PE20221629A1 - Analogos novedosos de nucleosidos sustituidos en el anillo aromatico biciclico 6-6 para su uso como inhibidores de prmt5 - Google Patents

Analogos novedosos de nucleosidos sustituidos en el anillo aromatico biciclico 6-6 para su uso como inhibidores de prmt5

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Publication number
PE20221629A1
PE20221629A1 PE2022000450A PE2022000450A PE20221629A1 PE 20221629 A1 PE20221629 A1 PE 20221629A1 PE 2022000450 A PE2022000450 A PE 2022000450A PE 2022000450 A PE2022000450 A PE 2022000450A PE 20221629 A1 PE20221629 A1 PE 20221629A1
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PE
Peru
Prior art keywords
aromatic ring
bicyclic aromatic
novel analogs
prmt5 inhibitors
nucleosides substituted
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PE2022000450A
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English (en)
Inventor
Tongfei Wu
Dirk Brehmer
Lijs Beke
An Boeckx
Gaston Stanislas Marcella Diels
Ronaldus Arnodus Hendrika Joseph Gilissen
Edward Charles Lawson
Vineet Pande
Cornelis Bernardus Catharina Parade
Wim Bert Griet Schepens
Johannes Wilhelmus John F Thuring
Marcel Viellevoye
Weimei Sun
Lieven Meerpoel
Original Assignee
Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20221629A1 publication Critical patent/PE20221629A1/es

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Abstract

SE REFIERE A COMPUESTOS ANALOGOS DE NUCLEOSIDOS SUSTITUIDOS EN EL ANILLO AROMATICO BICICLICO 6-6 DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H O -C-(=O)-(ALQUILO C1-C4); Y ES -O-; Z ES -CH2-, ETINILO, ENTRE OTROS; Ar ES UN SISTEMA ANULAR AROMATICO BICICLICO DE 10 MIEMBROS CONSTITUIDO POR DOS ANILLOS DE 6 MIEMBROS CONDENSADOS; Het ES UN SISTEMA ANULAR HETEROCICLICO AROMATICO BICICLICO. SIENDO UN COMPUESTO PREFERIDO EL DE FORMULA (i). TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA METILTRANSFERASA PRMT5 SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS AUTOINMUNITARIOS, CANCER, ENFERMEDAD NEURODEGENERATIVA.
PE2022000450A 2015-08-26 2016-08-25 Analogos novedosos de nucleosidos sustituidos en el anillo aromatico biciclico 6-6 para su uso como inhibidores de prmt5 PE20221629A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562209941P 2015-08-26 2015-08-26
EP15184011 2015-09-07
US201662306233P 2016-03-10 2016-03-10
PCT/EP2016/070097 WO2017032840A1 (en) 2015-08-26 2016-08-25 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors

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PE20221629A1 true PE20221629A1 (es) 2022-10-19

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PE2018000306A PE20180929A1 (es) 2015-08-26 2016-08-25 Analogos novedosos de nucleosidos sustituidos en el anillo aromatico biciclico 6-6 para su uso como inhibidores de prmt5

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