PE20140192A1 - Derivados de bencimidazol como inhibidores de cinasa pi3 - Google Patents
Derivados de bencimidazol como inhibidores de cinasa pi3Info
- Publication number
- PE20140192A1 PE20140192A1 PE2013000787A PE2013000787A PE20140192A1 PE 20140192 A1 PE20140192 A1 PE 20140192A1 PE 2013000787 A PE2013000787 A PE 2013000787A PE 2013000787 A PE2013000787 A PE 2013000787A PE 20140192 A1 PE20140192 A1 PE 20140192A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- alkyl
- benzhimidazole
- kinase
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
SE REFIERE A DERIVADOS DE BENCIMIDAZOL COMO INHIBIDORES DE CINASA PI3 DE FORMULA I, DONDE: R1 ES H, ALQUILO C1-C6, ALCOXI, ENTRE OTROS; R2 ES H, -NHRa, ALCOXI, ENTRE OTROS; R3 ES ARILO, HETEROARILO ENTRE OTROS; R4 ES H O Ra, DONDE Ra ES ALQUILO C1-C3; R5 ES ALQUILO C1-C6 Y n ES 0-2. TAMBIEN HACE REFERENCIA A UN COMPUESTO DE FORMULA (I)(C); DONDE R6, R7 Y R8 SON ALQUILO C1-C3, HALOGENO, CF3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(1-METIL-ETIL)-6-(4-MORFOLINIL)-1-(1-NAFTALENIL-METIL)-1H-BENCIMIDAZOL-4-OL, 2-ETIL-6-(4-MORFOLINIL)-1-(1-NAFTALENIL-METIL)-1H-BENCIMIDAZOL-4-OL, 1- (2,3-DICLORO-FENIL)-METIL -2-(1-METIL-ETIL)-6-(4-MORFOLINIL)-1H-BENCIMIDAZOL-4-OL, ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE CANCER.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39031410P | 2010-10-06 | 2010-10-06 | |
US201161528397P | 2011-08-29 | 2011-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20140192A1 true PE20140192A1 (es) | 2014-02-24 |
Family
ID=45925614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013000787A PE20140192A1 (es) | 2010-10-06 | 2011-09-23 | Derivados de bencimidazol como inhibidores de cinasa pi3 |
Country Status (37)
Country | Link |
---|---|
US (10) | US20130196990A1 (es) |
EP (2) | EP2624696B1 (es) |
JP (1) | JP5719028B2 (es) |
KR (1) | KR101594002B1 (es) |
CN (1) | CN103124496B (es) |
AR (1) | AR083296A1 (es) |
AU (1) | AU2011312594B2 (es) |
BR (1) | BR112013008259A2 (es) |
CA (1) | CA2812608C (es) |
CL (1) | CL2013000935A1 (es) |
CO (1) | CO6700852A2 (es) |
CR (1) | CR20130192A (es) |
CY (1) | CY1118792T1 (es) |
DK (1) | DK2624696T3 (es) |
DO (1) | DOP2013000059A (es) |
EA (1) | EA022623B1 (es) |
ES (2) | ES2714384T3 (es) |
HR (1) | HRP20170279T1 (es) |
HU (1) | HUE033209T2 (es) |
IL (1) | IL225140A (es) |
JO (1) | JO3194B1 (es) |
LT (1) | LT2624696T (es) |
MA (1) | MA34591B1 (es) |
ME (1) | ME02663B (es) |
MX (1) | MX337662B (es) |
MY (1) | MY170236A (es) |
NZ (1) | NZ608069A (es) |
PE (1) | PE20140192A1 (es) |
PL (1) | PL2624696T3 (es) |
PT (1) | PT2624696T (es) |
RS (1) | RS55662B1 (es) |
SG (1) | SG188974A1 (es) |
SI (1) | SI2624696T1 (es) |
TW (1) | TWI513690B (es) |
UY (1) | UY33648A (es) |
WO (1) | WO2012047538A1 (es) |
ZA (1) | ZA201301951B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2714384T3 (es) | 2010-10-06 | 2019-05-28 | Glaxosmithkline Llc | Derivados de bencimidazol como inhibidores de PI3 quinasa |
US8778937B2 (en) * | 2011-12-20 | 2014-07-15 | Glaxosmithkline Llc | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors |
JP2016504409A (ja) * | 2013-01-09 | 2016-02-12 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッドGlaxosmithkline Intellectual Property No.2 Limited | 組合せ |
WO2015042027A1 (en) * | 2013-09-19 | 2015-03-26 | Glaxosmithkline Llc | Combination drug therapy |
WO2015042029A1 (en) * | 2013-09-19 | 2015-03-26 | Glaxosmithkline Llc | Combination drug therapy |
JP6139789B2 (ja) * | 2013-10-16 | 2017-05-31 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合複素環化合物、その調製方法、医薬組成物及びその使用 |
CN103910682B (zh) * | 2013-11-28 | 2016-03-02 | 大连理工大学 | 一种基于邻苯二胺环化的苯并咪唑类化合物制备方法 |
EP3082422A4 (en) * | 2013-12-20 | 2017-07-05 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of mek type i and erk inhibitors |
CA2952037A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
CN106573922A (zh) | 2014-06-13 | 2017-04-19 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
