínio extracelular descrito aqui. outros aspectos da invenção referem-se a células compreendendo o car ou o tcr e seus usos em uma terapia de célula t.
BR112018070073-8A 2016-04-01 2017-03-31 receptores de antígeno quimérico e célula t e métodos de uso BR112018070073A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317258P 2016-04-01 2016-04-01
US62/317,258 2016-04-01
PCT/US2017/025351 WO2017173256A1 (en) 2016-04-01 2017-03-31 Chimeric antigen and t cell receptors and methods of use

Publications (1)

Publication Number Publication Date
BR112018070073A2 true BR112018070073A2 (pt) 2019-02-12

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BR112018070073-8A BR112018070073A2 (pt) 2016-04-01 2017-03-31 receptores de antígeno quimérico e célula t e métodos de uso

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US (2) US10603380B2 (pt)
EP (2) EP3984559A1 (pt)
JP (2) JP7034934B2 (pt)
KR (2) KR102427334B1 (pt)
CN (1) CN109328074A (pt)
AR (2) AR108427A1 (pt)
AU (2) AU2017240667C1 (pt)
BR (1) BR112018070073A2 (pt)
CA (1) CA3019149A1 (pt)
CL (2) CL2018002762A1 (pt)
CO (1) CO2018010453A2 (pt)
CR (1) CR20180461A (pt)
CU (1) CU20180121A7 (pt)
DO (1) DOP2018000213A (pt)
EA (1) EA201891965A1 (pt)
EC (1) ECSP18073833A (pt)
ES (1) ES2891578T3 (pt)
IL (2) IL261941B2 (pt)
MX (2) MX2018012017A (pt)
PE (1) PE20190173A1 (pt)
PH (1) PH12018550163A1 (pt)
PL (1) PL3436079T3 (pt)
PT (1) PT3436079T (pt)
SA (1) SA518400135B1 (pt)
SG (2) SG10201912489QA (pt)
SI (1) SI3436079T1 (pt)
SV (1) SV2018005756A (pt)
TW (3) TWI787599B (pt)
WO (1) WO2017173256A1 (pt)

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