CR20180495A - Deribados de indol sustituidos como inhibidores de replicación viral del dengue - Google Patents

Deribados de indol sustituidos como inhibidores de replicación viral del dengue

Info

Publication number
CR20180495A
CR20180495A CR20180495A CR20180495A CR20180495A CR 20180495 A CR20180495 A CR 20180495A CR 20180495 A CR20180495 A CR 20180495A CR 20180495 A CR20180495 A CR 20180495A CR 20180495 A CR20180495 A CR 20180495A
Authority
CR
Costa Rica
Prior art keywords
dengue
viral replication
replication inhibitors
indol derivatives
derivatives replaced
Prior art date
Application number
CR20180495A
Other languages
English (en)
Inventor
Pierre Jean-Marie Bernard Raboisson
Jean-François Bonfanti
Dorothée Alice Marie-Eve Bardiot
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Original Assignee
Univ Leuven Kath
Jassen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leuven Kath, Jassen Pharmaceuticals Inc filed Critical Univ Leuven Kath
Publication of CR20180495A publication Critical patent/CR20180495A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se refiere a derivados de indol sustituidos, a métodos para prevenir o tratar infecciones víricas por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferiblemente, para su uso cmo medicamento para tratar o prevenir infecciones víricas por dengue. La presente invención se refiere además a composiciones o preparados para su uso como un medicamento, más preferiblemente para la prevención o el tratamiento de infecciones víricas por dengue. La invención también se refiere a procesos para la preparación de los compuestos
CR20180495A 2016-03-31 2017-03-31 Deribados de indol sustituidos como inhibidores de replicación viral del dengue CR20180495A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16163312 2016-03-31
PCT/EP2017/057660 WO2017167950A1 (en) 2016-03-31 2017-03-31 Substituted indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
CR20180495A true CR20180495A (es) 2018-12-06

Family

ID=55650292

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180495A CR20180495A (es) 2016-03-31 2017-03-31 Deribados de indol sustituidos como inhibidores de replicación viral del dengue

Country Status (26)

Country Link
US (1) US10646469B2 (es)
EP (1) EP3436435B1 (es)
JP (1) JP6888021B2 (es)
KR (1) KR102359743B1 (es)
CN (1) CN108884033B (es)
AU (1) AU2017242893A1 (es)
BR (1) BR112018068676A2 (es)
CA (1) CA3013405A1 (es)
CL (1) CL2018002729A1 (es)
CO (1) CO2018009559A2 (es)
CR (1) CR20180495A (es)
DK (1) DK3436435T3 (es)
EA (1) EA201892214A1 (es)
EC (1) ECSP18073245A (es)
ES (1) ES2882488T3 (es)
HK (1) HK1258142A1 (es)
HR (1) HRP20210847T1 (es)
HU (1) HUE054936T2 (es)
IL (1) IL261944A (es)
LT (1) LT3436435T (es)
MX (1) MX2018011784A (es)
PH (1) PH12018502015A1 (es)
SG (1) SG11201808138YA (es)
SI (1) SI3436435T1 (es)
WO (1) WO2017167950A1 (es)
ZA (1) ZA201806473B (es)

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JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EA201992782A1 (ru) 2017-05-22 2020-03-24 Янссен Фармасьютикалз, Инк. Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
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JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
AU2018274101C1 (en) 2017-05-22 2022-09-15 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
EA201992782A1 (ru) 2017-05-22 2020-03-24 Янссен Фармасьютикалз, Инк. Замещенные производные индолина в качестве ингибиторов репликации вирусов денге

Also Published As

Publication number Publication date
CN108884033B (zh) 2021-03-09
JP6888021B2 (ja) 2021-06-16
HK1258142A1 (zh) 2019-11-08
CO2018009559A2 (es) 2018-09-20
EP3436435B1 (en) 2021-05-12
HRP20210847T1 (hr) 2021-07-23
DK3436435T3 (da) 2021-08-09
SG11201808138YA (en) 2018-10-30
HUE054936T2 (hu) 2021-10-28
JP2019510024A (ja) 2019-04-11
MX2018011784A (es) 2019-02-13
IL261944A (en) 2018-10-31
EP3436435A1 (en) 2019-02-06
ES2882488T3 (es) 2021-12-02
BR112018068676A2 (pt) 2019-01-15
US10646469B2 (en) 2020-05-12
LT3436435T (lt) 2021-08-25
EA201892214A1 (ru) 2019-03-29
KR102359743B1 (ko) 2022-02-07
CA3013405A1 (en) 2017-10-05
CL2018002729A1 (es) 2018-11-23
ECSP18073245A (es) 2018-10-31
US20190274999A1 (en) 2019-09-12
PH12018502015A1 (en) 2019-07-15
ZA201806473B (en) 2020-05-27
KR20180130498A (ko) 2018-12-07
WO2017167950A1 (en) 2017-10-05
AU2017242893A1 (en) 2018-08-09
SI3436435T1 (sl) 2021-08-31
CN108884033A (zh) 2018-11-23

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