NO985518L - Morfinanderivater og medisinsk anvendelse derav - Google Patents

Morfinanderivater og medisinsk anvendelse derav

Info

Publication number
NO985518L
NO985518L NO985518A NO985518A NO985518L NO 985518 L NO985518 L NO 985518L NO 985518 A NO985518 A NO 985518A NO 985518 A NO985518 A NO 985518A NO 985518 L NO985518 L NO 985518L
Authority
NO
Norway
Prior art keywords
medical use
morphine derivatives
morphinan derivatives
opioid
epsilon
Prior art date
Application number
NO985518A
Other languages
English (en)
Other versions
NO985518D0 (no
Inventor
Hiroshi Nagase
Hideaki Fujii
Takashi Endoh
Koji Kawai
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO985518D0 publication Critical patent/NO985518D0/no
Publication of NO985518L publication Critical patent/NO985518L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
NO985518A 1997-03-27 1998-11-26 Morfinanderivater og medisinsk anvendelse derav NO985518L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7634097 1997-03-27
PCT/JP1998/001376 WO1998043978A1 (fr) 1997-03-27 1998-03-27 Derives de morphinane et usage medical de ces derniers

Publications (2)

Publication Number Publication Date
NO985518D0 NO985518D0 (no) 1998-11-26
NO985518L true NO985518L (no) 1999-01-21

Family

ID=13602637

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985518A NO985518L (no) 1997-03-27 1998-11-26 Morfinanderivater og medisinsk anvendelse derav

Country Status (12)

Country Link
US (1) US6187782B1 (no)
EP (1) EP0915094B1 (no)
KR (1) KR20000016052A (no)
CN (1) CN1150196C (no)
AT (1) ATE377602T1 (no)
AU (1) AU743929B2 (no)
CA (1) CA2256897C (no)
DE (1) DE69838662T2 (no)
ES (1) ES2297882T3 (no)
NO (1) NO985518L (no)
NZ (1) NZ333101A (no)
WO (1) WO1998043978A1 (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219624B1 (en) * 1999-08-24 2008-07-09 Toray Industries, Inc. Remedies for neuropathic pain and model animals of neuropathic pain
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
US8134002B2 (en) * 2006-10-17 2012-03-13 Penick Corporation Process for preparing oxymorphone
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
CN102964302B (zh) * 2007-05-01 2015-10-21 康塞特医药品公司 ***烷化合物
HUE063526T2 (hu) 2007-05-01 2024-01-28 Concert Pharmaceuticals Ind Inc Morfinvegyületek
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
WO2009149347A1 (en) 2008-06-05 2009-12-10 President And Fellows Of Harvard College High-valent palladium fluoride complexes and uses thereof
ES2660001T3 (es) * 2008-10-24 2018-03-20 Toray Industries, Inc. Comprimido estable que contiene un derivado de 4,5-epoximorfinano
AU2009316478A1 (en) 2008-11-20 2010-05-27 President And Fellows Of Harvard College Fluorination of organic compounds
KR20110104097A (ko) * 2009-01-09 2011-09-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 불소 함유 화합물 및 이의 사용방법
JP2014073964A (ja) * 2011-01-28 2014-04-24 Kitasato Institute モルヒナン誘導体
US9150516B2 (en) 2011-04-12 2015-10-06 President And Fellows Of Harvard College Fluorination of organic compounds
US8952030B2 (en) 2011-09-09 2015-02-10 The Kitasato Institute Morphinan derivative
WO2014021273A1 (ja) * 2012-07-30 2014-02-06 学校法人北里研究所 モルヒナン誘導体
WO2014052622A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
WO2014102591A1 (en) 2012-12-31 2014-07-03 Rhodes Technologies PROCESS FOR PREPARING 7β-SUBSTITUTED 6α,14α -ETHENOMORPHINANS AND 7β-SUBSTITUTED 6α,14α-ETHANOMORPHINANS
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
WO2015058047A2 (en) 2013-10-18 2015-04-23 President And Fellows Of Harvard College Fluorination of organic compounds
JP6814470B2 (ja) * 2017-02-10 2021-01-20 国立大学法人 筑波大学 モルヒナン誘導体
JPWO2019045006A1 (ja) * 2017-08-31 2020-10-01 国立大学法人 筑波大学 モルヒナン誘導体
WO2019168025A1 (ja) * 2018-02-28 2019-09-06 日本ケミファ株式会社 モルヒナン誘導体の製造方法
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2229770A1 (de) * 1972-06-19 1974-01-10 Boehringer Sohn Ingelheim N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
ZA855058B (en) * 1984-07-05 1987-03-25 Du Pont Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes
PT95069B (pt) * 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
EP0846694A1 (en) 1992-01-23 1998-06-10 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications

Also Published As

Publication number Publication date
AU6518998A (en) 1998-10-22
KR20000016052A (ko) 2000-03-25
US6187782B1 (en) 2001-02-13
CN1150196C (zh) 2004-05-19
CA2256897A1 (en) 1998-10-08
NZ333101A (en) 2000-05-26
NO985518D0 (no) 1998-11-26
EP0915094A1 (en) 1999-05-12
WO1998043978A1 (fr) 1998-10-08
ES2297882T3 (es) 2008-05-01
AU743929B2 (en) 2002-02-07
CA2256897C (en) 2006-10-03
EP0915094A4 (en) 2004-09-22
DE69838662T2 (de) 2008-08-28
DE69838662D1 (de) 2007-12-20
CN1220667A (zh) 1999-06-23
ATE377602T1 (de) 2007-11-15
EP0915094B1 (en) 2007-11-07

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