PE20011213A1 - Sales de imidazo-3-aminas e imidazo-5-aminas biciclicas n-aciladas y sus productos de adicion con acidos, procedimientos para su preparacion y medicamentos que contienen estos compuestos - Google Patents

Sales de imidazo-3-aminas e imidazo-5-aminas biciclicas n-aciladas y sus productos de adicion con acidos, procedimientos para su preparacion y medicamentos que contienen estos compuestos

Info

Publication number
PE20011213A1
PE20011213A1 PE2001000355A PE2001000355A PE20011213A1 PE 20011213 A1 PE20011213 A1 PE 20011213A1 PE 2001000355 A PE2001000355 A PE 2001000355A PE 2001000355 A PE2001000355 A PE 2001000355A PE 20011213 A1 PE20011213 A1 PE 20011213A1
Authority
PE
Peru
Prior art keywords
imidazo
alkyl
amines
phenyl
compounds
Prior art date
Application number
PE2001000355A
Other languages
English (en)
Inventor
Corinna Maul
Matthias Gerlach
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20011213A1 publication Critical patent/PE20011213A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

SE REFIERE A SALES DE IMIDAZO-3-AMINAS E IMIDAZO-5-AMINAS BICICLICAS, N-ACILADAS DE FORMULA I DONDE R1 ES BUTILO, 1,1,3,3-TETRAMETILBUTILO, (CH2)nCN, FENILO, CICLOALQUILO C4-C8, CH2CH2R, CH2Ra, ENTRE OTROS; n ES 4-6; R ES 4-MORFOLINO; Ra ES H, ALQUILO C1-C8, FENILO, ENTRE OTROS; R2 ES H, CORb; Rb ES ALQUILO C1-C8, ALCOXI C1-C8, ENTRE OTROS; R3 ES ALQUILO C1-C6, CICLOALQUILO C3-C8, FENILO, 1-NAFTILO, ENTRE OTROS; A ES UN GRUPO a, b, c, ENTRE OTROS; R4, R5, R6, R7 SON H, ALQUILO C1-C8, F, Cl, NHRf, ENTRE OTROS; Rf ES H, ALQUILO C1-C8, ENTRE OTROS; R8 ES ALQUILO C1-C8, ARILO, HETEROARILO, CICLOALQUILO C3-C8, ENTRE OTROS; X ES EL ANION DE UN ACIDO ORGANICO O INORGANICO. SON COMPUESTOS PREFERIDOS CLORURO DE 7-ACETIL-5-TER-BUTILAMINO-6-FENIL-IMIDAZO[2,1-b]-TIAZOLILO-7; CLORURO DE 1-ACETIL-8-BENCILOXI-3-TER-BUTILAMINO-2-METIL-IMIDAZO-[1,2-a]-PIRIDINIO-1, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA TRATAR EL DOLOR, ABUSO DE DROGAS, ALCOHOL, DIARREA, GASTRITIS, ULCERAS , INCONTINENCIA URINARIA, DEPRESIONES, NARCOLEPSIA, ASMA, GLAUCOMA, PRURITO, SINDROME HIPERCINETICO, EPILEPSIA, ESQUIZOFRENIA, EFECTO ANESTESICO
PE2001000355A 2000-04-20 2001-04-19 Sales de imidazo-3-aminas e imidazo-5-aminas biciclicas n-aciladas y sus productos de adicion con acidos, procedimientos para su preparacion y medicamentos que contienen estos compuestos PE20011213A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10019714A DE10019714A1 (de) 2000-04-20 2000-04-20 Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen

Publications (1)

Publication Number Publication Date
PE20011213A1 true PE20011213A1 (es) 2001-12-29

Family

ID=7639529

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000355A PE20011213A1 (es) 2000-04-20 2001-04-19 Sales de imidazo-3-aminas e imidazo-5-aminas biciclicas n-aciladas y sus productos de adicion con acidos, procedimientos para su preparacion y medicamentos que contienen estos compuestos

Country Status (30)