MX2016016528A (es) | 2014-06-13 | 2017-03-27 | Gilead Sciences Inc | Inhibidores de fosfatidilinositol 3-quinasa. |
SG11201609527PA (en) | 2014-06-13 | 2016-12-29 | Gilead Sciences Inc | Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors |
CN106459005A (zh) | 2014-06-13 | 2017-02-22 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
EA029789B1 (ru) | 2014-12-19 | 2018-05-31 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ ИМИДАЗОПИРИДАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ |
ES2760507T3 (es) | 2014-12-19 | 2020-05-14 | Janssen Pharmaceutica Nv | Derivados de imidazopiridazina enlazados a heterociclilo como inhibidores de PI3Kß |
GB201504689D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
KR102630111B1 (ko) | 2015-10-09 | 2024-01-25 | 얀센 파마슈티카 엔브이 | PI3Kβ 저해제로서의 퀴녹살린 및 피리도피라진 유도체 |
EP3402795B1 (en) * | 2016-01-14 | 2019-10-30 | Bayer Pharma Aktiengesellschaft | 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines |
WO2017216293A1 (en) * | 2016-06-16 | 2017-12-21 | Janssen Pharmaceutica Nv | Azabenzimidazole derivatives as pi3k beta inhibitors |
EA037361B1 (ru) | 2016-06-16 | 2021-03-18 | Янссен Фармацевтика Нв | Производные бициклического пиридина, пиразина и пиримидина в качестве ингибиторов pi3k бета |
US10960008B2 (en) * | 2016-07-11 | 2021-03-30 | Dana-Farber Cancer Institute, Inc. | Methods for treating PTEN deficient epithelial cancers using a combination of anti-PI3KBETA and anti-immune checkpoint agents |
WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
US11459308B2 (en) | 2016-12-05 | 2022-10-04 | Microbiotix, Inc. | Broad spectrum inhibitors of filoviruses |
JP7053654B2 (ja) | 2017-03-29 | 2022-04-12 | ヤンセン ファーマシューティカ エヌ.ベー. | PI3Kβ阻害剤としてのキノキサリン及びピリドピラジン誘導体 |
UA125317C2 (uk) | 2017-07-28 | 2022-02-16 | Юхан Корпорейшн | Удосконалений спосіб отримання похідних амінопіримідину |
WO2019106605A1 (en) | 2017-12-01 | 2019-06-06 | Board Of Regents, The University Of Texas System | Combination treatment for cancer |
US11253189B2 (en) | 2018-01-24 | 2022-02-22 | Medtronic Ardian Luxembourg S.A.R.L. | Systems, devices, and methods for evaluating neuromodulation therapy via detection of magnetic fields |
CN111000847B (zh) * | 2020-01-02 | 2021-03-19 | 黑龙江中医药大学 | 一种治疗肺纤维化的药物制剂及其用途 |
CN111346095B (zh) * | 2020-03-14 | 2021-06-08 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 用于治疗神经外科术后头痛的药物制剂 |
Family Cites Families (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2016710A1 (en) | 1989-05-15 | 1990-11-15 | Prasun K. Chakravarty | Substituted benzimidazoles as angiotensin ii antagonists |
IL95975A (en) | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
US5559235A (en) | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
TW284688B (es) | 1991-11-20 | 1996-09-01 | Takeda Pharm Industry Co Ltd | |
US5502187A (en) | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
PL175327B1 (pl) | 1992-04-03 | 1998-12-31 | Upjohn Co | Dwupierścieniowe heterocykliczne aminy |
GB9210400D0 (en) | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
US5342947A (en) | 1992-10-09 | 1994-08-30 | Glaxo Inc. | Preparation of water soluble camptothecin derivatives |
JPH0867674A (ja) | 1993-07-02 | 1996-03-12 | Senju Pharmaceut Co Ltd | 眼圧降下剤 |
CZ154994A3 (en) | 1993-07-02 | 1995-09-13 | Senju Pharma Co | Visual hypotensive agent |
US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
ZA953311B (en) | 1994-04-29 | 1996-10-24 | Lilly Co Eli | Non-peptidyl tachykinin receptor antagonists |
US5491237A (en) | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
US5563143A (en) | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
DE19514579A1 (de) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
CA2242579A1 (en) | 1996-01-09 | 1997-07-17 | Eli Lilly And Company | Benzimidzolyl neuropeptide y receptor antagonists |
AU2139097A (en) | 1996-03-01 | 1997-09-16 | Eli Lilly And Company | Methods of treating or preventing sleep apnea |
CA2248013A1 (en) | 1996-03-11 | 1997-09-18 | Eli Lilly And Company | Methods of treating or preventing interstitial cystitis |
JP2001515482A (ja) | 1997-03-07 | 2001-09-18 | メタバシス・セラピューティクス・インコーポレイテッド | フルクトース−1,6−ビスホスファターゼの新規なベンズイミダゾールインヒビター |
GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
MXPA01009949A (es) | 1999-04-02 | 2003-07-14 | Neurogen Corp | Derivados aminoalquil-imidazol arilo y heteroarilo fusionados, moduladores selectivos de los receptores gaba a. |
US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
JP2000323278A (ja) | 1999-05-14 | 2000-11-24 | Toray Ind Inc | 発光素子 |
JP2003505369A (ja) | 1999-07-15 | 2003-02-12 | エヌピーエス アレリックス コーポレーション | 偏頭痛を治療するための複素環式化合物 |
AU6762400A (en) | 1999-08-12 | 2001-03-13 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
WO2001021634A1 (en) | 1999-09-21 | 2001-03-29 | Lion Bioscience Ag | Benzimidazole derivatives and combinatorial libraries thereof |
KR100613176B1 (ko) | 1999-12-03 | 2006-08-17 | 오노 야꾸힝 고교 가부시키가이샤 | 트리아자스피로[5.5]운데칸 유도체 및 이들을유효성분으로 하는 약제 |
WO2001057020A1 (en) | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa |
PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
US6472095B2 (en) | 2000-12-29 | 2002-10-29 | Utc Fuel Cells, Llc | Hybrid fuel cell reactant flow fields |
TW593278B (en) | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
US6951848B2 (en) | 2001-03-12 | 2005-10-04 | Millennium Pharmaceuticals, Inc., | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
HUP0400241A2 (hu) | 2001-03-19 | 2004-06-28 | Ono Pharmaceutical Co., Ltd. | Hatóanyagként triaza-spiro[5.5]undekán-származékokat tartalmazó gyógyszerkészítmények |
FR2822463B1 (fr) | 2001-03-21 | 2004-07-30 | Lipha | Derives bicycliques de guanidines et leurs applications en therapeutique |
WO2002076960A1 (en) | 2001-03-22 | 2002-10-03 | Abbott Gmbh & Co. Kg | Transition metal mediated process |
US7081454B2 (en) * | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
SK12002003A3 (en) * | 2001-03-28 | 2004-10-05 | Bristol Myers Squibb Co | Novel tyrosine kinase inhibitors |
TWI236474B (en) | 2001-04-03 | 2005-07-21 | Telik Inc | Antagonists of MCP-1 function and methods of use thereof |
JP2004526781A (ja) | 2001-04-20 | 2004-09-02 | ワイス | 5−ヒドロキシトリプトアミン−6リガンドとしてのヘテロシクリルアルコキシ−、−アルキルチオ−および−アルキルアミノベンザゾール誘導体 |
US6815456B2 (en) | 2001-04-20 | 2004-11-09 | Wyeth | Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands |
US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
EP1401431A4 (en) | 2001-06-15 | 2004-07-07 | Genentech Inc | HUMAN GROWTH HORMONE ANTAGONISTS |
US6841566B2 (en) | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
FR2827862A1 (fr) | 2001-07-27 | 2003-01-31 | Lipha | Derives imidazolylalkylarylalcanoiques et leurs applications en therapeutique |
DE10139416A1 (de) | 2001-08-17 | 2003-03-06 | Aventis Pharma Gmbh | Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
FR2829765A1 (fr) | 2001-09-14 | 2003-03-21 | Lipha | Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique |
US7087593B2 (en) | 2001-10-02 | 2006-08-08 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
WO2004089942A2 (en) | 2001-10-02 | 2004-10-21 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
ATE511840T1 (de) | 2001-10-09 | 2011-06-15 | Amgen Inc | Imidazolderivate als entzündungshemmende mittel |
EP1442028A4 (en) | 2001-11-06 | 2009-11-04 | Bristol Myers Squibb Co | SUBSTITUTED ACID DERIVATIVES, WHICH APPRECIATE AS ANTIDIBILICS AND AGENTS AGAINST OBESITAS, AND METHODS |
WO2003045929A1 (fr) | 2001-11-26 | 2003-06-05 | Takeda Chemical Industries, Ltd. | Derive bicyclique, procede de production de ce derive et utilisation correspondante |
EP1513522A2 (en) | 2002-01-18 | 2005-03-16 | Sri International | Methods of treating conditions associated with an edg receptor |
US20050176858A1 (en) | 2002-02-15 | 2005-08-11 | Bridgestone Corporation | Rubber composition and pneumatic tire made therefrom |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
