UY32611A - Compuestos de 1-cianoetilheterociclilcarboxamida sustituidos 750 - Google Patents
Compuestos de 1-cianoetilheterociclilcarboxamida sustituidos 750Info
- Publication number
- UY32611A UY32611A UY0001032611A UY32611A UY32611A UY 32611 A UY32611 A UY 32611A UY 0001032611 A UY0001032611 A UY 0001032611A UY 32611 A UY32611 A UY 32611A UY 32611 A UY32611 A UY 32611A
- Authority
- UY
- Uruguay
- Prior art keywords
- cyanoethylethyclic
- substituted compounds
- carboxamide substituted
- carboxamide
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención provee compuestos de fórmula (I) en donde y, m, n, R1, R2 y Q son como se definen en la memoria descriptiva, un proceso para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17627909P | 2009-05-07 | 2009-05-07 | |
US18562909P | 2009-06-10 | 2009-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY32611A true UY32611A (es) | 2010-12-31 |
Family
ID=42271991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001032611A UY32611A (es) | 2009-05-07 | 2010-05-06 | Compuestos de 1-cianoetilheterociclilcarboxamida sustituidos 750 |
Country Status (22)
Country | Link |
---|---|
US (2) | US8193239B2 (es) |
EP (1) | EP2427445A1 (es) |
JP (1) | JP2012526093A (es) |
KR (1) | KR20120034639A (es) |
CN (1) | CN102574830A (es) |
AR (1) | AR076551A1 (es) |
AU (1) | AU2010244218B2 (es) |
BR (1) | BRPI1015540A2 (es) |
CA (1) | CA2759581A1 (es) |
CL (1) | CL2011002787A1 (es) |
CO (1) | CO6450612A2 (es) |
CR (1) | CR20110579A (es) |
CU (1) | CU20110204A7 (es) |
EA (1) | EA201190235A1 (es) |
EC (1) | ECSP11011439A (es) |
IL (1) | IL215615A0 (es) |
MX (1) | MX2011011661A (es) |
SG (1) | SG175090A1 (es) |
TW (1) | TW201041889A (es) |
UY (1) | UY32611A (es) |
WO (1) | WO2010128324A1 (es) |
ZA (1) | ZA201108962B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2764653C (en) | 2009-06-10 | 2018-01-02 | Chugai Seiyaku Kabushiki Kaisha | Tetracyclic compounds |
TWI526441B (zh) | 2010-08-20 | 2016-03-21 | 中外製藥股份有限公司 | 包含四環化合物的組成物 |
CN103491777B (zh) * | 2011-02-11 | 2015-05-06 | 葛兰素史密斯克莱知识产权发展有限公司 | 组织蛋白酶c抑制剂 |
WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
SG10201704588XA (en) | 2012-09-25 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Ret inhibitor |
EP2970230B1 (en) | 2013-03-14 | 2019-05-22 | Boehringer Ingelheim International GmbH | Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
WO2014140091A1 (en) | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
NZ710034A (en) | 2013-03-14 | 2020-06-26 | Boehringer Ingelheim Int | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
EP2970228B1 (en) * | 2013-03-14 | 2017-05-10 | Boehringer Ingelheim International GmbH | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin c |
CA2914132A1 (en) | 2013-06-21 | 2014-12-24 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
EP3013810A1 (en) | 2013-06-24 | 2016-05-04 | Lupin Limited | Chromane and chromene derivatives and their use as crac modulators |
WO2015032945A1 (en) * | 2013-09-09 | 2015-03-12 | Prozymex A/S | Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors |
NO2699580T3 (es) | 2014-01-24 | 2018-02-24 | ||
CA2946518C (en) | 2014-04-25 | 2022-07-26 | Chugai Seiyaku Kabushiki Kaisha | Preparation containing tetracyclic compound at high dose |
CN106458967A (zh) | 2014-04-25 | 2017-02-22 | 中外制药株式会社 | 四环化合物的新结晶 |
WO2015189744A1 (en) | 2014-06-12 | 2015-12-17 | Pfizer Limited | Imidazopyridazine derivatives as modulators of the gabaa receptor activity. |
JP6529575B2 (ja) | 2014-08-01 | 2019-06-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換オキセタンおよびそれらのカテプシンcの阻害薬としての使用 |
TWI803187B (zh) | 2014-08-08 | 2023-05-21 | 日商中外製藥股份有限公司 | 包含4環性化合物的非晶質體之固體分散體及製劑 |
KR102510588B1 (ko) | 2014-09-12 | 2023-03-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 카텝신 c의 스피로사이클릭 억제제 |
TWI752901B (zh) | 2015-01-16 | 2022-01-21 | 日商中外製藥股份有限公司 | 合併用醫藥 |
WO2016139355A1 (en) | 2015-03-05 | 2016-09-09 | Prozymex A/S | N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors |
AU2016227618B2 (en) * | 2015-03-05 | 2020-06-04 | Neuprozyme Therapeutics ApS | Peptidyl nitril compounds as dipeptidyl peptidase I inhibitors |
CN106478629A (zh) * | 2015-08-24 | 2017-03-08 | 上海医药工业研究院 | 一种利格列汀的制备工艺 |
US11174250B2 (en) | 2016-03-01 | 2021-11-16 | Propellon Therapeutics Inc. | Substituted carboxamides as inhibitors of WDR5 protein-protein binding |
EA038109B1 (ru) | 2016-03-01 | 2021-07-07 | Пропеллон Терапьютикс Инк. | Ингибиторы связывания белка wdr5 с белками |
US20180028541A1 (en) * | 2016-07-29 | 2018-02-01 | Astrazeneca Ab | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors for treating bronchiectasis |
WO2020018551A1 (en) * | 2018-07-17 | 2020-01-23 | Insmed Incorporated | Certain (2s)- n-[(1s)-1-cyano-2-phenylethyl]-1,4- oxazepane-2-carboxamides for treating inflammatory bowel disease |
AU2019306532A1 (en) * | 2018-07-17 | 2021-03-04 | Insmed Incorporated | Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis |
CA3107270A1 (en) | 2018-09-04 | 2020-03-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing tetracyclic compound |
CN115996923A (zh) * | 2020-08-26 | 2023-04-21 | 四川海思科制药有限公司 | 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途 |
KR20230117738A (ko) | 2020-12-04 | 2023-08-09 | 레이스톤 바이오파마 컴퍼니 리미티드 | 카텝신 c의 소분자 억제제 및 이의 의약적 용도 |
AU2022218443A1 (en) * | 2021-02-05 | 2023-09-21 | Medshine Discovery Inc. | Fused ring derivatives containing 1,4-oxazepane |
WO2023160541A1 (zh) * | 2022-02-22 | 2023-08-31 | 四川海思科制药有限公司 | 一种含氮杂环化合物的制备方法 |
WO2024008680A1 (en) | 2022-07-06 | 2024-01-11 | Chiesi Farmaceutici S.P.A. | Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
MXPA02001014A (es) | 1999-07-30 | 2002-08-12 | Boehringer Ingelheim Pharma | Nuevos compuestos derivados de succinato utiles como inhibidores de cisteina-proteasa. |
WO2001047886A1 (en) | 1999-12-24 | 2001-07-05 | F. Hoffmann-La Roche Ag | Nitrile derivatives as cathepsin k inhibitors |
CA2450722A1 (en) | 2001-06-27 | 2003-01-09 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
US7183290B2 (en) | 2001-06-27 | 2007-02-27 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
ES2344057T3 (es) * | 2002-10-23 | 2010-08-17 | Bristol-Myers Squibb Company | Inhibidores de la dipeptidil peptidasa iv basados en nitrilos de glicina. |
EP1638925A1 (en) * | 2003-06-18 | 2006-03-29 | Prozymex A/S | Protease inhibitors |
US7504413B2 (en) * | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
-
2010
- 2010-05-05 AU AU2010244218A patent/AU2010244218B2/en not_active Ceased
- 2010-05-05 WO PCT/GB2010/050736 patent/WO2010128324A1/en active Application Filing
- 2010-05-05 BR BRPI1015540A patent/BRPI1015540A2/pt not_active IP Right Cessation
- 2010-05-05 CA CA2759581A patent/CA2759581A1/en not_active Abandoned
- 2010-05-05 CN CN2010800307151A patent/CN102574830A/zh active Pending
- 2010-05-05 MX MX2011011661A patent/MX2011011661A/es not_active Application Discontinuation
- 2010-05-05 EP EP10719056A patent/EP2427445A1/en not_active Withdrawn
- 2010-05-05 KR KR1020117029122A patent/KR20120034639A/ko not_active Application Discontinuation
- 2010-05-05 EA EA201190235A patent/EA201190235A1/ru unknown
- 2010-05-05 JP JP2012509091A patent/JP2012526093A/ja active Pending
- 2010-05-05 SG SG2011072774A patent/SG175090A1/en unknown
- 2010-05-06 US US12/774,996 patent/US8193239B2/en not_active Expired - Fee Related
- 2010-05-06 UY UY0001032611A patent/UY32611A/es not_active Application Discontinuation
- 2010-05-06 TW TW099114513A patent/TW201041889A/zh unknown
- 2010-05-07 AR ARP100101567A patent/AR076551A1/es unknown
-
2011
- 2011-10-06 IL IL215615A patent/IL215615A0/en unknown
- 2011-10-31 CO CO11147437A patent/CO6450612A2/es not_active Application Discontinuation
- 2011-11-07 EC EC2011011439A patent/ECSP11011439A/es unknown
- 2011-11-07 CR CR20110579A patent/CR20110579A/es unknown
- 2011-11-07 CL CL2011002787A patent/CL2011002787A1/es unknown
- 2011-11-07 CU CU20110204A patent/CU20110204A7/es unknown
- 2011-12-06 ZA ZA2011/08962A patent/ZA201108962B/en unknown
-
2012
- 2012-06-04 US US13/488,248 patent/US20120329775A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8193239B2 (en) | 2012-06-05 |
WO2010128324A1 (en) | 2010-11-11 |
CU20110204A7 (es) | 2012-03-15 |
AU2010244218B2 (en) | 2012-07-19 |
SG175090A1 (en) | 2011-11-28 |
TW201041889A (en) | 2010-12-01 |
CL2011002787A1 (es) | 2012-06-22 |
CN102574830A (zh) | 2012-07-11 |
ECSP11011439A (es) | 2011-12-30 |
US20120329775A1 (en) | 2012-12-27 |
US20100286118A1 (en) | 2010-11-11 |
MX2011011661A (es) | 2011-11-18 |
ZA201108962B (en) | 2012-08-29 |
JP2012526093A (ja) | 2012-10-25 |
AR076551A1 (es) | 2011-06-22 |
CR20110579A (es) | 2012-01-09 |
EP2427445A1 (en) | 2012-03-14 |
CO6450612A2 (es) | 2012-05-31 |
KR20120034639A (ko) | 2012-04-12 |
IL215615A0 (en) | 2011-12-29 |
CA2759581A1 (en) | 2010-11-11 |
AU2010244218A1 (en) | 2011-11-03 |
EA201190235A1 (ru) | 2012-05-30 |
BRPI1015540A2 (pt) | 2019-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20181127 |