AR005347A1 - Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos - Google Patents

Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos

Info

Publication number
AR005347A1
AR005347A1 ARP970100015A ARP970100015A AR005347A1 AR 005347 A1 AR005347 A1 AR 005347A1 AR P970100015 A ARP970100015 A AR P970100015A AR P970100015 A ARP970100015 A AR P970100015A AR 005347 A1 AR005347 A1 AR 005347A1
Authority
AR
Argentina
Prior art keywords
compounds
pharmaceutical
hydroxy
manufacture
dependence
Prior art date
Application number
ARP970100015A
Other languages
English (en)
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AR005347A1 publication Critical patent/AR005347A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se desciben compuestos de fórmula (I) donde A es hidrógeno, hidroxi, donde R1 es hidrógeno, un grupo alquilo de 1 a 6 carbonos eventualmente substituídocon substitución hidroxi, alcoxi, o amino; arilo o heteroarilo eventualmente substituído conh alógeno, hidroxi o alcoxi; o bencilo eventualmente substituídocon halógeno, hidroxi o alcoxi; n es un número entero de 1 o 2 ; Z es N, CH o C(CH); m es un número entero de 1 a 3 , y X es hidrógeno, hidroxi o alcoxi, ysus sales farmacéuticamenteace ptables y sus isómeros geométricos u ópticos o las mezclas racémicas, cuando sea aplicable. Los compuestos de fórmula (I) seobtienen mediante el siguiente esquema de reacción de fórmula (II) También se describe uso de dichos copuestos I parala f abricación de medicamentos para eltratamiento de la ansiedad, de alteraciones psiquiatricas, de la náusea, el vómito y de la dependencia de fármacos.
ARP970100015A 1996-01-05 1997-01-03 Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos AR005347A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58331996A 1996-01-05 1996-01-05

Publications (1)

Publication Number Publication Date
AR005347A1 true AR005347A1 (es) 1999-04-28

Family

ID=24332609

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100015A AR005347A1 (es) 1996-01-05 1997-01-03 Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos

Country Status (14)

Country Link
EP (1) EP0874833A1 (es)
JP (1) JP3161737B2 (es)
KR (1) KR100308748B1 (es)
CN (1) CN1214046A (es)
AR (1) AR005347A1 (es)
AU (1) AU710059B2 (es)
BR (1) BR9612578A (es)
CA (1) CA2241845C (es)
HU (1) HUP9903706A3 (es)
IL (1) IL125197A0 (es)
NO (1) NO983100L (es)
NZ (1) NZ325587A (es)
WO (1) WO1997025317A1 (es)
ZA (1) ZA9725B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002015906A1 (en) * 2000-08-21 2002-02-28 Georgetown University 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon
EP1492796B1 (en) * 2002-04-02 2007-09-05 Janssen Pharmaceutica N.V. Substituted amino isoxazoline derivatives and their use as anti-depressants.
AR040967A1 (es) 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
ES2339444T3 (es) * 2002-08-15 2010-05-20 Janssen Pharmaceutica Nv Derivados de isoxazolina heterociclicos condensados y su uso como antidepresivos.
WO2004018482A2 (en) 2002-08-21 2004-03-04 Janssen Pharmaceutica N.V. C6- and c9-substituted chromeno[4, 3-c]isoxazoline derivatives and their use as anti-depressants
US8025859B2 (en) 2007-05-18 2011-09-27 Cesl Limited Process for gold and silver recovery from a sulphide concentrate
ES2759949T3 (es) 2009-10-29 2020-05-12 Bristol Myers Squibb Co Compuestos heterocíclicos tricíclicos
EP3507278B1 (en) 2016-09-02 2021-01-27 Bristol-Myers Squibb Company Substituted tricyclic heterocyclic compounds
WO2019032632A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company ALKYLPHENYL COMPOUNDS
US11059784B2 (en) 2017-08-09 2021-07-13 Bristol-Myers Squibb Company Oxime ether compounds
KR102002633B1 (ko) 2018-07-19 2019-07-22 김태효 완충이격부가 구비된 논슬립 발의류
KR102429797B1 (ko) 2019-12-31 2022-08-05 주식회사 제이패션 기능성 무재봉 덧신 및 이를 제조하는 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2119977A1 (en) * 1971-04-23 1971-12-16 Teikoku Hormone Manufacturing Co , Ltd, Tokio Antiphlogistic and antisecretory napththisoxazoles - from 1-hydroxyim - 2-carbonyl derivs by intramolecular condensation
ATE126512T1 (de) * 1989-05-19 1995-09-15 Hoechst Roussel Pharma N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
AU5341394A (en) * 1992-10-23 1994-05-24 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands

Also Published As

Publication number Publication date
KR100308748B1 (ko) 2001-12-12
JPH11510816A (ja) 1999-09-21
AU1412697A (en) 1997-08-01
WO1997025317A1 (en) 1997-07-17
ZA9725B (en) 1997-07-07
BR9612578A (pt) 1999-07-27
JP3161737B2 (ja) 2001-04-25
KR19990077033A (ko) 1999-10-25
NO983100L (no) 1998-09-04
HUP9903706A2 (hu) 2000-08-28
CA2241845C (en) 2002-10-01
HUP9903706A3 (en) 2000-09-28
CN1214046A (zh) 1999-04-14
AU710059B2 (en) 1999-09-09
CA2241845A1 (en) 1997-07-17
EP0874833A1 (en) 1998-11-04
NO983100D0 (no) 1998-07-03
IL125197A0 (en) 1999-03-12
NZ325587A (en) 1999-02-25

Similar Documents

Publication Publication Date Title
RU94031155A (ru) Амидин - производные, способ их получения, их использование в качестве ингибиторов no - синтазы, фармсостав, способ лечения
PT98393A (pt) Processo para a preparacao de derivados de quinuclidina
AR005347A1 (es) Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos
CY1105035T1 (el) Συγχωνευμενα με αρυλιο ή ετεροαρυλιο παραγωγα της ιμιδαζολης ως αντιφλεγμονωδεις και αναλγητικοι παραγοντες
DK0447285T3 (da) Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
NO942304D0 (no) Nye fosfonoravsyrederivater, fremgangsmåte for fremstilling derav, samt legemiddel inneholdende derivatene
NO965334D0 (no) Nye 4,6-diarylpyrimidin-derivater og salter derav
DK151800C (da) Analogifremgangsmaade til fremstilling af et 2-phenylenmorpholinderivat, herunder dettes optiske isomere, eller et farmaceutisk acceptabelt syreadditionssalt deraf
AR008291A1 (es) Derivados de tetrahidroisoquinolina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y su uso para la preparacionde un medicamento.
PT1216245E (pt) Derivados sulfonil-hidrazida farmaceuticamente activos
ES2147749T3 (es) Procedimiento para la preparacion de derivados de ciano-metoxiiminometilo.
AR013152A1 (es) Derivados de 2-alquilheterodihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n.
ES2183492T3 (es) Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
NO164593C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive karbamat- eller urea-derivater.
MX9405111A (es) Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina).
PT1178047E (pt) Derivados diazabiciclooctano e seus usos terapeuticos
PT91880A (pt) Processo para a preparacao de derivados ariloxi-,ariltio-,heteroariloxi- ou heteroariltio-alcenilenicos de aminas e de composicoes farmaceuticas que os contem
JPS5649374A (en) Novel 33aminoo11benzoxepin derivative* its manufacture and gastroointestinal movement trouble therapeutic drug containing it
AR006553A1 (es) COMPUESTOS ESPIRO[CICLOPENT[b] INDOLPIPERIDINAS] PARTICULARMENTE UTILES PARA ALIVIAR LA DISFUNCION DE LA MEMORIA, INTERMEDIARIOS, COMPOSICIONESFARMACEUTICAS, USOS Y PROCEDIMIENTOS DE PREPARACION DE DICHOS COMPUESTOS.
PT82634B (pt) Processo para a preparacao de novos compostos alcaloides contendo um nucleo berbano uteis como medicamentos
ATE195936T1 (de) Bis-imide derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitung
IT1304656B1 (it) Derivati dell'acido retinoico per uso medicinale e relativometodo di preparazione.
EA200100344A2 (ru) Новые циклобутаиндолкарбоксамидные производные, способ их получения и содержащие их фармацевтические композиции
EA200200563A1 (ru) Новые соединения инденоиндолона, способ их получения и фармацевтические композиции, их содержащие
DE3667976D1 (de) 3-iminopyridazinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.