SG148857A1 (en) | 2002-03-13 | 2009-01-29 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
BR0306016A (pt) | 2002-03-13 | 2005-01-04 | Array Biopharma Inc | Derivados de benzimidazol n3 alquilado como inibidores da mek |
UA76837C2 (uk) | 2002-03-13 | 2006-09-15 | Еррей Байофарма Інк. | N3 алкіловані похідні бензімідазолу як інгібітори мек |
SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
US7205412B2 (en) | 2002-07-03 | 2007-04-17 | Samsung Electronics Co., Ltd. | Antibiotic additive and ink composition comprising the same |
DE10229777A1 (de) | 2002-07-03 | 2004-01-29 | Bayer Ag | Indolin-Phenylsulfonamid-Derivate |
WO2004014905A1 (en) | 2002-08-08 | 2004-02-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzimidazole compounds |
US20040063938A1 (en) | 2002-09-30 | 2004-04-01 | Pfizer Inc | Process for preparing haloalkyl pyrimidines |
WO2004043913A2 (en) | 2002-11-08 | 2004-05-27 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
US7759336B2 (en) | 2002-12-10 | 2010-07-20 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compounds and medicinal use thereof |
TW200418806A (en) | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
US20050020654A1 (en) | 2003-03-15 | 2005-01-27 | Pershadsingh Harrihar A. | Novel PPAR agonists, pharmaceutical compositions and uses thereof |
KR20050119201A (ko) * | 2003-04-09 | 2005-12-20 | 니뽄 다바코 산교 가부시키가이샤 | 5원 헤테로방향족 고리 화합물 및 이의 의약적 용도 |
JPWO2004093912A1 (ja) | 2003-04-23 | 2006-07-13 | 協和醗酵工業株式会社 | 好中球性炎症疾患の予防および/または治療剤 |
EP1620413A2 (en) | 2003-04-30 | 2006-02-01 | Cytokinetics, Inc. | Compounds, compositions, and methods |
SE0301699D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
BRPI0412003A (pt) | 2003-07-02 | 2006-08-15 | Sugen Inc | arilmetil triazol e imidazopirazinas como inibidores de c-met |
US7312215B2 (en) * | 2003-07-29 | 2007-12-25 | Bristol-Myers Squibb Company | Benzimidazole C-2 heterocycles as kinase inhibitors |
DE10342503A1 (de) | 2003-09-12 | 2005-04-14 | Merck Patent Gmbh | Benzyl-Benzimidazolylderivate |
JP5042626B2 (ja) | 2003-09-22 | 2012-10-03 | エス*バイオ プライベート リミティッド | ベンズイミダゾール誘導体:製造及び医薬適用 |
WO2005051928A1 (en) | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | Process for production of tetrazolyl compounds |
WO2005051929A1 (en) | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | Conversion of aromatic nitriles into tetrazoles |
US20050137234A1 (en) | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
US20050209284A1 (en) | 2004-02-12 | 2005-09-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Tec kinase inhibitors |
EP1724271A4 (en) | 2004-02-26 | 2013-01-23 | Kyowa Hakko Kirin Co Ltd | PREVENTIVE AND / OR THERAPEUTIC AGENT AGAINST NEUTROPHIC INFLAMMATORY DISEASE |
WO2005090303A1 (en) | 2004-03-15 | 2005-09-29 | Eli Lilly And Company | 4- (5- (aminomethyl) -indole-1-ylmethyl) -benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity |
CA2558389C (en) | 2004-03-15 | 2013-10-08 | Anormed, Inc. | Process for the synthesis of a cxcr4 antagonist |
CA2565200C (en) | 2004-05-07 | 2013-12-24 | Exelixis, Inc. | Raf modulators and methods of use |
WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006000020A1 (en) | 2004-06-29 | 2006-01-05 | European Nickel Plc | Improved leaching of base metals |
CA2577100A1 (en) | 2004-08-16 | 2006-03-02 | Smithkline Beecham Corporation | Chemical compounds |
NZ588431A (en) | 2004-09-17 | 2012-02-24 | Whitehead Biomedical Inst | Using Benzimidazole or Indole compounds with a 1,2-diazole group to Inhibit Alpha-Synuclein Toxicity |
AU2005302519A1 (en) | 2004-11-01 | 2006-05-11 | Nuada, Llc | Compounds and methods of use thereof |
WO2007134169A2 (en) | 2006-05-10 | 2007-11-22 | Nuada, Llc | Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof |
US20090264384A1 (en) | 2004-11-01 | 2009-10-22 | Nuada, Inc. | Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof |
US8003806B2 (en) | 2004-11-12 | 2011-08-23 | OSI Pharmaceuticals, LLC | Integrin antagonists useful as anticancer agents |
US20100093767A1 (en) | 2004-12-03 | 2010-04-15 | Takeda San Diego, Inc. | Mitotic Kinase Inhibitors |
EP1856096B1 (en) | 2005-01-10 | 2010-09-01 | Bristol-Myers Squibb Company | Phenylglycinamide derivatives useful as anticoagulants |
US7429608B2 (en) | 2005-01-20 | 2008-09-30 | Amgen Inc. | Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments |
CN1834090B (zh) | 2005-03-18 | 2011-06-29 | 中国科学院上海药物研究所 | 苯并咪唑类化合物、其制备方法以及用途 |
WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
US7470827B2 (en) | 2005-06-03 | 2008-12-30 | Ppg Industries Ohio, Inc. | Composition for the vapor phase dehydrohalogenation of 1,1,2-trihaloethane to 1,1-dihaloethylene and methods for preparing and using such composition |
BRPI0611707A2 (pt) | 2005-06-29 | 2012-04-24 | Compumedics Ltd | conjunto de sensor com ponte condutiva |
JP2009500451A (ja) | 2005-07-11 | 2009-01-08 | スミスクライン ビーチャム コーポレーション | ピラノピリジン化合物 |
JP2007063261A (ja) | 2005-08-01 | 2007-03-15 | Kyowa Hakko Kogyo Co Ltd | X線照射による肺障害の予防及び/または治療剤 |
WO2007023880A1 (ja) | 2005-08-24 | 2007-03-01 | Kyowa Hakko Kogyo Co., Ltd. | ケモカイン産生阻害剤 |
JP2009507792A (ja) | 2005-08-29 | 2009-02-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非受容体型チロシンキナーゼのtecファミリーの阻害剤として有用な3,5−二置換ピリド−2−オン |
TW200720261A (en) | 2005-08-31 | 2007-06-01 | Sankyo Co | Phenylene derivatives |
WO2007030080A1 (en) | 2005-09-08 | 2007-03-15 | S*Bio Pte Ltd | Heterocyclic compounds |
WO2007054965A2 (en) | 2005-09-23 | 2007-05-18 | Alembic Limited | Process for preparation of tetrazoles from aromatic cyano derivatives |
GB0520164D0 (en) | 2005-10-04 | 2005-11-09 | Novartis Ag | Organic compounds |
US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
NZ569607A (en) | 2005-12-20 | 2011-06-30 | Astrazeneca Ab | Substituted cinnoline derivatives as GABBA-receptor modulators and method for their synthesis |
US20080312211A1 (en) | 2005-12-23 | 2008-12-18 | Astrazeneca Ab | Antibacterial Pyrrolopyridines, Pyrrolopyrimidines and Pyrroloazepines-154 |
US7691902B2 (en) | 2005-12-28 | 2010-04-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
JP2009525955A (ja) | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
NZ570103A (en) | 2006-01-26 | 2011-11-25 | Foldrx Pharmaceuticals Inc | Compounds and methods for modulating protein trafficking |
WO2007091950A1 (en) | 2006-02-07 | 2007-08-16 | Astrazeneca Ab | Benzimidazoles and imidazopyridines useful in the treatment of diseases or disorders associated with cannabinoid receptor 2 (cb2) such as pain |
WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
JP2009532381A (ja) | 2006-03-31 | 2009-09-10 | アストラゼネカ アクチボラグ | 二環式ベンズイミダゾール化合物、および代謝型グルタミン酸受容体増強剤としての該化合物の使用 |
DE102006025777A1 (de) | 2006-05-31 | 2007-12-06 | Merck Patent Gmbh | Neue Materialien für organische Elektrolumineszenzvorrichtungen |
EP1873157A1 (en) | 2006-06-21 | 2008-01-02 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
EP1878724A1 (en) | 2006-07-15 | 2008-01-16 | sanofi-aventis | A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles |
WO2008012623A1 (en) | 2006-07-25 | 2008-01-31 | Pfizer Products Inc. | Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor |
WO2008019309A1 (en) | 2006-08-04 | 2008-02-14 | Metabasis Therapeutics, Inc. | Novel inhibitors of fructose 1,6-bisphosphatase |
WO2008020920A1 (en) | 2006-08-15 | 2008-02-21 | Duke University | Ros-sensitive iron chelators and methods of using the same |
WO2008032086A1 (en) * | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 2-benzimidazolyl-6-morpholino-4-phenylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
EP2078018B1 (en) | 2006-10-19 | 2012-03-14 | Signal Pharmaceuticals LLC | Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors |
WO2008052072A2 (en) | 2006-10-24 | 2008-05-02 | Acadia Pharmaceuticals Inc. | Compounds for the treatment of pain and screening methods therefor |
PE20090054A1 (es) | 2007-01-23 | 2009-01-26 | Palau Pharma Sa | Derivados de purina |
JP4866901B2 (ja) | 2007-02-07 | 2012-02-01 | 協和発酵キリン株式会社 | 3環系化合物 |
EP2131840B1 (en) | 2007-03-07 | 2018-10-17 | MEI Pharma, Inc. | Combination of benzimidazole anti-cancer agent and a second anti-cancer agent |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
CN101778838A (zh) | 2007-05-24 | 2010-07-14 | 惠氏有限责任公司 | 作为组胺-3拮抗剂的氮杂环基苯甲酰胺衍生物 |
TW200906825A (en) | 2007-05-30 | 2009-02-16 | Scripps Research Inst | Inhibitors of protein kinases |
BRPI0813271A2 (pt) | 2007-06-26 | 2014-12-30 | Sanofi Aventis | Síntese regiosseletiva catalisada por cobre de benzimidazóis e azabenzimidazóis |
EP2014663A1 (de) | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma AG | Thienopyrimidylamine als Modulatoren des EP2-Rezeptors |
EP2014662A1 (de) | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma Aktiengesellschaft | Indolylalkylthienopyrimidylamine als Modulatoren des EP2-Rezeptors |
US7939671B2 (en) | 2007-08-21 | 2011-05-10 | Senomyx, Inc. | Compounds that inhibit (block) bitter taste in composition and use thereof |
WO2009027736A2 (en) | 2007-08-27 | 2009-03-05 | Astrazeneca Ab | 2,4 diaminopyrimid'lnes for the treatment of myeloproliferative disorders and cancer |
JP2010539239A (ja) | 2007-09-17 | 2010-12-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Pi3キナーゼ阻害剤としてのピリドピリミジン誘導体 |
US20090118301A1 (en) | 2007-11-02 | 2009-05-07 | Arbor Vita Corporation | Compositions and Methods for Treating Cancer |
EA201000797A1 (ru) | 2007-11-27 | 2011-02-28 | Целльзом Лимитид | Аминотриазолы в качестве ингибиторов pi3k |
EP2234486A4 (en) | 2007-12-19 | 2011-09-14 | Scripps Research Inst | BENZIMIDAZOLE AND ANALOGUE AS RHO-KINASEHEMMER |
AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
ES2442930T3 (es) | 2008-01-11 | 2014-02-14 | Novartis Ag | Pirimidinas como inhibidores de cinasas |
CN102014914A (zh) | 2008-01-15 | 2011-04-13 | 惠氏有限责任公司 | 3h-[1,2,3]***并[4,5-d]嘧啶化合物、其作为mtor激酶和pi3激酶抑制剂的用途、以及它们的合成 |
JP2011510030A (ja) | 2008-01-22 | 2011-03-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換アミノ−ベンゾイミダゾール類、該化合物を含む医薬、これらの使用及びこれらの製造方法 |
FR2928924B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
MX2010010406A (es) | 2008-03-27 | 2010-10-25 | Janssen Pharmaceutica Nv | Tetrahidrofenantridinonas y tetrahidrociclopentaquinolinonas como inhibidores de la polimerizacion de poli(adp-ribosa)polimerasa-1 y tubulina. |
JP5464609B2 (ja) | 2008-03-27 | 2014-04-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チューブリン重合阻害剤としてのキナゾリノン誘導体 |
US20090253161A1 (en) | 2008-04-03 | 2009-10-08 | Duke University | Fluorescent prochelators for cellular iron detection |
AR072249A1 (es) | 2008-04-09 | 2010-08-18 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de acido graso. usos. metodos. |
MX2010013249A (es) | 2008-06-04 | 2010-12-21 | Astrazeneca Ab | Derivados de tiazolo[5,4-b]piridina y oxazolo[5,4-b]piridina como agentes antibacterianos. |
JP2010031250A (ja) | 2008-06-23 | 2010-02-12 | Sumitomo Chemical Co Ltd | 組成物及び該組成物を用いてなる発光素子 |
WO2010000020A1 (en) | 2008-06-30 | 2010-01-07 | Cathrx Ltd | A catheter |
WO2010003048A1 (en) | 2008-07-03 | 2010-01-07 | Sirtris Pharmaceuticals, Inc. | Benzimidazoles and related analogs as sirtuin modulators |
WO2010005558A2 (en) * | 2008-07-07 | 2010-01-14 | Xcovery, Inc. | Pi3k isoform selective inhibitors |
WO2010006096A1 (en) | 2008-07-11 | 2010-01-14 | Smithkline Beecham Corporation | Processes for the preparation of anti-viral compounds and compositions containing them |
US8501957B2 (en) | 2008-12-10 | 2013-08-06 | China Medical University | Benzimidazole compounds and their use as anticancer agents |
JP5802136B2 (ja) | 2009-01-23 | 2015-10-28 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Jak経路の阻害のための組成物および方法 |
KR101411889B1 (ko) | 2009-02-27 | 2014-06-27 | 이난타 파마슈티칼스, 인코포레이티드 | C형 간염 바이러스 억제제 |
US8975247B2 (en) | 2009-03-18 | 2015-03-10 | The Board Of Trustees Of The Leland Stanford Junion University | Methods and compositions of treating a flaviviridae family viral infection |
US20120006688A1 (en) | 2009-03-18 | 2012-01-12 | Basf Se | Electrolyte and surface-active additives for the electrochemical deposition of smooth, dense aluminum layers from ionic liquids |
EP2408753A4 (en) | 2009-03-20 | 2012-11-07 | Univ Brandeis | COMPOUNDS AND METHOD FOR THE TREATMENT OF MICROBIAL STOMACH DARM INFECTIONS IN MAMMALS |
WO2010114726A1 (en) | 2009-03-31 | 2010-10-07 | Merck Sharp & Dohme Corp. | Aminobenzotriazole derivatives |
SI2414369T1 (sl) | 2009-04-02 | 2015-12-31 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Derivati imidazo(2,1-b)(1,3,4)tiadiazola |
US20100305093A1 (en) | 2009-04-09 | 2010-12-02 | Exelixis, Inc. | Inhibitors of mTOR and Methods of Making and Using |
WO2010126745A1 (en) | 2009-04-27 | 2010-11-04 | High Point Pharmaceuticals, Llc | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS |
WO2010126922A1 (en) | 2009-04-30 | 2010-11-04 | Glaxosmithkline Llc | Benzimidazolecarboxamides as inhibitors of fak |
CA2763099A1 (en) | 2009-05-22 | 2010-11-25 | Exelixis, Inc. | Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases |
BRPI1010896A2 (pt) | 2009-05-26 | 2019-09-24 | Exelixis Inc | benzoxazepinas como inibidores de pi3k/mtor e métodos de seus usos e fabricação |
WO2010141360A1 (en) | 2009-06-05 | 2010-12-09 | Merck Sharp & Dohme Corp. | Biaryl benzotriazole derivatives |
US9221765B2 (en) | 2009-06-10 | 2015-12-29 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives |
WO2011000020A1 (en) | 2009-06-12 | 2011-01-06 | Sbc Research Pty Ltd | Enhanced method of detection |
JP2011003793A (ja) | 2009-06-19 | 2011-01-06 | Idemitsu Kosan Co Ltd | 有機el素子 |
US20120178769A1 (en) | 2009-07-15 | 2012-07-12 | The University Of Medicine And Dentistry | Novel compounds for inhibiting eef-2 kinase activity |
NZ600240A (en) | 2009-10-29 | 2014-04-30 | Bristol Myers Squibb Co | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
US8754113B2 (en) | 2009-12-15 | 2014-06-17 | Shionogi & Co., Ltd. | Oxadiazole derivative having endothelial lipase inhibitory activity |
ES2362337B1 (es) | 2009-12-17 | 2012-05-16 | Consejo Superior De Investigaciones Cient�?Ficas (Csic) | Derivados de aminociclitoles, procedimiento de obtencion y usos. |
ES2714384T3 (es) * | 2010-10-06 | 2019-05-28 | Glaxosmithkline Llc | Derivados de bencimidazol como inhibidores de PI3 quinasa |
US20160242436A1 (en) | 2013-10-11 | 2016-08-25 | Unicharm Corporation | Pet food |
-
2011
- 2011-09-23 ES ES16204387T patent/ES2714384T3/es active Active
- 2011-09-23 NZ NZ608069A patent/NZ608069A/en not_active IP Right Cessation
- 2011-09-23 CA CA2812608A patent/CA2812608C/en active Active
- 2011-09-23 HU HUE11831214A patent/HUE033209T2/hu unknown
- 2011-09-23 US US13/876,853 patent/US20130196990A1/en not_active Abandoned
- 2011-09-23 MA MA35789A patent/MA34591B1/fr unknown
- 2011-09-23 BR BR112013008259A patent/BR112013008259A2/pt not_active Application Discontinuation
- 2011-09-23 PE PE2013000787A patent/PE20140192A1/es active IP Right Grant
- 2011-09-23 PL PL11831214T patent/PL2624696T3/pl unknown
- 2011-09-23 SI SI201131123A patent/SI2624696T1/sl unknown
- 2011-09-23 ES ES11831214.9T patent/ES2616238T3/es active Active
- 2011-09-23 EA EA201390302A patent/EA022623B1/ru not_active IP Right Cessation
- 2011-09-23 PT PT118312149T patent/PT2624696T/pt unknown
- 2011-09-23 KR KR1020137011735A patent/KR101594002B1/ko active IP Right Grant
- 2011-09-23 EP EP11831214.9A patent/EP2624696B1/en active Active
- 2011-09-23 MX MX2013003918A patent/MX337662B/es active IP Right Grant
- 2011-09-23 SG SG2013018437A patent/SG188974A1/en unknown
- 2011-09-23 DK DK11831214.9T patent/DK2624696T3/en active
- 2011-09-23 EP EP16204387.1A patent/EP3170813B1/en active Active
- 2011-09-23 WO PCT/US2011/052857 patent/WO2012047538A1/en active Application Filing
- 2011-09-23 CN CN201180048753.4A patent/CN103124496B/zh active Active
- 2011-09-23 ME MEP-2017-59A patent/ME02663B/me unknown
- 2011-09-23 AU AU2011312594A patent/AU2011312594B2/en not_active Ceased
- 2011-09-23 RS RS20170140A patent/RS55662B1/sr unknown
- 2011-09-23 JP JP2013532826A patent/JP5719028B2/ja active Active
- 2011-09-23 MY MYPI2013700531A patent/MY170236A/en unknown
- 2011-09-23 LT LTEP11831214.9T patent/LT2624696T/lt unknown
- 2011-10-03 US US13/251,476 patent/US8435988B2/en active Active
- 2011-10-04 TW TW100135950A patent/TWI513690B/zh not_active IP Right Cessation
- 2011-10-04 JO JOP/2011/0306A patent/JO3194B1/ar active
- 2011-10-04 UY UY0001033648A patent/UY33648A/es not_active Application Discontinuation
- 2011-10-04 AR ARP110103677A patent/AR083296A1/es unknown
-
2013
- 2013-03-10 IL IL225140A patent/IL225140A/en active IP Right Grant
- 2013-03-13 US US13/798,923 patent/US8541411B2/en active Active
- 2013-03-14 ZA ZA2013/01951A patent/ZA201301951B/en unknown
- 2013-03-15 DO DO2013000059A patent/DOP2013000059A/es unknown
- 2013-04-05 CL CL2013000935A patent/CL2013000935A1/es unknown
- 2013-04-08 CO CO13090997A patent/CO6700852A2/es active IP Right Grant
- 2013-05-02 CR CR20130192A patent/CR20130192A/es unknown
- 2013-09-19 US US14/031,136 patent/US8674090B2/en active Active
-
2014
- 2014-01-27 US US14/164,414 patent/US8865912B2/en active Active
- 2014-09-09 US US14/481,098 patent/US9062003B2/en active Active
-
2015
- 2015-05-15 US US14/712,991 patent/US9156797B2/en active Active
- 2015-09-03 US US14/844,051 patent/US9872860B2/en active Active
-
2017
- 2017-02-20 HR HRP20170279TT patent/HRP20170279T1/hr unknown
- 2017-03-03 CY CY20171100283T patent/CY1118792T1/el unknown
-
2018
- 2018-01-09 US US15/865,703 patent/US10314845B2/en active Active
-
2019
- 2019-04-24 US US16/393,210 patent/US10660898B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20140192A1 (es) | Derivados de bencimidazol como inhibidores de cinasa pi3 | |
ES2521596T3 (es) | Combinación del compuesto GlyT1 con antipsicóticos | |
AR082799A1 (es) | Derivados de quinolina y quinoxalina como inhibidores de quinasa | |
PE20120058A1 (es) | Derivados de imidazopirazina como inhibidores de syk | |
PE20100138A1 (es) | Derivados de morfolino pirimidina usados en enfermedades relacionadas en mtor quinasa y/o pi3k | |
PE20170677A1 (es) | Nuevos compuestos como inhibidores de reorganizado durante la transfeccion (ret) | |
PE20121695A1 (es) | 5-alquinil-pirimidinas | |
PE20190656A1 (es) | Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 | |
PE20171177A1 (es) | Compuestos aminopirimidinilo inhibidores de jak | |
MX2015012427A (es) | Compuestos de morfolinona de acido heteroarilo como inhibidores mdm2 para el tratamiento de cancer. | |
PE20141380A1 (es) | Imidazopiridazinas como inhibidores de quinasa akt | |
EA201291356A1 (ru) | Пиперидиноновые производные как ингибиторы mdm2 для лечения рака | |
PE20160540A1 (es) | Inhibidores de bromodominios | |
PE20170664A1 (es) | Agonistas del receptor de apelina(apj) y usos de los mismos | |
EA201001683A1 (ru) | Производные фенил- или пиридинилзамещенных индазолов | |
EA201591753A1 (ru) | 3-пиримидин-4-илоксазолидин-2-оны в качестве ингибиторов мутантного idh | |
EA201100447A1 (ru) | Органические соединения | |
PE20110419A1 (es) | Compuestos de pirrolo-pirimidina como inhibidores de cdk | |
PE20140918A1 (es) | Compuestos de benzoxepina inhibidores de la pi3k | |
AR070828A1 (es) | Derivados de azetidina y ciclobutano como inhibidores de jak | |
PE20141075A1 (es) | 4-aril-n-fenil-1,3,5-triazin-2-aminas que contienen un grupo sulfoximina | |
EA201400333A1 (ru) | Бензонитрильные производные в качестве ингибиторов киназ | |
AR059957A1 (es) | DERIVADOS DE ESPIROINDOLINONA, MÉTODOS PARA SU PREPARACIoN, UNA COMPOSICIoN FARMACÉUTICA QUE LOS CONTIENE Y SU USO EN LA FABRICACIoN DE MEDICAMENTOS PARA EL TRATAMIENTO DEL CÁNCER. | |
PE20160654A1 (es) | Compuestos de inhibidor de autotaxina | |
MX352672B (es) | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |