UY37378A - Compuestos tricíclicos fusionados de piridazinona útiles para tratar infecciones de orthomyxovirus - Google Patents
Compuestos tricíclicos fusionados de piridazinona útiles para tratar infecciones de orthomyxovirusInfo
- Publication number
- UY37378A UY37378A UY0001037378A UY37378A UY37378A UY 37378 A UY37378 A UY 37378A UY 0001037378 A UY0001037378 A UY 0001037378A UY 37378 A UY37378 A UY 37378A UY 37378 A UY37378 A UY 37378A
- Authority
- UY
- Uruguay
- Prior art keywords
- piridazinone
- fusioned
- compounds useful
- tricyclic compounds
- treat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
La invención proporciona compuestos de la Fórmula (I), como se describe adicionalmente en la presente, así como composiciones farmacéuticas que comprenden dichos compuestos, y procedimientos para usar los compuestos y composiciones farmacéuticas para el tratamiento de ciertos trastornos víricos, incluyendo la influenza
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662380712P | 2016-08-29 | 2016-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37378A true UY37378A (es) | 2018-03-23 |
Family
ID=59923494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037378A UY37378A (es) | 2016-08-29 | 2017-08-28 | Compuestos tricíclicos fusionados de piridazinona útiles para tratar infecciones de orthomyxovirus |
Country Status (15)
Country | Link |
---|---|
US (3) | US11098051B2 (es) |
EP (3) | EP4356969A2 (es) |
JP (2) | JP7221861B2 (es) |
CN (2) | CN109863151B (es) |
AR (1) | AR109438A1 (es) |
CA (1) | CA3035302A1 (es) |
ES (1) | ES2859510T3 (es) |
JO (1) | JOP20170169A1 (es) |
MX (1) | MX2019002438A (es) |
PL (2) | PL3848372T3 (es) |
PT (2) | PT3504214T (es) |
SI (2) | SI3848372T1 (es) |
TW (2) | TWI803467B (es) |
UY (1) | UY37378A (es) |
WO (1) | WO2018042303A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2923075C (en) * | 2013-09-12 | 2022-07-26 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
RU2745071C2 (ru) | 2015-12-15 | 2021-03-18 | Сионоги Энд Ко., Лтд. | Лекарственный препарат для лечения гриппа, характеризующийся тем, что в нем объединены ингибитор кэп-зависимой эндонуклеазы и лекарственное средство против гриппа |
US10858366B2 (en) | 2016-03-08 | 2020-12-08 | Novartis Ag | Tricyclic compounds useful to treat orthomyxovirus infections |
CN110494141A (zh) | 2016-08-10 | 2019-11-22 | 盐野义制药株式会社 | 含有被取代的多环性吡啶酮衍生物及其前药的药物组合物 |
JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
CA3088926A1 (en) | 2018-01-17 | 2019-07-25 | Jiangxi Caishi Pharmaceutical Technology Co., Ltd. | Pyridone derivative, composition and use as antiviral drug thereof |
MX2020008959A (es) * | 2018-02-28 | 2020-10-05 | Novartis Ag | Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza. |
CN108440564B (zh) * | 2018-04-11 | 2019-08-06 | 安帝康(无锡)生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
JP2022512676A (ja) * | 2018-10-10 | 2022-02-07 | ヤンセン バイオファーマ インク. | 大環状インフルエンザエンドヌクレアーゼ阻害剤 |
WO2022105669A1 (zh) * | 2020-11-17 | 2022-05-27 | 南京明德新药研发有限公司 | 含Se大环类化合物 |
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GB8501542D0 (en) | 1985-01-22 | 1985-02-20 | Erba Farmitalia | 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives |
AUPM354694A0 (en) | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
JP4338192B2 (ja) | 2001-08-10 | 2009-10-07 | 塩野義製薬株式会社 | 抗ウイルス剤 |
WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
WO2005087766A1 (en) | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv integrase inhibitors |
FR2901795A1 (fr) | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
RS55365B1 (sr) | 2008-10-31 | 2017-03-31 | Shionogi & Co | Cefalosporin sa kateholskom grupom |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
WO2010110231A1 (ja) | 2009-03-26 | 2010-09-30 | 塩野義製薬株式会社 | 置換された3-ヒドロキシ-4-ピリドン誘導体 |
LT2444400T (lt) * | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Pakeistasis policiklinis karbamoilpiridono darinys |
JP2013515734A (ja) | 2009-12-23 | 2013-05-09 | エラン ファーマシューティカルズ,インコーポレイテッド | ポロ様キナーゼの阻害薬としてのプテリジノン |
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US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
HUE039859T2 (hu) * | 2010-09-24 | 2019-02-28 | Shionogi & Co | Helyettesített policiklusos karbamoil-piridon-származék prodrug |
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AU2012321762A1 (en) * | 2011-10-12 | 2014-04-17 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
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CA2923075C (en) * | 2013-09-12 | 2022-07-26 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
MX370085B (es) | 2013-09-12 | 2019-11-29 | Janssen Biopharma Inc | Compuestos de piridazinona y usos de los mismos. |
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US10858366B2 (en) | 2016-03-08 | 2020-12-08 | Novartis Ag | Tricyclic compounds useful to treat orthomyxovirus infections |
WO2017156407A1 (en) | 2016-03-10 | 2017-09-14 | Alios Biopharma, Inc. | Method of preparing aza-pyridone compounds |
WO2018005863A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
JP2019520379A (ja) | 2016-07-01 | 2019-07-18 | ジー1 セラピューティクス, インコーポレイテッド | ピリミジン系の抗増殖剤 |
CN110494141A (zh) | 2016-08-10 | 2019-11-22 | 盐野义制药株式会社 | 含有被取代的多环性吡啶酮衍生物及其前药的药物组合物 |
JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
JP2019059697A (ja) * | 2017-09-28 | 2019-04-18 | 塩野義製薬株式会社 | 置換された多環性ピリダジン誘導体およびそのプロドラッグ |
CN110041327B (zh) | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
CA3088926A1 (en) | 2018-01-17 | 2019-07-25 | Jiangxi Caishi Pharmaceutical Technology Co., Ltd. | Pyridone derivative, composition and use as antiviral drug thereof |
CA3087994A1 (en) | 2018-02-28 | 2019-09-06 | Japan Tobacco Inc. | 4-methyldihydropyrimidinone compounds and pharmaceutical use thereof |
JP7200005B2 (ja) | 2018-02-28 | 2023-01-06 | 日本たばこ産業株式会社 | 飽和環縮合ジヒドロピリミジノン又はジヒドロトリアジノン化合物及びその医薬用途 |
MX2020008959A (es) | 2018-02-28 | 2020-10-05 | Novartis Ag | Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza. |
AU2019228654A1 (en) | 2018-02-28 | 2020-09-03 | F. Hoffmann-La Roche Ag | 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer |
-
2016
- 2016-08-29 JO JOP/2017/0169A patent/JOP20170169A1/ar unknown
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2017
- 2017-08-25 CN CN201780065653.XA patent/CN109863151B/zh active Active
- 2017-08-25 EP EP23217305.4A patent/EP4356969A2/en active Pending
- 2017-08-25 US US16/328,616 patent/US11098051B2/en active Active
- 2017-08-25 EP EP20210329.7A patent/EP3848372B1/en active Active
- 2017-08-25 PL PL20210329.7T patent/PL3848372T3/pl unknown
- 2017-08-25 US US15/686,652 patent/US10160764B2/en active Active
- 2017-08-25 PT PT177715877T patent/PT3504214T/pt unknown
- 2017-08-25 CA CA3035302A patent/CA3035302A1/en active Pending
- 2017-08-25 PT PT202103297T patent/PT3848372T/pt unknown
- 2017-08-25 WO PCT/IB2017/055137 patent/WO2018042303A1/en unknown
- 2017-08-25 EP EP17771587.7A patent/EP3504214B1/en active Active
- 2017-08-25 CN CN202110956692.7A patent/CN113683614A/zh active Pending
- 2017-08-25 SI SI201731493T patent/SI3848372T1/sl unknown
- 2017-08-25 PL PL17771587T patent/PL3504214T3/pl unknown
- 2017-08-25 MX MX2019002438A patent/MX2019002438A/es unknown
- 2017-08-25 ES ES17771587T patent/ES2859510T3/es active Active
- 2017-08-25 SI SI201730650T patent/SI3504214T1/sl unknown
- 2017-08-25 JP JP2019511749A patent/JP7221861B2/ja active Active
- 2017-08-28 TW TW106129086A patent/TWI803467B/zh active
- 2017-08-28 UY UY0001037378A patent/UY37378A/es unknown
- 2017-08-28 TW TW112101158A patent/TW202342482A/zh unknown
- 2017-08-29 AR ARP170102385A patent/AR109438A1/es unknown
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2021
- 2021-07-13 US US17/374,237 patent/US11912715B2/en active Active
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2022
- 2022-11-22 JP JP2022186394A patent/JP2023027102A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3848372A1 (en) | 2021-07-14 |
US20180057501A1 (en) | 2018-03-01 |
JP7221861B2 (ja) | 2023-02-14 |
PT3504214T (pt) | 2021-03-04 |
AR109438A1 (es) | 2018-11-28 |
US10160764B2 (en) | 2018-12-25 |
JOP20170169A1 (ar) | 2019-01-30 |
US11912715B2 (en) | 2024-02-27 |
EP4356969A2 (en) | 2024-04-24 |
PL3504214T3 (pl) | 2021-07-19 |
TWI803467B (zh) | 2023-06-01 |
TW202342482A (zh) | 2023-11-01 |
CA3035302A1 (en) | 2018-03-08 |
ES2859510T3 (es) | 2021-10-04 |
CN109863151B (zh) | 2021-09-10 |
US11098051B2 (en) | 2021-08-24 |
SI3848372T1 (sl) | 2024-04-30 |
WO2018042303A1 (en) | 2018-03-08 |
CN109863151A (zh) | 2019-06-07 |
CN113683614A (zh) | 2021-11-23 |
US20200123167A1 (en) | 2020-04-23 |
EP3848372B1 (en) | 2023-12-20 |
SI3504214T1 (sl) | 2021-04-30 |
US20220041610A1 (en) | 2022-02-10 |
PL3848372T3 (pl) | 2024-04-22 |
JP2023027102A (ja) | 2023-03-01 |
EP3504214B1 (en) | 2020-12-02 |
MX2019002438A (es) | 2019-07-08 |
TW201811800A (zh) | 2018-04-01 |
JP2019532033A (ja) | 2019-11-07 |
PT3848372T (pt) | 2024-03-22 |
EP3504214A1 (en) | 2019-07-03 |
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