Country Link
US (2) US7087607B2 (es)
EP (1) EP1274709B1 (es)
JP (1) JP2003531208A (es)
KR (1) KR100756594B1 (es)
CN (1) CN1232520C (es)
AR (1) AR030559A1 (es)
AT (1) ATE277045T1 (es)
AU (2) AU5830501A (es)
BR (1) BR0110357A (es)
CA (1) CA2402808A1 (es)
CZ (1) CZ20023476A3 (es)
DE (2) DE10019714A1 (es)
DK (1) DK1274709T3 (es)
ES (1) ES2227186T3 (es)
HK (1) HK1052703B (es)
HU (1) HUP0300532A3 (es)
IL (2) IL152352A0 (es)
MX (1) MXPA02009602A (es)
NO (1) NO323542B1 (es)
NZ (1) NZ521069A (es)
PE (1) PE20011213A1 (es)
PL (1) PL365676A1 (es)
PT (1) PT1274709E (es)
RU (1) RU2268888C2 (es)
SI (1) SI1274709T1 (es)
SK (1) SK15022002A3 (es)
TR (1) TR200402755T4 (es)
UY (1) UY26675A1 (es)
WO (1) WO2001081344A1 (es)
ZA (1) ZA200209408B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10019714A1 (de) 2000-04-20 2002-01-10 Gruenenthal Gmbh Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen
DE10050663A1 (de) † 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
MX2007014510A (es) 2005-05-20 2008-02-05 Array Biopharma Inc Compuestos inhibidores de raf y metodos de uso de los mismos.
CA2620223A1 (en) 2005-09-02 2007-03-08 Abbott Laboratories Novel imidazo based heterocycles
AU2006331673B2 (en) 2005-12-23 2013-02-28 Ariad Pharmaceuticals, Inc. Bicyclic heteroaryl compounds
JP4610668B2 (ja) * 2006-03-17 2011-01-12 アムビト ビオスシエンセス コルポラチオン 疾患を治療するためのイミダゾロチアゾール化合物
EA200870592A1 (ru) * 2006-05-31 2009-08-28 Галапагос Н.В. Триазолопиразиновые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний
EP2068869A4 (en) * 2006-10-06 2011-05-25 Abbott Lab NEW IMIDAZOTHIAZOLE AND IMIDAZOXAZOLE
US7985375B2 (en) * 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
US8703492B2 (en) 2007-04-06 2014-04-22 Qiagen Gaithersburg, Inc. Open platform hybrid manual-automated sample processing system
WO2009038757A2 (en) * 2007-09-19 2009-03-26 Ambit Biosciences Corporation Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith
US9953141B2 (en) 2009-11-18 2018-04-24 Becton, Dickinson And Company Laboratory central control unit method and system
KR200453430Y1 (ko) * 2011-01-10 2011-05-03 백현숙 싱크대용 선반
AU2013251683A1 (en) 2012-04-26 2014-12-18 Bristol-Myers Squibb Company Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
AU2013251680A1 (en) 2012-04-26 2014-11-13 Bristol-Myers Squibb Company Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
SI3243826T1 (sl) 2012-04-26 2020-03-31 Bristol-Myers Squibb Company Derivati imidazotiadiazola in imidazopirazina kot proteazno aktivirani receptor 4 (PAR4) inhibitorji za zdravljenje agregacije trombocitov
US9617279B1 (en) 2014-06-24 2017-04-11 Bristol-Myers Squibb Company Imidazooxadiazole compounds
US9598419B1 (en) 2014-06-24 2017-03-21 Universite De Montreal Imidazotriazine and imidazodiazine compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2857776A (en) 1955-01-13 1958-10-28 American Metal Prod Lead screw selectively operable and releasable under load
US3489755A (en) 1966-08-03 1970-01-13 Pfizer & Co C Imidazo (1,2-b) pyridazines
US3792166A (en) * 1970-11-16 1974-02-12 American Cyanamid Co Method of using substituted imidazo (2,1-b)thiazoles as anthelmintic agents
US3894022A (en) * 1973-06-25 1975-07-08 Sandoz Ag Tetracyclic quinazolinones and quinazolinium salts
JPS5398997A (en) * 1977-02-09 1978-08-29 Sumitomo Chem Co Ltd Fused pyridine derivertives and process for their preparation
GB2039882A (en) * 1979-01-05 1980-08-20 Ciba Geigy Ag Bicyclic thiadiaza compounds and their use as medicaments
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2568880B1 (fr) * 1984-08-07 1986-12-12 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2627491B1 (fr) * 1988-02-18 1992-01-24 Roussel Uclaf Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
JPH0753730B2 (ja) * 1988-07-26 1995-06-07 三共株式会社 イミダゾピラゾール誘導体
US5536853A (en) * 1994-04-11 1996-07-16 Chiron Corporation Opiate receptor ligands
DE10019714A1 (de) 2000-04-20 2002-01-10 Gruenenthal Gmbh Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen

Also Published As

Publication number Publication date
HUP0300532A3 (en) 2009-01-28
SK15022002A3 (sk) 2003-04-01
MXPA02009602A (es) 2003-03-10
EP1274709A1 (de) 2003-01-15
WO2001081344A1 (de) 2001-11-01
CA2402808A1 (en) 2001-11-01
JP2003531208A (ja) 2003-10-21
KR100756594B1 (ko) 2007-09-10
NO323542B1 (no) 2007-06-11
ATE277045T1 (de) 2004-10-15
ZA200209408B (en) 2004-02-19
US7087607B2 (en) 2006-08-08
US20060217378A1 (en) 2006-09-28
PT1274709E (pt) 2005-01-31
DE10019714A1 (de) 2002-01-10
RU2268888C2 (ru) 2006-01-27
CN1232520C (zh) 2005-12-21
AU5830501A (en) 2001-11-07
IL152352A (en) 2009-09-22
HUP0300532A2 (hu) 2003-07-28
NO20024838D0 (no) 2002-10-07
PL365676A1 (en) 2005-01-10
NO20024838L (no) 2002-10-07
US20030119842A1 (en) 2003-06-26
HK1052703A1 (en) 2003-09-26
CN1422270A (zh) 2003-06-04
SI1274709T1 (en) 2005-02-28
AU2001258305B2 (en) 2005-08-18
US7153873B2 (en) 2006-12-26
KR20020087497A (ko) 2002-11-22
NZ521069A (en) 2004-07-30
UY26675A1 (es) 2001-05-31
RU2002130245A (ru) 2004-03-27
TR200402755T4 (tr) 2004-12-21
ES2227186T3 (es) 2005-04-01
CZ20023476A3 (cs) 2003-01-15
HK1052703B (zh) 2005-04-22
IL152352A0 (en) 2003-05-29
DK1274709T3 (da) 2004-07-12
EP1274709B1 (de) 2004-09-22
DE50103764D1 (de) 2004-10-28
AR030559A1 (es) 2003-08-27
BR0110357A (pt) 2004-04-20

Similar Documents

Publication Publication Date Title
PE20011213A1 (es) Sales de imidazo-3-aminas e imidazo-5-aminas biciclicas n-aciladas y sus productos de adicion con acidos, procedimientos para su preparacion y medicamentos que contienen estos compuestos
FR2809396B1 (fr) Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
ES520987A0 (es) Procedimiento para la preparacion de derivados de acido espiro (4.(3+n))-2-aza-3carboxilico.
DE3760532D1 (en) Benzoûb¨thiophene and benzoûb¨furancarboxamide derivatives, processes for their preparation and therapeutical agents containing them
FI945538A (fi) 7-(2-Aminoetyyli)-bentsotiatsolonit
DK0446141T3 (da) Imidazo(1,2-c)quinazolinderivater og fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende dem
ES2094742T3 (es) Aminocarbonilcarbamatos relacionados con fisostigmina, un procedimiento para su preparacion y su uso como medicamentos.
MX21088A (es) N-heteroanil-purin-6-aminas, y un proceso para su preparacion y su uso como medicamentos.
PT93535A (pt) Processo para preparacao de derivados da eserolina e de composicoes farmaceuticas que os contem
KR940009185A (ko) 피라졸로[4,3-c]피리딘 및 세로토닌 재흡수 억제제로서의 이의 용도
RU2220953C2 (ru) Ненасыщенные производные гидроксимовой кислоты в качестве ингибиторов nadnad+ - adp-рибозилтрансферазы
AR005347A1 (es) Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos
DE3787844D1 (de) Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
PE20030758A1 (es) 1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion
NO151121C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive (1,2)-kondenserte 7-fenyl-1,4-benzodiazepinderivater
ES2190426T3 (es) Derivados de acidos arilo o heteroarilo quinolinil-fosfonicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
JPS6413063A (en) Tartaric acid amide derivative
BR8600409A (pt) Processo para a preparacao de 5-sulfonamido-1-aril-pirazois,composicao herbicida,processos para o combate de ervas daninhas e para a preparacao de composicoes
KR870006058A (ko) 6H-이소옥사졸로 [3,4-d]피라졸로 [3,4-b]피리딘 및 이의 제조방법
TH36106A (th) สารประกอบตัวใหม่ที่มีผลทำให้ไม่รู้สึกเจ็บปวด

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed