BR112017006708A2 - indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue - Google Patents
indóis mono- ou dissubstituídos como inibidores da replicação viral de dengueInfo
- Publication number
- BR112017006708A2 BR112017006708A2 BR112017006708A BR112017006708A BR112017006708A2 BR 112017006708 A2 BR112017006708 A2 BR 112017006708A2 BR 112017006708 A BR112017006708 A BR 112017006708A BR 112017006708 A BR112017006708 A BR 112017006708A BR 112017006708 A2 BR112017006708 A2 BR 112017006708A2
- Authority
- BR
- Brazil
- Prior art keywords
- mono
- compounds
- inhibitors
- dengue viral
- viral replication
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
a presente invenção diz respeito a compostos de indol mono- ou dissubstituídos da fórmula (i) que são úteis para prevenir ou tratar infeções virais de dengue e se relaciona também com os referidos compostos para uso como um medicamento, mais preferencialmente para uso como um medicamento para tratar ou prevenir infeções virais de dengue. a presente invenção relaciona-se além disso com composições farmacêuticas ou preparações de combinação dos compostos, com as composições ou preparações para uso como um medicamento, mais preferencialmente para a prevenção ou tratamento de infeções virais de dengue. a invenção relaciona-se também com processos para preparação dos compostos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14187373 | 2014-10-01 | ||
EP15156073 | 2015-02-23 | ||
PCT/EP2015/072534 WO2016050831A1 (en) | 2014-10-01 | 2015-09-30 | Mono- or di-substituted indoles as dengue viral replication inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017006708A2 true BR112017006708A2 (pt) | 2017-12-26 |
Family
ID=54207512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017006708A BR112017006708A2 (pt) | 2014-10-01 | 2015-09-30 | indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue |
Country Status (30)
Country | Link |
---|---|
US (1) | US10206902B2 (pt) |
EP (1) | EP3201177B1 (pt) |
JP (1) | JP6701185B2 (pt) |
KR (1) | KR102478309B1 (pt) |
CN (1) | CN107001265B (pt) |
AU (1) | AU2015326920A1 (pt) |
BR (1) | BR112017006708A2 (pt) |
CA (1) | CA2958022A1 (pt) |
CL (1) | CL2017000742A1 (pt) |
CY (1) | CY1121972T1 (pt) |
DK (1) | DK3201177T3 (pt) |
EA (1) | EA033845B1 (pt) |
ES (1) | ES2711117T3 (pt) |
HR (1) | HRP20190139T1 (pt) |
HU (1) | HUE042628T2 (pt) |
IL (1) | IL251401A0 (pt) |
LT (1) | LT3201177T (pt) |
MA (1) | MA40769B1 (pt) |
ME (1) | ME03344B (pt) |
MX (1) | MX2017004298A (pt) |
PH (1) | PH12017500503A1 (pt) |
PL (1) | PL3201177T3 (pt) |
PT (1) | PT3201177T (pt) |
RS (1) | RS58394B1 (pt) |
SG (1) | SG11201702464WA (pt) |
SI (1) | SI3201177T1 (pt) |
TW (1) | TW201619130A (pt) |
UY (1) | UY36339A (pt) |
WO (1) | WO2016050831A1 (pt) |
ZA (1) | ZA201702299B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
KR102457840B1 (ko) | 2014-10-01 | 2022-10-21 | 메르크 파텐트 게엠베하 | 보론산 유도체 |
JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
MX2018011784A (es) | 2016-03-31 | 2019-02-13 | Janssen Pharmaceuticals Inc | Derivados de indol sustituidos como inhibidores de la replicacion virica del dengue. |
BR112018068956A2 (pt) * | 2016-04-01 | 2019-01-22 | Janssen Pharmaceuticals Inc | derivados do composto indol substituídos como inibidores da replicação viral da dengue |
JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
ES2929667T3 (es) | 2017-05-22 | 2022-11-30 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
CN114989131B (zh) * | 2022-05-30 | 2023-10-24 | 云南大学 | N’-(2-(苯并[1,3]二氧戊烷-5-基)酰基)芳酰肼类化合物及其合成和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
AU2009283195A1 (en) * | 2008-08-18 | 2010-02-25 | Yale University | MIF modulators |
GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
SG11201702463YA (en) * | 2014-10-01 | 2017-04-27 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
-
2015
- 2015-09-30 ME MEP-2019-37A patent/ME03344B/me unknown
- 2015-09-30 PT PT15771593T patent/PT3201177T/pt unknown
- 2015-09-30 DK DK15771593.9T patent/DK3201177T3/en active
- 2015-09-30 AU AU2015326920A patent/AU2015326920A1/en not_active Abandoned
- 2015-09-30 ES ES15771593T patent/ES2711117T3/es active Active
- 2015-09-30 PL PL15771593T patent/PL3201177T3/pl unknown
- 2015-09-30 EP EP15771593.9A patent/EP3201177B1/en active Active
- 2015-09-30 MA MA40769A patent/MA40769B1/fr unknown
- 2015-09-30 MX MX2017004298A patent/MX2017004298A/es unknown
- 2015-09-30 CA CA2958022A patent/CA2958022A1/en not_active Abandoned
- 2015-09-30 JP JP2017517658A patent/JP6701185B2/ja active Active
- 2015-09-30 KR KR1020177009096A patent/KR102478309B1/ko active IP Right Grant
- 2015-09-30 US US15/515,563 patent/US10206902B2/en active Active
- 2015-09-30 HU HUE15771593A patent/HUE042628T2/hu unknown
- 2015-09-30 LT LTEP15771593.9T patent/LT3201177T/lt unknown
- 2015-09-30 BR BR112017006708A patent/BR112017006708A2/pt not_active Application Discontinuation
- 2015-09-30 SG SG11201702464WA patent/SG11201702464WA/en unknown
- 2015-09-30 WO PCT/EP2015/072534 patent/WO2016050831A1/en active Application Filing
- 2015-09-30 RS RS20190141A patent/RS58394B1/sr unknown
- 2015-09-30 TW TW104132007A patent/TW201619130A/zh unknown
- 2015-09-30 SI SI201530583T patent/SI3201177T1/sl unknown
- 2015-09-30 EA EA201790700A patent/EA033845B1/ru not_active IP Right Cessation
- 2015-09-30 CN CN201580053468.XA patent/CN107001265B/zh active Active
- 2015-10-01 UY UY0001036339A patent/UY36339A/es unknown
-
2017
- 2017-03-16 PH PH12017500503A patent/PH12017500503A1/en unknown
- 2017-03-27 IL IL251401A patent/IL251401A0/en unknown
- 2017-03-28 CL CL2017000742A patent/CL2017000742A1/es unknown
- 2017-03-31 ZA ZA2017/02299A patent/ZA201702299B/en unknown
-
2019
- 2019-01-21 HR HRP20190139TT patent/HRP20190139T1/hr unknown
- 2019-02-08 CY CY20191100171T patent/CY1121972T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112017006708A2 (pt) | indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue | |
BR112017023904A2 (pt) | derivados indol mono- ou dissubstituídos como inibidores da replicação viral da dengue | |
BR112017006299A2 (pt) | derivados indol mono- ou dissubstituídos como inibidores da replicação viral da dengue | |
BR112017015123A2 (pt) | derivados de indol como inibidores da replicação viral do dengue | |
BR112018068956A2 (pt) | derivados do composto indol substituídos como inibidores da replicação viral da dengue | |
PH12018502016A1 (en) | Substituted indole derivatives as dengue viral replication inhibitors | |
CO2018003369A2 (es) | Derivados de indol mono - o disustituidos como inhibidores de la replicación viral del dengue | |
PH12019502201A1 (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
BR112018068676A2 (pt) | derivados de indol substituídos como inibidores da replicação viral do dengue | |
CO2018003471A2 (es) | Derivados de indol mono - o disustituidos como inhibidores de la replicación viral del dengue | |
PH12018502077A1 (en) | Substituted indoline derivatives as dengue viral replication inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |